LOCUS       XM_006238570            7749 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus LDL receptor related protein 8 (Lrp8),
            transcript variant X1, mRNA.
ACCESSION   XM_006238570
VERSION     XM_006238570.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051340.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_006238570.4.
            
            On Jan 21, 2021 this sequence version replaced XM_006238570.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7749
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..7749
                     /gene="Lrp8"
                     /note="LDL receptor related protein 8; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 24 ESTs, 2 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     25 samples with support for all annotated introns"
                     /db_xref="GeneID:362558"
                     /db_xref="RGD:1305729"
     CDS             178..3219
                     /gene="Lrp8"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     8 isoform X1"
                     /protein_id="XP_006238632.1"
                     /db_xref="GeneID:362558"
                     /db_xref="RGD:1305729"
                     /translation="MGRPERGALRPLALLLLLLLLLLQLQHLSTADPLPGGQGPVKEC
                     EEDQFRCRNERCIPSVWRCDEDNDCSDNSDEDDCPKRTCTDSDFTCDNGHCIPERWKC
                     DGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC
                     PTLCAPHEFQCSNRSCLASVFVCDGDDDCGDGSDERGCSDPACPPREFRCGGGGTCIP
                     ERWVCDGQFDCEDRSDEAAELCGRAGQGTTATPAACAPTTQFTCRSGECIHLGWRCDG
                     DRDCKDKSDEADCSAPGPCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGCLQEST
                     CEGPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQKVCVAPIFQGNRRRPRGLNECLH
                     NNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCE
                     CHPGYEMDTLTKNCKAVAGRSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVE
                     VDTNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIGEQLHSPEGLAVDWVHKHIYWTDS
                     GNKTVSVATTDGRRRCTLFNRDLSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGAD
                     RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPF
                     GVAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPKAADAC
                     ELSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPPSTSTTTLAS
                     AMTRTVPATTGAPGTTIHDSTYQNHSTEMPSQTAAVPHSVNIPKAHSTSPSTLSPATS
                     NHSQHYGNEGSQMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNP
                     VYRKTTEEEEEDELHIGRTAQIGHVYPAAISSYDRPLWAEPCLGETRDLEDPAPAHKE
                     LFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP"
ORIGIN      
        1 ccgccgagcg tcaccgaacc tgcttgaaat gcagccgggg agccggggcg ggcggcagcg
       61 gtggtggtgg cggcggcggc agcggcagcc ccggcgccgc ggcaaggact tggcgggctg
      121 aggcgcggcg gcggcgcggg ggtctcgggg cgcggcggcc ggagccccgg gcccgccatg
      181 ggccgcccag agcggggcgc gctccggccg ctggcgttgt tgctgttgct gctgctgctg
      241 ctgctacagc ttcagcatct ttccacagcg gatccgctgc ctggcggcca agggccggtc
      301 aaggaatgtg aagaggacca gtttcggtgt cggaacgagc gttgtatccc ctcggtgtgg
      361 agatgcgatg aagacaacga ctgctcggac aacagcgacg aggacgactg ccccaagagg
      421 acctgcacag acagcgactt tacctgtgat aatggccact gcatcccgga gcggtggaag
      481 tgtgacggcg aggaggagtg tcctgatgga tctgatgaat cgaaggccac gtgttccagt
      541 gaagaatgtc ctgccgagaa gctaagctgc ggacccacca gccacaagtg tgtgcctgcc
      601 tcatggcgct gtgacgggga gaaggactgt gagggtggag cagacgaggc cggctgtcct
      661 accttgtgcg ccccgcacga gttccagtgc agcaaccgct cctgcctggc ctctgtgttc
      721 gtgtgcgatg gtgacgatga ctgcggcgac ggcagcgacg agcgaggctg ctcggacccg
      781 gcctgcccgc cccgcgagtt ccgctgtgga ggaggcggca cctgcatccc tgagcgctgg
      841 gtctgcgacg gccagttcga ctgcgaggac cgctcggatg aggccgctga gctctgcggg
      901 cgagcgggcc aggggaccac ggccacgcca gcagcctgcg cccctaccac ccagttcacc
      961 tgccgcagcg gcgagtgcat acacctgggc tggcgctgcg atggcgaccg cgactgcaag
     1021 gacaagtctg acgaggccga ctgctcagca ccaggaccct gccgtgagaa tgacttccag
     1081 tgtggggatg ggacttgcat tcttgcaatc aaacggtgca accaggagcg ggactgcctg
     1141 gacgggagtg atgaagccgg ctgcctgcag gagtcaactt gtgagggtcc ccgcagattt
     1201 cagtgtaaga gtggcgagtg cgtggacggc gggaaagtgt gtgatgatca gagggactgc
     1261 cgggactggt cggatgagcc tcagaaagtg tgtgttgcac caatattcca gggaaacagg
     1321 aggaggccca gggggctgaa cgagtgtctg cacaacaatg gtggctgctc ccacatctgc
     1381 actgacctca agatcggctt tgagtgtaca tgcccagcag gcttccagct cttggaccaa
     1441 aagacctgtg gtgacattga cgaatgccag gacccagatg cctgcagcca aatctgtgtg
     1501 aattacaagg gctactttaa gtgtgaatgc caccccggct atgagatgga tacgctgacc
     1561 aagaactgta aagctgtagc tggcaggagc ccatccctaa tcttcacgaa ccgacacgaa
     1621 gtacggcgaa tagacctggt gaagcgggac tactcacgcc tcatccccat gctcaagaat
     1681 gtcgtggcgc tggacgtgga agtggatacc aatcgaatat attggtgtga cctttcctac
     1741 cgcaagatct acagcgccca catggacaag gccagtatcc cggacgagca ggtggtcctc
     1801 attggtgagc agctgcactc tccagagggc ctggcggtgg actgggtcca taagcacatc
     1861 tactggacag actcaggcaa taagaccgtc tcagtcgcca caaccgatgg acgccgccgc
     1921 tgtactctct tcaaccgtga tctcagcgag ccccgagcca ttgctgtcga ccccctgcga
     1981 gggttcatgt actggtctga ctggggtttc caggcaaaga ttgagaaggc tgggctcaat
     2041 ggtgcagacc ggcaaacact ggtttcagac aacatcgagt ggcccaacgg aatcaccctg
     2101 gacttgctga gccagcgttt gtactgggtg gactccaagc tgcaccagct atccagcatc
     2161 gacttcaatg gaggcaacag aaagatgctg attttctcca ctgacttcct gagtcaccct
     2221 tttggggtag ctgtatttga ggacaaggta ttctggacgg atctggagaa tgaggccatt
     2281 ttcagcgcaa atcggctcaa tggcctggag atctccatcc tggctgagaa ccttaataac
     2341 ccacatgaca ttgtaatctt ccatgagctg aagcagccaa aggctgcaga tgcctgtgag
     2401 ctgagtgccc agcccaatgg cggctgtgaa tacctgtgcc ttcctgctcc tcagatctcc
     2461 agccactctc ccaagtacac ctgtgcctgt cctgacacaa tgtggctggg cccagacatg
     2521 aagagatgct accgagcacc tccgtctacc tcaactacaa ccttagcctc tgctatgaca
     2581 aggacagtac ctgctactac gggagcccct gggacaacca tccacgactc tacctaccag
     2641 aaccacagca cagagatgcc aagccagaca gctgccgtcc ctcactcagt gaacatccct
     2701 aaggctcaca gcaccagccc gtccaccctg agccctgcaa ccagcaacca ctcccagcac
     2761 tatgggaatg aaggcagcca gatgggttca acagtcaccg ctgctgtcat tgggatcatc
     2821 gtgcccatag tggtaatagc cctgctgtgt atgagtgggt acctcatctg gagaaactgg
     2881 aagcggaaga ataccaagag catgaatttc gacaacccag tgtacaggaa gacaacagaa
     2941 gaggaagagg aagatgaact tcacataggg aggacggctc agattggcca tgtctacccc
     3001 gcagcaatca gcagctatga tcgcccactg tgggcagagc cctgtcttgg ggagaccaga
     3061 gacctggaag acccagcccc tgcccacaag gagctttttg tcttgccggg agaaccaagg
     3121 tcacagctgc accaactccc gaagaaccct ctttccgagc tgcctgtcgt caagtgcaag
     3181 cgagtggcat taagtcttga agatgacgga ctgccctgag gatgggcccg cccacttcgt
     3241 gcctcatgga gttcagtcct atgcactact ctctctggat ggtgtgtgat tggatgaatg
     3301 ccatttctat atatgggtct gtgtgagcgt gtgtgagtgc gtgtaacttt ttttaaattt
     3361 atgttgcgga aaggtaacca caaagttatg atgaactgca gacatccaaa ggatgtgaac
     3421 gtttttatat gtataatgtt ttatacactt tttaactggt tgcactaccc gtgaagaatt
     3481 catgggacag ccactgctga gtgactaaca tgatgcacat aaccaaacgg ggccaatggt
     3541 acaaacttta ctcatcattt gaatacagta tttacagagg atgtttgatt tgagagcttt
     3601 tttaggtttg aggagcttgg tttttttttt tttttttgta aataaaatta tgctttgtgg
     3661 ctatccatca acataagtat aaaaagaaag aacacttcaa ctcctttccc catctagatt
     3721 atttattaac atatttcaaa agtaaggtta gctctataaa taatttagag aagcgagagt
     3781 atttattttt ggtatgattg gcccactgca cagactctgt gtttatgtgt gtgtgtttgt
     3841 gtgagagaaa aaaacctgta gggaagaggc gcgctatgac tattgctcac atacatacaa
     3901 acagttattt taaaatggtc cacaagaggg gtgtctagtt ttcagagaca ccttcagaaa
     3961 ctttgctcag agaacacaga tgccatggtt tgtgcagaga tgtggtggga aaggtagatc
     4021 ttttcaccta tggctactcc tgaggtcctg acaagccagc acaaagcttt tcagttcctc
     4081 tgaggctgtc atgatgccca cctaggcttt ctggtcagtg tgcagatact gcacgggggt
     4141 tacaagccct catgagctca agacagcaga gtccttcctt caaaattcag cttagtgagg
     4201 gctcgggtca gcttcagtaa gcttcctctg aagcacctga aggtcgggcc tttagagcag
     4261 ctgttctcaa cctttgtagg tcaaaaagac cctttcacaa gggtcactta aggcatcgga
     4321 aaacacagat tcttacatta tggtccataa cagtagcaaa attacagtta tgaagtagaa
     4381 atgaagtgat gttatggttg ggtcagtaca acatggactg tattaaagct tctgaggcgt
     4441 taggaaggct gagaacccct actctagagc taagtgaagg catttctagg atttccaagt
     4501 ttactgtaag aacaggctca ggcactgaag ctctgagtcg cgtgaatgag gacgacaatt
     4561 ttggaatagg tttggttaca cctatttctc atccccttac tttctaccat ttttcttacg
     4621 taggggaaac attttaagaa aatacacatt tcttacgacc gtatgttcac atggataaga
     4681 ctaagtccaa aagtgtgaat acgtccaaat ttatattttg gggaaatacc atgagatatt
     4741 atagcatatc gggcatgttt cattgcttta taaataaaag gagaaactct aggtgtttgt
     4801 atagaatttt cttcatatgt aacaccttta cattttctga gccttgggga tggggtggga
     4861 gaaatgccat ttttctgtct gtggaatcct ctattggaaa tgtaatccca tagtcccaga
     4921 aggaattcag tccccactag ctctctctgt tctataatcc actccagctg aatgaccagg
     4981 acaactatga cacttctgtg tttggcttaa gtggtggcag actaatgtct aaatttggca
     5041 caactggaat ttgacatttg agacatatgt ttccgtgttc ccacatgaca gcttccccca
     5101 aaccggtgaa gctcgaatgg ctcacctgct tgacgccctt tcgacttcca ggcaggccat
     5161 ctggaggcct gtcctcctct tcccaggagc ttgctctgtg tcactcatgt tgtcctaacc
     5221 tttaaaaaat ggctgtgttc caagcttggc cattatgtct ggcgacttct ttttggatgc
     5281 gtgtgttgat ggtcttgaga tattaattga ataaatgcgg ctggcccctg actccattcc
     5341 agtctcaaga acaggtagcc caactcctct ggagctcacc catctctgtt catccaggga
     5401 tgaaaaggaa aatcagttct tactgaaaat aaggtggaag tgaaagcatc aaaatttata
     5461 caaggcaggc attgtctttt tctttttttc tttaatctgc cttcaaggaa accgagaccg
     5521 tgatagttag tgcatagttt ctgaactttt agtcagatcc tagccttcac aacagggttg
     5581 aaacatacca tctagggttt ccaaaaggtg attaataaga ttaaattatt atcaaaatac
     5641 catgtttcct gaatgcgcga cagctgcagt ctgaaagtaa cctacagtaa acagacggac
     5701 aaatccaggg gcggctggag agcggaagca ctctgaggag gcagacccac ttcctcctat
     5761 cctcggagac ttttcgagcc gcagtctggg tttaattcag atcttctgtt gcccttctcc
     5821 tctgcatgtg tatccacagc tggtaacatc cagaagaaag cttagtgata aaccaagagg
     5881 gcagaaagtt cagctaacta cttatgaaaa cgaagcgaac cctctcttct ctggaagaga
     5941 actttgggcg gcctgagcaa ggtctcaagc ctgcttcctc tcccacagct ctctgccctg
     6001 tgggttgatg aaggcactaa cagagatgac cttcccgaaa catcagacta taactttgtt
     6061 tactcttcag catgtgtgta cacggagagg gacagactga gatggcttct gactcaagga
     6121 gtaagaagaa tgagagggga tttaaatgga tggcagtgaa tcctgttgag cccttcagtt
     6181 attctcatgt ctttgcaaca tactctctaa aacgattcac tagctgctgt gtgcccggca
     6241 ttgcaaacat cacaggtgca ttcaacgttt ttcacccttt cagaactcac agcagtacat
     6301 gtggatacaa gaaaagaaag taaatttccc atagatttca cttagactac tcccagggca
     6361 gagagagaga gagagagaga gagagagaga gagagagaga gagaccattt tacctgaaga
     6421 ggtgaaaaaa ttcggtctac atagaagtgc cccaaagcca agtcttaaac attaaaaagt
     6481 ggtgttcagg ctgcttctgt gagaagagag attgggctaa gactgaggag tgaatcggca
     6541 acaggacttt taaggaaaac atggattcat tacacctgga ataaagaact ttaagaggtt
     6601 tggcaagatg tgaaactgga tggaagaaaa tttcaacata ggcactttat aaaataatgt
     6661 ctgatctaag taagtggaca tttctttggt cagttcctgt gtgcaaggca tcatgggaaa
     6721 ctcactgcca gcactttgca ggcatccacc tcaagctgtc cggtggccac ggggagatga
     6781 cgttatttac ttattcgagt cagagatttt gatgtggtta gtgagaacag acaggcagtg
     6841 ggattttgaa ctgaagcatg ccatgttgcc gagcagcacc tttgagatgt tctcgcctgt
     6901 gaggaagaga agatgataaa gagacagaat ctggagaggg caccccaatc acactacagt
     6961 caggtgctac cgggtggagg agaaaccatt ctaaccccac agcactacaa gactcctatc
     7021 ccaccacgca ttcaccattt cacgaaacgg cagtaagtca gcagtttcaa attatgtgat
     7081 ttccttcccc ataaatgcat gcagataggg agtcggtctc cgtacactat atttttaggg
     7141 tgtttgggag tttccaggat gtgaagaatt tagaaggcgg aggattcagg gcctcagatt
     7201 ctcagctaac tagataaagc ttcagtcagg ctgggcacca tgtgcacagt cttaagaatc
     7261 agcaggaaat gcatttgcaa aacacatgct gtaaaaaatt aattttaaaa aagctacctg
     7321 tataaatata tatatttaaa agcaaggttt tgatactttt ttttacaaaa actacaagag
     7381 aagactgtac aacccacagg cttttaaaat agcattttgt tctctataag ctgttaatat
     7441 gaggggtaag gtactggttt gcaaactcac acaatccaat ggattttctt gtttgtcacc
     7501 ccgctctcca aattaccata attggtgtaa tagtagggca tgtaaagtta ttgggtcaca
     7561 taaaccattt ctgctcttgt catcctgggt tccgttagct cctgtactca ggaatctagc
     7621 ttcttccaga ggcagaggga ccgaagcaag tgtgctccat ttcactcgct gtactgacat
     7681 catccaaatg tggacatttg taaaatcagc acactatttc tatagagaca ttaaattcat
     7741 tttttaaaa
//
