LOCUS       XM_039111153            7446 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus LDL receptor related protein 8 (Lrp8),
            transcript variant X10, mRNA.
ACCESSION   XM_039111153
VERSION     XM_039111153.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051340.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039111153.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7446
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..7446
                     /gene="Lrp8"
                     /note="LDL receptor related protein 8; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 25 ESTs, 1 long SRA read, 3 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 59 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:362558"
                     /db_xref="RGD:1305729"
     CDS             175..2916
                     /gene="Lrp8"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     8 isoform X10"
                     /protein_id="XP_038967081.1"
                     /db_xref="GeneID:362558"
                     /db_xref="RGD:1305729"
                     /translation="MGRPERGALRPLALLLLLLLLLLQLQHLSTADPLPGGQGPVKEC
                     EEDQFRCRNERCIPSVWRCDEDNDCSDNSDEDDCPKRTCTDSDFTCDNGHCIPERWKC
                     DGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC
                     PTLCAPHEFQCSNRSCLASVFVCDGDDDCGDGSDERGCSDPACPPREFRCGGGGTCIP
                     ERWVCDGQFDCEDRSDEAAELCGRAGQGTTATPAACAPTTQFTCRSGECIHLGWRCDG
                     DRDCKDKSDEADCSAPGPCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGCLQVAP
                     IFQGNRRRPRGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDP
                     DACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGRSPSLIFTNRHEVRRIDLVKRD
                     YSRLIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIGEQLHSP
                     EGLAVDWVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRAIAVDPLRGFMYWS
                     DWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNG
                     GNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPH
                     DIVIFHELKQPKAADACELSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDM
                     KRCYRAPPSTSTTTLASAMTRTVPATTGAPGTTIHDSTYQNHSTEMPSQTAAVPHSVN
                     IPKAHSTSPSTLSPATSNHSQHYGNEGSQMGSTVTAAVIGIIVPIVVIALLCMSGYLI
                     WRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPARVALSLEDDGLP"
ORIGIN      
        1 ccgagcgtca ccgaacctgc ttgaaatgca gccggggagc cggggcgggc ggcagcggtg
       61 gtggtggcgg cggcggcagc ggcagccccg gcgccgcggc aaggacttgg cgggctgagg
      121 cgcggcggcg gcgcgggggt ctcggggcgc ggcggccgga gccccgggcc cgccatgggc
      181 cgcccagagc ggggcgcgct ccggccgctg gcgttgttgc tgttgctgct gctgctgctg
      241 ctacagcttc agcatctttc cacagcggat ccgctgcctg gcggccaagg gccggtcaag
      301 gaatgtgaag aggaccagtt tcggtgtcgg aacgagcgtt gtatcccctc ggtgtggaga
      361 tgcgatgaag acaacgactg ctcggacaac agcgacgagg acgactgccc caagaggacc
      421 tgcacagaca gcgactttac ctgtgataat ggccactgca tcccggagcg gtggaagtgt
      481 gacggcgagg aggagtgtcc tgatggatct gatgaatcga aggccacgtg ttccagtgaa
      541 gaatgtcctg ccgagaagct aagctgcgga cccaccagcc acaagtgtgt gcctgcctca
      601 tggcgctgtg acggggagaa ggactgtgag ggtggagcag acgaggccgg ctgtcctacc
      661 ttgtgcgccc cgcacgagtt ccagtgcagc aaccgctcct gcctggcctc tgtgttcgtg
      721 tgcgatggtg acgatgactg cggcgacggc agcgacgagc gaggctgctc ggacccggcc
      781 tgcccgcccc gcgagttccg ctgtggagga ggcggcacct gcatccctga gcgctgggtc
      841 tgcgacggcc agttcgactg cgaggaccgc tcggatgagg ccgctgagct ctgcgggcga
      901 gcgggccagg ggaccacggc cacgccagca gcctgcgccc ctaccaccca gttcacctgc
      961 cgcagcggcg agtgcataca cctgggctgg cgctgcgatg gcgaccgcga ctgcaaggac
     1021 aagtctgacg aggccgactg ctcagcacca ggaccctgcc gtgagaatga cttccagtgt
     1081 ggggatggga cttgcattct tgcaatcaaa cggtgcaacc aggagcggga ctgcctggac
     1141 gggagtgatg aagccggctg cctgcaggtt gcaccaatat tccagggaaa caggaggagg
     1201 cccagggggc tgaacgagtg tctgcacaac aatggtggct gctcccacat ctgcactgac
     1261 ctcaagatcg gctttgagtg tacatgccca gcaggcttcc agctcttgga ccaaaagacc
     1321 tgtggtgaca ttgacgaatg ccaggaccca gatgcctgca gccaaatctg tgtgaattac
     1381 aagggctact ttaagtgtga atgccacccc ggctatgaga tggatacgct gaccaagaac
     1441 tgtaaagctg tagctggcag gagcccatcc ctaatcttca cgaaccgaca cgaagtacgg
     1501 cgaatagacc tggtgaagcg ggactactca cgcctcatcc ccatgctcaa gaatgtcgtg
     1561 gcgctggacg tggaagtgga taccaatcga atatattggt gtgacctttc ctaccgcaag
     1621 atctacagcg cccacatgga caaggccagt atcccggacg agcaggtggt cctcattggt
     1681 gagcagctgc actctccaga gggcctggcg gtggactggg tccataagca catctactgg
     1741 acagactcag gcaataagac cgtctcagtc gccacaaccg atggacgccg ccgctgtact
     1801 ctcttcaacc gtgatctcag cgagccccga gccattgctg tcgaccccct gcgagggttc
     1861 atgtactggt ctgactgggg tttccaggca aagattgaga aggctgggct caatggtgca
     1921 gaccggcaaa cactggtttc agacaacatc gagtggccca acggaatcac cctggacttg
     1981 ctgagccagc gtttgtactg ggtggactcc aagctgcacc agctatccag catcgacttc
     2041 aatggaggca acagaaagat gctgattttc tccactgact tcctgagtca cccttttggg
     2101 gtagctgtat ttgaggacaa ggtattctgg acggatctgg agaatgaggc cattttcagc
     2161 gcaaatcggc tcaatggcct ggagatctcc atcctggctg agaaccttaa taacccacat
     2221 gacattgtaa tcttccatga gctgaagcag ccaaaggctg cagatgcctg tgagctgagt
     2281 gcccagccca atggcggctg tgaatacctg tgccttcctg ctcctcagat ctccagccac
     2341 tctcccaagt acacctgtgc ctgtcctgac acaatgtggc tgggcccaga catgaagaga
     2401 tgctaccgag cacctccgtc tacctcaact acaaccttag cctctgctat gacaaggaca
     2461 gtacctgcta ctacgggagc ccctgggaca accatccacg actctaccta ccagaaccac
     2521 agcacagaga tgccaagcca gacagctgcc gtccctcact cagtgaacat ccctaaggct
     2581 cacagcacca gcccgtccac cctgagccct gcaaccagca accactccca gcactatggg
     2641 aatgaaggca gccagatggg ttcaacagtc accgctgctg tcattgggat catcgtgccc
     2701 atagtggtaa tagccctgct gtgtatgagt gggtacctca tctggagaaa ctggaagcgg
     2761 aagaatacca agagcatgaa tttcgacaac ccagtgtaca ggaagacaac agaagaggaa
     2821 gaggaagatg aacttcacat agggaggacg gctcagattg gccatgtcta ccccgcacga
     2881 gtggcattaa gtcttgaaga tgacggactg ccctgaggat gggcccgccc acttcgtgcc
     2941 tcatggagtt cagtcctatg cactactctc tctggatggt gtgtgattgg atgaatgcca
     3001 tttctatata tgggtctgtg tgagcgtgtg tgagtgcgtg taactttttt taaatttatg
     3061 ttgcggaaag gtaaccacaa agttatgatg aactgcagac atccaaagga tgtgaacgtt
     3121 tttatatgta taatgtttta tacacttttt aactggttgc actacccgtg aagaattcat
     3181 gggacagcca ctgctgagtg actaacatga tgcacataac caaacggggc caatggtaca
     3241 aactttactc atcatttgaa tacagtattt acagaggatg tttgatttga gagctttttt
     3301 aggtttgagg agcttggttt tttttttttt ttttgtaaat aaaattatgc tttgtggcta
     3361 tccatcaaca taagtataaa aagaaagaac acttcaactc ctttccccat ctagattatt
     3421 tattaacata tttcaaaagt aaggttagct ctataaataa tttagagaag cgagagtatt
     3481 tatttttggt atgattggcc cactgcacag actctgtgtt tatgtgtgtg tgtttgtgtg
     3541 agagaaaaaa acctgtaggg aagaggcgcg ctatgactat tgctcacata catacaaaca
     3601 gttattttaa aatggtccac aagaggggtg tctagttttc agagacacct tcagaaactt
     3661 tgctcagaga acacagatgc catggtttgt gcagagatgt ggtgggaaag gtagatcttt
     3721 tcacctatgg ctactcctga ggtcctgaca agccagcaca aagcttttca gttcctctga
     3781 ggctgtcatg atgcccacct aggctttctg gtcagtgtgc agatactgca cgggggttac
     3841 aagccctcat gagctcaaga cagcagagtc cttccttcaa aattcagctt agtgagggct
     3901 cgggtcagct tcagtaagct tcctctgaag cacctgaagg tcgggccttt agagcagctg
     3961 ttctcaacct ttgtaggtca aaaagaccct ttcacaaggg tcacttaagg catcggaaaa
     4021 cacagattct tacattatgg tccataacag tagcaaaatt acagttatga agtagaaatg
     4081 aagtgatgtt atggttgggt cagtacaaca tggactgtat taaagcttct gaggcgttag
     4141 gaaggctgag aacccctact ctagagctaa gtgaaggcat ttctaggatt tccaagttta
     4201 ctgtaagaac aggctcaggc actgaagctc tgagtcgcgt gaatgaggac gacaattttg
     4261 gaataggttt ggttacacct atttctcatc cccttacttt ctaccatttt tcttacgtag
     4321 gggaaacatt ttaagaaaat acacatttct tacgaccgta tgttcacatg gataagacta
     4381 agtccaaaag tgtgaatacg tccaaattta tattttgggg aaataccatg agatattata
     4441 gcatatcggg catgtttcat tgctttataa ataaaaggag aaactctagg tgtttgtata
     4501 gaattttctt catatgtaac acctttacat tttctgagcc ttggggatgg ggtgggagaa
     4561 atgccatttt tctgtctgtg gaatcctcta ttggaaatgt aatcccatag tcccagaagg
     4621 aattcagtcc ccactagctc tctctgttct ataatccact ccagctgaat gaccaggaca
     4681 actatgacac ttctgtgttt ggcttaagtg gtggcagact aatgtctaaa tttggcacaa
     4741 ctggaatttg acatttgaga catatgtttc cgtgttccca catgacagct tcccccaaac
     4801 cggtgaagct cgaatggctc acctgcttga cgccctttcg acttccaggc aggccatctg
     4861 gaggcctgtc ctcctcttcc caggagcttg ctctgtgtca ctcatgttgt cctaaccttt
     4921 aaaaaatggc tgtgttccaa gcttggccat tatgtctggc gacttctttt tggatgcgtg
     4981 tgttgatggt cttgagatat taattgaata aatgcggctg gcccctgact ccattccagt
     5041 ctcaagaaca ggtagcccaa ctcctctgga gctcacccat ctctgttcat ccagggatga
     5101 aaaggaaaat cagttcttac tgaaaataag gtggaagtga aagcatcaaa atttatacaa
     5161 ggcaggcatt gtctttttct ttttttcttt aatctgcctt caaggaaacc gagaccgtga
     5221 tagttagtgc atagtttctg aacttttagt cagatcctag ccttcacaac agggttgaaa
     5281 cataccatct agggtttcca aaaggtgatt aataagatta aattattatc aaaataccat
     5341 gtttcctgaa tgcgcgacag ctgcagtctg aaagtaacct acagtaaaca gacggacaaa
     5401 tccaggggcg gctggagagc ggaagcactc tgaggaggca gacccacttc ctcctatcct
     5461 cggagacttt tcgagccgca gtctgggttt aattcagatc ttctgttgcc cttctcctct
     5521 gcatgtgtat ccacagctgg taacatccag aagaaagctt agtgataaac caagagggca
     5581 gaaagttcag ctaactactt atgaaaacga agcgaaccct ctcttctctg gaagagaact
     5641 ttgggcggcc tgagcaaggt ctcaagcctg cttcctctcc cacagctctc tgccctgtgg
     5701 gttgatgaag gcactaacag agatgacctt cccgaaacat cagactataa ctttgtttac
     5761 tcttcagcat gtgtgtacac ggagagggac agactgagat ggcttctgac tcaaggagta
     5821 agaagaatga gaggggattt aaatggatgg cagtgaatcc tgttgagccc ttcagttatt
     5881 ctcatgtctt tgcaacatac tctctaaaac gattcactag ctgctgtgtg cccggcattg
     5941 caaacatcac aggtgcattc aacgtttttc accctttcag aactcacagc agtacatgtg
     6001 gatacaagaa aagaaagtaa atttcccata gatttcactt agactactcc cagggcagag
     6061 agagagagag agagagagag agagagagag agagagagag accattttac ctgaagaggt
     6121 gaaaaaattc ggtctacata gaagtgcccc aaagccaagt cttaaacatt aaaaagtggt
     6181 gttcaggctg cttctgtgag aagagagatt gggctaagac tgaggagtga atcggcaaca
     6241 ggacttttaa ggaaaacatg gattcattac acctggaata aagaacttta agaggtttgg
     6301 caagatgtga aactggatgg aagaaaattt caacataggc actttataaa ataatgtctg
     6361 atctaagtaa gtggacattt ctttggtcag ttcctgtgtg caaggcatca tgggaaactc
     6421 actgccagca ctttgcaggc atccacctca agctgtccgg tggccacggg gagatgacgt
     6481 tatttactta ttcgagtcag agattttgat gtggttagtg agaacagaca ggcagtggga
     6541 ttttgaactg aagcatgcca tgttgccgag cagcaccttt gagatgttct cgcctgtgag
     6601 gaagagaaga tgataaagag acagaatctg gagagggcac cccaatcaca ctacagtcag
     6661 gtgctaccgg gtggaggaga aaccattcta accccacagc actacaagac tcctatccca
     6721 ccacgcattc accatttcac gaaacggcag taagtcagca gtttcaaatt atgtgatttc
     6781 cttccccata aatgcatgca gatagggagt cggtctccgt acactatatt tttagggtgt
     6841 ttgggagttt ccaggatgtg aagaatttag aaggcggagg attcagggcc tcagattctc
     6901 agctaactag ataaagcttc agtcaggctg ggcaccatgt gcacagtctt aagaatcagc
     6961 aggaaatgca tttgcaaaac acatgctgta aaaaattaat tttaaaaaag ctacctgtat
     7021 aaatatatat atttaaaagc aaggttttga tacttttttt tacaaaaact acaagagaag
     7081 actgtacaac ccacaggctt ttaaaatagc attttgttct ctataagctg ttaatatgag
     7141 gggtaaggta ctggtttgca aactcacaca atccaatgga ttttcttgtt tgtcaccccg
     7201 ctctccaaat taccataatt ggtgtaatag tagggcatgt aaagttattg ggtcacataa
     7261 accatttctg ctcttgtcat cctgggttcc gttagctcct gtactcagga atctagcttc
     7321 ttccagaggc agagggaccg aagcaagtgt gctccatttc actcgctgta ctgacatcat
     7381 ccaaatgtgg acatttgtaa aatcagcaca ctatttctat agagacatta aattcatttt
     7441 ttaaaa
//
