LOCUS       NP_001029311             795 aa            linear   ROD 24-JUN-2024
DEFINITION  volume-regulated anion channel subunit LRRC8E [Rattus norvegicus].
ACCESSION   NP_001029311 XP_221814
VERSION     NP_001029311.1
DBSOURCE    REFSEQ: accession NM_001034139.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 795)
  AUTHORS   Lutter,D., Ullrich,F., Lueck,J.C., Kempa,S. and Jentsch,T.J.
  TITLE     Selective transport of neurotransmitters and modulators by distinct
            volume-regulated LRRC8 anion channels
  JOURNAL   J Cell Sci 130 (6), 1122-1133 (2017)
   PUBMED   28193731
REFERENCE   2  (residues 1 to 795)
  AUTHORS   Syeda,R., Qiu,Z., Dubin,A.E., Murthy,S.E., Florendo,M.N.,
            Mason,D.E., Mathur,J., Cahalan,S.M., Peters,E.C., Montal,M. and
            Patapoutian,A.
  TITLE     LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense
            Ionic Strength
  JOURNAL   Cell 164 (3), 499-511 (2016)
   PUBMED   26824658
REFERENCE   3  (residues 1 to 795)
  AUTHORS   Voss,F.K., Ullrich,F., Munch,J., Lazarow,K., Lutter,D., Mah,N.,
            Andrade-Navarro,M.A., von Kries,J.P., Stauber,T. and Jentsch,T.J.
  TITLE     Identification of LRRC8 heteromers as an essential component of the
            volume-regulated anion channel VRAC
  JOURNAL   Science 344 (6184), 634-638 (2014)
   PUBMED   24790029
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Oct 14, 2005 this sequence version replaced XP_221814.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105779.1, DN948377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093042, SAMN16093045
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     Protein         1..795
                     /product="volume-regulated anion channel subunit LRRC8E"
                     /note="leucine-rich repeat-containing protein 8E; leucine
                     rich repeat containing 8 family, member E"
                     /calculated_mol_wt=90314
     Region          1..330
                     /region_name="Pannexin_like"
                     /note="Pannexin-like TM region of LRRC8; pfam12534"
                     /db_xref="CDD:463622"
     Site            23..43
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Site            63
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Site            117..137
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Site            265..285
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Site            301
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Site            313..333
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Region          508..532
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          535..556
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Region          536..558
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          558..578
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Region          559..582
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          562..>764
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          582..603
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Region          583..605
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          605..626
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Region          606..630
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          630..651
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Region          631..653
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          653..674
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Region          654..676
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          676..697
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Region          677..699
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          699..720
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Region          700..722
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          722..743
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Region          723..745
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          745..766
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KRC6.1)"
     Region          746..766
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..795
                     /gene="Lrrc8e"
                     /gene_synonym="RGD1311979"
                     /coded_by="NM_001034139.2:73..2460"
                     /db_xref="GeneID:304203"
                     /db_xref="RGD:1311979"
ORIGIN      
        1 mipvaefkqf teqqpafkvl kpwwdvlaey ltvamlmigv fgctlqvtqd kiiclpshes
       61 rensseapcq qllpqgiseq igglrelsgl knnldlqqys finqlcyeta lhwyakyfpy
      121 lvvihtlifm vctsfwfkfp gtsskiehfi silgkcfdsp wttralsevs genhkgpaag
      181 ratvttvttv gtgtgkvgeg ekekvliepe kvvteppavt lldkkegeqa kalfekvkkf
      241 rvhveegdil ysmyirqtvl kvckffailv ynlvyvekis flvacrvets eitgyasfcc
      301 nhtkahlfsk lafcyisfvc vygitclytl ywlfhrplke ysfrsvreet gmndipdvrn
      361 dfafmlhlid qydslyskrf avflsevses rlkqlnlnhe wtpdklrqkl qrnargrlel
      421 slcmlpglpd tvfelsevea lrleaicdis fppglsqlvn lqelsllhsp arlpfssqif
      481 lrdrlkvicv kfeelrevpl wvfglrglee lhleglfppe margatlesl relkqlkvls
      541 lrsnagkvpa svtdvaghlq rlslhndgar llalnslkkl avlrelelva cgleriphai
      601 fslgalqeld lkdnhlrsie eilsfqhcrk lvilrlwhnq iayvpehvrk lrsleqlyls
      661 hnkletlpaq lgqcfglrll dvshnglrsl ppelgllqsl qhlalsynal eslpdelffc
      721 hklrtlllgy nhltqfsphv aalqalsrle lkgnrlealp eelgdckglk ksgllvedtl
      781 yeglpaevre kmeee
//
