LOCUS       NM_001106321            5101 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus LDL receptor related protein 5 (Lrp5), mRNA.
ACCESSION   NM_001106321 XM_001067386 XM_215187
VERSION     NM_001106321.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5101)
  AUTHORS   Ubels,J.L., Lin,C.M., Antonetti,D.A., Diaz-Coranguez,M.,
            Diegel,C.R. and Williams,B.O.
  TITLE     Structure and function of the retina of low-density lipoprotein
            receptor-related protein 5 (Lrp5)-deficient rats
  JOURNAL   Exp Eye Res 217, 108977 (2022)
   PUBMED   35139333
  REMARK    GeneRIF: Structure and function of the retina of low-density
            lipoprotein receptor-related protein 5 (Lrp5)-deficient rats.
REFERENCE   2  (bases 1 to 5101)
  AUTHORS   Ju,S., Lim,L., Wi,K., Park,C., Ki,Y.J., Choi,D.H. and Song,H.
  TITLE     LRP5 Regulates HIF-1alpha Stability via Interaction with PHD2 in
            Ischemic Myocardium
  JOURNAL   Int J Mol Sci 22 (12), 6581 (2021)
   PUBMED   34205318
  REMARK    GeneRIF: LRP5 Regulates HIF-1alpha Stability via Interaction with
            PHD2 in Ischemic Myocardium.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5101)
  AUTHORS   Ubels,J.L., Diegel,C.R., Foxa,G.E., Ethen,N.J., Lensing,J.N.,
            Madaj,Z.B. and Williams,B.O.
  TITLE     Low-Density Lipoprotein Receptor-Related Protein 5-Deficient Rats
            Have Reduced Bone Mass and Abnormal Development of the Retinal
            Vasculature
  JOURNAL   CRISPR J 3 (4), 284-298 (2020)
   PUBMED   32833527
  REMARK    GeneRIF: Low-Density Lipoprotein Receptor-Related Protein
            5-Deficient Rats Have Reduced Bone Mass and Abnormal Development of
            the Retinal Vasculature.
REFERENCE   4  (bases 1 to 5101)
  AUTHORS   Ergun,S.G., Akay,G.G., Ergun,M.A. and Percin,E.F.
  TITLE     LRP5-linked osteoporosis-pseudoglioma syndrome mimicking isolated
            microphthalmia
  JOURNAL   Eur J Med Genet 60 (3), 200-204 (2017)
   PUBMED   28111184
REFERENCE   5  (bases 1 to 5101)
  AUTHORS   Huang,W., Li,Q., Amiry-Moghaddam,M., Hokama,M., Sardi,S.H.,
            Nagao,M., Warman,M.L. and Olsen,B.R.
  TITLE     Critical Endothelial Regulation by LRP5 during Retinal Vascular
            Development
  JOURNAL   PLoS One 11 (3), e0152833 (2016)
   PUBMED   27031698
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5101)
  AUTHORS   Kato,M., Patel,M.S., Levasseur,R., Lobov,I., Chang,B.H., Glass,D.A.
            2nd, Hartmann,C., Li,L., Hwang,T.H., Brayton,C.F., Lang,R.A.,
            Karsenty,G. and Chan,L.
  TITLE     Cbfa1-independent decrease in osteoblast proliferation, osteopenia,
            and persistent embryonic eye vascularization in mice deficient in
            Lrp5, a Wnt coreceptor
  JOURNAL   J Cell Biol 157 (2), 303-314 (2002)
   PUBMED   11956231
REFERENCE   7  (bases 1 to 5101)
  AUTHORS   Gong,Y., Slee,R.B., Fukai,N., Rawadi,G., Roman-Roman,S.,
            Reginato,A.M., Wang,H., Cundy,T., Glorieux,F.H., Lev,D.,
            Zacharin,M., Oexle,K., Marcelino,J., Suwairi,W., Heeger,S.,
            Sabatakos,G., Apte,S., Adkins,W.N., Allgrove,J.,
            Arslan-Kirchner,M., Batch,J.A., Beighton,P., Black,G.C.,
            Boles,R.G., Boon,L.M., Borrone,C., Brunner,H.G., Carle,G.F.,
            Dallapiccola,B., De Paepe,A., Floege,B., Halfhide,M.L., Hall,B.,
            Hennekam,R.C., Hirose,T., Jans,A., Juppner,H., Kim,C.A.,
            Keppler-Noreuil,K., Kohlschuetter,A., LaCombe,D., Lambert,M.,
            Lemyre,E., Letteboer,T., Peltonen,L., Ramesar,R.S., Romanengo,M.,
            Somer,H., Steichen-Gersdorf,E., Steinmann,B., Sullivan,B.,
            Superti-Furga,A., Swoboda,W., van den Boogaard,M.J., Van Hul,W.,
            Vikkula,M., Votruba,M., Zabel,B., Garcia,T., Baron,R., Olsen,B.R.
            and Warman,M.L.
  CONSRTM   Osteoporosis-Pseudoglioma Syndrome Collaborative Group
  TITLE     LDL receptor-related protein 5 (LRP5) affects bone accrual and eye
            development
  JOURNAL   Cell 107 (4), 513-523 (2001)
   PUBMED   11719191
REFERENCE   8  (bases 1 to 5101)
  AUTHORS   Mao,J., Wang,J., Liu,B., Pan,W., Farr,G.H. 3rd, Flynn,C., Yuan,H.,
            Takada,S., Kimelman,D., Li,L. and Wu,D.
  TITLE     Low-density lipoprotein receptor-related protein-5 binds to Axin
            and regulates the canonical Wnt signaling pathway
  JOURNAL   Mol Cell 7 (4), 801-809 (2001)
   PUBMED   11336703
REFERENCE   9  (bases 1 to 5101)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   10 (bases 1 to 5101)
  AUTHORS   Dong,Y., Lathrop,W., Weaver,D., Qiu,Q., Cini,J., Bertolini,D. and
            Chen,D.
  TITLE     Molecular cloning and characterization of LR3, a novel LDL receptor
            family protein with mitogenic activity
  JOURNAL   Biochem Biophys Res Commun 251 (3), 784-790 (1998)
   PUBMED   9790987
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166786.1.
            
            On May 20, 2008 this sequence version replaced NM_001106321.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166786.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5101
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42-q43"
     gene            1..5101
                     /gene="Lrp5"
                     /note="LDL receptor related protein 5"
                     /db_xref="GeneID:293649"
                     /db_xref="RGD:1309329"
     exon            1..171
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..4883
                     /gene="Lrp5"
                     /note="low-density lipoprotein receptor-related protein 5"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     5 precursor"
                     /protein_id="NP_001099791.2"
                     /db_xref="GeneID:293649"
                     /db_xref="RGD:1309329"
                     /translation="METAPTRAPPPPPQPLLLLLALCCSLVPAAASPLLLFANRRDVR
                     LVDAGGVKLESTIVASGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAAQNI
                     VISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDP
                     AHGYMYWTDWGEAPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSF
                     IHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEKRKEILS
                     ALYSPMDIQVLSQERQPPFHTPCEEGNGGCSHLCLLSPREPFYSCACPTGVQLQDNGK
                     TCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVGDIRHAIAIDYDPLEGYVYWTDD
                     EVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
                     KILVSEDLDEPRAIVLHPVMGLMYWTDWGENPKIECANLDGRDRHVLVNTSLGWPNGL
                     ALDLQEGKLYWGDAKTDKIEVINIDGTKRQTLLEDKLPHIFGFTLLGDFIYWTDWQRR
                     SIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADGNGGCSHLCFFTPHATK
                     CGCPIGLELLSDMKTCIIPEAFLVFTSRATIHRISLETNNNDVAIPLTGVKEASALDF
                     DVSNNHIYWTDVSLKTISRAFMNGSSVEHVIEFGLDYPEGMAVDWMGKNLYWADTGTN
                     RIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMT
                     LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERMVIADDLPYPFGLTQYSD
                     YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCVHSNGQCG
                     QLCLAIPGGHRCGCASHYTLDPSSRNCSPPSTFLLFSQKFAISRMIPDDQLSPDLILP
                     LHGLRNVKAINYDPLDKFIYWVDGRQNIKRAKDDGTQPSMLTSPSQSLSPDRQPHDLS
                     IDIYSRTLFWTCEATNTINVHRLDGDAMGVVLRGDRDRPRAIAVNAERGYMYFTNMQD
                     HAAKIERASLDGTEREVLFTTGLIRPVALVVDNALGKLFWVDADLKRIESCDLSGANR
                     LTLEDANIVQPVGLTVLGRHLYWIDRQQQMIERVEKTTGDKRTRVQGRVTHLTGIHAV
                     EEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPD
                     QFACATGEIDCIPGAWRCDGFPECADQSDEEGCPVCSASQFPCARGQCVDLRLRCDAV
                     CLPNQFRCASGQCVLIKQQCDSFPDCADGSDELMCEINKPPSDDVPAHSSAIGPVIGI
                     ILSLFVMGGVYFVCQRVMCQRYTGASGPFPHEYVGGTPHVPLNFIAPGGSQHGPFPGI
                     PCSKSMMSSVSLVGGRGSVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPS
                     LYNMDMFYSSNIPSTARPYRPYIIRGMAPPTTPCSTDVCDSDYSTSRWKTSKYYLDLN
                     SDSDPYPPPPTPHSQYLSAEDSCPPSPVTERSYCHLFPPPPSPCTDSS"
     exon            172..568
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            569..766
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            767..963
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1095
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1492
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1664
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1881
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2171
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2398
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2583
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2907
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3107
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3316
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3507
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3717
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..3843
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..4035
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4146
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4147..4383
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4384..4523
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4524..4621
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4622..5086
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggagccgc gagggtccac cgccgccgcg cgcgccatgg agcccgagtg agcgcgcggc
       61 gctcccggcc gccggacgac atggaaacgg cgccgacccg ggcccctccg ccgccgccgc
      121 agccgctgtt gctgctgctg gcgctgtgct gcagcctagt ccccgctgcg gcctcaccac
      181 tcctgttgtt tgccaaccgc cgggatgtac gactagtgga tgctggtgga gtgaagctgg
      241 agtccaccat tgtggccagt ggtctggagg acgcagctgc tgtagacttc cagttctcca
      301 agggtgctgt gtactggaca gatgtgagcg aggaggccat caaacagacc tacctgaacc
      361 agactggagc tgctgcacag aacattgtca tctctggcct tgtatcacct gatggcctgg
      421 cctgtgactg ggttggcaag aagctgtact ggacagactc agagaccaac cgcatcgagg
      481 tggccaacct caatgggacg tcccgtaagg ttctcttctg gcaggacctg gaccagccaa
      541 gggccattgc cctggatcct gcacatgggt acatgtactg gactgactgg ggggaagcac
      601 cccggatcga gcgggcaggg atggatggca gtacccggaa gatcattgta gactccgaca
      661 tttactggcc caatgggctg accattgatc tggaggagca gaagctgtac tgggctgatg
      721 ccaaactcag cttcatccac cgtgccaacc tggacggctc cttccggcag aaggtggtgg
      781 agggcagcct cactcacccc tttgccctga cactctctgg ggacacactc tactggacag
      841 actggcagac ccgttctatc cacgcctgca acaagtggac aggggagaaa aggaaggaga
      901 tcctcagtgc tctgtattca cccatggaca ttcaggtgct gagccaggag cggcagcctc
      961 ccttccacac gccatgtgag gaaggcaacg gcggctgctc ccacctgtgc ctgctgtccc
     1021 cgagggagcc cttctactcc tgcgcctgcc ctactggtgt acagttgcag gacaatggca
     1081 agacgtgtaa ggcaggggct gaggaagtgc tgctgctggc ccggaggaca gacctgagaa
     1141 ggatctctct ggacacccct gacttcacag acatagtgct gcaagtgggc gacattcggc
     1201 atgccatcgc catcgactat gacccactgg agggctacgt gtactggaca gatgacgagg
     1261 tgcgggctat ccgcagggcg tacctggatg gctcaggtgc gcagaccctt gtgaacaccg
     1321 agatcaatga tcccgatggc attgccgtgg actgggtcgc ccggaacctc tactggacag
     1381 atacaggcac tgacagaatt gaggtgactc gcctcaacgg cacctcccga aagatcctgg
     1441 tgtccgagga cctggacgaa cctcgcgcca ttgtgttgca ccctgtgatg ggcctcatgt
     1501 actggacaga ctggggagag aaccccaaaa tcgaatgtgc caacctagat gggcgagatc
     1561 ggcatgtcct ggtgaacacc tcccttgggt ggcccaatgg actggccctg gacctgcagg
     1621 agggcaagct gtactggggg gatgccaaaa ctgataaaat tgaggtgatc aacatagacg
     1681 ggacaaagcg gcagaccctg ctagaggaca agctcccgca catttttggg ttcactctgc
     1741 ttggggactt catctactgg acagattggc agcgacgcag tattgagagg gtacacaagg
     1801 tcaaggccag ccgggatgtc atcatcgatc aactccccga cctgatggga ctcaaagcag
     1861 tgaacgtggc caaggttgtc ggaaccaacc cgtgtgcgga tggaaatgga gggtgcagcc
     1921 atctgtgctt cttcacccca cacgccacca agtgcggttg ccccataggc ctggagctgc
     1981 tgagtgacat gaagacctgc ataatccctg aagccttcct ggtgttcacc agcagagcca
     2041 ccatccacag gatctccctg gagactaaca acaatgacgt ggccatcccg ctcaccggtg
     2101 tcaaggaggc ctctgcactg gactttgatg tgtccaacaa ccacatctac tggactgatg
     2161 tcagcctcaa gactatcagc cgagccttca tgaatgggag ctcagtggag cacgtgattg
     2221 agtttggcct cgactaccct gaaggaatgg ccgtggattg gatgggcaag aacctctatt
     2281 gggctgacac ggggaccaac aggattgagg tggcccgact ggatgggcag ttccggcagg
     2341 tgctggtgtg gagagacctt gacaacccca ggtcgctggc tctggatcct actaaaggct
     2401 acatctactg gaccgagtgg ggaggcaagc caaggatcgt gcgggccttc atggatggga
     2461 ccaattgtat gacactggta gacaaggtgg gccgggccaa tgacctcacc attgattacg
     2521 ccgaccagcg actgtactgg actgacctgg acaccaacat gattgagtcc tccaacatgc
     2581 tgggtcagga gcgcatggtg atagctgatg atctgcccta cccctttggc ctgactcaat
     2641 atagcgatta catctactgg accgactgga acctgcatag cattgaacgg gccgacaaga
     2701 ccagcgggcg gaaccgtacc ctcatccagg gtcacctgga cttcgtcatg gacatcctgg
     2761 tgtttcactc ctcccgtcag gatggcctca acgactgcgt gcacagcaat ggccagtgtg
     2821 ggcagctgtg cctcgccatc cccggaggcc accgctgcgg ctgtgcttcc cactacacgc
     2881 tggaccccag cagccgcaac tgcagcccgc cctccacctt cttgctgttc agccagaaat
     2941 ttgccatcag ccggatgatc cccgatgacc agctcagtcc ggaccttatc ctacccctac
     3001 acgggctgag gaatgtcaaa gccatcaact acgacccgct ggacaagttc atctactggg
     3061 tggatgggcg tcagaacatc aagagggcca aggacgacgg tacccagccc tccatgctga
     3121 cctctcccag ccaaagcctg agcccagacc gacagccaca tgacctcagc attgacatct
     3181 acagccggac actgttctgg acctgtgagg ccaccaacac catcaatgtc caccggctgg
     3241 atggggatgc catgggagtg gtgcttcgag gggaccgtga cagaccaagg gccattgctg
     3301 tcaatgctga gcgagggtac atgtacttta ccaacatgca ggaccatgct gccaagattg
     3361 agcgagcctc cctggatggc acggagcgtg aggttctctt caccaccggc cttatccgtc
     3421 ctgtggccct tgtggtggac aatgccctgg gcaagctctt ctgggtggat gcagacctaa
     3481 agcgcattga aagctgcgac ctctcagggg ccaaccgcct gaccctggaa gatgccaaca
     3541 tcgtgcagcc agtaggtctg acggtgctgg ggaggcacct ctactggatc gaccgccagc
     3601 agcagatgat tgagcgtgtg gagaagacca ctggggacaa gaggactagg gttcagggcc
     3661 gtgtcaccca cctgacgggc atccatgctg tggaggaagt cagcctggag gagttctcag
     3721 cccatccttg tgcccgagac aatggcggct gctcccatat ctgcatcgcc aagggtgatg
     3781 ggacaccgcg ctgctcatgc ccagtccacc tcgtgctcct gcagaacctg ctgacttgtg
     3841 gtgagcctcc tacctgctcc cctgatcagt ttgcatgtgc cactggtgag attgactgca
     3901 tccctggagc ctggcgctgt gacggcttcc ctgagtgtgc tgaccagagt gatgaggaag
     3961 gctgcccagt gtgctctgcc tctcagttcc cctgtgctcg aggccagtgc gtggacctgc
     4021 gtttacgctg cgatgctgtc tgtctcccca atcagttccg gtgcgccagt ggccagtgcg
     4081 tcctcatcaa gcagcagtgc gattccttcc ccgactgtgc tgatggatct gatgagctca
     4141 tgtgtgaaat caacaagcca ccttctgatg acgtaccagc ccacagcagc gccattgggc
     4201 ctgtcattgg catcatcctg tccctcttcg tcatgggcgg ggtctacttt gtctgccagc
     4261 gtgtgatgtg ccagcgttac acaggggcca gtggtccctt tccccacgag tatgttggtg
     4321 gaacccctca tgtgcctctc aacttcatag ccccaggtgg ctcacagcac ggtcccttcc
     4381 caggcatccc gtgcagcaag tccatgatga gttctgtgag cctggtgggg gggcggggca
     4441 gcgtgcccct ctatgaccgg aatcacgtca ccggggcctc atccagcagt tcatccagca
     4501 caaaggccac actctatcca ccgatcctga acccaccacc gtccccggcc acagacccct
     4561 ccctgtacaa catggacatg ttttattctt caaacatccc atccactgcc agaccataca
     4621 ggccctacat cattcgaggt atggcacccc caacaacacc ttgcagcaca gacgtgtgtg
     4681 acagcgacta cagcaccagt cgctggaaga ccagcaagta ctacctggac ttgaattcgg
     4741 actcagaccc ctacccgccc ccgcccactc cccacagcca gtacctgtct gcagaggata
     4801 gctgtccacc ctctcctgtc actgagagaa gctactgcca cctcttccca ccccctccat
     4861 ccccctgcac ggactcgtcc tgacctcggc cgtccacccc ggcctcgctg cctccctgta
     4921 aatattttta aatatgaaca aaggaaaaat atattttatg atttaaaaaa taaatataat
     4981 tgggattttt aagaagtgag aaatgtgagc ggtgaagggg tgggcagggc tgggaaaact
     5041 ttgtacagtg gagaaaatat ttataaactt aattttttaa aacataaaaa aaaaaaaaaa
     5101 a
//
