LOCUS       NM_057142               6891 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus leucine rich repeat containing 7 (Lrrc7),
            transcript variant 2, mRNA.
ACCESSION   NM_057142 XM_346645
VERSION     NM_057142.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6891)
  AUTHORS   Dosemeci,A., Tao-Cheng,J.H., Loo,H. and Reese,T.S.
  TITLE     Distribution of densin in neurons
  JOURNAL   PLoS One 13 (10), e0205859 (2018)
   PUBMED   30325965
  REMARK    GeneRIF: Analysis of densin at the ultrastructural level reveals
            potential sites that can support specific interactions of densin.
            Densin molecules firmly embedded within the postsynaptic densities
            (PSD) may target a minor pool of CaMKII to substrates at the PSD
            core
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6891)
  AUTHORS   Liu,D.C., Jow,G.M., Chuang,C.C., Peng,Y.J., Hsu,P.H. and Tang,C.Y.
  TITLE     Densin-180 is not a transmembrane protein
  JOURNAL   Cell Biochem Biophys 67 (2), 773-783 (2013)
   PUBMED   23516094
  REMARK    GeneRIF: topology of densin involves the membrane association
            configuration
REFERENCE   3  (bases 1 to 6891)
  AUTHORS   Coultrap,S.J. and Bayer,K.U.
  TITLE     CaMKII regulation in information processing and storage
  JOURNAL   Trends Neurosci 35 (10), 607-618 (2012)
   PUBMED   22717267
  REMARK    Review article
REFERENCE   4  (bases 1 to 6891)
  AUTHORS   Jiao,Y., Jalan-Sakrikar,N., Robison,A.J., Baucum,A.J. 2nd,
            Bass,M.A. and Colbran,R.J.
  TITLE     Characterization of a central Ca2+/calmodulin-dependent protein
            kinase IIalpha/beta binding domain in densin that selectively
            modulates glutamate receptor subunit phosphorylation
  JOURNAL   J Biol Chem 286 (28), 24806-24818 (2011)
   PUBMED   21610080
  REMARK    GeneRIF: Characterization of a central Ca2+/calmodulin-dependent
            protein kinase IIalpha/beta binding domain in densin that
            selectively modulates glutamate receptor subunit phosphorylation.
REFERENCE   5  (bases 1 to 6891)
  AUTHORS   Lin,H.M., Liu,C.Y., Jow,G.M. and Tang,C.Y.
  TITLE     Toluene disrupts synaptogenesis in cultured hippocampal neurons
  JOURNAL   Toxicol Lett 184 (2), 90-96 (2009)
   PUBMED   19038319
REFERENCE   6  (bases 1 to 6891)
  AUTHORS   Ohtakara,K., Nishizawa,M., Izawa,I., Hata,Y., Matsushima,S.,
            Taki,W., Inada,H., Takai,Y. and Inagaki,M.
  TITLE     Densin-180, a synaptic protein, links to PSD-95 through its direct
            interaction with MAGUIN-1
  JOURNAL   Genes Cells 7 (11), 1149-1160 (2002)
   PUBMED   12390249
REFERENCE   7  (bases 1 to 6891)
  AUTHORS   Walikonis,R.S., Oguni,A., Khorosheva,E.M., Jeng,C.J., Asuncion,F.J.
            and Kennedy,M.B.
  TITLE     Densin-180 forms a ternary complex with the (alpha)-subunit of
            Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin
  JOURNAL   J Neurosci 21 (2), 423-433 (2001)
   PUBMED   11160423
REFERENCE   8  (bases 1 to 6891)
  AUTHORS   Strack,S., Robison,A.J., Bass,M.A. and Colbran,R.J.
  TITLE     Association of calcium/calmodulin-dependent kinase II with
            developmentally regulated splice variants of the postsynaptic
            density protein densin-180
  JOURNAL   J Biol Chem 275 (33), 25061-25064 (2000)
   PUBMED   10827168
REFERENCE   9  (bases 1 to 6891)
  AUTHORS   Yang,L., Guan,T. and Gerace,L.
  TITLE     Integral membrane proteins of the nuclear envelope are dispersed
            throughout the endoplasmic reticulum during mitosis
  JOURNAL   J Cell Biol 137 (6), 1199-1210 (1997)
   PUBMED   9182656
REFERENCE   10 (bases 1 to 6891)
  AUTHORS   Apperson,M.L., Moon,I.S. and Kennedy,M.B.
  TITLE     Characterization of densin-180, a new brain-specific synaptic
            protein of the O-sialoglycoprotein family
  JOURNAL   J Neurosci 16 (21), 6839-6852 (1996)
   PUBMED   8824323
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 2, 2021 this sequence version replaced NM_057142.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: U66707.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-657               JAXUCZ010000002.1  250293062-250293718 c
            658-755             JAXUCZ010000002.1  250192009-250192106 c
            756-831             JAXUCZ010000002.1  250153577-250153652 c
            832-1034            JAXUCZ010000002.1  250092214-250092416 c
            1035-1152           JAXUCZ010000002.1  250057952-250058069 c
            1153-1231           JAXUCZ010000002.1  250033307-250033385 c
            1232-1321           JAXUCZ010000002.1  250008400-250008489 c
            1322-1378           JAXUCZ010000002.1  250005450-250005506 c
            1379-1442           JAXUCZ010000002.1  249945520-249945583 c
            1443-1517           JAXUCZ010000002.1  249917949-249918023 c
            1518-1662           JAXUCZ010000002.1  249912005-249912149 c
            1663-1735           JAXUCZ010000002.1  249907229-249907301 c
            1736-1865           JAXUCZ010000002.1  249895290-249895419 c
            1866-1981           JAXUCZ010000002.1  249893962-249894077 c
            1982-2051           JAXUCZ010000002.1  249890209-249890278 c
            2052-2151           JAXUCZ010000002.1  249888138-249888237 c
            2152-2276           JAXUCZ010000002.1  249885529-249885653 c
            2277-2525           JAXUCZ010000002.1  249883572-249883820 c
            2526-2726           JAXUCZ010000002.1  249878801-249879001 c
            2727-2838           JAXUCZ010000002.1  249870185-249870296 c
            2839-3019           JAXUCZ010000002.1  249869802-249869982 c
            3020-4700           JAXUCZ010000002.1  249866024-249867704 c
            4701-4820           JAXUCZ010000002.1  249854435-249854554 c
            4821-5042           JAXUCZ010000002.1  249841042-249841263 c
            5043-5135           JAXUCZ010000002.1  249833995-249834087 c
            5136-5210           JAXUCZ010000002.1  249819712-249819786 c
            5211-6891           JAXUCZ010000002.1  249805448-249807128 c
FEATURES             Location/Qualifiers
     source          1..6891
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..6891
                     /gene="Lrrc7"
                     /note="leucine rich repeat containing 7"
                     /db_xref="GeneID:117284"
                     /db_xref="RGD:708527"
     exon            1..657
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            658..755
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            756..831
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     CDS             831..5318
                     /gene="Lrrc7"
                     /function="postsynaptic density protein"
                     /note="isoform 2 is encoded by transcript variant 2;
                     leucine-rich repeat-containing protein 7; densin 13T-17;
                     densin 13T-43; densin 13T-29; densin 13T-23; densin
                     13T-72; densin 13T-41; densin 13T-16; densin 13T-89;
                     densin 13T-57; densin 13T-57C; densin-180"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 7 isoform
                     2"
                     /protein_id="NP_476483.1"
                     /db_xref="GeneID:117284"
                     /db_xref="RGD:708527"
                     /translation="MQCLEMTTKRKLIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPK
                     EVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSSLPTSIASLVNLKEL
                     DISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPA
                     NFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFSELPEVLDQIQNLRELW
                     MDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDS
                     IGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPPTIGYLHSLRTLAV
                     DENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNLPFSF
                     TKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFN
                     PTLWEEQRQQRMTVAFEFEDKKEDDESAGKVKALSCQAPWDRGQRGITLQPARLSGDC
                     CTPWARCDQQIQDMPVPQSDPQLAWGCISGLQQERSMCAPLPVAAQSTTLPSLSGRQV
                     EINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENANPTANTEQTVKEKFEHKWPV
                     APKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHC
                     LNNSVSSGTYSDYSPSQASSASSNTRVKVGSLQPTTKDAVHNSLWGNRIAPPFPQPLD
                     AKPLLTQREAVPPGNLPQRPDRLPMSDAFPDNWTDGSHYDNTGFVSEEATGENANNNP
                     LLSSKARSVPAHGRRPLIRQERIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSP
                     FEDRTAFPSKLETTPTTSPLPERKDHMKEPTETPGPFSPGVPWEYHDPTPNRSLGNVF
                     SQIHCRPDSSKGVIAISKSTERLSPLMKDIKSNKFKKSQSIDEIDVGTYKVYNIPLEN
                     YASGSDHLGSHERPDKFLGPEHGMSSMSRSQSVPMLDDEMLMYGSSKGPPQQKASMTK
                     KVYQFDQSFNPQGAVEVKAEKRIPPPFAHNSEYVQQPGKNIAKDLVSPRAYRGYPPME
                     QMFSFSQPSVNEDAMVNAQFASQGPRAGFLRRADSLASSTEMAMFRRVSEPHELPPGD
                     RYGRAAYRGGLEGQSSVSMTDPQFLKRNGRYEDEHPSYQEVKAQAGSFPAKNLTQRRP
                     LSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKTSDNSDIKTRPTPV
                     KGEESCGKMPADWRQQLLRHIEARRLDRTPSQQSNILDNGQEDVSPSGQWNPYPLGRR
                     DVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQ
                     ATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKG
                     IFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELT
                     V"
     exon            832..1034
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1152
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1231
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1321
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1378
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1442
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1517
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1662
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1735
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1865
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1981
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2051
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2151
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2276
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2525
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2726
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2838
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..3019
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..4700
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            4701..4820
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            4821..5042
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            5043..5135
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            5136..5210
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
     exon            5211..6891
                     /gene="Lrrc7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgccaat cctggcacct gtgcgccaag ccgcggcacc gcggaggacc ccgctctggg
       61 ccaaccccgg gctccgagcc acggccaccc agcctctggg ccagcgcgac ctgcaaccgc
      121 ccacccagga cccccgccgc cacccgcagt tgcgggagcg gaggagcccg gccactgcct
      181 gctgcgcccc tggccacggg gtccctcgcc tcttgagagg cgtcgcggcc gtccggggca
      241 gcaaccgagt tgggtacacg attcgcccgc gctgccgttc tcttctccac ccaggattta
      301 ttgtctgtgg agccttctgg gggcggggag ggagctgcgc ctccgccgcc gccgccgcca
      361 ctgctgctgc tacggtcgct agcgcggcgc tctgggcggg cggaggccgg ggactggccg
      421 cagtggtgtt cccggcgggc tcctggttcc cccggggcac ctctccatcc ctgcacctga
      481 agggcagtgg caccatggtc tgacaccgca tctgcccgga gtcccctctg cctttgcttt
      541 cggaggactt ccctactggc ttcactgcgg accccagagc actttaagga gtaaccctcg
      601 gcagctgcaa ggccttcgct ccctggaccc tcatgggtag tttctgcttc ctgcgatgat
      661 ggagaaccta atacggggaa ggaatccccc acaatatcag agaagtcctt gtaaggaggc
      721 ccgtgcagca cttcggaaga ggcctgaaga agagtgagcc cgctacatga aaagaatgca
      781 agtcaaagtg cccacagcct agaagtcttc agagacagga gtgactagca atgcagtgcc
      841 tggagatgac caccaaacgg aagctcatcg gccgcctggt gccatgccgc tgcttccgtg
      901 gcgaggaaga gatcatctcg gtgttggatt actcccactg cagcctgcaa caggtaccca
      961 aggaggtctt caacttcgaa cgtacactag aagagctcta tctagatgcc aatcagattg
     1021 aggagctacc caagcaattg ttcaactgtc aagctctaag gaaactaagc attcctgata
     1081 atgacctctc aagtctgccg acctccattg ctagcctagt taatctgaaa gaactcgaca
     1141 tcagtaaaaa cggtgtacaa gaatttccag aaaacataaa gtgctgtaag tgtttaacca
     1201 ttattgaagc cagtgtcaat cccatttcta aactacccga tggcttcacg cagcttctta
     1261 acctgaccca gctctacctg aatgacgcct tcctcgaatt tcttccagct aattttggaa
     1321 gacttgtcaa attgcgaatc ttggagttaa gagaaaatca cttgaaaact ctaccaaagt
     1381 caatgcacaa gctggcccag ctggaaagac ttgacctagg caataatgaa ttcagcgagc
     1441 tgcctgaagt tctggatcaa attcagaatt tgagggagct gtggatggat aacaacgcat
     1501 tgcaagtgct gcctgggtct atagggaagt taaagatgtt ggtatacctg gatatgtcaa
     1561 aaaacaggat agaaacggtt gacatggata tttctggatg tgaagccctc gaggacctct
     1621 tactatcatc caatatgttg caacagctgc cggactctat aggattgctg aaaaagttaa
     1681 caactctaaa agtagatgac aatcagctta caatgctacc caacacaatc ggaaacttat
     1741 ctttattaga agaattcgac tgcagttgca atgagctgga gtccctccct cccaccattg
     1801 gttacctgca cagcctgcga accttagctg tggacgagaa tttcctccca gagttgccca
     1861 gagaaattgg aagctgtaag aacgtcaccg ttatgtctct acgctccaat aagctagaat
     1921 ttcttcctga agaaatcggg cagatgcaga gacttcgagt cttaaatcta agtgataata
     1981 ggttgaagaa cttgccattc tccttcacca aactcaaaga gcttgcagca ttgtggcttt
     2041 ctgataatca gtccaaggcc ctcatccctc tgcaaacaga agcccatcca gaaaccaagc
     2101 aaagggtact gaccaactac atgtttcccc agcagccccg tggtgatgaa gatttccagt
     2161 cagacagcga cagcttcaac cccaccctgt gggaggagca gagacaacag cgcatgactg
     2221 ttgcctttga atttgaggat aaaaaagaag atgacgaaag tgctgggaaa gttaaggctc
     2281 tctcctgcca agccccctgg gacaggggcc agcgtgggat tactctccaa cctgccaggc
     2341 tgtctggcga ttgctgcaca ccatgggcca ggtgtgatca gcagatccaa gatatgcccg
     2401 tcccccagag tgacccccag ctggcatggg gttgtataag tggcctccag caggagagga
     2461 gcatgtgtgc tccattacca gtggcagccc aatccaccac tcttccctct ctaagtggca
     2521 gacaggttga aataaaccta aaacgatatc caactcctta cccggaggat ttaaagaaca
     2581 tggtaaaatc tgttcaaaat ctggtgggta agccaagcca tggagtgcgc gttgagaacg
     2641 caaacccaac agctaacacg gagcaaactg tgaaagaaaa gtttgaacac aagtggccgg
     2701 tggccccaaa ggagattaca gtggaggatt cttttgttca tccagctaat gaaatgagga
     2761 ttggggaact tcacccttca ttagctgaga cccctctgta cccacccaaa cttgttctgc
     2821 tagggaagga caaaaaagaa tcaactgatg agtctgaagt tgacaaaact cactgtctga
     2881 ataacagtgt ctcctcaggc acctactcag actactcgcc ctcccaggct tcctcagcat
     2941 cctccaacac ccgggtgaaa gtggggtcct tgcagccaac aactaaagat gccgtgcata
     3001 actctttgtg gggtaacagg attgcaccac ctttcccaca gcctctagat gcaaagccat
     3061 tactcaccca acgggaggct gtccctccag ggaacctccc ccagcgtcct gatcggctgc
     3121 caatgagtga tgctttccct gacaactgga ccgatggctc ccattacgat aacacaggtt
     3181 ttgtctccga ggaagccaca ggcgagaatg ccaacaataa ccctctctta agctccaagg
     3241 ctagaagcgt acctgctcat gggcgcaggc ctttaatcag gcaagaaagg attgtcggtg
     3301 ttcccctgga actggagcag tccacccaca gacacacacc agaaacagaa gtgcctcctt
     3361 ccaatccctg gcagaattgg accagaaccc ccagtccatt tgaggacagg actgcttttc
     3421 cctccaaatt agaaacaacc cctactacca gtcccttgcc tgaaagaaaa gaccacatga
     3481 aggagcctac agagacacca ggtccctttt ctccaggagt gccatgggag taccacgacc
     3541 ccacccccaa ccggagtctc ggtaatgtct tttctcaaat ccactgccgc ccagattcgt
     3601 ctaaaggtgt tattgcaatt agcaaaagca cggagaggct ttccccgctc atgaaagata
     3661 taaagtccaa caagttcaaa aagtcccaga gtattgatga gattgacgtc ggtacctaca
     3721 aggtctataa cattccactg gaaaactatg cctctggaag cgatcactta ggaagccacg
     3781 agcggccaga caagttcttg ggaccagagc acggcatgtc cagtatgtcc aggagccagt
     3841 cggtacccat gctggatgac gaaatgctca tgtacggaag tagtaaaggc ccaccccaac
     3901 aaaaagcatc tatgactaag aaggtctatc agtttgacca aagcttcaat ccacaaggag
     3961 cggtggaagt aaaagcagag aagaggatcc cacccccttt tgcacacaat tctgagtatg
     4021 tacaacagcc cggtaaaaac atcgccaagg atctcgtcag ccccagagcc tatagaggat
     4081 acccacccat ggagcagatg ttctcctttt cccaaccatc tgtaaatgag gatgccatgg
     4141 tgaatgctca gttcgccagc caggggccca gggcaggctt cctaaggagg gctgactccc
     4201 tggccagctc cacagagatg gccatgttca gaagggtcag tgagccccac gagctgcccc
     4261 ctggtgacag gtatggccga gcagcctata ggggagggct ggaaggccag agcagcgttt
     4321 caatgactga tccccaattc ctcaagagga atggcaggta cgaagatgag cacccttcat
     4381 atcaagaagt gaaagcgcag gcgggaagtt ttcctgctaa aaaccttacc cagaggaggc
     4441 cactgtctgc caggagctac agcacagaga gttacggggc ctcccaaacc aggccagttt
     4501 cagctaggcc taccatggca gccctcctgg aaaaaatacc atctgactat aacttgggta
     4561 actatggtga caagacatca gataacagtg atataaagac aaggcccacc cctgtgaagg
     4621 gagaggagag ctgtggcaaa atgccggcag actggagaca gcagctgctt agacatatag
     4681 aagctagaag gttagacagg accccgtccc agcaaagcaa cattttagac aatggacaag
     4741 aagatgtctc tcctagtggc caatggaatc cttacccact tgggaggcgg gatgtacctc
     4801 cggacaccat tactaaaaag gcaggcagcc acattcagac cctgatgggg tcacagagcc
     4861 ttcagcaccg cagccgggag cagcagccat atgaagggaa catcaacaaa gtgaccattc
     4921 agcagttcca gtcgccactg cccatccaga tcccctcatc acaggccacc cggggacccc
     4981 agcctggacg gtgcttaatt caaacgaaag ggcagaggag tatggacggt tatcccgagc
     5041 agttctgtgt gagaatagaa aagaaccctg ggcttggatt tagtatcagc ggtggaatta
     5101 gtgggcaagg aaatcctttc aaaccttccg acaagggtat ctttgttact agggttcagc
     5161 ctgatggacc agcatccaac cttctacagc ccggggataa aatccttcag gcaaatggac
     5221 acagttttgt gcatatggaa cacgaaaaag ctgttttact actgaagagc ttccagaaca
     5281 cagtagacct agttattcaa cgtgagctca ctgtctaaat gtttttataa atagtgaaga
     5341 tatgtcaggc cagagataat gtttaaaaat aaatttatac atagaaacaa attttgccag
     5401 ttgctggacc aatggcaaac atcagtgcca ggtgtataat attgtacgtt agccttgacc
     5461 accctggaaa atgttactta taatcacggc gtttgcgcgg ttctgtatca gttccagcgg
     5521 cagcctctgg ctgtgcattg gtgcggtttt gtttctgttt ttgtttttgt ttttgttttt
     5581 ttaaaatcaa ataagttgtc ttctcaaagt ggatttccta tcatttcgga gcacggaagc
     5641 acacacaagc tctttacaag ttatgctctc catcagagat actgcctcaa aaaaaattgt
     5701 atataaagag ttgtaacccc ataaagtatt tctagcacaa ggtatatgtt ggcatataaa
     5761 caaaaaaaga atatagaaaa acgatatttt cgtaaacatc ttggaccgag aaagaaaata
     5821 tatcttaaaa ataagacttt actatattga atctttttca ataaaaaaat tacatgatta
     5881 cgccttatgg aagcaactgt acataaagta taaaggattt atatttggtt ccacagccat
     5941 ttgctaaatt cccacggtag agtggaatga ttcataatta tccattaatc tctgggacct
     6001 gagtaaaaac cggagaaggt aaatctgttc aaggccttta gctaatttag aggacacgag
     6061 cagacttcag agacagacca caggctactg cggactggcc tcttcaccaa atccacaagc
     6121 agtgagtgat gggtggcggg gaaggcttaa tgctttaatg ttctgttttc tcggggttat
     6181 gtttactata aactgtggcc cctgtgatcc ctttactgta aatgtggaac ttctctgtgt
     6241 gccgatttat ttaatttgct acacttttaa atcattttaa atgaattttg ggaattgata
     6301 acgtttatta tagagaaaga cttgtcagaa agctacggtg gtttcaaaac tttggtattg
     6361 aaatatgaaa cttcagatat gatttctcag agctgtggtc tactgatatc attaatctta
     6421 attcctgttt tgttttgtgg acagaaatag acaaattgtt ttttttctct ccaaatgaaa
     6481 agttttaagg aacataaaca tgaattcaat tatactagag agtgaaaaca gcctagttaa
     6541 tgtgcttttt gcactctgtt tccctgtgtc aaaattcaaa atttgtttta taatccttta
     6601 aagtatttct ttttatatta gtcattaatt tgattagaat attaatttaa aaatttcaga
     6661 tcagctttcc ataattggtt gtatacattc cctgaaatat ctacatcact ttttttatac
     6721 aataaattta tctcgtatgg tagtgtttaa atattctata gaattttaca gtaaaatcac
     6781 acgtggatgt caccagagct ctgaggataa tatttgtaag tttgttttat ggggacattg
     6841 aaaatattgt atttttgtag gatctattaa aatgagtgtc acttattaga a
//
