LOCUS       NM_001014268            1935 bp    mRNA    linear   ROD 17-MAR-2024
DEFINITION  Rattus norvegicus leucine rich repeat containing 1 (Lrrc1), mRNA.
ACCESSION   NM_001014268 XM_345954
VERSION     NM_001014268.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Wang,Y., Li,X., Guan,X., Song,Z., Liu,H., Guan,Z., Wang,J., Zhu,L.,
            Zhang,D., Zhao,L., Xie,P., Wei,X., Shang,N., Liu,Y., Jin,Z., Ji,Z.
            and Dai,G.
  TITLE     The Upregulation of Leucine-Rich Repeat Containing 1 Expression
            Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by
            Stabilizing Phosphorylated Smad2/3
  JOURNAL   Int J Mol Sci 25 (5), 2735 (2024)
   PUBMED   38473980
  REMARK    GeneRIF: The Upregulation of Leucine-Rich Repeat Containing 1
            Expression Activates Hepatic Stellate Cells and Promotes Liver
            Fibrosis by Stabilizing Phosphorylated Smad2/3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079423.1.
            
            On Apr 20, 2005 this sequence version replaced XM_345954.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1935
                     /gene="Lrrc1"
                     /note="leucine rich repeat containing 1"
                     /db_xref="GeneID:367113"
                     /db_xref="RGD:1549773"
     exon            1..259
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1675
                     /gene="Lrrc1"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 1"
                     /protein_id="NP_001014290.1"
                     /db_xref="GeneID:367113"
                     /db_xref="RGD:1549773"
                     /translation="MFHCIPLWRCNRHVEAIDKRHCSLVYVPEEIYRYARSLEELLLD
                     ANQLRELPEQFFQLVKLRKLGLSDNEVQRLPPEIANFMQLVELDVSRNDIPEIPESIS
                     FCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRE
                     NLLTYLPDSLTQLRRLEELDLGNNEIYSLPESIGALLHLKDLWLDGNQLSELPQEIGN
                     LRNLLCLDVSENRLERLPEEISGLISLTDLVVSQNLLETVPDGIGKLKKLSILKLDQN
                     RLTQLPEAIGDCENLTELVLTENRLLTLPTSIGKLKKLNNLNADRNKLVSLPKEIGGC
                     CSLTVFCIRDNRLTRIPSEVSQAMELHVLDVAGNRLHHLPLSLTTLKLKALWLSDNQS
                     QPLLTFQTDVDHTTGEKILTCVLLPQMPSEPICQESLPRCGAMESLVNDVSEEAWDDH
                     SVHRVSAIRFLEDEKDEEENQTRTLQRRATPHPGELKNMKKTVENLRNDMNAAKGLDS
                     NKNEVNHATERVTTSV"
     exon            260..377
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..456
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..546
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..603
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..667
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..742
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..887
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1006
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1090
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1206
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1379
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1516
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1910
                     /gene="Lrrc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcggcgg gcggggagca gcggggcggc cgggcggagc gggctccgag ccccgggctc
       61 cgcggctcgg cgggacacga ctctggtgtt ggaggcggcg atgttccact gcattcccct
      121 gtggcggtgc aaccgtcatg tggaggccat cgacaagcgc cactgctcgc tggtctacgt
      181 cccggaggag atctatcgct atgcccgcag cctggaggag ctgctgctgg acgccaacca
      241 gctccgggag ctccccgagc aatttttcca gctagtgaaa ttacggaagc ttggactcag
      301 tgataatgaa gttcagcggc tccctccgga aatagcaaac ttcatgcagc tggtggaact
      361 cgatgtgtct cggaatgata tacccgagat tccagaaagc atctccttct gcaaagcgct
      421 gcaggtagct gacttcagcg gaaaccctct caccaggttg cccgagagct tccctgaact
      481 acagaactta acatgccttt ctgtaaatga catctcgcta cagtctctgc cggagaatat
      541 tggaaatctc tataacctgg cttcactgga actgagagag aaccttctta cgtatcttcc
      601 tgactctctt acccaactaa ggagactaga agaacttgat ttaggaaaca atgaaatcta
      661 tagtttgcca gaatcaattg gggcgctcct acatctgaag gatctctggt tggatggaaa
      721 tcaactgtct gagttacctc aggaaatagg gaatctgagg aacctgctct gcttagatgt
      781 gtctgaaaac aggctggaaa ggcttcctga ggaaatcagc ggcctgattt ccttgacaga
      841 cttggtcgtt tcccagaact tgctagaaac agttcccgac ggcattggaa aactaaagaa
      901 gctgtcaatc ttgaagttgg atcagaacag actcacacag ttgcctgaag caattgggga
      961 ttgtgaaaat ctcaccgaat tagttcttac ggaaaaccgg ctcctgacct tacctacgag
     1021 cattggaaaa cttaagaagt tgaacaactt gaatgcagac aggaataaac tagtgtcatt
     1081 accaaaagag attggcggat gctgcagcct caccgtgttc tgcatacggg acaacagact
     1141 gacccgaata ccttcagaag tatcacaggc catggaactt cacgtcctcg atgtggcagg
     1201 gaacaggtta caccatctgc ccttatcgct gaccaccctg aagttaaagg ccctgtggtt
     1261 atctgacaac cagtcccagc ctctcctcac gttccagaca gacgtagacc acaccaccgg
     1321 ggagaagatt ttaacgtgtg tcttacttcc tcagatgcct tctgagccca tctgccaaga
     1381 gagcctgccg cgctgtggtg ccatggagag cctggtaaat gacgtctctg aggaagcctg
     1441 ggatgaccac tccgtccaca gagttagcgc tatccgcttt ttggaagatg agaaggatga
     1501 agaggaaaac caaacgagaa cacttcagag gcgagccact ccacacccag gggaattaaa
     1561 gaacatgaaa aagacggtgg agaatttacg gaatgacatg aatgctgcca aaggactgga
     1621 ttcaaacaaa aacgaggtca accacgccac cgagcgcgtg accacgtcgg tgtaacagtc
     1681 acctccgagt cttacctgct gtgtcttccc tgctgtagag atgccccgtg cacctgagga
     1741 gcctcctgcc tgccgtcctt gtgcccacca tccctccgcc aggatgctgc tctcgctcgc
     1801 accaagtgcc ttatgcatcc ctcagtccat cagcgtacca gtagcctccc atcctgatta
     1861 tgttcaatat tagttgtgca tactaagtag aatacactac tgtcaacatc aaaaaaaaaa
     1921 aaaaaaaaaa aaaaa
//
