LOCUS       NM_145083               5501 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus leucine rich repeat containing 15 (Lrrc15), mRNA.
ACCESSION   NM_145083 XM_006248482
VERSION     NM_145083.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5501)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 5501)
  AUTHORS   O'Prey,J., Wilkinson,S. and Ryan,K.M.
  TITLE     Tumor antigen LRRC15 impedes adenoviral infection: implications for
            virus-based cancer therapy
  JOURNAL   J Virol 82 (12), 5933-5939 (2008)
   PUBMED   18385238
REFERENCE   3  (bases 1 to 5501)
  AUTHORS   Satoh,K., Hata,M., Shimizu,T., Yokota,H., Akatsu,H., Yamamoto,T.,
            Kosaka,K. and Yamada,T.
  TITLE     Lib, transcriptionally induced in senile plaque-associated
            astrocytes, promotes glial migration through extracellular matrix
  JOURNAL   Biochem Biophys Res Commun 335 (2), 631-636 (2005)
   PUBMED   16098915
REFERENCE   4  (bases 1 to 5501)
  AUTHORS   Satoh,K., Hata,M. and Yokota,H.
  TITLE     A novel member of the leucine-rich repeat superfamily induced in
            rat astrocytes by beta-amyloid
  JOURNAL   Biochem Biophys Res Commun 290 (2), 756-762 (2002)
   PUBMED   11785964
REFERENCE   5  (bases 1 to 5501)
  AUTHORS   Condorelli,M., Rasetti,G., Rengo,F., Ricciardelli,B., Sacca,L.,
            Trimarco,B. and Volpe,M.
  TITLE     Effects of guanethidine on histamine release during reflex
            vasodilatation in the dog
  JOURNAL   Br J Pharmacol 60 (3), 379-384 (1977)
   PUBMED   70253
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On or before Oct 20, 2022 this sequence version replaced
            XM_006248482.4, NM_145083.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1012546.1,
                                           SRR26360176.1520600.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680421
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000011.1  83974708-83974796
            90-5501             JAXUCZ010000011.1  83983746-83989157
FEATURES             Location/Qualifiers
     source          1..5501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..5501
                     /gene="Lrrc15"
                     /gene_synonym="Lib"
                     /note="leucine rich repeat containing 15"
                     /db_xref="GeneID:246296"
                     /db_xref="RGD:70551"
     exon            1..89
                     /gene="Lrrc15"
                     /gene_synonym="Lib"
                     /inference="alignment:Splign:2.1.0"
     exon            90..5501
                     /gene="Lrrc15"
                     /gene_synonym="Lib"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1829
                     /gene="Lrrc15"
                     /gene_synonym="Lib"
                     /note="leucine-rich repeat-containing protein 15; rLib;
                     leucine-rich repeat protein induced by amyloid-beta;
                     leucine-rich repeat protein induced by beta-amyloid"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 15
                     precursor"
                     /protein_id="NP_659551.2"
                     /db_xref="GeneID:246296"
                     /db_xref="RGD:70551"
                     /translation="MPLKHYLLLLVGCQAWALGLAYYGCPSECTCSRASQVECTGARI
                     VAMPTPLPWNAMSLQVVNTHITELPENLFLNISALIALKMEKNELSTIMPGAFRNLGS
                     LRYLSLANNKLRMLPIRVFQDVNNLESLLLSNNQLVQIQPAQFSQFSNLRELQLHGNN
                     LESIPEEAFDHLVGLTKLNLGRNSFTHLSPRLFQHLGNLQVLRLHENRLSDIPMGTFD
                     ALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHISQLPPGIFMQLPQLNKLTL
                     FGNSLRELSPGVFGPMPNLRELWLYNNHITSLADNTFSHLNQLQVLILSHNQLTYISP
                     GAFNGLTNLRELSLHTNALQDLDSNVFRSLANLQNISLQSNRLRQLPGSIFANVNGLT
                     TIQLQNNNLENLPLGIFDHLVNLCELRLYDNPWRCDSDILPLHNWLLLNRARLGTDTL
                     PVCSSPPNVRGQSLVIININFPGPSVQGPETPEVPSYPDTASYPDTTSVSSTTEITSA
                     VDDYTDLTTIEATDDRNTWGMTEAQSGLAIAAIVIGIIALACSLAACICCCCCKKRSQ
                     AVLMQMKAPNEC"
ORIGIN      
        1 actcatgctg cagtcttgag cctgtcctgg tcctcctcct ctcttcgctg cctccctctt
       61 gttgatccgg cagccgcgtg gagctgctgg ccatgccgct gaaacattac ctcctcttgc
      121 tggtgggctg ccaggcctgg gctctaggtt tggcctacta tggctgcccc agtgaatgca
      181 cctgttcccg ggcctcccag gtggagtgca caggagcgag gattgtggcg atgcctaccc
      241 ccctgccctg gaatgctatg agcctgcagg tcgttaacac gcacattact gagctccctg
      301 agaacctgtt cctcaacatt tcagcgctca ttgccctaaa gatggagaag aatgagctgt
      361 caaccatcat gccgggtgcc ttccgcaatc tgggctctct gcgctacctc agcctcgcca
      421 acaacaaact gaggatgctg cccatcaggg tcttccagga cgtaaacaat ctggagtccc
      481 ttctgctctc caataaccag ctggtgcaga tccagccagc ccagttctcc cagtttagta
      541 atcttaggga actccagttg catggcaaca atctggaatc cattcccgaa gaagccttcg
      601 accacctagt aggactcacc aaactcaacc tgggcaggaa cagcttcacc cacctatcgc
      661 ctaggctctt tcagcatctg ggcaacctcc aggtgctccg gctacacgag aacaggcttt
      721 cagacatccc catgggcacg ttcgatgcac tcggcaacct ccaggagctt gccctccaag
      781 agaaccagat tggcaccctc tcccctggct tgttccacaa taaccgtaac ctccagagac
      841 tgtatctgtc caacaaccac atctcccagc tgccccctgg catcttcatg cagctgcccc
      901 agcttaacaa gctcacactc tttgggaatt ccctgaggga gctttccccg ggggtcttcg
      961 ggcccatgcc caacctgagg gagctttggc tctacaacaa ccacatcacc tccctcgccg
     1021 acaacacctt cagccacctg aaccagctgc aggtcctgat tctcagtcac aaccagctca
     1081 cttacatctc cccaggagcc ttcaatgggc tgacgaacct ccgagaactg tccctccaca
     1141 ccaacgctct acaggacctg gacagcaacg tcttccgatc gctggccaac ctgcagaaca
     1201 tctcgctcca gagtaaccgc ctccgacagc ttccgggcag catctttgcc aacgtcaacg
     1261 gcctcacaac catccaactg cagaacaaca atctagaaaa cttgcctttg ggcatctttg
     1321 atcacttggt gaacctgtgt gagcttcgcc tctacgacaa cccctggaga tgtgactcag
     1381 atatcctccc acttcataac tggctccttc tcaacagagc caggctgggg acagacactc
     1441 ttccagtgtg ttccagtccc cccaacgtcc gaggccagtc cctcgtcatc atcaatatca
     1501 atttccctgg acccagtgtc cagggcccag agacccctga agtacctagt tacccagata
     1561 cggccagcta tcccgacacc acatctgttt cctctaccac ggagatcacc agcgccgtcg
     1621 acgactacac cgatctaacc accattgaag ccaccgatga ccgaaatacg tggggcatga
     1681 ctgaggccca gagcgggctg gccattgctg ccatcgtgat cggcatcata gctttggcct
     1741 gttccctagc cgcctgcatc tgctgctgct gctgcaaaaa gaggagccaa gcagtcctga
     1801 tgcagatgaa ggctcccaat gagtgctagg gaggcaggct cgagcagggc tggggaaggg
     1861 tgaaaccaga ggatctgaga atgtcaccgt gcagcttcca aacctgggcc cacacagcca
     1921 ggctctggtg gccccagggg aaatgtgccc ccatcttgtc ctgtgcccct gagtcttctg
     1981 tagagaagca ggcatttcag gaccttctat tcccaaagga atctaattgg tcattttaaa
     2041 aaagcaagac agacagacag acagacagga agaatctaat tggtcattaa aaaaaagcaa
     2101 gcaagcaaga aagacagaca gacagaaaga gagagagaga cagaaagaaa gaaagaaaga
     2161 aagaaagaaa gaaagaaaga gagagagaaa gagagagaga aagaaaaaaa gaaagaaacc
     2221 aacccaggaa tctctaggtc agtacctagg aaactttcag aggggccctc tccacatcct
     2281 cactacttcc aagaacaagt ttccctctgc ccagccccgt ccagcctctg tagacttgat
     2341 gtcaaggcct gctcacatgg tgagatagtt ctctgctggc acaatcagtg cctcaaagta
     2401 ttacatatgc tgctttctac cccttccccc ttgcttctct ttttatgcca tggcttgact
     2461 ctgtctcttc aagcgaggga tctccctttg tttatctgct gctgaaggca gactatgttc
     2521 tctctccgag aaggtttgac tcttttagct cactgcgccg gcttggaggg tgctctgcag
     2581 gacagaaaga cacctgtgcc atctgattcc aggcggaatt gtcataggca tctgttgcac
     2641 caagttcagc cttttagaga agactgttta acatctcaag cgttcctcca aagagctaac
     2701 ccttgatggt ataacaatca cgctgagtgg ctaagttctc agaacatgaa agtcagctgg
     2761 ttgaaactgg ctgaagaatg caacctgctg ccgggggtcc ttgcacaccc tgctgcgctt
     2821 gcctctttct gattccgtat tgaagcatca cacacataca gaaagtggga gtgcggtagt
     2881 ggacagcccc tgagcgttct cagtgatctc aatagatacc tgggtgattg gcatgatacc
     2941 aaggaatgat atcgcagtgc cccccactcc aagcttgtcc tgggggactt ctgagggtgc
     3001 tggagacttt ctagcttccc acaggctagt agaggattct tacaacctcc ccttacctct
     3061 ccatggcaag cctttgccag gcccagctgt taggagtgaa agagatgtag gcgcagtcag
     3121 gacaggaggc tgccatgctg gccagaccag aagcgtatga actaccgtgg tttccccaac
     3181 agcaagtcct gtactgctca ttggctgcat tctactgagc cttttatggg cattataggc
     3241 ccgtatctgt ttctaatttc tgttctccac tcaggggaag caaaatagct cagagatgag
     3301 atcttccagc tgaacgacca aatgaaacgg aaaccaggat tccgtctata ctgtggtcaa
     3361 ttttccttca gcattagtca gctgtagcta gactacagtg tgtttacaga cagcggatat
     3421 tggggtacgc tggaagctca cagggtgtgg ggctgctctg cagaaccttc tgcctgtggt
     3481 ctggttgtga gctgaatggt ttagtttaga gttttctctt tgggtgacag tcacaacaca
     3541 tcctccttgg gtctctttcc tgctacgcat gtatctattt ctgtacatta aacagttctg
     3601 gtaagacgac acagccttct caggatgact gatacacctg tgcagaagtc aaagctttga
     3661 aacaagtgaa catggtggct catgccttta gcgagttcaa gggtagcctg gtctacagag
     3721 tgagttccag gatggccagg gctatgtaga aagaccctcc ctcaaaaaca acacagggaa
     3781 gcagagaatt tcaggtttcc ccaccagtga ggacagggat ttggaaatct agatccatgg
     3841 ggtgcacttc acaaactcaa aggctggaga taaatgaggt aatgctcaca aggcaaatta
     3901 gaaatccccc tgggtcttgg caatggggag cctacacaat gtccagactt cccctccaga
     3961 tccctgacag aatacttcag aaggaatgct tgcgagagcc agcacgctcg gtggcccagg
     4021 gaagctgatg tcggtcaaaa gacatcatct ttccaaggcc aatctgggtc tccaaagtgt
     4081 ttgcaaagtc gctatagcaa ctggtacgca ccaaccaagg ctgtctccaa ccccagagtg
     4141 agtgtgggct tgcttctgct gactgtggct tgctggtaag tcctggggcg aagggaagga
     4201 gctgagcctg ctttattgca gatggatgtt tgacacagta ctatgttccc cggaaatagt
     4261 tgtgacataa ctccttgtga attatgtcca gcctcagtgg gctagggata gagagaggta
     4321 gaatccagtc aatcataacc cggaaacact ggtcgcttct gacatcggct atgacagtgg
     4381 catacctcac tggctcaaag gctggtctaa ggacagctgt cttctaccgg cttccccagg
     4441 agcagaaagc aaagtagaca gttcctccaa atcacatctt ctagttaggg aaagagttgc
     4501 cagaaacact gggtggaggg tcctttccag tagggtaatc cattttgctc agttcttggg
     4561 ctggaatgag ctctgtggtc cctcgaagtc tgtgagggtg cagagttcaa cccacttagc
     4621 ccatctgttc actgttttcc ggactaccac cccagccttt gtgcagatcg gggagaacag
     4681 ttgattctgg aaggctaata aaggccaact agaaccagct tgttaacaga tagatgtttg
     4741 gaggactggg tgtccttcaa agctcctgat gtgcattctc ctaaccctct cggcaccttg
     4801 caaaattagt tccaccatta gcttttgtgt tggggtcttt tctgcgcagt gcccagcaga
     4861 caatccctgt agaaacttca tgggctgtct agggctttcg tcgggagact gtaggagaca
     4921 gctacagctg gggacttgga gcttctcact cacagctgta cagttcctgc aggcatcaag
     4981 atggcggaat ggaactgtgg aagccagttc cagccttggg agagcatgaa caggctaata
     5041 acctgagtca ggaagcaggc cttgcatgtg tcccagactt aactactcaa agattcggcc
     5101 ctggactcag tgctcagaac cagatctggc cgtagaagag aatctgactg ttgatgatct
     5161 caggagggaa gccattactg ttgttcgaca gagtgtaggt aacagttccg tagcaggtaa
     5221 cttccacgtg gagcctcacc cagtcagggc ccttctccta aagagagagc gttcttgcct
     5281 cccattgcct tcactctgct tctacaacaa tcatgcttgc cttactactc ggtctttgca
     5341 aatagtccca gttgcttggt agtgcactta gagatttcta ggctcccggg gttttataga
     5401 atgtgagccc tggtgggcag ggttggggaa atctgtcctt tgctagatgc cgcttgtaac
     5461 agacttggtg tccaggatca ataataaacg gtgtacggag g
//
