LOCUS       NM_001170434            3955 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus leucine rich repeat containing 32 (Lrrc32), mRNA.
ACCESSION   NM_001170434
VERSION     NM_001170434.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3955)
  AUTHORS   Wu BX, Li A, Lei L, Kaneko S, Wallace C, Li X and Li Z.
  TITLE     Glycoprotein A repetitions predominant (GARP) positively regulates
            transforming growth factor (TGF) beta3 and is essential for mouse
            palatogenesis
  JOURNAL   J Biol Chem 292 (44), 18091-18097 (2017)
   PUBMED   28912269
REFERENCE   2  (bases 1 to 3955)
  AUTHORS   Wang R, Zhu J, Dong X, Shi M, Lu C and Springer TA.
  TITLE     GARP regulates the bioavailability and activation of TGFbeta
  JOURNAL   Mol Biol Cell 23 (6), 1129-1139 (2012)
   PUBMED   22278742
REFERENCE   3  (bases 1 to 3955)
  AUTHORS   Stockis J, Colau D, Coulie PG and Lucas S.
  TITLE     Membrane protein GARP is a receptor for latent TGF-beta on the
            surface of activated human Treg
  JOURNAL   Eur J Immunol 39 (12), 3315-3322 (2009)
   PUBMED   19750484
REFERENCE   4  (bases 1 to 3955)
  AUTHORS   Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D and Shevach EM.
  TITLE     GARP (LRRC32) is essential for the surface expression of latent
            TGF-beta on platelets and activated FOXP3+ regulatory T cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (32), 13445-13450 (2009)
   PUBMED   19651619
REFERENCE   5  (bases 1 to 3955)
  AUTHORS   Wang R, Wan Q, Kozhaya L, Fujii H and Unutmaz D.
  TITLE     Identification of a regulatory T cell specific cell surface
            molecule that mediates suppressive signals and induces Foxp3
            expression
  JOURNAL   PLoS One 3 (7), e2705 (2008)
   PUBMED   18628982
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000042.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001170434.3.
            
            On Feb 10, 2021 this sequence version replaced NM_001170434.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM029675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                JACYVU010000042.1  3249166-3249218
            54-148              JACYVU010000042.1  3253212-3253306
            149-3955            JACYVU010000042.1  3257222-3261028
FEATURES             Location/Qualifiers
     source          1..3955
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3955
                     /gene="Lrrc32"
                     /gene_synonym="Garp"
                     /note="leucine rich repeat containing 32"
                     /db_xref="GeneID:293135"
                     /db_xref="RGD:1309087"
     exon            1..53
                     /gene="Lrrc32"
                     /gene_synonym="Garp"
                     /inference="alignment:Splign:2.1.0"
     exon            54..148
                     /gene="Lrrc32"
                     /gene_synonym="Garp"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2053
                     /gene="Lrrc32"
                     /gene_synonym="Garp"
                     /note="glycoprotein A repetitions predominant;
                     leucine-rich repeat-containing protein 32; transforming
                     growth factor beta activator LRRC32"
                     /codon_start=1
                     /product="transforming growth factor beta activator LRRC32
                     precursor"
                     /protein_id="NP_001163905.1"
                     /db_xref="GeneID:293135"
                     /db_xref="RGD:1309087"
                     /translation="MSYQILILLAMLTLGLAISQRRDQVPCRTVNKEALCHGLSLLQV
                     PSVLSLDIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEH
                     LNLAHNRLAAGMALNSGGLGRLPLVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAEN
                     SLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTCISDFSL
                     QQLQVLDLSCNSIETFQTAPESQAQFQLAWLDLRENKLLHFPDLAMFPRLIYLNVSNN
                     LIQLPTGLPQDSEDLHAPSEGWSASLLSNPSRNASIHPLSQLLNLDLSYNEIELVPAG
                     FLEHLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEALELGTKVLGSLKTL
                     LLQDNTLRELPPYTFAGLASLQRLNLQGNQVSPCGGQAEPGPPGCVDFSGIPTLHFLN
                     MAGNSMETLRAGSFLHTPLTELDLSANPGLDVATGALVGLEASLEVLELQGNGLVVLR
                     VDLPCFRRLKRLNLAENRLSHLPAWTRAVSLEVLDLRNNSFSLLPGNAMGGLETSLRR
                     LYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLICRFGSQEEVSLSLVRPEDCEKGGL
                     KNVNLIIILSFTLVSAIVLTTLATCCFLRRQKLSQQYKA"
     exon            149..3955
                     /gene="Lrrc32"
                     /gene_synonym="Garp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgtgcgaa cgatgttcgg aggagtcggg cggcggcggc ggcgctgagc caggcagagc
       61 catgagctac cagatcctga tactcctggc catgctgacc ctgggcctgg ctatctctca
      121 gcgccgagac caagtgccct gtaggacggt gaacaaggag gccttgtgcc acggcctcag
      181 cctgcttcag gtcccctcgg tgctctcatt ggacatccaa gctctctact tgtccgggaa
      241 ccggctgcag agcatcctgg tctccccgtt gagcttctat acagcacttc gccacctgga
      301 tttaagtgac aacgagatta gcttcctcca gccgggggtc ttccaggccc tgccctacct
      361 ggagcacctc aacctggccc acaaccggct tgccgcgggc atggcattga acagtggtgg
      421 tctgggccgc ttgccccttg tggtctccct ggacctgtct gggaacagcc tgcatggcag
      481 tctggtggag cggctgttgg gtgaggctcc gaggctgcgc acgctctccc tggcagagaa
      541 cagcctcact cgcctggcac gccacacctt ctggggtatg ccagccatgg agcaactgga
      601 ccttcacagc aacgtcctga tggacattga ggatggtgcc tttgaggccc tgccccagct
      661 gactcacctc aatctctccc gcaactccct cacgtgcatc tcggacttca gcctccagca
      721 gctgcaggta cttgacctga gctgcaacag cattgagacc ttccagacgg ccccagaatc
      781 acaggcccag ttccagctgg cctggcttga cctacgggag aacaagctgc tccacttccc
      841 tgacctggcc atgttcccca gactcatcta cctgaatgtg tctaacaacc tcatccagct
      901 ccctacaggg ctgccccagg acagcgagga cctccatgca ccgtcggaag gctggtcagc
      961 ctctctactg tccaacccca gtcggaatgc cagcatccac cccctctccc agctcctaaa
     1021 cctggacctg agttacaatg agattgaatt ggtccctgct ggctttcttg agcatctgac
     1081 ctccctgcgc ttcctcaacc tcagcagaaa ctgtcttcga tcctttgagg ctcggcgagc
     1141 gggctccctg ccctgcctgg tacttctgga cttgagccac aatgtgctgg aagcgttaga
     1201 actgggtacc aaagtcctgg ggtccctgaa gacattgctt ctgcaggaca acaccttgcg
     1261 agaacttcca ccctacacct ttgctggcct ggccagcctg cagaggctca acctacaggg
     1321 aaaccaggtc agcccctgtg ggggacaagc agagccaggt cccccaggct gtgtggactt
     1381 ctctgggatc cccaccctcc attttcttaa catggcgggg aactcgatgg aaacactcag
     1441 ggcaggcagc ttcctccaca ccccacttac tgagctggac ctctctgcca atcctggtct
     1501 ggatgtggcc acgggagcct tggtgggcct ggaggcatcc ttggaggtcc tggagcttca
     1561 aggcaacggg ctggtggtac tgagagtaga cttgccctgc ttccgtcgtc tcaagcgcct
     1621 taaccttgct gagaaccgct taagccacct gcctgcttgg acacgggctg tgtccctgga
     1681 ggtgctggat ctgcggaaca acagcttcag cctcttgccg ggcaatgcca tgggtggcct
     1741 ggagaccagt ctccggcggc tgtacttgca gggaaatcca ctcagctgct gcggcaatgg
     1801 ctggctggcg gcccagttgc accagggccg agtggatgtg gacgccactc aggacctcat
     1861 ctgccgcttc ggctcccagg aggaggtgtc cctgagccta gtgcgtccag aggactgtga
     1921 gaaggggggg ctgaagaatg tcaacctcat catcatcctt agcttcacac tggtctccgc
     1981 catagtcctt accacgctgg ccacctgctg cttcctccgc aggcagaagc tcagccaaca
     2041 gtacaaagcc tgatggggct gggggagcct cttcccactc cctgaggaag ccagaggggc
     2101 agggaagctg gggtccaact caggttacac agtggccagg gacttggtgt cccacacact
     2161 gccacgtgga ctacatacgt ggtccagctg tggcgctcaa agtgggacag ttcactgaac
     2221 aggggatgcc aatagctctc cactgagcat gtttcaggcc acacccatct ccgagtacta
     2281 gtaagtgaaa cacgtgccta tcctctggca agagaggctg tcacagaacc acacagtgac
     2341 cccgtcgtat gatgggcttg aggtggggag gcgatgggcc cccagaccct gcagccccca
     2401 gctggtcatg gagaaccatc ctgactggcc cgtgagactg gcccgtgaga ggatctgtct
     2461 gagccttttc cacccagagc tctgtcgcat ctgccgataa tgactttcag cctctctgga
     2521 aatgaagaac ttgtgacctg aagagagagc cagaactcac ccagaggtct taaatctagc
     2581 ctcctgggct agactgcagc tccacagaac cagcttcaag tgtggtcacc taggcttcca
     2641 cgagggcccg ggccatcctg tagcctgcct ctgacaggcc tttctctcca gcacgctctt
     2701 ctacacacac actgaccctg gtgctgcctg ttccccaagc ccctgctcag gcctccttcc
     2761 atcccggccc caccctggct tttgagccaa gagagggaga gcctcagcaa tctggttctg
     2821 ctttgtgctc aacttagcag ctgcagaggc aaattcaagc caactctcag aggtttccat
     2881 gttatctggg ttacacacaa gaagaaaaca aggttcctta cgtgtctcct ctgagagcct
     2941 cgtggctgag agagatgccg aagccagaaa tgagtcaagt ccatgccctc ccacctctgg
     3001 ggccgaggcc tcgccagtgc ggtgcctgta ggctgtcaag tggacaggaa ggggccctac
     3061 cctaaccagg atccaagcat acctgctgcg tatacccact ccctctcaga caggcaccca
     3121 cagaccctct gtctccctgc ctcagtgacc cttctctgta gaagagtatg aattcttcct
     3181 tctcttcttg cttcccaaat ctcatccctg gagtttgaaa ccattggctg taatctcccc
     3241 actgaacaaa tagggaaact taggtgcagg gccttgctca gaatcacaca agtcagtgga
     3301 agaaaccgtg ggggggggat gcagctgcag ctgcaggggg tttgctttgt ttgctcaaag
     3361 ccctgagccc catgcctgca tttccctcct ctcaacagtc acagcaaggc cggctatcat
     3421 tccagtcctc accaggcatg ggaaataaga gggtagaacc ccccccaaca cacacccgag
     3481 acacacacac acacacacac acacacacac acacacacac acacaccact cactctccag
     3541 acccatgggc ttcagggaga aaggggagcc ctgggtccag tcacagagct tccatcatca
     3601 gctcctctgt gctccgccca caggctgcca cagcatcagt aaccgtccaa gaagatgaaa
     3661 acaccactct ctgccccact ctacagggga gggaactgag gcccagagaa ggttaaaggc
     3721 tcagagaacc gatgggcaga tccggggcta gaaccctcac tgggatagct catggcacta
     3781 ggtgctgctg cacacggcac tcctcggcct ggaggccaag gcctggcccc tgtgcccgag
     3841 ctctgaaaac actatatcaa tgctgctctc acttcccagg actggcctcc accaggccct
     3901 gggacctgct ctttgtataa ctcacatgaa tgtattaaag tataattttg gagaa
//
