LOCUS       NM_001107892            5092 bp    mRNA    linear   ROD 29-MAY-2023
DEFINITION  Rattus norvegicus LDL receptor related protein 6 (Lrp6), transcript
            variant 1, mRNA.
ACCESSION   NM_001107892 XM_001071349 XM_232466
VERSION     NM_001107892.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5092)
  AUTHORS   Xie XM, Cao QL, Sun YJ, Zhang J, Liu KL, Qin YF, Long WJ, Luo ZJ,
            Li XW, Liang XH, Yuan GD, Luo XP and Xuan XP.
  TITLE     LRP6 Bidirectionally Regulates Insulin Sensitivity through Insulin
            Receptor and S6K Signaling in Rats with CG-IUGR
  JOURNAL   Curr Med Sci 43 (2), 274-283 (2023)
   PUBMED   36913109
  REMARK    GeneRIF: LRP6 Bidirectionally Regulates Insulin Sensitivity through
            Insulin Receptor and S6K Signaling in Rats with CG-IUGR.
REFERENCE   2  (bases 1 to 5092)
  AUTHORS   Cao,Q., Li,X., Xuan,X., Huang,S. and Xie,X.
  TITLE     Changes of LRP6/beta-catenin pathway in adipose tissue of rats with
            intrauterine growth restriction with catch-up growth
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 50 (6), 755-761 (2021)
   PUBMED   35347917
  REMARK    GeneRIF: Changes of LRP6/beta-catenin pathway in adipose tissue of
            rats with intrauterine growth restriction with catch-up growth.
REFERENCE   3  (bases 1 to 5092)
  AUTHORS   Yuan T, Wang S, Hu C, Wu Y, Liang D, Li L, Liu Y, Li J and Chen YH.
  TITLE     Low-density lipoprotein receptor-related protein 6 regulates
            alternative pre-mRNA splicing
  JOURNAL   J Cell Mol Med 22 (10), 4653-4663 (2018)
   PUBMED   30070011
  REMARK    GeneRIF: LRP6 regulates alternative pre-mRNA splicing.
REFERENCE   4  (bases 1 to 5092)
  AUTHORS   Chen Z, Li Y, Jiang G, Yang C, Wang Y, Wang X, Fang B, Zhang G, Sun
            Y, Qian J, Gong H and Zou Y.
  TITLE     Knockdown of LRP6 activates Drp1 to inhibit survival of
            cardiomyocytes during glucose deprivation
  JOURNAL   Biomed Pharmacother 103, 1408-1414 (2018)
   PUBMED   29864925
  REMARK    GeneRIF: knockdown of LRP6 inhibited the cell viability by
            activation of Drp1 in glucose deprived-cardiomyocytes.
REFERENCE   5  (bases 1 to 5092)
  AUTHORS   Li J, Li C, Liang D, Lv F, Yuan T, The E, Ma X, Wu Y, Zhen L, Xie
            D, Wang S, Liu Y, Huang J, Shi J, Liu Y, Shi D, Xu L, Lin L, Peng
            L, Cui J, Zhu W and Chen YH.
  TITLE     LRP6 acts as a scaffold protein in cardiac gap junction assembly
  JOURNAL   Nat Commun 7, 11775 (2016)
   PUBMED   27250245
  REMARK    GeneRIF: LRP6 acts as a scaffold protein in cardiac gap junction
            assembly and intracellular protein trafficking.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5092)
  AUTHORS   Pinson KI, Brennan J, Monkley S, Avery BJ and Skarnes WC.
  TITLE     An LDL-receptor-related protein mediates Wnt signalling in mice
  JOURNAL   Nature 407 (6803), 535-538 (2000)
   PUBMED   11029008
REFERENCE   7  (bases 1 to 5092)
  AUTHORS   Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F,
            Saint-Jeannet JP and He X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   8  (bases 1 to 5092)
  AUTHORS   Carter M, Ulrich S, Oofuji Y, Williams DA and Ross ME.
  TITLE     Crooked tail (Cd) models human folate-responsive neural tube
            defects
  JOURNAL   Hum Mol Genet 8 (12), 2199-2204 (1999)
   PUBMED   10545599
REFERENCE   9  (bases 1 to 5092)
  AUTHORS   Sofaer,J.A.
  TITLE     Tooth development in the 'crooked' mouse
  JOURNAL   J Embryol Exp Morphol 41, 279-287 (1977)
   PUBMED   591875
REFERENCE   10 (bases 1 to 5092)
  AUTHORS   Gruneberg,H.
  TITLE     Genes and genotypes affecting the teeth of the mouse
  JOURNAL   J Embryol Exp Morphol 14 (2), 137-159 (1965)
   PUBMED   5893447
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473964.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001071349.1, XM_232466.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..5092
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q43"
     gene            1..5092
                     /gene="Lrp6"
                     /note="LDL receptor related protein 6"
                     /db_xref="GeneID:312781"
                     /db_xref="RGD:1304749"
     exon            1..394
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            395..592
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             399..4103
                     /gene="Lrp6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     low-density lipoprotein receptor-related protein 6"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     6 isoform 1"
                     /protein_id="NP_001101362.1"
                     /db_xref="GeneID:312781"
                     /db_xref="RGD:1304749"
                     /translation="MYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDYEERK
                     LYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKY
                     TGEGLREIHSNIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACP
                     TGVKLLESGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDP
                     VEGYVYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRI
                     EVTRLNGTMRKILISEDLEEPRAIVLDPMAGYMYWTDWGEIPKIERAALDGSDRVVLV
                     NTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGD
                     YVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATSVHRVIGSNPCAEENGGCSH
                     LCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLT
                     GVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGK
                     NLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDR
                     AAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLP
                     HPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWN
                     ECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVI
                     DEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQGFTVVVSSV
                     PNQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVN
                     PEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPVALALDSKLSRLFWADSDL
                     RRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKV
                     QARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQD
                     ELSCGEPPTCSPQQFTCFTGDIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCAS
                     GQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCVGKHKKCDHNVDCSDRS
                     DELDCYFEPTTILQAVQLPALCTAHYTLQH"
     exon            593..789
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            790..921
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1318
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1490
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1707
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1997
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2224
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2409
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2736
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2939
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3151
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3342
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3552
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3678
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3915
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3916..4026
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4027..4046
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4047..5092
                     /gene="Lrp6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccccttt gttgctttat gcaaacagac gggacttgag attggttgat gctacaaatg
       61 gcaaagagaa tgcgacgatt gtagttggag gcttggagga tgcagctgcg gtggactttg
      121 tgtttggtca tggcttgata tactggagtg acgtcagcga agaagccatt aaacgaacag
      181 aatttaacaa aactgagagt gtacagaatg tcgttgtttc tggattattg tccccggatg
      241 ggctggcatg tgattggctt ggagaaaaat tgtactggac agattctgaa actaatcgta
      301 ttgaagtttc taatttagat ggatctttac gaaaagtttt attttggcaa gagttggatc
      361 aacccagagc tattgcctta gatccatcaa gtgggttcat gtactggaca gactggggag
      421 aagtgccaaa gatagaacgt gctggaatgg atggttcaag tcgctttgtt ataataaaca
      481 ctgagattta ctggccaaat ggactgactc tggattatga ggagcggaag ctttattggg
      541 cagatgcaaa acttaatttc atccataaat caaacctgga cggaacaaat cgacaggcag
      601 tggttaaagg ttcccttcca catccttttg ccttgacgtt atttgaggac acattgtact
      661 ggactgactg gaatacacac tctattttgg cttgcaacaa gtatactggc gagggtctgc
      721 gtgaaattca ttctaacatc ttctctccca tggatataca tgctttcagc caacagaggc
      781 agccaaatgc tacaaatcca tgtggaattg ataatggtgg ttgttcccat ttgtgtttga
      841 tgtctccagt caagcctttt tatcagtgtg cttgtccaac tggggtcaag cttctggaga
      901 gtggaaaaac ctgcaaagat ggtgccactg aactattgct gttagcccga cggacagact
      961 tgaggcgcat ctctttggat acaccagatt tcaccgacat tgtcctacag ttagaagaca
     1021 tccgacatgc cattgccata gactacgacc ccgtggaagg ctacgtctac tggacggacg
     1081 atgaagtacg ggccatccgt cgctccttca ttgatggatc tggcagtcag tttgtggtca
     1141 cggcccagat tgcccatcct gatggtattg ctgttgactg ggtggcaaga aacctgtact
     1201 ggacagacac tggcactgat cggatagaag tgacaaggct caatgggacc atgaggaaga
     1261 tcctgatttc agaggactta gaggagcccc gggctattgt gttagatccc atggctgggt
     1321 acatgtactg gacggactgg ggagaaatcc caaaaatcga gcgagctgct ctggacggat
     1381 ctgaccgagt agttcttgtt aacacttccc ttggttggcc aaatggctta gccctggatt
     1441 atgatgaagg cacaatatac tggggagatg ccaaaacaga caaaattgag gttatgaata
     1501 ctgatggcac tgggaggcga gtgctggtgg aagacaagat ccctcacata tttgggttta
     1561 ccttgctggg cgactatgtt tactggactg actggcagag gcggagcatc gagagagtgc
     1621 acaagcggag tgcagagagg gaggtcataa tagaccagct gccagacctc atgggactga
     1681 aggccacaag cgttcacaga gtcattggtt ctaacccctg tgctgaggag aatggaggat
     1741 gtagccatct ttgcctctac aggcctcagg gacttcgatg tgcctgtccc attggctttg
     1801 agctcattag tgacatgaag acatgcattg ttcctgaggc tttccttctg ttctcacgga
     1861 gagcagatat aagacgcatc tctttggaaa caaacaacaa caatgtggcc attcctctca
     1921 cgggtgtcaa agaagcttct gctttggatt ttgatgtcac agacaacaga atttactgga
     1981 ccgatatatc cctgaagact attagcagag cttttatgaa tggcagtgca ctggaacatg
     2041 tggtagagtt cggcttagat tacccagaag gcatggcagt ggactggctt gggaagaact
     2101 tatactgggc agacacagga acaaatcgca ttgaggtgtc aaagttggat ggacagcacc
     2161 gacaggtttt ggtatggaaa gaccttgaca gtccccgagc tctggcattg gatcctgctg
     2221 aaggatttat gtattggact gagtggggag ggaagcctaa gattgacaga gcggctatgg
     2281 atggaagtga acgcactaca ttagttccaa atgtgggtcg agcaaatggc cttaccatcg
     2341 actatgctaa gaggcggctt tactggacag acctggacac taacttaata gaatcttcaa
     2401 atatgctcgg actcaaccgt gaagttatag cagatgactt gcctcatcct tttggcttaa
     2461 ctcagtacca agattacatc tactggacag actggagccg acgcagcatt gaacgtgcca
     2521 acaaaaccag tggccaaaac cgcaccatca tccagggcca tttggattat gtgatggaca
     2581 tcctagtctt tcactcttcc cggcaggcag ggtggaatga atgtgcctcc agcaacgggc
     2641 actgctccca cctttgcttg gctgtgcctg ttggaggttt tgtgtgtgga tgccctgccc
     2701 actactccct gaatgctgac aacaggacct gtagtgctcc taccaccttc ctgctcttca
     2761 gtcagaagag cgccatcaac cgcatggtga ttgatgaaca acagagtcct gacatcatcc
     2821 ttcctatcca cagccttcgg aacgtccggg ccattgatta tgaccctttg gacaagcagc
     2881 tctactggat tgactctcga caaaacatga tacgaaaggc acaagaagat ggtggccagg
     2941 gttttactgt agttgtaagc tcggttccaa atcagaacct tgaaatacag ccctatgatc
     3001 tcagcattga tatttatagc cgttacatct attggacctg tgaagctacc aatgtcattg
     3061 atgtgacgag attagatggt cgatcagttg gagtggtcct aaaaggcgag caagacagac
     3121 ctcgagccat tgtggtaaac cctgagaaag ggtatatgta ttttaccaat cttcaggaaa
     3181 gatctcccaa aattgaacgg gctgccttgg atggaacaga acgggaggtt ctctttttca
     3241 gtggcctgag taagcccgtc gctttggctc tcgacagcaa gctgagcagg ctcttctggg
     3301 ctgactccga cctccggcga attgagagca gcgacctctc aggtgccaac aggatcgtgc
     3361 tagaggactc taatatattg cagcctgtgg gtctgaccgt gtttgagaac tggctctact
     3421 ggattgataa gcagcaacag atgattgaaa aaattgacat gactggtcgc gaaggcagaa
     3481 ccaaggtcca ggctcggatt gctcagctca gtgacatcca tgcagtgaag gagctgaacc
     3541 ttcaggaata cagacagcac ccgtgtgccc aggataatgg tggctgttca catatttgcc
     3601 ttgtaaaagg agatggtacc acaagatgct cctgtcccat gcatttagtt ctgcttcagg
     3661 atgagctgtc ctgtggagag cctccaacat gttctcctca gcagtttacg tgtttcactg
     3721 gggacattga ctgcatccct gtggcctggc ggtgtgatgg gtttactgaa tgtgaagacc
     3781 acagtgatga gctcaactgt cctgtgtgct cggagtctca gttccagtgt gccagcgggc
     3841 agtgcattga cggcgccctt cgatgcaatg gtgacgcgaa ctgccaggat aaatcggatg
     3901 agaagaactg tgaagtgctt tgtctaattg atcagttccg ctgtgccaat ggtcagtgcg
     3961 ttggaaaaca caagaaatgc gaccacaatg tggactgcag tgacagatct gatgaactgg
     4021 actgctattt tgaacccacc accatcctac aggccgtaca gctaccggca ctttgcaccg
     4081 cccactacac cctgcagcac tgatgtctgt gacagtgact atgctcctag ccggagaatg
     4141 acctcagtgg caacagccaa gggctacacc agtgacttga actatgactc agaacctgtg
     4201 cccccaccac ccacaccccg aagccagtac ttgtcggcag aggagaacta tgaaagctgc
     4261 cccccttctc catacactga gaggagttac tcccatcacc tctacccacc accaccttcc
     4321 ccctgcacgg actcctcctg aggagggccc ctcctcctct gactgcctcc accgggacat
     4381 gtaaatacac atctggttga gatctggagg gggggaggga gctacagaaa agagtgaggc
     4441 agacctgtac agttaacata aagtgggtgg ggtacctgag atatttgtac agaagaaaag
     4501 gatatttata tattttctta aaacagcaga tttgctgctt gtgccataaa agtttgtata
     4561 aaaaataaat ttgtactaaa agttttattt ttacaaacta aatacacaga gcatgcctta
     4621 agcccagtga agaaactgag tacaaaggaa gcgggacagt aaaggcatca ctcaccagga
     4681 atgtctgggc tttaatgata ccaaaaatac aaaggagaaa gtaatgccat ctccaagtgg
     4741 ccaacttgga aggagccaaa ttgccttcag ggtagctaac atttgagggc cccgaaagaa
     4801 aaaagaacag taccaacttt ggacaaaggg ctttgttttc tccaacagtt cacgaggaaa
     4861 gtagatattt gtgagatcca ttttgagtgt tgctgtcgta ggagctgaag tgtctcttgc
     4921 aggacgccgc agagctgctg agctctcacg cctgtcacag ttcacgctaa caccagccgc
     4981 tttcacggtc tgcctcccca gcaccttgga gacccgtttt gctaagagcc atgatttatt
     5041 taaaaatgtg aggaattgag taaatggaat ttcctaaacg cgagattgga ct
//
