LOCUS       NP_001178553            2013 aa            linear   ROD 24-JUN-2024
DEFINITION  leucine-rich repeat serine/threonine-protein kinase 1 [Rattus
            norvegicus].
ACCESSION   NP_001178553 XP_063118546 XP_218760
VERSION     NP_001178553.1
DBSOURCE    REFSEQ: accession NM_001191624.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 2013)
  AUTHORS   Xing,W., Liu,J., Cheng,S., Vogel,P., Mohan,S. and Brommage,R.
  TITLE     Targeted disruption of leucine-rich repeat kinase 1 but not
            leucine-rich repeat kinase 2 in mice causes severe osteopetrosis
  JOURNAL   J Bone Miner Res 28 (9), 1962-1974 (2013)
   PUBMED   23526378
REFERENCE   2  (residues 1 to 2013)
  AUTHORS   Berwick,D.C. and Harvey,K.
  TITLE     LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic
            proteins and membrane-localized LRP6
  JOURNAL   Hum Mol Genet 21 (22), 4966-4979 (2012)
   PUBMED   22899650
REFERENCE   3  (residues 1 to 2013)
  AUTHORS   Civiero,L., Vancraenenbroeck,R., Belluzzi,E., Beilina,A.,
            Lobbestael,E., Reyniers,L., Gao,F., Micetic,I., De Maeyer,M.,
            Bubacco,L., Baekelandt,V., Cookson,M.R., Greggio,E. and
            Taymans,J.M.
  TITLE     Biochemical characterization of highly purified leucine-rich repeat
            kinases 1 and 2 demonstrates formation of homodimers
  JOURNAL   PLoS One 7 (8), e43472 (2012)
   PUBMED   22952686
REFERENCE   4  (residues 1 to 2013)
  AUTHORS   Klein,C.L., Rovelli,G., Springer,W., Schall,C., Gasser,T. and
            Kahle,P.J.
  TITLE     Homo- and heterodimerization of ROCO kinases: LRRK2 kinase
            inhibition by the LRRK2 ROCO fragment
  JOURNAL   J Neurochem 111 (3), 703-715 (2009)
   PUBMED   19712061
REFERENCE   5  (residues 1 to 2013)
  AUTHORS   Westerlund,M., Belin,A.C., Anvret,A., Bickford,P., Olson,L. and
            Galter,D.
  TITLE     Developmental regulation of leucine-rich repeat kinase 1 and 2
            expression in the brain and other rodent and human organs:
            Implications for Parkinson's disease
  JOURNAL   Neuroscience 152 (2), 429-436 (2008)
   PUBMED   18272292
  REMARK    GeneRIF: Lrrk1 is found in many areas of the P1 rat. Lrrk1 is
            present in adult rat brain, adrenal gland, liver, lung, spleen and
            kidney and also in embryonic brain, with declining gene activity
            after birth.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Jun 10, 2024 this sequence version replaced
            XP_063118546.1, XP_218760.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.2687.1,
                                           SRR26643290.2218.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2013
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     Protein         1..2013
                     /product="leucine-rich repeat serine/threonine-protein
                     kinase 1"
                     /EC_number="2.7.11.1"
                     /calculated_mol_wt=225318
     Region          58..>218
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          91..119
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(126,129..131,133..134,138,141,154,156,158..159,
                     162..164,166..167,171,175,186,188,195,199..200,203..205,
                     207..208,212,215)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          156..186
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          188..218
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <264..581
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          281..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..330
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          331..381
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          382..405
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          406..451
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          452..474
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          475..498
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          499..549
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          550..572
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          639..821
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            645..652
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206648"
     Site            order(647..653,702,757..758,760,805..807)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206648"
     Site            672
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206648"
     Site            674..676
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206648"
     Site            699..702
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206648"
     Site            order(701..702,718..719)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206648"
     Site            757..760
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206648"
     Site            805..807
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206648"
     Region          844..1036
                     /region_name="COR"
                     /note="C-terminal of Roc, COR, domain; pfam16095"
                     /db_xref="CDD:406489"
     Region          1248..1523
                     /region_name="STKc_LRRK1"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Leucine-Rich Repeat Kinase 1; cd14067"
                     /db_xref="CDD:270969"
     Site            order(1248..1252,1256,1268,1270,1320,1334..1337,1341,1343,
                     1386,1388,1390..1391,1393,1409,1412,1426..1429)
                     /site_type="active"
                     /db_xref="CDD:270969"
     Site            order(1248..1252,1256,1268,1270,1320,1334..1337,1341,1386,
                     1388,1390..1391,1393,1409)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270969"
     Site            order(1252,1341,1343,1386,1388,1390,1412,1426..1429)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270969"
     Site            1408..1429
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270969"
     CDS             1..2013
                     /gene="Lrrk1"
                     /coded_by="NM_001191624.2:243..6284"
                     /db_xref="GeneID:308703"
                     /db_xref="RGD:1308000"
ORIGIN      
        1 maavsqrpps mywcvgtegs vvcpgpamet hngaedmgsk lslpggnspv qspnmeeiht
       61 aykqrnlsra rdllrevcee sespqekgql lsisaahgdl etvrflltek rvelpmeptd
      121 dnpavvaahf ghaevvhell eslsgpcasq rllnwmlala cqrghlevvk llvlthgadp
      181 enyavrknef pvivrlplya aikagnedia ifllrhgayf csyilldspd pskhllrkyf
      241 ieasalpssc pgktalcvkw shlklpwvdl dwlldiscqi teldlsancl sslpsiipwg
      301 linlkklnls nnhlgelpcv qssdeiicsr lveidissnk lshlppgflh lsklerltas
      361 knylerlfee enatnwiglr kleeldladn rltelpvqfm hsfksltnln vsrnslksfp
      421 dpwscplkcc kasknalesl pdkmavfwkn hlrdvdfsen slkavplgvf qldalmflrl
      481 qgnlllslph hekwtcrqlk tldlsrnqlg knedglktkr islfttrgrq rsgtetasvl
      541 efpaflsesl evlclndnhl davppsvcll knlselylgn npglrelppe lgqlgnlwql
      601 diedlnignv paevrkegpk atlsflraql rkaekcklmk milvgpprqg kstlleilqt
      661 gkapqpahse atvrttkwel qrpagskakv esvefnvwdi ggpasmatvn qcfftdkaly
      721 vvvwnlalge eavanlqfwl lnieakapna vvlvvgthld lieakfrver iatlrayvla
      781 lcrspsgsra tgfpditfkh lheiscknle gqeglrqlif hvtcnmkdvg stigcqklag
      841 rliprsyisl qeavlaeqqr rsledqvqyl tdrqleqlve qtpgndikdy edlqsaisfl
      901 ietgtllhfp dtshglrnly fldpiwlsec lqrifnikgs rsvakngvir aedlrmllvg
      961 tgftqqteeq yfqflakfei alpvandsyl lphllpskpg ldthsmrhpm antiqrvfkm
     1021 sfvpvgfwqr fiarmlisla emdlqlfenk kntksrnrkv tiysftgnqr nrcstfrvrr
     1081 nqtiywqegl lvtfdggyls vessdvnwkk kksggikivc qsemrdfsam afitdhvnsl
     1141 idqwfpalta tesdgtplme qyvpcpvcea swaqhadpne rsesvqyfdm edcvltaieg
     1201 nfiscprhpd lpvplqelvp elfmtdfpar lflenskleh tegensilgq ggsgtviyqa
     1261 qyqgqpvavk rfhikkfkns anapadtmlr hlramdamkn fsdfrqeasm lhalqhpciv
     1321 sligisihpl cfalelaplg slntvlsena kdssfmplgh mltqkiayqi asglaylhkk
     1381 niifcdlksd nilvwslsvk eliniklsdy gisrqsfheg algvegtpgy qapeirpriv
     1441 ydekvdmfsy gmvlyellsg qrpalghhql qivkklskgi rpvlgqpeev qfyrlqalmm
     1501 ecwdtkpekr plalsvvsqm kdptfatfmy mlpcgkqssf fssqsqeytv vfwdgkeesr
     1561 nytvvntekg llevqrmtcp gmklscqlkv qssvwlated qkiyiyslkg mcplsmpqqa
     1621 ldtpavvtcf lavpvikkns flvlagladg lvavfsmarg tpkescsylc shtanrskfc
     1681 ipdedsrqnp ypvramevvn sgsevwysng pglliidcai ldisrrlepy aapsvvtslv
     1741 cssdcrgeet vwclddkgns lvmyhsatyq lcaryfcgdp splrdtfsvq psvpespirh
     1801 ittskepeee ciadvsimys eelgmqilth qdsltdycsv ssysstphpd pksptslpss
     1861 ltsyssvpfs anyedpdrlq epsvtpdrte hdlspmdget fsqhlqavkv lavqdliwvp
     1921 rhggdiivig lekdsgaqrg rviavlkare lnphgvlvda avvakdtvvc gfanentewc
     1981 lavwrgwgar efdifyqsye elgrleacpr krr
//
