LOCUS       NM_001037336            3597 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus leucine rich repeat containing 4 (Lrrc4), mRNA.
ACCESSION   NM_001037336
VERSION     NM_001037336.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3597)
  AUTHORS   Kobayakawa,K., DePetro,K.A., Zhong,H., Pham,B., Hara,M., Harada,A.,
            Nogami,J., Ohkawa,Y. and Edgerton,V.R.
  TITLE     Locomotor Training Increases Synaptic Structure With High NGL-2
            Expression After Spinal Cord Hemisection
  JOURNAL   Neurorehabil Neural Repair 33 (3), 225-231 (2019)
   PUBMED   30782076
  REMARK    GeneRIF: Study shows that locomotor training increases synaptic
            structure with high NGL-2 expression after spinal cord hemisection.
            Study identified Lrrc4 (coding NGL-2) as the most highly expressed
            synapse-related gene in trained compared with nontrained rats after
            hemisection injury.
REFERENCE   2  (bases 1 to 3597)
  AUTHORS   Xu,G., Wang,R., Wang,Z., Lei,Q., Yu,Z., Liu,C., Li,P., Yang,Z.,
            Cheng,X., Li,G. and Wu,M.
  TITLE     NGL-2 Is a New Partner of PAR Complex in Axon Differentiation
  JOURNAL   J Neurosci 35 (18), 7153-7164 (2015)
   PUBMED   25948265
  REMARK    GeneRIF: NGL-2 plays a critical role in regulating axon
            differentiation in hippocampal neurons.
REFERENCE   3  (bases 1 to 3597)
  AUTHORS   Matsukawa,H., Akiyoshi-Nishimura,S., Zhang,Q., Lujan,R.,
            Yamaguchi,K., Goto,H., Yaguchi,K., Hashikawa,T., Sano,C.,
            Shigemoto,R., Nakashiba,T. and Itohara,S.
  TITLE     Netrin-G/NGL complexes encode functional synaptic diversification
  JOURNAL   J Neurosci 34 (47), 15779-15792 (2014)
   PUBMED   25411505
REFERENCE   4  (bases 1 to 3597)
  AUTHORS   Berg,A., Zelano,J. and Cullheim,S.
  TITLE     Netrin G-2 ligand mRNA is downregulated in spinal motoneurons after
            sciatic nerve lesion
  JOURNAL   Neuroreport 21 (11), 782-785 (2010)
   PUBMED   20577133
  REMARK    GeneRIF: axotomized motoneurons decrease their NGL-2 expression and
            that the restoration of NGL-2 expression mirrors the restoration of
            synaptic inputs.
REFERENCE   5  (bases 1 to 3597)
  AUTHORS   Kim,S., Burette,A., Chung,H.S., Kwon,S.K., Woo,J., Lee,H.W.,
            Kim,K., Kim,H., Weinberg,R.J. and Kim,E.
  TITLE     NGL family PSD-95-interacting adhesion molecules regulate
            excitatory synapse formation
  JOURNAL   Nat Neurosci 9 (10), 1294-1301 (2006)
   PUBMED   16980967
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ119102.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DQ119102.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3597
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..3597
                     /gene="Lrrc4"
                     /note="leucine rich repeat containing 4"
                     /db_xref="GeneID:641521"
                     /db_xref="RGD:1560026"
     exon            1..3597
                     /gene="Lrrc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2061
                     /gene="Lrrc4"
                     /note="leucine-rich repeat-containing protein 4; protein
                     NGL-2; netrin-G2 ligand; leucine rich repeat containing 4
                     protein"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 4
                     precursor"
                     /protein_id="NP_001032413.1"
                     /db_xref="GeneID:641521"
                     /db_xref="RGD:1560026"
                     /translation="MKLLWQVTVHHTWNAVLLPVVYLTAQVWILCAAIAAAASAGPQN
                     CPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEV
                     LQLGRNAIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIES
                     IPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVG
                     LEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNN
                     LSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHM
                     RGRYLVEVDQASFQCSAPFIMDAPRDLNISEDRMAELKCRTPPMSSVKWLLPNGTVLS
                     HASRHPRISVLNDGTLNFSRVLLIDTGVYTCMVTNVAGNSNASAYLNVSSAELNTPNF
                     SFFTTVTVETTEISPEDITRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVPVPST
                     DTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVE
                     IIQVDEDIPAAASAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGN
                     SLHPTVTTISEPYIIQTHTKDKVQETQI"
ORIGIN      
        1 agatggaaag aggagctcct agctcactta agccggggta aggctggttc tcttttccaa
       61 gccaaaatcc caggcgatgg tgaattatga acgtgccaca ccatgaagct cttgtggcag
      121 gtaactgtgc accacacctg gaatgccgtc ctgcttcccg tcgtctacct cacggcgcaa
      181 gtgtggattc tgtgtgcagc catcgctgct gccgcttcag ctgggcccca gaactgcccc
      241 tccgtctgtt cctgcagtaa ccagttcagc aaggtggtgt gcacccgccg gggactctct
      301 gaggtcccgc agggtattcc ttccaacacc cggtatctca acctcatgga aaacaacatc
      361 cagatgattc aggccgacac cttcaggcac ctccaccacc tggaggtcct gcagctgggc
      421 aggaacgcca tcaggcagat cgaggtgggg gccttcaatg gcctcgccag cctcaacacc
      481 ttggaactgt ttgacaactg gctgactgtc atccccagtg gggcctttga gtacctgtcc
      541 aaactgcggg agctctggct tcgaaacaac cctattgaga gcatcccctc ttatgccttc
      601 aaccgggtgc cctccctcat gcgtctggac ttgggggaac tcaagaagct ggagtatatc
      661 tctgaggggg cttttgaggg gctgttcaac ctcaagtacc tgaacttggg catgtgtaac
      721 attaaggaca tgcccaatct tacacccctg gtggggctag aggagcttga gatgtcaggg
      781 aaccactttc ctgagatcag gcctgggtcc ttccatggcc taagctccct caaaaaactg
      841 tgggtgatga actcacaggt cagcctgatt gagcggaatg cttttgatgg actggcttcc
      901 cttgtggaac tcaacttagc ccacaataac ctctcatctt tgccccatga cctcttcact
      961 cccctgagat acctagtgga gttgcaccta caccacaatc cttggaactg tgattgtgat
     1021 attctgtggc tggcttggtg gcttcgggag tatataccca ccaattctac ttgctgtggc
     1081 cgctgtcacg ctcccatgca tatgcgaggc cgctacctgg tagaggtgga ccaggcctcc
     1141 tttcagtgct ctgccccctt catcatggat gcaccccggg acctcaatat ctctgaggat
     1201 cggatggcag aactgaagtg tcggactccc cctatgtcct ctgtgaagtg gttgctgccc
     1261 aatgggacag tgctcagcca cgcctcccgg cacccacgga tctccgttct caatgatggc
     1321 accttgaact tttctcgtgt gctgctcata gacactggag tatacacatg catggtgacc
     1381 aacgtggcag gcaactccaa tgcctcggcc tacctcaatg tgagctcggc cgagctcaat
     1441 acccccaact tcagcttctt caccactgta acagtggaga ccacagagat atcacctgag
     1501 gacataacac ggaagtacaa gcctgttccc accacgtcca ctggttacca gccggcatat
     1561 accacctcca ccacggtgct cattcagacc acccgtgtgc ccaagcaggt gccagtaccc
     1621 tcgacagata ccactgacaa gatgcagacc agtctggatg aagtcatgaa gaccaccaag
     1681 atcatcattg gctgctttgt ggcagtgact ctcctagctg ctgccatgtt gattgtcttc
     1741 tataaacttc gcaagcggca ccagcagcgg agtacggtca cagctgccag gacagtagag
     1801 attatccagg tggatgaaga catcccagca gcagcatctg cagcagcaac agcagctccg
     1861 tccggtgtat caggtgaggg ggcagtagtg ctgcccacaa tccatgacca tattaactac
     1921 aacacctaca aaccagcaca tggggcccac tggacagaaa acagcctggg gaactctctg
     1981 caccccacag tcaccactat ctctgaacct tatataattc agacccatac caaggacaag
     2041 gtacaggaaa ctcaaatatg actccccctc cctcaaaaac ttataaaatg caatagaatg
     2101 cacaaaaaag agcaactttt gtacagagtg gggagagact ttttcttgta tatgcttata
     2161 tattaaatct atgggctggt taaaaaagat tatattaaaa tttaaaaaca aaaaaaatca
     2221 aaacaaaact attttctaac ttgtaagttc tatttaaagg gggagggaag ggaatcttgg
     2281 taatgctgtg ggtaggagcc tcaagtcaac tggtggaagg tggaaactgc taagacaaaa
     2341 caaactaaaa caaccaacac ccctaaagtg gcagggggtg ggctgctggg ggaggaaggg
     2401 tagactgcat ctgtcaattt ttagaagaca cttcacagga tctaggaata ccatttctac
     2461 agacatcttt cttaagctga gagctgtctt tacagatcta tctatcttat taaaaaaata
     2521 attttaaaaa agcatcacaa atttgtactg tgccaaaagg ttgagaggca atattttttt
     2581 tccttcagag acaatgggga agatagatct gtaaatatta ttttaagtag gaaaaccacc
     2641 aaaattccaa ctaatcctta caggggctgt ttctttgtac atgtgcacaa gtcctctggg
     2701 tttgtgctta agactggcat gtgtctcccc tgacagtgct caggacagcc tggaaggaga
     2761 ggagctggcg tagctctcag tcaaatgctt tcacattgca ccagattcct gcagttgggc
     2821 ataacccact ctgcaaggca tgtgtctatt cagggtttcc ccgggaggag gcggcctgaa
     2881 gggggtgcgg cacgggaaga agggaagcag agcagcagag gggatgattc acaggaggga
     2941 ggccataaat cagcattgtg ccgtgtccac ctgttgttcc gggtatctga caaatgattg
     3001 tagacaatga tgacatttta tgatttttca gaaaagatct tgcttgtttt aaggtgggaa
     3061 aggaggatag gctggggatg gggacttggg ggagtggaag cttttctcat gcttacggtt
     3121 tagtgactat tcattctaaa tgctgattca ttagggatta ttacagctga tgccaactag
     3181 ttgtggtgat agagtggggg cagaacatga gtcgagaggg gaaaaggaga gctaaaaagg
     3241 gcacaggctc catttaaaga agcctttgcc aaccaggatg ttttgtgtgt gtgtggggca
     3301 tgctacaaca aaactgacaa ggggaacaag ttgggcatgg agttctgttg aatggggcat
     3361 caaggtggga agcttccctc ccctaggcct acctccagta gttacaagca ggggcaagat
     3421 ctgttattct ggtccattta atgatgtaac tttcagttat tactttagct ttaagaggaa
     3481 ataaaagggt tcagatttga aatggggtgg tacgggtggg ggatgccaac aaaagaacac
     3541 tgattgtaat gtgagaaaag tgtatttttg tattttaata aatattgttc aattttt
//
