LOCUS       NM_001169113            1414 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus LDL receptor related protein associated protein 1
            (Lrpap1), mRNA.
ACCESSION   NM_001169113 XM_001058156 XM_341239
VERSION     NM_001169113.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1414)
  AUTHORS   Zhao,Z., Sagare,A.P., Ma,Q., Halliday,M.R., Kong,P., Kisler,K.,
            Winkler,E.A., Ramanathan,A., Kanekiyo,T., Bu,G., Owens,N.C.,
            Rege,S.V., Si,G., Ahuja,A., Zhu,D., Miller,C.A., Schneider,J.A.,
            Maeda,M., Maeda,T., Sugawara,T., Ichida,J.K. and Zlokovic,B.V.
  TITLE     Central role for PICALM in amyloid-beta blood-brain barrier
            transcytosis and clearance
  JOURNAL   Nat Neurosci 18 (7), 978-987 (2015)
   PUBMED   26005850
  REMARK    Erratum:[Nat Neurosci. 2024 Jan;27(1):208. doi:
            10.1038/s41593-023-01509-y.. PMID: 37985802]
REFERENCE   2  (bases 1 to 1414)
  AUTHORS   Zhang,R.K., Yang,L.K., Huang,L.J., Zhao,Q. and Cai,D.Z.
  TITLE     [Expression of lipoprotein related genes in subchondral bone of
            early experimental osteoarthritis]
  JOURNAL   Zhongguo Gu Shang 27 (1), 54-57 (2014)
   PUBMED   24754147
REFERENCE   3  (bases 1 to 1414)
  AUTHORS   Rushworth,J.V., Griffiths,H.H., Watt,N.T. and Hooper,N.M.
  TITLE     Prion protein-mediated toxicity of amyloid-beta oligomers requires
            lipid rafts and the transmembrane LRP1
  JOURNAL   J Biol Chem 288 (13), 8935-8951 (2013)
   PUBMED   23386614
REFERENCE   4  (bases 1 to 1414)
  AUTHORS   Bell,R.D., Deane,R., Chow,N., Long,X., Sagare,A., Singh,I.,
            Streb,J.W., Guo,H., Rubio,A., Van Nostrand,W., Miano,J.M. and
            Zlokovic,B.V.
  TITLE     SRF and myocardin regulate LRP-mediated amyloid-beta clearance in
            brain vascular cells
  JOURNAL   Nat Cell Biol 11 (2), 143-153 (2009)
   PUBMED   19098903
REFERENCE   5  (bases 1 to 1414)
  AUTHORS   Pandey,P., Pradhan,S. and Mittal,B.
  TITLE     LRP-associated protein gene (LRPAP1) and susceptibility to
            degenerative dementia
  JOURNAL   Genes Brain Behav 7 (8), 943-950 (2008)
   PUBMED   18721259
REFERENCE   6  (bases 1 to 1414)
  AUTHORS   Willnow,T.E., Armstrong,S.A., Hammer,R.E. and Herz,J.
  TITLE     Functional expression of low density lipoprotein receptor-related
            protein is controlled by receptor-associated protein in vivo
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4537-4541 (1995)
   PUBMED   7538675
REFERENCE   7  (bases 1 to 1414)
  AUTHORS   Abbate,M., Bachinsky,D.R., McCluskey,R.T. and Brown,D.
  TITLE     Expression of gp330 and gp330/alpha 2-macroglobulin
            receptor-associated protein in renal tubular differentiation
  JOURNAL   J Am Soc Nephrol 4 (12), 2003-2015 (1994)
   PUBMED   7522607
REFERENCE   8  (bases 1 to 1414)
  AUTHORS   Kanalas,J.J. and Makker,S.P.
  TITLE     Analysis of a 45-kDa protein that binds to the Heymann nephritis
            autoantigen GP330
  JOURNAL   J Biol Chem 268 (11), 8188-8192 (1993)
   PUBMED   7681839
REFERENCE   9  (bases 1 to 1414)
  AUTHORS   Herz,J., Goldstein,J.L., Strickland,D.K., Ho,Y.K. and Brown,M.S.
  TITLE     39-kDa protein modulates binding of ligands to low density
            lipoprotein receptor-related protein/alpha 2-macroglobulin receptor
  JOURNAL   J Biol Chem 266 (31), 21232-21238 (1991)
   PUBMED   1718973
REFERENCE   10 (bases 1 to 1414)
  AUTHORS   Pietromonaco,S., Kerjaschki,D., Binder,S., Ullrich,R. and
            Farquhar,M.G.
  TITLE     Molecular cloning of a cDNA encoding a major pathogenic domain of
            the Heymann nephritis antigen gp330
  JOURNAL   Proc Natl Acad Sci U S A 87 (5), 1811-1815 (1990)
   PUBMED   2408041
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM055449.1, BC098947.1 and M31051.1.
            
            On or before Dec 16, 2009 this sequence version replaced
            XM_001058156.1, XM_341239.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M31051.1, Z11994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                FM055449.1         3-37
            36-1382             BC098947.1         1-1347
            1383-1414           M31051.1           1227-1258
FEATURES             Location/Qualifiers
     source          1..1414
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1414
                     /gene="Lrpap1"
                     /note="LDL receptor related protein associated protein 1"
                     /db_xref="GeneID:116565"
                     /db_xref="RGD:620700"
     exon            1..246
                     /gene="Lrpap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1116
                     /gene="Lrpap1"
                     /note="alpha-2-macroglobulin receptor-associated protein;
                     RAP; alpha-2-MRAP; gp330-binding 45 kDa protein; low
                     density lipoprotein receptor-related protein-associated
                     protein 1"
                     /codon_start=1
                     /product="alpha-2-macroglobulin receptor-associated
                     protein precursor"
                     /protein_id="NP_001162584.1"
                     /db_xref="GeneID:116565"
                     /db_xref="RGD:620700"
                     /translation="MAPLRDRVSTLPRLQLLVLLLLPLLLVPQPIAGHGGKYSREKNE
                     PEMAAKRESGEEFRMEKLNQLWEKAKRLHLSPVRLAELHSDLKIQERDELNWKKLKVE
                     GLDGDGEKEAKLVHNLNVILARYGLDGRKDTQTVHSNALNEDTQDELGDPRLEKLWHK
                     AKTSGKFSSEELDKLWREFLHYKEKIHEYNVLLDTLSRAEEGYENLLSPSDMTHIKSD
                     TLASKHSELKDRLRSINQGLDRLRKVSHQGYGPATEFEEPRVIDLWDLAQSANFTEKE
                     LESFREELKHFEAKIEKHNHYQKQLEISHQKLKHVESIGDPEHISRNKEKYVLLEEKT
                     KELGYKVKKHLQDLSSRVSRARHNEL"
     exon            247..391
                     /gene="Lrpap1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..513
                     /gene="Lrpap1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..634
                     /gene="Lrpap1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..793
                     /gene="Lrpap1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..876
                     /gene="Lrpap1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1053
                     /gene="Lrpap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1414
                     /gene="Lrpap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcctgtca gtctgctagc tctgcagagg aagatggcgc ctcttagaga cagggtctct
       61 acgctgcccc ggctccaact gctagtgctg ttgttgctgc cgctgctgct tgtgccccag
      121 cccatcgcag gtcatggcgg caagtactcg cgggagaaga atgagcccga gatggccgcc
      181 aagcgtgagt ccggggagga gttccgcatg gagaagctga accagctatg ggagaaggcc
      241 aagcggctgc atctgtctcc tgtgaggctg gccgagctgc attctgacct gaagatacaa
      301 gagagggatg aactcaactg gaagaagctg aaggtggaag gcctagacgg ggatggggag
      361 aaagaagcaa aactggtcca caatctcaat gtcatcctgg ccaggtacgg actggatggg
      421 aggaaggaca cccagacagt gcacagcaac gccctcaatg aagacaccca ggatgagctg
      481 ggggacccca ggttggaaaa gctgtggcac aaggcaaaga catcagggaa attctccagt
      541 gaagaactgg acaagctgtg gcgagagttt ctgcactaca aagagaagat ccacgagtac
      601 aatgtactgc tagatacact gagcagagct gaagaaggtt atgagaacct tctcagcccc
      661 tctgacatga cccacatcaa gagtgacacc ctggccagca agcacagtga actgaaggac
      721 agactgcgta gtatcaacca gggcctagac cgcctgagga aggtcagcca ccagggctac
      781 ggccccgcca ctgagtttga agagccccga gtgatagatc tgtgggacct ggctcagtct
      841 gccaacttca ccgagaagga actggagtcg ttcagggagg agcttaagca cttcgaggcc
      901 aaaatcgaaa agcacaacca ctaccagaag cagctggaga tttcccacca gaagctgaag
      961 cacgtggaga gcatcggtga ccccgagcac atcagccgca acaaggagaa gtacgtcctg
     1021 ctggaggaga agacaaagga gctgggctac aaggtgaaga agcatctgca ggacctgtcc
     1081 agcagggtct caagggctcg gcacaatgag ctctgagacc agaagccact ggcagtagcc
     1141 tagagaggct cttgaagaca ctgggaactg tcaacttgtc atactggtgt ggctgtccac
     1201 agtggcaagg agaaataccg atctgatcct gctgcggctg gcaaggacta attttctttc
     1261 aagcaagtgt agctgtcacc gccctggttg agggctttgg gtacatctac caatgagata
     1321 tgaccggtct ccatgctgca gcaaaagttt acattgaaat tatataaatc tgtcactgga
     1381 aatgttatgt acagagtcct taaatacatg gcag
//
