LOCUS       NM_001401820            5833 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus LDL receptor related protein 6 (Lrp6), transcript
            variant 2, mRNA.
ACCESSION   NM_001401820 XM_017592658
VERSION     NM_001401820.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5833)
  AUTHORS   Xie,X.M., Cao,Q.L., Sun,Y.J., Zhang,J., Liu,K.L., Qin,Y.F.,
            Long,W.J., Luo,Z.J., Li,X.W., Liang,X.H., Yuan,G.D., Luo,X.P. and
            Xuan,X.P.
  TITLE     LRP6 Bidirectionally Regulates Insulin Sensitivity through Insulin
            Receptor and S6K Signaling in Rats with CG-IUGR
  JOURNAL   Curr Med Sci 43 (2), 274-283 (2023)
   PUBMED   36913109
  REMARK    GeneRIF: LRP6 Bidirectionally Regulates Insulin Sensitivity through
            Insulin Receptor and S6K Signaling in Rats with CG-IUGR.
REFERENCE   2  (bases 1 to 5833)
  AUTHORS   Cao,Q., Li,X., Xuan,X., Huang,S. and Xie,X.
  TITLE     Changes of LRP6/beta-catenin pathway in adipose tissue of rats with
            intrauterine growth restriction with catch-up growth
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 50 (6), 755-761 (2021)
   PUBMED   35347917
  REMARK    GeneRIF: Changes of LRP6/beta-catenin pathway in adipose tissue of
            rats with intrauterine growth restriction with catch-up growth.
REFERENCE   3  (bases 1 to 5833)
  AUTHORS   Yuan,T., Wang,S., Hu,C., Wu,Y., Liang,D., Li,L., Liu,Y., Li,J. and
            Chen,Y.H.
  TITLE     Low-density lipoprotein receptor-related protein 6 regulates
            alternative pre-mRNA splicing
  JOURNAL   J Cell Mol Med 22 (10), 4653-4663 (2018)
   PUBMED   30070011
  REMARK    GeneRIF: LRP6 regulates alternative pre-mRNA splicing.
REFERENCE   4  (bases 1 to 5833)
  AUTHORS   Chen,Z., Li,Y., Jiang,G., Yang,C., Wang,Y., Wang,X., Fang,B.,
            Zhang,G., Sun,Y., Qian,J., Gong,H. and Zou,Y.
  TITLE     Knockdown of LRP6 activates Drp1 to inhibit survival of
            cardiomyocytes during glucose deprivation
  JOURNAL   Biomed Pharmacother 103, 1408-1414 (2018)
   PUBMED   29864925
  REMARK    GeneRIF: knockdown of LRP6 inhibited the cell viability by
            activation of Drp1 in glucose deprived-cardiomyocytes.
REFERENCE   5  (bases 1 to 5833)
  AUTHORS   Li,J., Li,C., Liang,D., Lv,F., Yuan,T., The,E., Ma,X., Wu,Y.,
            Zhen,L., Xie,D., Wang,S., Liu,Y., Huang,J., Shi,J., Liu,Y., Shi,D.,
            Xu,L., Lin,L., Peng,L., Cui,J., Zhu,W. and Chen,Y.H.
  TITLE     LRP6 acts as a scaffold protein in cardiac gap junction assembly
  JOURNAL   Nat Commun 7, 11775 (2016)
   PUBMED   27250245
  REMARK    GeneRIF: LRP6 acts as a scaffold protein in cardiac gap junction
            assembly and intracellular protein trafficking.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5833)
  AUTHORS   Pinson,K.I., Brennan,J., Monkley,S., Avery,B.J. and Skarnes,W.C.
  TITLE     An LDL-receptor-related protein mediates Wnt signalling in mice
  JOURNAL   Nature 407 (6803), 535-538 (2000)
   PUBMED   11029008
REFERENCE   7  (bases 1 to 5833)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   8  (bases 1 to 5833)
  AUTHORS   Carter,M., Ulrich,S., Oofuji,Y., Williams,D.A. and Ross,M.E.
  TITLE     Crooked tail (Cd) models human folate-responsive neural tube
            defects
  JOURNAL   Hum Mol Genet 8 (12), 2199-2204 (1999)
   PUBMED   10545599
REFERENCE   9  (bases 1 to 5833)
  AUTHORS   Sofaer,J.A.
  TITLE     Tooth development in the 'crooked' mouse
  JOURNAL   J Embryol Exp Morphol 41, 279-287 (1977)
   PUBMED   591875
REFERENCE   10 (bases 1 to 5833)
  AUTHORS   Gruneberg,H.
  TITLE     Genes and genotypes affecting the teeth of the mouse
  JOURNAL   J Embryol Exp Morphol 14 (2), 137-159 (1965)
   PUBMED   5893447
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Feb 25, 2022 this sequence version replaced XM_017592658.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.2972733.1,
                                           SRR22582419.541142.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               JAXUCZ010000004.1  169131376-169131716 c
            342-735             JAXUCZ010000004.1  169104708-169105101 c
            736-933             JAXUCZ010000004.1  169083524-169083721 c
            934-1130            JAXUCZ010000004.1  169074714-169074910 c
            1131-1262           JAXUCZ010000004.1  169072369-169072500 c
            1263-1659           JAXUCZ010000004.1  169068838-169069234 c
            1660-1831           JAXUCZ010000004.1  169067764-169067935 c
            1832-2048           JAXUCZ010000004.1  169042065-169042281 c
            2049-2338           JAXUCZ010000004.1  169041324-169041613 c
            2339-2565           JAXUCZ010000004.1  169039850-169040076 c
            2566-2750           JAXUCZ010000004.1  169037305-169037489 c
            2751-3077           JAXUCZ010000004.1  169036408-169036734 c
            3078-3280           JAXUCZ010000004.1  169027742-169027944 c
            3281-3492           JAXUCZ010000004.1  169025911-169026122 c
            3493-3683           JAXUCZ010000004.1  169024444-169024634 c
            3684-3893           JAXUCZ010000004.1  169021348-169021557 c
            3894-4019           JAXUCZ010000004.1  169019673-169019798 c
            4020-4256           JAXUCZ010000004.1  169011440-169011676 c
            4257-4367           JAXUCZ010000004.1  169010422-169010532 c
            4368-4598           JAXUCZ010000004.1  169006630-169006860 c
            4599-4735           JAXUCZ010000004.1  169005421-169005557 c
            4736-4833           JAXUCZ010000004.1  169004397-169004494 c
            4834-5833           JAXUCZ010000004.1  169001264-169002263 c
FEATURES             Location/Qualifiers
     source          1..5833
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q43"
     gene            1..5833
                     /gene="Lrp6"
                     /note="LDL receptor related protein 6"
                     /db_xref="GeneID:312781"
                     /db_xref="RGD:1304749"
     exon            1..341
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..5128
                     /gene="Lrp6"
                     /note="isoform 2 is encoded by transcript variant 2;
                     low-density lipoprotein receptor-related protein 6"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     6 isoform 2"
                     /protein_id="NP_001388749.1"
                     /db_xref="GeneID:312781"
                     /db_xref="RGD:1304749"
                     /translation="MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENAT
                     IVVGGLEDAAAVDFVFGHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLAC
                     DWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEV
                     PKIERAGMDGSSRFVIINTEIYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNRQA
                     VVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREIHSNIFSPMDIHAFSQ
                     QRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLESGKTCKDGATELLLLA
                     RRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGS
                     GSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
                     IVLDPMAGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGD
                     AKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAERE
                     VIIDQLPDLMGLKATSVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDM
                     KTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDIS
                     LKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQ
                     VLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTI
                     DYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIE
                     RANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVGGFVC
                     GCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDY
                     DPLDKQLYWIDSRQNMIRKAQEDGGQGFTVVVSSVPNQNLEIQPYDLSIDIYSRYIYW
                     TCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAAL
                     DGTEREVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANRIVLEDSNILQ
                     PVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQ
                     HPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGDID
                     CIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEK
                     NCEVLCLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDCYPTEEPAPQATNTVGSVI
                     GVIVTIFVSGTIYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSL
                     PGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATE
                     RSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVAT
                     AKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCT
                     DSS"
     exon            342..735
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            736..933
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1130
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1262
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1659
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1831
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..2048
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2338
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2565
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2750
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..3077
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3280
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3492
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3683
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3684..3893
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3894..4019
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4256
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4257..4367
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4368..4598
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4599..4735
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4736..4833
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4834..5833
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccctgcgc cgctgcgaga ggaagaggct gaatgaggcg ccgcgcgggg gacgtggggc
       61 gccgcgggag gaggcggcgg catgggggca ggcgctggcg tcgcgcgagc ccgggccgga
      121 gcggcgcgct agatccctga cgtgcgccct tttctttctt ctcccggccg cggaaagcat
      181 gagcgtgcag acccgccgct gcggcggccg ccccggctcc tcgcccgcgc gtcccctggc
      241 cgccggtcgc cggtgagggc cgcgagcgcg cgcggtgggg gggaagatgg gggccgtgct
      301 gaggagcctc ctggcctgca gcttctgcgt gctgctgaga gcggcccctt tgttgcttta
      361 tgcaaacaga cgggacttga gattggttga tgctacaaat ggcaaagaga atgcgacgat
      421 tgtagttgga ggcttggagg atgcagctgc ggtggacttt gtgtttggtc atggcttgat
      481 atactggagt gacgtcagcg aagaagccat taaacgaaca gaatttaaca aaactgagag
      541 tgtacagaat gtcgttgttt ctggattatt gtccccggat gggctggcat gtgattggct
      601 tggagaaaaa ttgtactgga cagattctga aactaatcgt attgaagttt ctaatttaga
      661 tggatcttta cgaaaagttt tattttggca agagttggat caacccagag ctattgcctt
      721 agatccatca agtgggttca tgtactggac agactgggga gaagtgccaa agatagaacg
      781 tgctggaatg gatggttcaa gtcgctttgt tataataaac actgagattt actggccaaa
      841 tggactgact ctggattatg aggagcggaa gctttattgg gcagatgcaa aacttaattt
      901 catccataaa tcaaacctgg acggaacaaa tcgacaggca gtggttaaag gttcccttcc
      961 acatcctttt gccttgacgt tatttgagga cacattgtac tggactgact ggaatacaca
     1021 ctctattttg gcttgcaaca agtatactgg cgagggtctg cgtgaaattc attctaacat
     1081 cttctctccc atggatatac atgctttcag ccaacagagg cagccaaatg ctacaaatcc
     1141 atgtggaatt gataatggtg gttgttccca tttgtgtttg atgtctccag tcaagccttt
     1201 ttatcagtgt gcttgtccaa ctggggtcaa gcttctggag agtggaaaaa cctgcaaaga
     1261 tggtgccact gaactattgc tgttagcccg acggacagac ttgaggcgca tctctttgga
     1321 tacaccagat ttcaccgaca ttgtcctaca gttagaagac atccgacatg ccattgccat
     1381 agactacgac cccgtggaag gctacgtcta ctggacggac gatgaagtac gggccatccg
     1441 tcgctccttc attgatggat ctggcagtca gtttgtggtc acggcccaga ttgcccatcc
     1501 tgatggtatt gctgttgact gggtggcaag aaacctgtac tggacagaca ctggcactga
     1561 tcggatagaa gtgacaaggc tcaatgggac catgaggaag atcctgattt cagaggactt
     1621 agaggagccc cgggctattg tgttagatcc catggctggg tacatgtact ggacggactg
     1681 gggagaaatc ccaaaaatcg agcgagctgc tctggacgga tctgaccgag tagttcttgt
     1741 taacacttcc cttggttggc caaatggctt agccctggat tatgatgaag gcacaatata
     1801 ctggggagat gccaaaacag acaaaattga ggttatgaat actgatggca ctgggaggcg
     1861 agtgctggtg gaagacaaga tccctcacat atttgggttt accttgctgg gcgactatgt
     1921 ttactggact gactggcaga ggcggagcat cgagagagtg cacaagcgga gtgcagagag
     1981 ggaggtcata atagaccagc tgccagacct catgggactg aaggccacaa gcgttcacag
     2041 agtcattggt tctaacccct gtgctgagga gaatggagga tgtagccatc tttgcctcta
     2101 caggcctcag ggacttcgat gtgcctgtcc cattggcttt gagctcatta gtgacatgaa
     2161 gacatgcatt gttcctgagg ctttccttct gttctcacgg agagcagata taagacgcat
     2221 ctctttggaa acaaacaaca acaatgtggc cattcctctc acgggtgtca aagaagcttc
     2281 tgctttggat tttgatgtca cagacaacag aatttactgg accgatatat ccctgaagac
     2341 tattagcaga gcttttatga atggcagtgc actggaacat gtggtagagt tcggcttaga
     2401 ttacccagaa ggcatggcag tggactggct tgggaagaac ttatactggg cagacacagg
     2461 aacaaatcgc attgaggtgt caaagttgga tggacagcac cgacaggttt tggtatggaa
     2521 agaccttgac agtccccgag ctctggcatt ggatcctgct gaaggattta tgtattggac
     2581 tgagtgggga gggaagccta agattgacag agcggctatg gatggaagtg aacgcactac
     2641 attagttcca aatgtgggtc gagcaaatgg ccttaccatc gactatgcta agaggcggct
     2701 ttactggaca gacctggaca ctaacttaat agaatcttca aatatgctcg gactcaaccg
     2761 tgaagttata gcagatgact tgcctcatcc ttttggctta actcagtacc aagattacat
     2821 ctactggaca gactggagcc gacgcagcat tgaacgtgcc aacaaaacca gtggccaaaa
     2881 ccgcaccatc atccagggcc atttggatta tgtgatggac atcctagtct ttcactcttc
     2941 ccggcaggca gggtggaatg aatgtgcctc cagcaacggg cactgctccc acctttgctt
     3001 ggctgtgcct gttggaggtt ttgtgtgtgg atgccctgcc cactactccc tgaatgctga
     3061 caacaggacc tgtagtgctc ctaccacctt cctgctcttc agtcagaaga gcgccatcaa
     3121 ccgcatggtg attgatgaac aacagagtcc tgacatcatc cttcctatcc acagccttcg
     3181 gaacgtccgg gccattgatt atgacccttt ggacaagcag ctctactgga ttgactctcg
     3241 acaaaacatg atacgaaagg cacaagaaga tggtggccag ggttttactg tagttgtaag
     3301 ctcggttcca aatcagaacc ttgaaataca gccctatgat ctcagcattg atatttatag
     3361 ccgttacatc tattggacct gtgaagctac caatgtcatt gatgtgacga gattagatgg
     3421 tcgatcagtt ggagtggtcc taaaaggcga gcaagacaga cctcgagcca ttgtggtaaa
     3481 ccctgagaaa gggtatatgt attttaccaa tcttcaggaa agatctccca aaattgaacg
     3541 ggctgccttg gatggaacag aacgggaggt tctctttttc agtggcctga gtaagcccgt
     3601 cgctttggct ctcgacagca agctgagcag gctcttctgg gctgactccg acctccggcg
     3661 aattgagagc agcgacctct caggtgccaa caggatcgtg ctagaggact ctaatatatt
     3721 gcagcctgtg ggtctgaccg tgtttgagaa ctggctctac tggattgata agcagcaaca
     3781 gatgattgaa aaaattgaca tgactggtcg cgaaggcaga accaaggtcc aggctcggat
     3841 tgctcagctc agtgacatcc atgcagtgaa ggagctgaac cttcaggaat acagacagca
     3901 cccgtgtgcc caggataatg gtggctgttc acatatttgc cttgtaaaag gagatggtac
     3961 cacaagatgc tcctgtccca tgcatttagt tctgcttcag gatgagctgt cctgtggaga
     4021 gcctccaaca tgttctcctc agcagtttac gtgtttcact ggggacattg actgcatccc
     4081 tgtggcctgg cggtgtgatg ggtttactga atgtgaagac cacagtgatg agctcaactg
     4141 tcctgtgtgc tcggagtctc agttccagtg tgccagcggg cagtgcattg acggcgccct
     4201 tcgatgcaat ggtgacgcga actgccagga taaatcggat gagaagaact gtgaagtgct
     4261 ttgtctaatt gatcagttcc gctgtgccaa tggtcagtgc gttggaaaac acaagaaatg
     4321 cgaccacaat gtggactgca gtgacagatc tgatgaactg gactgctatc caactgagga
     4381 gccagcacca caggccacca acacagttgg ttccgttatc ggagtaattg tcaccatttt
     4441 tgtgtctgga accatatact ttatctgcca aaggatgctg tgtcctcgta tgaaggggga
     4501 tggggaaacc atgactaatg actacgtggt tcacggccca gcttctgtgc cccttggtta
     4561 tgttcctcac ccaagctctc tgtctggatc tcttccaggg atgtctcgag gcaaatcaat
     4621 gatcagttct ctcagtatca tgggggggag cagtgggccc ccctacgatc gagcacacgt
     4681 cacgggagcg tcctcaagca gctcttccag taccaaaggc acttacttcc ctgcaatttt
     4741 gaacccacca ccatcgcctg ccacagagcg atcccattat accatggagt ttggctattc
     4801 ttccaacagt ccttccacac ataggtccta cagctacagg ccgtacagct accggcactt
     4861 tgcaccgccc actacaccct gcagcactga tgtctgtgac agtgactatg ctcctagccg
     4921 gagaatgacc tcagtggcaa cagccaaggg ctacaccagt gacttgaact atgactcaga
     4981 acctgtgccc ccaccaccca caccccgaag ccagtacttg tcggcagagg agaactatga
     5041 aagctgcccc ccttctccat acactgagag gagttactcc catcacctct acccaccacc
     5101 accttccccc tgcacggact cctcctgagg agggcccctc ctcctctgac tgcctccacc
     5161 gggacatgta aatacacatc tggttgagat ctggaggggg ggagggagct acagaaaaga
     5221 gtgaggcaga cctgtacagt taacataaag tgggtggggt acctgagata tttgtacaga
     5281 agaaaaggat atttatatat tttcttaaaa cagcagattt gctgcttgtg ccataaaagt
     5341 ttgtataaaa aataaatttg tactaaaagt tttattttta caaactaaat acacagagca
     5401 tgccttaagc ccagtgaaga aactgagtac aaaggaagcg ggacagtaaa ggcatcactc
     5461 accaggaatg tctgggcttt aatgatacca aaaatacaaa ggagaaagta atgccatctc
     5521 caagtggcca acttggaagg agccaaattg ccttcagggt agctaacatt tgagggcccc
     5581 gaaagaaaaa agaacagtac caactttgga caaagggctt tgttttctcc aacagttcac
     5641 gaggaaagta gatatttgtg agatccattt tgagtgttgc tgtcgtagga gctgaagtgt
     5701 ctcttgcagg acgccgcaga gctgctgagc tctcacgcct gtcacagttc acgctaacac
     5761 cagccgcttt cacggtctgc ctccccagca ccttggagac ccgttttgct aagagccatg
     5821 atttatttaa aaa
//
