LOCUS       NM_031322               7784 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus LDL receptor related protein 4 (Lrp4), mRNA.
ACCESSION   NM_031322 XM_342464
VERSION     NM_031322.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7784)
  AUTHORS   Wang,J., Qiu,X., Xu,T., Sheng,Z. and Yao,L.
  TITLE     Sclerostin/Receptor Related Protein 4 and Ginkgo Biloba Extract
            Alleviates beta-Glycerophosphate-Induced Vascular Smooth Muscle
            Cell Calcification By Inhibiting Wnt/beta-Catenin Pathway
  JOURNAL   Blood Purif 47 Suppl 1 (Suppl 1), 17-23 (2019)
   PUBMED   30699436
  REMARK    GeneRIF: beta-GP induced VSMC calcification by activating the
            Wnt/beta-catenin signaling pathway. Sclerostin and Lrp4 were
            involved in beta-GP-induced VSMC calcification and play an
            important role. GBE could alleviate VSMC calcification induced by
            beta-GP through inhibiting the Wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 7784)
  AUTHORS   Hoshi,T., Tezuka,T., Yokoyama,K., Iemura,S., Natsume,T. and
            Yamanashi,Y.
  TITLE     Mesdc2 plays a key role in cell-surface expression of Lrp4 and
            postsynaptic specialization in myotubes
  JOURNAL   FEBS Lett 587 (23), 3749-3754 (2013)
   PUBMED   24140340
REFERENCE   3  (bases 1 to 7784)
  AUTHORS   Witzemann,V., Chevessier,F., Pacifici,P.G. and Yampolsky,P.
  TITLE     The neuromuscular junction: selective remodeling of synaptic
            regulators at the nerve/muscle interface
  JOURNAL   Mech Dev 130 (6-8), 402-411 (2013)
   PUBMED   23032192
  REMARK    Review article
REFERENCE   4  (bases 1 to 7784)
  AUTHORS   Yumoto,N., Kim,N. and Burden,S.J.
  TITLE     Lrp4 is a retrograde signal for presynaptic differentiation at
            neuromuscular synapses
  JOURNAL   Nature 489 (7416), 438-442 (2012)
   PUBMED   22854782
REFERENCE   5  (bases 1 to 7784)
  AUTHORS   Zong,Y., Zhang,B., Gu,S., Lee,K., Zhou,J., Yao,G., Figueiredo,D.,
            Perry,K., Mei,L. and Jin,R.
  TITLE     Structural basis of agrin-LRP4-MuSK signaling
  JOURNAL   Genes Dev 26 (3), 247-258 (2012)
   PUBMED   22302937
  REMARK    GeneRIF: present the first crystal structure of an agrin-LRP4
            complex which is essential for neuronal agrin-induced acetylcholine
            receptor (AChR) clustering
REFERENCE   6  (bases 1 to 7784)
  AUTHORS   Simon-Chazottes,D., Tutois,S., Kuehn,M., Evans,M., Bourgade,F.,
            Cook,S., Davisson,M.T. and Guenet,J.L.
  TITLE     Mutations in the gene encoding the low-density lipoprotein receptor
            LRP4 cause abnormal limb development in the mouse
  JOURNAL   Genomics 87 (5), 673-677 (2006)
   PUBMED   16517118
REFERENCE   7  (bases 1 to 7784)
  AUTHORS   Li,Y., Chen,J., Lu,W., McCormick,L.M., Wang,J. and Bu,G.
  TITLE     Mesd binds to mature LDL-receptor-related protein-6 and antagonizes
            ligand binding
  JOURNAL   J Cell Sci 118 (Pt 22), 5305-5314 (2005)
   PUBMED   16263759
REFERENCE   8  (bases 1 to 7784)
  AUTHORS   Johnson,E.B., Hammer,R.E. and Herz,J.
  TITLE     Abnormal development of the apical ectodermal ridge and
            polysyndactyly in Megf7-deficient mice
  JOURNAL   Hum Mol Genet 14 (22), 3523-3538 (2005)
   PUBMED   16207730
REFERENCE   9  (bases 1 to 7784)
  AUTHORS   Tomita,Y., Kim,D.H., Magoori,K., Fujino,T. and Yamamoto,T.T.
  TITLE     A novel low-density lipoprotein receptor-related protein with type
            II membrane protein-like structure is abundant in heart
  JOURNAL   J Biochem 124 (4), 784-789 (1998)
   PUBMED   9756624
REFERENCE   10 (bases 1 to 7784)
  AUTHORS   Nakayama,M., Nakajima,D., Nagase,T., Nomura,N., Seki,N. and
            Ohara,O.
  TITLE     Identification of high-molecular-weight proteins with multiple
            EGF-like motifs by motif-trap screening
  JOURNAL   Genomics 51 (1), 27-34 (1998)
   PUBMED   9693030
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB073317.3.
            
            On Apr 16, 2011 this sequence version replaced NM_031322.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB073317.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..7784
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..7784
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /note="LDL receptor related protein 4"
                     /db_xref="GeneID:83469"
                     /db_xref="RGD:619731"
     exon            1..65
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..5731
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /note="low-density lipoprotein receptor-related protein 4;
                     multiple epidermal growth factor-like domains 7; LRP-4"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     4 precursor"
                     /protein_id="NP_112612.2"
                     /db_xref="GeneID:83469"
                     /db_xref="RGD:619731"
                     /translation="MRRWWGALLLGALLCAHGTASNLECACGRSHFTCAVSALGECTC
                     IPAQWQCDGDNDCGDHSDEDGCTLPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE
                     QDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSC
                     IAEHWYCDGDTDCKDGSDEESCPSAVPSPPCNLEEFQCAYGRRILDIYHCDGDDDCGD
                     WSDESDCSSHQPCRSGEFMCDSGLCVNAGWRCDGDADCDDQSDERNCTTSMCTAEQFR
                     CRSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCASDQFLCWNGRCIGQRKLCNGV
                     NDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMIRGAVQCTCHTGYRLTEDGRT
                     CQDVNECAEEGYCSQGCTNSEGAFQCWCEAGYELRPDRRSCKALGPEPVLLFANRIDI
                     RQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVST
                     GLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQSLEKPRAIALHPMEG
                     TIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIER
                     ANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLH
                     FPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKINSHACAQSL
                     DKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTIS
                     RAKWDGTGQKVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWE
                     NLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASNRQVIISSNLTWPNGLAIDYGS
                     QRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGQRIYWTDWQTKSIQSAD
                     RLTGLDRETLQENLENLMDIHVFHRQRPPVTTPCAVENGGCSHLCLRSPSPSGFSCTC
                     PTGINLLLDGKTCSPGMNSFLIFARRIDVRMVSLDIPYFADVVVPINMTMKNTIAIGV
                     DPLEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTN
                     RIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRTV
                     LINNNLGWPNGLTVDKTSSQLLWADAHTERIEVADLNGANRHTLVSPVQHPYGLTLLD
                     SYIYWTDWQTRSIHRADKSTGSNVILVRSNLPGLMDIQAVDRAQPLGFNKCGSRNGGC
                     SHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTDDHTDVH
                     VPVPGLNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTDGLAVD
                     WVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIA
                     KIERANLDGSERKVLINADLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVL
                     VSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQR
                     QTGTNACGVNNGGCSHLCFARASDFVCACPDEPDSHPCSLVPGLMPPAPRATSLNEKS
                     PVLPNTLPTTLHSSTTRTRTSPEGAEGRCSERDAQLGLCAHSNEAVPAAPGEGLHVSY
                     AVGGLLSVLLILLVTAALMLYRHRKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAAPKP
                     AMYNQLCYKKEGGPDHSYTKEKIKIVEGIHLLAGHDAEWGDLKQLRSSRGGLLRDHVC
                     MKTDTVSIQASSGSLDDTETEQLLQEEQSECSSVHTATTPERRGSLPDTGWKHERKLS
                     SESQV"
     exon            66..212
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            213..329
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            330..443
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            444..560
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            561..689
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            690..809
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            810..935
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1061
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1196
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1322
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1553
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1710
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1928
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2105
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2228
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2437
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2519
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2625
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2827
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..3017
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3149
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3290
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3377
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3549
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3712
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..3938
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            3939..4242
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            4243..4461
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            4462..4596
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            4597..4705
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            4706..4850
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            4851..4964
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            4965..5100
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            5101..5168
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            5169..5256
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            5257..5398
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            5399..7784
                     /gene="Lrp4"
                     /gene_synonym="Megf7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcagc accatgaggc ggtggtgggg cgcgctgctg ctcggcgccc tgctctgcgc
       61 acacggcaca gccagcaatc tggagtgtgc gtgtggtcgg agccacttca catgtgcagt
      121 gagcgcgctc ggcgaatgta cctgcatccc cgcccagtgg cagtgtgatg gtgacaatga
      181 ctgtggagac cacagcgatg aggatggctg tacgctgcct acctgttccc ctctggactt
      241 ccactgtgac aacggcaagt gcatccgacg ctcctgggtg tgtgatgggg acaatgactg
      301 tgaagatgac tccgatgagc aggactgtcc cccccgggag tgtgaggagg acgagttccc
      361 ctgccagaac ggctactgca tccggagtct gtggcactgt gatggggaca atgactgtgg
      421 tgacaacagt gacgaacagt gcgacatgcg caagtgctca gacaaggaat tccgctgcag
      481 tgatgggagc tgcattgctg agcattggta ctgtgatgga gacacagact gcaaagacgg
      541 ctctgatgag gaaagctgcc cctcagcagt accctctcct ccttgcaacc tggaagagtt
      601 ccagtgtgcc tacggccgcc gcatccttga catctaccac tgtgacgggg atgatgactg
      661 cggagactgg tcagacgagt ccgactgctc ctcccaccag ccctgccgct ctggggaatt
      721 catgtgtgac agtggcctgt gcgtcaacgc aggctggcgc tgtgatggtg atgcggactg
      781 cgatgaccag tctgatgaac gtaactgcac cacctccatg tgcacagctg aacagtttcg
      841 ctgtcggtca ggccgctgtg tccgtctgtc ctggcgctgt gatggggagg atgactgcgc
      901 ggacaacagt gatgaagaaa actgtgagaa cacaggaagc ccccaatgcg cctctgacca
      961 gttcctgtgt tggaatgggc gttgtattgg gcagaggaag ctctgcaatg gggtcaatga
     1021 ctgcggcgac aacagtgacg aaagcccaca gcagaactgt cggccccgga cgggtgagga
     1081 gaactgcaat gttaacaacg gtggctgtgc ccagaagtgt cagatgattc gaggggcagt
     1141 gcagtgtacc tgccacacag gctaccggct cacagaggat gggagaacgt gccaggatgt
     1201 gaatgaatgt gctgaggagg gatactgcag ccagggctgc acaaacagcg aaggggcttt
     1261 ccagtgctgg tgcgaagccg gttatgagct gcggcccgat cggcgcagct gcaaggctct
     1321 ggggccggaa cctgtgctac tgtttgccaa tcgcatcgac atccggcagg tgctcccgca
     1381 ccgctccgaa tacacgctgc tactgaacaa cctggagaac gccattgccc ttgactttca
     1441 tcatcggcgg gagctggtct tctggtctga tgtcaccctg gaccgcatcc tccgtgccaa
     1501 ccttaatggc agcaatgtgg aggaggtggt gtctactggg ctagagagcc caggcggctt
     1561 ggctgtggat tgggtccatg acaagctcta ctggactgac tccgggacgt cgaggattga
     1621 ggtggctaat ctggacgggg cccaccggaa ggtgctgctg tggcagagcc tggagaagcc
     1681 cagggccatt gccctgcacc ccatggaggg aaccatctat tggacagact ggggcaacac
     1741 cccccgcatc gaggcctcca gcatggacgg ctctggacgt cgcatcattg ctgacactca
     1801 tcttttctgg cccaacggcc tcaccatcga ctacgctgga cgccgtatgt actgggtgga
     1861 cgctaagcac cacgtcatcg agagagccaa tctagatggg agtcaccgca aggctgtcat
     1921 tagccagggc ctcccacatc cctttgccat cacagtgttt gaagacagct tgtattggac
     1981 agactggcac accaagagca tcaatagtgc caacaagttc actgggaaga accaggagat
     2041 cattcgcaac aagctccact ttcctatgga cattcatacc ttgcaccccc agcgccagcc
     2101 tgcagggaaa aaccgctgcg gggacaacaa cggaggttgc actcacctgt gtctacccag
     2161 tggccagaac tacacttgtg cctgccccac cggcttccga aaaatcaaca gccacgcctg
     2221 tgcccagagt cttgacaagt tcctgctttt tgcccgaagg atggacatcc gtcggatcag
     2281 cttcgacaca gaggacctgt ccgacgatgt catcccactg gctgacgtgc gcagtgctgt
     2341 ggcccttgac tgggactccc gggatgacca cgtgtactgg acagatgtca gcactgatac
     2401 catcagcagg gccaagtggg atggaacagg acagaaggtg gtagttgaca ccagtttgga
     2461 gagccctgct ggcctggcaa ttgattgggt caccaacaaa ctctactgga cagatgcagg
     2521 tacagaccgg attgaagtgg ccaacacgga cggcagcatg aggacagtgc tcatctggga
     2581 gaaccttgat cgtcctcggg acatcgtggt agaacccatg ggcgggtaca tgtattggac
     2641 tgactggggt gcaagtccca agattgaacg agctggcatg gatgcctcca accgacaagt
     2701 catcatctct tcgaatctga catggcctaa tggattagct attgactatg ggtcccagcg
     2761 gctgtactgg gctgatgccg gcatgaagac tattgaattt gctgggctgg atggcagcaa
     2821 gaggaaggta ctaattggaa gtcaactccc ccaccctttc gggctgactc tatacggaca
     2881 gcgcatctat tggactgact ggcagaccaa aagtatccaa agtgctgacc ggctgactgg
     2941 gctagaccgg gagactctgc aggagaacct ggagaatctt atggacatcc atgtcttcca
     3001 ccgccagagg cctccagtga cgacaccatg tgctgtggag aatggcggct gcagccattt
     3061 gtgtcttcgg tccccaagtc cgagcggctt cagctgtacc tgccccacag gtatcaacct
     3121 gctgcttgat ggcaagacat gctcaccagg catgaacagt ttcctcatct tcgccaggag
     3181 gattgatgtt cgcatggtct ccttggacat cccttatttt gctgatgtgg tggtacccat
     3241 caacatgacc atgaagaaca ccattgccat tggagtggac ccgctggaag gaaaagtgta
     3301 ctggtctgac agcacactgc acaggatcag ccgtgccagc ctggatggct cacagcacga
     3361 ggacatcatc actacaggtt tgcagaccac agatggactt gcagtggatg ccatcggccg
     3421 gaaagtgtat tggacagaca cgggaacgaa tcggattgaa gttggcaacc tggatgggtc
     3481 tatgcggaaa gtgttggtgt ggcagaacct tgacagtccc cgggccattg tgctatacca
     3541 tgaaatgggg ttcatgtact ggacagactg gggggagaat gccaaactag agcgttccgg
     3601 gatggatggc tcagaccgta ctgtgctcat caacaacaac ctagggtggc ctaacggact
     3661 gactgtggac aagaccagct cccaactgct gtgggctgat gcccatactg agagaattga
     3721 ggtggctgac ctgaacggtg ccaatcggca tacattggtg tcaccagtgc agcacccata
     3781 tggcctcact ctgcttgact cttacatcta ctggactgac tggcagaccc gtagcatcca
     3841 ccgggccgac aagagtactg gcagcaatgt tatcctcgtg aggtccaacc tgccaggcct
     3901 catggacatc caagctgttg accgggcaca gccactgggt tttaataagt gtggttcgag
     3961 aaatggcggc tgctcccacc tctgtttacc tcggccctct ggtttctcct gtgcctgccc
     4021 cactggcatt cagctgaagg gggatgggaa gacctgtgac ccctctccgg agacctacct
     4081 gctcttctct agccggggct ccattcgccg tatctcactg gacaccgatg accacacaga
     4141 cgtgcatgtc cctgttcctg ggctcaacaa tgtcatctcc ctagactatg acagtgtgga
     4201 tggaaaggtc tattacacag acgtgttcct ggatgttatc aggcgagcag acctgaatgg
     4261 cagcaacatg gagactgtta ttgggcatgg gctgaagacc actgatgggc tggcagtgga
     4321 ctgggttgcc agaaacctgt actggacaga tacaggccga aataccatcg aagcatctcg
     4381 gctagatggt tcctgtcgca aagtgctaat caacaacagt ctggacgagc cccgggccat
     4441 tgctgttttc cccagaaagg ggtacctctt ctggacagac tggggccaca ttgccaagat
     4501 tgaacgggca aacctggatg gttctgagag gaaggtcctc atcaatgcag acctaggctg
     4561 gcccaatggc cttaccttgg actatgatac ccgcaggatc tactgggtag atgcacatct
     4621 ggatcggatt gagagtgctg acctcaatgg gaagctgagg caggtcttgg tcagccatgt
     4681 gtcccacccc tttgccctca cacagcagga caggtggatc tactggacag actggcagac
     4741 caaatccatc cagcgtgtcg acaagtactc aggccgcaac aaggagacag tgctggccaa
     4801 tgtggaggga ctcatggata tcatcgtggt gtcccctcaa cggcagacag ggaccaatgc
     4861 ctgtggtgtg aacaatggtg gctgtagcca cctctgcttt gccagagcct ctgactttgt
     4921 gtgcgcctgt cctgatgagc cagacagtca tccctgctcc ctcgtgcctg gcctcatgcc
     4981 tcctgctccc agagctacca gcctgaatga aaagagccca gtgctcccca acacattgcc
     5041 caccacctta cattcttcta ccaccaggac ccgcacatct ccagaggggg cagaaggaag
     5101 atgctctgaa agggacgccc agctgggcct ctgtgcacat tccaatgaag ctgtacctgc
     5161 tgctccaggt gaaggactgc atgtcagcta cgccgttggt ggactcctca gcgtcctgct
     5221 gattttgttg gtgactgcag ctttgatgct atacagacac agaaaatcca aattcacgga
     5281 tcctggaatg ggaaacctga cctacagcaa cccctcctac cgaacttcca ctcaggaagt
     5341 gaaaattgaa gcagctccca aaccagccat gtataatcag ctgtgctata agaaagaggg
     5401 tggacctgac cacagctaca ccaaggagaa gatcaagatt gtagagggaa ttcacctcct
     5461 ggctgggcat gatgctgaat ggggtgacct caagcaactg cgcagctcca gggggggcct
     5521 tctacgggat cacgtatgca tgaagacaga cacggtgtcc atccaggcca gctctggctc
     5581 cctagatgac acggagacag agcagctgct gcaggaagag cagtctgagt gtagcagtgt
     5641 tcacactgca accactccag agagacgggg ctctctgcca gacacaggct ggaaacatga
     5701 acgcaagctc tcctcagaaa gccaggtcta agtgcccaca ttctcttccc tgcctgcctg
     5761 ttcgttcttc tctgtggact tctgatcctt gtgctcacaa agcaacgggc cctttcccgt
     5821 gcactcatct tcctcctccc acccaaaagt gttcccacga ccccatagaa cctgttactc
     5881 acctgagtct gaaactacct ggggacaaga agtgagggca catctcaaga atttagacct
     5941 ggattttacc atgaacttca cctcttgcac tctatcctgg gccccctgaa gctgggctca
     6001 gtgtaatacc ttgtcagcac agcatcttcc tttgccctgg catcctatgt gtctgcccca
     6061 cggcaccgat gcaattggtg atgtaagact ttggtcttcc ccatcacagc tgacatgatg
     6121 gcctctctgt gaactggcct accaggggct gggactggag gtcacaggta aaaggtaatg
     6181 aatggataga ggttgagaga aggaagaacc agcccagctg gtctgggtgt ttgggaaacc
     6241 tccagcctca agtgttggta attatgaaaa acctttgggg gaaggcactt gagccctggg
     6301 atctcgtcca ttgctggcag tggacgttct cacccaggtg aagtgtgggt atggcctaag
     6361 ttcttcttcc tcctgctgga atgtctgggg ccactatcta ccttcagtaa ctggaggcct
     6421 ctgtcatggc aactcactaa taggaattcc ctcctggtgc tgctactggc cagtactttt
     6481 cttaagcctt taactatgct gtgagcttga gtgaacattg gtcgggcctt ggagagtagg
     6541 cctctagaac gtttaagaag ctctgcaaag atcaagaaca gtatcttacc tgagcctcac
     6601 tactctgccc ttttttctcc cattctctgg gattctaagg gaagcaattc tatcacagcc
     6661 tttcaaagaa tggctagaca ttttcctaaa tggtcaggaa gagcaactag agagacacaa
     6721 gacacccagg ggctcaggag aagtatcgtg aggttgaact tcttgagttc attctcaggt
     6781 gctcagggac ccaagcctgg ggcactaagg tcatgtgcca actcttctcg gcctctgccc
     6841 acactaaagt gccaccatta gctgcatgct tctttaggcc aagggcttct ctcaggggag
     6901 ctgagagtct ttttgtgctg ccctagaatt tcatcctagt gtttcacttc tgagagaggg
     6961 gaatctagac ttgttttctc taaccgatcc tgtatcacct tggtctccat tgtccagtga
     7021 tgagtgagga ggttcaatga agatgcaaag tggtgagcag ggagtggaga ggtggtgaga
     7081 ttaggtccag agcaagtcta ggcacttctc catagaaact gaagcacagg agagattgac
     7141 aggagctgaa catggagggg agggttttta ggggaagttt tctgacttaa aacatctttc
     7201 atggttattg ctacacagag atcagcagcc aggcatatgc atgaaaaaca ggacaagatc
     7261 aaatcttttc tggtcagtta ttaggagtag gagacagatg tcaaaccatt agtctcgttg
     7321 tcactagcta ggcccagacc tatgtctaca catagagaac caaggcaggc caaaggcctt
     7381 ttccagtaca ccaactgaga aaagaacagt gccattttta agaggaaaga cagacatttc
     7441 acacagaatg aggcaacatt tgagccttta aacccgtagc tggggaggag gaagaaaaca
     7501 ggagtgtggt gtcctcctga gtggaaaggg caaggttctt attgcactcg ggctgttcag
     7561 aatgtagaaa ggacgcattt gagggaatat ctatttgagc actgatttac tctgtaaaga
     7621 gggcaaaatc tctctgtcct aaactaatgg aagtgatttt cccatgctca tgtgtaatga
     7681 ttttaacatt actcactgga gagattggac tttctggagt tatttaacca ctatgttcag
     7741 tattttaggg ctttatgata atttaatata aatttagctt tctt
//
