LOCUS       XM_039092968            4050 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus LDL receptor related protein 3 (Lrp3),
            transcript variant X1, mRNA.
ACCESSION   XM_039092968
VERSION     XM_039092968.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039092968.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4050
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..4050
                     /gene="Lrp3"
                     /note="LDL receptor related protein 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 24 ESTs, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 56 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:89787"
                     /db_xref="RGD:619729"
     CDS             406..2838
                     /gene="Lrp3"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     3 isoform X1"
                     /protein_id="XP_038948896.1"
                     /db_xref="GeneID:89787"
                     /db_xref="RGD:619729"
                     /translation="MEKRAAAGPEGAPGARAPLAVVCLVNLFLTGRLSSAVPALAACS
                     GKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLD
                     WLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGK
                     LGQASCQTDEFRCDNGKCLPGPWQCNMVDECGDGSDEGNCSAPASEPPGSLCPGGTFP
                     CSGARSTRCLPVERRCDGTQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARG
                     PSDLHCTWLVDTQDPRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPV
                     SLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSEGDDGSTGEQGCF
                     SEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYAPADRCNNQKSCPDGADEK
                     NCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVC
                     GLLLVIALGCAFKLYSLRTQEYRWAPRGGLAPRFFRFPGENRTTFQAMGWVIPIQEDC
                     FFVCMAFETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRT
                     AMRRQMRRHASRRGPSRRRLGRLWNRLFHRPRAPRGQIPLLTAARTSQTVLGDGLLQA
                     APGPVPDPPVPNTDTGSPREAGDGPPSGSGHAPEVGPSVPPPPLNLRDPEYRPEDKER
                     KACVDPLEDSPAPVDTPPEPCLAQDPHPQTPTASGIQDPHSAEPLGVCRSPPPTCSPI
                     LEASDDEALLVC"
ORIGIN      
        1 gggcttaggc gaggggccgg ccgggaggac ggacggaccg atcgacgcac cctcgttgac
       61 atcgtgcggc gcggcgcggc gcgggcggcc cggggaccga cgggcaggcg caccggggca
      121 tgggcgcgcc ggaggtctcg gtgtgcaggc agggctgggt gcgccggccg gggctcgggg
      181 acagcggcgg gctcaggtct tccctggcga ccgctgctga gcccccgcgg ggcccgtgac
      241 gccgcggccg atgtggccca gcgcgttgcg ggcctgcacc gccgctgcac aaagacgccg
      301 ccgcagccgc cgcccgcacc ccggccgcag ccgccgcgcc agccctagcc ccaggcggag
      361 tcccggccgc agggcagcag gcgtccgcgc gcggccggcc acggcatgga gaagcgcgcg
      421 gccgcggggc cggagggggc gccgggcgcc agggcgccgc tcgcagtcgt ctgcctggtg
      481 aacctctttc tcactgggag actcagcagt gcagttcctg ccttagctgc ctgcagtggg
      541 aagttggaac agcacactga acggcgaggg gttatctaca gcccagcctg gcccctcaac
      601 taccctccag gcaccaactg cagctggtac attcaaggtg accgtggtga catgatcacc
      661 atcagtttcc gaaactttga tgtagaggag tctcaccagt gttccctgga ctggctcctg
      721 ctgggcccag cagctccccc tcgccaggag gccttccgcc tctgtggttc agccatccca
      781 ccagccttca tctctgcccg tgaccacgtc tggatcttct tccactcaga cgcctccagt
      841 tccggccagg cccagggttt tcgcctctcc tatatccgag ggaagctggg tcaggcatcc
      901 tgccagacag atgagttccg ctgtgacaac ggtaaatgct tgcctggtcc ttggcagtgc
      961 aacatggtgg atgagtgtgg agatggctcg gatgagggta actgttcggc acctgcctca
     1021 gagccaccag gcagcctgtg ccccgggggc accttcccgt gcagcggagc tcgctccaca
     1081 cgctgcctgc cggtagagcg gcgctgcgac ggcacccagg actgcggtga tggctctgat
     1141 gaggctggct gccccgacct agcatgtggc cggcggctag gcagtttcta cggttccttc
     1201 gcctccccag acctgtttgg tgccgcccgt gggccttcgg accttcactg cacatggctg
     1261 gtggacacgc aggacccgag gcgtgtgctg ctgcagctgg agctacgact gggttatgat
     1321 gactatgtcc aggtgtatga aggcctgggc gagcgtgggg accgtctgct gcaaacgctt
     1381 tcctaccgca gcaaccaccg gcctgtgagc ctggaagcag cgcagggccg cctcactgtg
     1441 gcctaccatg ctcgcgcccg cagtgctggt cacggcttca acgccacata ccaggtgaag
     1501 ggctactgcc tcccatggga gcagccgtgt gggagcagca gcgagggaga tgacggcagc
     1561 acaggggaac agggctgctt ctcagagcca cagcgctgtg atggctggtg gcattgtgcg
     1621 agcggccggg atgagcaggg ctgtccagca tgccctccgg accagtatcc ctgtgagggt
     1681 ggtagcggcc tgtgctatgc acctgccgat cgttgcaaca accagaaaag ctgccccgat
     1741 ggcgccgatg aaaagaactg cttttcctgc cagccgggca ccttccactg tggtacgaac
     1801 ctgtgcatct ttgagacatg gcgctgtgac ggtcaggagg actgccaaga tggcagcgat
     1861 gagcacggct gcctggctgc cgtgccccgc aaggtcatca ccgccgccct cattggtagc
     1921 ctagtatgcg gactgctgct tgttattgcc ctaggctgtg ccttcaaact ctactccctg
     1981 cgcacgcagg agtacaggtg ggcaccacgt ggtggcctgg cgccccggtt cttccgtttc
     2041 cctggagaaa atcgcactac attccaggct atgggttggg tcatcccgat acaggaggac
     2101 tgtttctttg tgtgcatggc ctttgagacc caaatgacac gtttagaggc tgagtttgtg
     2161 cggcgcgagg cgcccccatc ctacggtcag ctcatcgcac agggcctcat accacccgtt
     2221 gaggattttc ctgtctacag tgcatcccag gcttcagtgc tacagaacct tcgcacagcc
     2281 atgcgacgac agatgcgtcg gcatgcctcc cgcagggggc catctcgtcg cagactgggc
     2341 cgcctctgga acaggctctt ccaccggcca cgggcacctc gaggccagat cccactgctg
     2401 actgccgccc gtacctcaca gaccgtgctg ggtgatgggc tcctccaggc agcaccaggg
     2461 cctgtaccag accccccagt gcccaataca gacacaggca gccccaggga ggctggagat
     2521 gggcctccta gtggctctgg ccatgcacca gaagtggggc cttcagtgcc gcccccgccc
     2581 ttgaaccttc gagacccaga gtacaggcca gaggacaagg agagaaaggc ctgtgtggac
     2641 cctctggaag acagtccagc ccctgtggac acacctccag agccctgctt ggcccaagac
     2701 ccccaccccc agactcccac tgccagtggc atccaagatc cccactcagc agagccactg
     2761 ggggtctgca ggagccctcc accaacctgc tccccaatat tggaggctag tgatgatgag
     2821 gccctgctgg tctgctgacc cattggacac actggtgact gccacagccc cgctttggaa
     2881 ccagggaata cacagtcatt tctaccctgc ctctgcattc tttcttacag agacccacct
     2941 agcagctccg gtgaagggcc tgggcactca gtcagtgggc tacctgtgca gtcctattgc
     3001 tctgaagggc attactgtca ggggcttcgg gggtggacct gggaaagagg gaccgaccac
     3061 ctttgagatc agcatgagca tagccccttg gagtctcaca gcaaattgct ccctgctaca
     3121 ctaatctcgg gactcatttc cagaaaagca ggagagccag aaccaggctt tccggaatgt
     3181 tttctgtggc ttctcagttt atccaccctg cagtggcacc agctgctcat cctcagacct
     3241 gtgccaggag ctgtagttga ggcctaaaaa ggccatgaga ggggtagggt ggacctcatt
     3301 catggtgagt actatattca tccttcccca cagggtccct aggaaagatg ggctagtggc
     3361 ttctgcccca gtctcatgcc tatggtggca gcataggcct ggctaggctg ggtcagtccc
     3421 caagtatcat gggtaaggct aaaagtatga gataggatga ccacaagaga ggccattcta
     3481 tgccttcaaa ggagacagaa gccaaggtac tggctgacaa tggaaataac cattctgtct
     3541 tgcctcagag tctcagtttc cccacctgaa gagagggctg tgctatcata agtaatagca
     3601 ttcactctgg tgatttatgg gaaggacagt agttccagct ggggaatttc tgggttcttc
     3661 tggatggcca agttcaaggt ggcgtggagg gttatggatg gagcctcatt gtcttctatg
     3721 ggccccatgg agccagcctc aggttcaacc agcaaaaccc actagggctg aaaacctcct
     3781 ccatagcacc ttcccagcta gcaacccata taccgcgctg aggcatgtct ccatgaactc
     3841 cccttacaca cagaacaacc agccctgttt atttacagac ttttctggag aagctagcag
     3901 ggcattgcta aggcaggaag cccgacccca gtggccagtc ccttacaata ggcctctaag
     3961 ggtcgggtct ctttttttgt gcagaaaaaa aaatttttga aaacaaaaca gaacacaaac
     4021 cccttctcaa taaacaacat gtaaacagaa
//
