LOCUS       NM_001037179            2883 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus leucine rich repeat containing 8 VRAC subunit C
            (Lrrc8c), mRNA.
ACCESSION   NM_001037179 XM_213999
VERSION     NM_001037179.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2883)
  AUTHORS   Deneka,D., Sawicka,M., Lam,A.K.M., Paulino,C. and Dutzler,R.
  TITLE     Structure of a volume-regulated anion channel of the LRRC8 family
  JOURNAL   Nature 558 (7709), 254-259 (2018)
   PUBMED   29769723
REFERENCE   2  (bases 1 to 2883)
  AUTHORS   Schober,A.L., Wilson,C.S. and Mongin,A.A.
  TITLE     Molecular composition and heterogeneity of the LRRC8-containing
            swelling-activated osmolyte channels in primary rat astrocytes
  JOURNAL   J Physiol 595 (22), 6939-6951 (2017)
   PUBMED   28833202
REFERENCE   3  (bases 1 to 2883)
  AUTHORS   Syeda,R., Qiu,Z., Dubin,A.E., Murthy,S.E., Florendo,M.N.,
            Mason,D.E., Mathur,J., Cahalan,S.M., Peters,E.C., Montal,M. and
            Patapoutian,A.
  TITLE     LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense
            Ionic Strength
  JOURNAL   Cell 164 (3), 499-511 (2016)
   PUBMED   26824658
REFERENCE   4  (bases 1 to 2883)
  AUTHORS   Voss,F.K., Ullrich,F., Munch,J., Lazarow,K., Lutter,D., Mah,N.,
            Andrade-Navarro,M.A., von Kries,J.P., Stauber,T. and Jentsch,T.J.
  TITLE     Identification of LRRC8 heteromers as an essential component of the
            volume-regulated anion channel VRAC
  JOURNAL   Science 344 (6184), 634-638 (2014)
   PUBMED   24790029
REFERENCE   5  (bases 1 to 2883)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2883)
  AUTHORS   Tominaga,K., Kondo,C., Kagata,T., Hishida,T., Nishizuka,M. and
            Imagawa,M.
  TITLE     The novel gene fad158, having a transmembrane domain and
            leucine-rich repeat, stimulates adipocyte differentiation
  JOURNAL   J Biol Chem 279 (33), 34840-34848 (2004)
   PUBMED   15184384
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100076.1.
            
            On Nov 18, 2005 this sequence version replaced XM_213999.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100076.1, CV077646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2883
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2883
                     /gene="Lrrc8c"
                     /gene_synonym="RGD1306585"
                     /note="leucine rich repeat containing 8 VRAC subunit C"
                     /db_xref="GeneID:289443"
                     /db_xref="RGD:1306585"
     exon            1..201
                     /gene="Lrrc8c"
                     /gene_synonym="RGD1306585"
                     /inference="alignment:Splign:2.1.0"
     exon            202..272
                     /gene="Lrrc8c"
                     /gene_synonym="RGD1306585"
                     /inference="alignment:Splign:2.1.0"
     exon            273..414
                     /gene="Lrrc8c"
                     /gene_synonym="RGD1306585"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..2688
                     /gene="Lrrc8c"
                     /gene_synonym="RGD1306585"
                     /note="leucine-rich repeat-containing protein 8C; leucine
                     rich repeat containing 8 family, member C"
                     /codon_start=1
                     /product="volume-regulated anion channel subunit LRRC8C"
                     /protein_id="NP_001032256.1"
                     /db_xref="GeneID:289443"
                     /db_xref="RGD:1306585"
                     /translation="MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCT
                     LQVMQDKIICLPKRVQPAQNHSSLSNVSQTVINTTPLPPPKPSPTNPATVEMKGLKTD
                     LDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS
                     ILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNRSNTIQSGPEGSLVKSQSLKSIPE
                     KFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLII
                     IAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTC
                     LYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFL
                     SEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLK
                     LEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPP
                     WMYGLRNLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSH
                     LQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL
                     KSIEEIVSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLC
                     NKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNS
                     LSVLSPKIGNLLFLSYLDIKGNHFEVLPPELGDCRALKRAGLVVEDALFETLPSDVRE
                     QMKAD"
     exon            415..2855
                     /gene="Lrrc8c"
                     /gene_synonym="RGD1306585"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctggggcg ttagctgcgt cccggctcag agcccgcgaa gaggacgagg accgaggcgc
       61 cgccgcgtcc ctggccgtag cactctggtc gcgacaagcc atgagcagcg acgccgcggt
      121 cgctggccgt cgctgagccc aacccggaca cagctcgccg cgccctggca tcctgttttg
      181 cggacaccct cgcccccaga gattaatgtg gctgcttatg actaagaatt ctgggaccac
      241 agatgttcag agaagtaaca tatacatata agaaacatga ttccagtgac cgagttccgg
      301 cagttctccg agcagcagcc tgccttccgg gtgctgaagc cgtggtggga tgtgttcacg
      361 gactacctct cggtggccat gctgatgatc ggggtgtttg gatgtacttt acaagtcatg
      421 caagacaaga tcatctgcct cccaaaaaga gtgcagcctg ctcagaacca ctcttccctc
      481 tccaacgtct cccagactgt gatcaatacc accccgctgc ccccacctaa accctctccg
      541 accaacccgg cgaccgtgga gatgaaggga ctgaagacag acctggacct ccagcagtac
      601 agtttcatca accagatgtg ctacgagcga gccctccact ggtatgccaa gtacttcccg
      661 taccttgtgc tcatccacac cctggtcttc atgctctgca gcaacttctg gttcaagttc
      721 cctggatcta gttccaaaat agaacatttc atctccatcc tggggaagtg cttcgactcc
      781 ccgtggacca ctcgggctct ctccgaggtg tctggcgagg actccgaaga gaaggacaat
      841 aggaagaaca acatgaacag gtccaacacc atccagtccg gtccggaagg cagcctggtc
      901 aagtcccagt ctctcaagtc aattcccgag aagttcgtgg ttgacaaatc cactgcgggg
      961 gctctggaca agaaggaagg tgaacaggcc aaggccttgt tcgagaaggt taagaagttc
     1021 agactgcacg tggaggaagg tgacatcctg tatgccatgt atgtgcggca gactgtgctt
     1081 aaggtcatca agttcctgat catcatcgcc tacaacagtg ctctggtttc caaagtccag
     1141 ttcaccgtgg actgcaatgt ggacatccag gacatgacgg gctataagaa cttttcctgc
     1201 aatcacacca tggctcattt gttctccaaa ctctcctttt gctacctgtg ctttgtaagc
     1261 atctacggcc tgacgtgcct ttataccttg tactggctgt tctaccgttc tctgagggag
     1321 tactcttttg agtatgtccg gcaggagact ggaatcgatg acattccgga cgtgaaaaat
     1381 gactttgcct ttatgctcca tatgatagac cagtatgacc ctctctattc caagaggttt
     1441 gcggtgttcc tctctgaggt cagcgagaac aagttaaagc agctcaactt aaataacgag
     1501 tggacccccg acaagctgcg gcagaagctg cagacgaatg cccacaaccg cctggagctg
     1561 cctctcatca tgctgtctgg cctcccagac accgtgttcg agatcacgga gttacagtcc
     1621 ctgaagctgg agatcattaa gaacgtcatg atacccgcca ccatcgccca gctagacaac
     1681 cttcaggagc tctccctcca ccagtgctcc gtcaagatcc acagtgcggc actctccttc
     1741 ctgaaggaga atctcaaggt cttgagcgtc aagttcgatg acatgaggga gctgcccccc
     1801 tggatgtacg gcctccggaa tctggaagag ctctatctgg ttggctctct gagtcacgac
     1861 atctccaaaa acgtcaccct ggagtccctg cgggacctca aaagccttaa aatcctttcc
     1921 atcaagagca acgtctccaa gatccctcag gccgtggtgg atgtgtccag ccacctccag
     1981 aagatgtgca ttcacaacga cggcaccaag ctggtaatgc tcaacaacct gaagaagatg
     2041 accaacctga ccgagctgga actggtccac tgcgacctgg aacgcattcc ccacgccgtg
     2101 ttcagcctgc tcagtctcca ggagctggac ctgaaggaga acaacctgaa gtccatagag
     2161 gagatcgtga gtttccagca cttgagaaag ctaaccgtgc tcaaactgtg gtataacagc
     2221 atcgcttaca tcccagagca catcaagaaa ctgaccagcc tggagcgact gtttttcagc
     2281 cacaataagg tagaagtgct tccctcccac ctcttcctgt gcaacaaaat cagatacctg
     2341 gacctgtcct ataacgacat tcgcttcatc ccgcccgaaa tcggggttct gcaaagttta
     2401 cagtatttct ccatcacctg taacaaagtg gagagcctcc cggatgaact ctacttctgc
     2461 aagaaactta aaacattgaa gatcgggaaa aacagcctct ctgtactttc accaaaaatt
     2521 ggaaacttac tatttctttc ctacttagac atcaaaggca atcactttga agtcctccct
     2581 cccgagctgg gagactgccg ggctctgaaa cgagccgggc tggttgtgga agacgctctg
     2641 tttgagactc tgccctcaga tgtccgggag caaatgaaag cagactaact tatttttcat
     2701 caaaatatga ctgaaacatg cttctaccaa atacaatata aagaattagg tagtcctaat
     2761 gcctttccta tattattttt tttcttttcc acaccaagac atgtacacaa agatcgagta
     2821 aggagtatgt attttttaat aaaagtttaa ttgtaaaaaa aaaaaaaaaa aaaaaaaaaa
     2881 aaa
//
