LOCUS       NP_001099791            1600 aa            linear   ROD 24-JUN-2024
DEFINITION  low-density lipoprotein receptor-related protein 5 precursor
            [Rattus norvegicus].
ACCESSION   NP_001099791 XP_001067386 XP_215187
VERSION     NP_001099791.2
DBSOURCE    REFSEQ: accession NM_001106321.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1600)
  AUTHORS   Ubels,J.L., Lin,C.M., Antonetti,D.A., Diaz-Coranguez,M.,
            Diegel,C.R. and Williams,B.O.
  TITLE     Structure and function of the retina of low-density lipoprotein
            receptor-related protein 5 (Lrp5)-deficient rats
  JOURNAL   Exp Eye Res 217, 108977 (2022)
   PUBMED   35139333
  REMARK    GeneRIF: Structure and function of the retina of low-density
            lipoprotein receptor-related protein 5 (Lrp5)-deficient rats.
REFERENCE   2  (residues 1 to 1600)
  AUTHORS   Ju,S., Lim,L., Wi,K., Park,C., Ki,Y.J., Choi,D.H. and Song,H.
  TITLE     LRP5 Regulates HIF-1alpha Stability via Interaction with PHD2 in
            Ischemic Myocardium
  JOURNAL   Int J Mol Sci 22 (12), 6581 (2021)
   PUBMED   34205318
  REMARK    GeneRIF: LRP5 Regulates HIF-1alpha Stability via Interaction with
            PHD2 in Ischemic Myocardium.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1600)
  AUTHORS   Ubels,J.L., Diegel,C.R., Foxa,G.E., Ethen,N.J., Lensing,J.N.,
            Madaj,Z.B. and Williams,B.O.
  TITLE     Low-Density Lipoprotein Receptor-Related Protein 5-Deficient Rats
            Have Reduced Bone Mass and Abnormal Development of the Retinal
            Vasculature
  JOURNAL   CRISPR J 3 (4), 284-298 (2020)
   PUBMED   32833527
  REMARK    GeneRIF: Low-Density Lipoprotein Receptor-Related Protein
            5-Deficient Rats Have Reduced Bone Mass and Abnormal Development of
            the Retinal Vasculature.
REFERENCE   4  (residues 1 to 1600)
  AUTHORS   Ergun,S.G., Akay,G.G., Ergun,M.A. and Percin,E.F.
  TITLE     LRP5-linked osteoporosis-pseudoglioma syndrome mimicking isolated
            microphthalmia
  JOURNAL   Eur J Med Genet 60 (3), 200-204 (2017)
   PUBMED   28111184
REFERENCE   5  (residues 1 to 1600)
  AUTHORS   Huang,W., Li,Q., Amiry-Moghaddam,M., Hokama,M., Sardi,S.H.,
            Nagao,M., Warman,M.L. and Olsen,B.R.
  TITLE     Critical Endothelial Regulation by LRP5 during Retinal Vascular
            Development
  JOURNAL   PLoS One 11 (3), e0152833 (2016)
   PUBMED   27031698
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1600)
  AUTHORS   Kato,M., Patel,M.S., Levasseur,R., Lobov,I., Chang,B.H., Glass,D.A.
            2nd, Hartmann,C., Li,L., Hwang,T.H., Brayton,C.F., Lang,R.A.,
            Karsenty,G. and Chan,L.
  TITLE     Cbfa1-independent decrease in osteoblast proliferation, osteopenia,
            and persistent embryonic eye vascularization in mice deficient in
            Lrp5, a Wnt coreceptor
  JOURNAL   J Cell Biol 157 (2), 303-314 (2002)
   PUBMED   11956231
REFERENCE   7  (residues 1 to 1600)
  AUTHORS   Gong,Y., Slee,R.B., Fukai,N., Rawadi,G., Roman-Roman,S.,
            Reginato,A.M., Wang,H., Cundy,T., Glorieux,F.H., Lev,D.,
            Zacharin,M., Oexle,K., Marcelino,J., Suwairi,W., Heeger,S.,
            Sabatakos,G., Apte,S., Adkins,W.N., Allgrove,J.,
            Arslan-Kirchner,M., Batch,J.A., Beighton,P., Black,G.C.,
            Boles,R.G., Boon,L.M., Borrone,C., Brunner,H.G., Carle,G.F.,
            Dallapiccola,B., De Paepe,A., Floege,B., Halfhide,M.L., Hall,B.,
            Hennekam,R.C., Hirose,T., Jans,A., Juppner,H., Kim,C.A.,
            Keppler-Noreuil,K., Kohlschuetter,A., LaCombe,D., Lambert,M.,
            Lemyre,E., Letteboer,T., Peltonen,L., Ramesar,R.S., Romanengo,M.,
            Somer,H., Steichen-Gersdorf,E., Steinmann,B., Sullivan,B.,
            Superti-Furga,A., Swoboda,W., van den Boogaard,M.J., Van Hul,W.,
            Vikkula,M., Votruba,M., Zabel,B., Garcia,T., Baron,R., Olsen,B.R.
            and Warman,M.L.
  CONSRTM   Osteoporosis-Pseudoglioma Syndrome Collaborative Group
  TITLE     LDL receptor-related protein 5 (LRP5) affects bone accrual and eye
            development
  JOURNAL   Cell 107 (4), 513-523 (2001)
   PUBMED   11719191
REFERENCE   8  (residues 1 to 1600)
  AUTHORS   Mao,J., Wang,J., Liu,B., Pan,W., Farr,G.H. 3rd, Flynn,C., Yuan,H.,
            Takada,S., Kimelman,D., Li,L. and Wu,D.
  TITLE     Low-density lipoprotein receptor-related protein-5 binds to Axin
            and regulates the canonical Wnt signaling pathway
  JOURNAL   Mol Cell 7 (4), 801-809 (2001)
   PUBMED   11336703
REFERENCE   9  (residues 1 to 1600)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   10 (residues 1 to 1600)
  AUTHORS   Dong,Y., Lathrop,W., Weaver,D., Qiu,Q., Cini,J., Bertolini,D. and
            Chen,D.
  TITLE     Molecular cloning and characterization of LR3, a novel LDL receptor
            family protein with mitogenic activity
  JOURNAL   Biochem Biophys Res Commun 251 (3), 784-790 (1998)
   PUBMED   9790987
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166786.1.
            
            On May 20, 2008 this sequence version replaced NP_001099791.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166786.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1600
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42-q43"
     Protein         1..1600
                     /product="low-density lipoprotein receptor-related protein
                     5 precursor"
                     /note="low-density lipoprotein receptor-related protein 5"
                     /calculated_mol_wt=174296
     sig_peptide     1..31
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3153
     Region          23..214
                     /region_name="YncE"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; COG3391"
                     /db_xref="CDD:442618"
     Region          102..142
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          163..203
                     /region_name="Ldl_recept_b"
                     /note="Low-density lipoprotein receptor repeat class B;
                     pfam00058"
                     /db_xref="CDD:459654"
     Region          187..229
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          230..271
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          299..336
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          366..406
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          408..450
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          451..494
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          495..537
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          538..571
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          605..640
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <654..782
                     /region_name="YncE"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; COG3391"
                     /db_xref="CDD:442618"
     Region          710..752
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          799..838
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          838..879
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          906..941
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          970..1009
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1060..1103
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1104..1146
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1217..1253
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          1259..1295
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1264,1274,1285..1286)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1278,1281,1285,1291..1292)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1288..1292
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1321..1355
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1326,1334,1345..1346)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1338,1341,1345,1351..1352)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1348..1352
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     CDS             1..1600
                     /gene="Lrp5"
                     /coded_by="NM_001106321.2:81..4883"
                     /db_xref="GeneID:293649"
                     /db_xref="RGD:1309329"
ORIGIN      
        1 metaptrapp pppqplllll alccslvpaa asplllfanr rdvrlvdagg vklestivas
       61 gledaaavdf qfskgavywt dvseeaikqt ylnqtgaaaq nivisglvsp dglacdwvgk
      121 klywtdsetn rievanlngt srkvlfwqdl dqpraialdp ahgymywtdw geaprierag
      181 mdgstrkiiv dsdiywpngl tidleeqkly wadaklsfih ranldgsfrq kvvegslthp
      241 faltlsgdtl ywtdwqtrsi hacnkwtgek rkeilsalys pmdiqvlsqe rqppfhtpce
      301 egnggcshlc llsprepfys cacptgvqlq dngktckaga eevlllarrt dlrrisldtp
      361 dftdivlqvg dirhaiaidy dplegyvywt ddevrairra yldgsgaqtl vnteindpdg
      421 iavdwvarnl ywtdtgtdri evtrlngtsr kilvsedlde praivlhpvm glmywtdwge
      481 npkiecanld grdrhvlvnt slgwpnglal dlqegklywg daktdkievi nidgtkrqtl
      541 ledklphifg ftllgdfiyw tdwqrrsier vhkvkasrdv iidqlpdlmg lkavnvakvv
      601 gtnpcadgng gcshlcfftp hatkcgcpig lellsdmktc iipeaflvft sratihrisl
      661 etnnndvaip ltgvkeasal dfdvsnnhiy wtdvslktis rafmngssve hviefgldyp
      721 egmavdwmgk nlywadtgtn rievarldgq frqvlvwrdl dnprslaldp tkgyiywtew
      781 ggkprivraf mdgtncmtlv dkvgrandlt idyadqrlyw tdldtnmies snmlgqermv
      841 iaddlpypfg ltqysdyiyw tdwnlhsier adktsgrnrt liqghldfvm dilvfhssrq
      901 dglndcvhsn gqcgqlclai pgghrcgcas hytldpssrn csppstfllf sqkfaisrmi
      961 pddqlspdli lplhglrnvk ainydpldkf iywvdgrqni krakddgtqp smltspsqsl
     1021 spdrqphdls idiysrtlfw tceatntinv hrldgdamgv vlrgdrdrpr aiavnaergy
     1081 myftnmqdha akierasldg terevlfttg lirpvalvvd nalgklfwvd adlkriescd
     1141 lsganrltle danivqpvgl tvlgrhlywi drqqqmierv ekttgdkrtr vqgrvthltg
     1201 ihaveevsle efsahpcard nggcshicia kgdgtprcsc pvhlvllqnl ltcgepptcs
     1261 pdqfacatge idcipgawrc dgfpecadqs deegcpvcsa sqfpcargqc vdlrlrcdav
     1321 clpnqfrcas gqcvlikqqc dsfpdcadgs delmceinkp psddvpahss aigpvigiil
     1381 slfvmggvyf vcqrvmcqry tgasgpfphe yvggtphvpl nfiapggsqh gpfpgipcsk
     1441 smmssvslvg grgsvplydr nhvtgassss ssstkatlyp pilnpppspa tdpslynmdm
     1501 fyssnipsta rpyrpyiirg mappttpcst dvcdsdysts rwktskyyld lnsdsdpypp
     1561 pptphsqyls aedscppspv tersychlfp pppspctdss
//
