LOCUS       NM_053541               3892 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus LDL receptor related protein 3 (Lrp3), mRNA.
ACCESSION   NM_053541
VERSION     NM_053541.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3892)
  AUTHORS   Elsafadi,M., Manikandan,M., Alajez,N.M., Hamam,R., Dawud,R.A.,
            Aldahmash,A., Iqbal,Z., Alfayez,M., Kassem,M. and Mahmood,A.
  TITLE     MicroRNA-4739 regulates osteogenic and adipocytic differentiation
            of immortalized human bone marrow stromal cells via targeting LRP3
  JOURNAL   Stem Cell Res 20, 94-104 (2017)
   PUBMED   28340487
REFERENCE   2  (bases 1 to 3892)
  AUTHORS   Takatsu,H., Katoh,Y., Shiba,Y. and Nakayama,K.
  TITLE     Golgi-localizing, gamma-adaptin ear homology domain,
            ADP-ribosylation factor-binding (GGA) proteins interact with acidic
            dileucine sequences within the cytoplasmic domains of sorting
            receptors through their Vps27p/Hrs/STAM (VHS) domains
  JOURNAL   J Biol Chem 276 (30), 28541-28545 (2001)
   PUBMED   11390366
REFERENCE   3  (bases 1 to 3892)
  AUTHORS   Dammers,P.M., Visser,A., Popa,E.R., Nieuwenhuis,P. and Kroese,F.G.
  TITLE     Most marginal zone B cells in rat express germline encoded Ig VH
            genes and are ligand selected
  JOURNAL   J Immunol 165 (11), 6156-6169 (2000)
   PUBMED   11086049
REFERENCE   4  (bases 1 to 3892)
  AUTHORS   Ishii,H., Kim,D.H., Fujita,T., Endo,Y., Saeki,S. and Yamamoto,T.T.
  TITLE     cDNA cloning of a new low-density lipoprotein receptor-related
            protein and mapping of its gene (LRP3) to chromosome bands
            19q12-q13. 2
  JOURNAL   Genomics 51 (1), 132-135 (1998)
   PUBMED   9693042
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053541.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB009463.1, SRR26643298.2536.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-441               JAXUCZ010000001.1  96995617-96996057   c
            442-489             JAXUCZ010000001.1  96993991-96994038   c
            490-628             JAXUCZ010000001.1  96986953-96987091   c
            629-843             JAXUCZ010000001.1  96985631-96985845   c
            844-1960            JAXUCZ010000001.1  96984203-96985319   c
            1961-2093           JAXUCZ010000001.1  96983864-96983996   c
            2094-3892           JAXUCZ010000001.1  96981815-96983613   c
FEATURES             Location/Qualifiers
     source          1..3892
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3892
                     /gene="Lrp3"
                     /note="LDL receptor related protein 3"
                     /db_xref="GeneID:89787"
                     /db_xref="RGD:619729"
     exon            1..441
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..2681
                     /gene="Lrp3"
                     /note="low-density lipoprotein receptor-related protein 3;
                     rLRp105; LRP-3; 105 kDa low-density lipoprotein
                     receptor-related protein"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     3 precursor"
                     /protein_id="NP_445993.1"
                     /db_xref="GeneID:89787"
                     /db_xref="RGD:619729"
                     /translation="MEKRAAAGPEGAPGARAPLAVVCLVNLFLTGRLSSAVPALAACS
                     GKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLD
                     WLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGK
                     LGQASCQTDEFRCDNGKCLPGPWQCNMVDECGDGSDEGNCSAPASEPPGSLCPGGTFP
                     CSGARSTRCLPVERRCDGTQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARG
                     PSDLHCTWLVDTQDPRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPV
                     SLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSEGDDGSTGEQGCF
                     SEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYAPADRCNNQKSCPDGADEK
                     NCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVC
                     GLLLVIALGCAFKLYSLRTQEYRAFETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVE
                     DFPVYSASQASVLQNLRTAMRRQMRRHASRRGPSRRRLGRLWNRLFHRPRAPRGQIPL
                     LTAARTSQTVLGDGLLQAAPGPVPDPPVPNTDTGSPREAGDGPPSGSGHAPEVGPSVP
                     PPPLNLRDPEYRPEDKERKACVDPLEDSPAPVDTPPEPCLAQDPHPQTPTASGIQDPH
                     SAEPLGVCRSPPPTCSPILEASDDEALLVC"
     exon            442..489
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            490..628
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            629..843
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1960
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2093
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..3892
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgatcgacg caccctcgtt gacatcgtgc ggcgcggcgc ggcgcgggcg gcccggggac
       61 cgacgggcag gcgcaccggg gcatgggcgc gccggaggtc tcggtgtgca ggcagggctg
      121 ggtgcgccgg ccggggctcg gggacagcgg cgggctcagg tcttccctgg cgaccgctgc
      181 tgagcccccg cggggcccgt gacgccgcgg ccgatgtggc ccagcgcgtt gcgggcctgc
      241 accgccgctg cacaaagacg ccgccgcagc cgccgcccgc accccggccg cagccgccgc
      301 gccagcccta gccccaggcg gagtcccggc cgcagggcag caggcgtccg cgcgcggccg
      361 gccacggcat ggagaagcgc gcggccgcgg ggccggaggg ggcgccgggc gccagggcgc
      421 cgctcgcagt cgtctgcctg gtgaacctct ttctcactgg gagactcagc agtgcagttc
      481 ctgccttagc tgcctgcagt gggaagttgg aacagcacac tgaacggcga ggggttatct
      541 acagcccagc ctggcccctc aactaccctc caggcaccaa ctgcagctgg tacattcaag
      601 gtgaccgtgg tgacatgatc accatcagtt tccgaaactt tgatgtagag gagtctcacc
      661 agtgttccct ggactggctc ctgctgggcc cagcagctcc ccctcgccag gaggccttcc
      721 gcctctgtgg ttcagccatc ccaccagcct tcatctctgc ccgtgaccac gtctggatct
      781 tcttccactc agacgcctcc agttccggcc aggcccaggg ttttcgcctc tcctatatcc
      841 gagggaagct gggtcaggca tcctgccaga cagatgagtt ccgctgtgac aacggtaaat
      901 gcttgcctgg tccttggcag tgcaacatgg tggatgagtg tggagatggc tcggatgagg
      961 gtaactgttc ggcacctgcc tcagagccac caggcagcct gtgccccggg ggcaccttcc
     1021 cgtgcagcgg agctcgctcc acacgctgcc tgccggtaga gcggcgctgc gacggcaccc
     1081 aggactgcgg tgatggctct gatgaggctg gctgccccga cctagcatgt ggccggcggc
     1141 taggcagttt ctacggttcc ttcgcctccc cagacctgtt tggtgccgcc cgtgggcctt
     1201 cggaccttca ctgcacatgg ctggtggaca cgcaggaccc gaggcgtgtg ctgctgcagc
     1261 tggagctacg actgggttat gatgactatg tccaggtgta tgaaggcctg ggcgagcgtg
     1321 gggaccgtct gctgcaaacg ctttcctacc gcagcaacca ccggcctgtg agcctggaag
     1381 cagcgcaggg ccgcctcact gtggcctacc atgctcgcgc ccgcagtgct ggtcacggct
     1441 tcaacgccac ataccaggtg aagggctact gcctcccatg ggagcagccg tgtgggagca
     1501 gcagcgaggg agatgacggc agcacagggg aacagggctg cttctcagag ccacagcgct
     1561 gtgatggctg gtggcattgt gcgagcggcc gggatgagca gggctgtcca gcatgccctc
     1621 cggaccagta tccctgtgag ggtggtagcg gcctgtgcta tgcacctgcc gatcgttgca
     1681 acaaccagaa aagctgcccc gatggcgccg atgaaaagaa ctgcttttcc tgccagccgg
     1741 gcaccttcca ctgtggtacg aacctgtgca tctttgagac atggcgctgt gacggtcagg
     1801 aggactgcca agatggcagc gatgagcacg gctgcctggc tgccgtgccc cgcaaggtca
     1861 tcaccgccgc cctcattggt agcctagtat gcggactgct gcttgttatt gccctaggct
     1921 gtgccttcaa actctactcc ctgcgcacgc aggagtacag ggcctttgag acccaaatga
     1981 cacgtttaga ggctgagttt gtgcggcgcg aggcgccccc atcctacggt cagctcatcg
     2041 cacagggcct cataccaccc gttgaggatt ttcctgtcta cagtgcatcc caggcttcag
     2101 tgctacagaa ccttcgcaca gccatgcgac gacagatgcg tcggcatgcc tcccgcaggg
     2161 ggccatctcg tcgcagactg ggccgcctct ggaacaggct cttccaccgg ccacgggcac
     2221 ctcgaggcca gatcccactg ctgactgccg cccgtacctc acagaccgtg ctgggtgatg
     2281 ggctcctcca ggcagcacca gggcctgtac cagacccccc agtgcccaat acagacacag
     2341 gcagccccag ggaggctgga gatgggcctc ctagtggctc tggccatgca ccagaagtgg
     2401 ggccttcagt gccgcccccg cccttgaacc ttcgagaccc agagtacagg ccagaggaca
     2461 aggagagaaa ggcctgtgtg gaccctctgg aagacagtcc agcccctgtg gacacacctc
     2521 cagagccctg cttggcccaa gacccccacc cccagactcc cactgccagt ggcatccaag
     2581 atccccactc agcagagcca ctgggggtct gcaggagccc tccaccaacc tgctccccaa
     2641 tattggaggc tagtgatgat gaggccctgc tggtctgctg acccattgga cacactggtg
     2701 actgccacag ccccgctttg gaaccaggga atacacagtc atttctaccc tgcctctgca
     2761 ttctttctta cagagaccca cctagcagct ccggtgaagg gcctgggcac tcagtcagtg
     2821 ggctacctgt gcagtcctat tgctctgaag ggcattactg tcaggggctt cgggggtgga
     2881 cctgggaaag agggaccgac cacctttgag atcagcatga gcatagcccc ttggagtctc
     2941 acagcaaatt gctccctgct acactaatct cgggactcat ttccagaaaa gcaggagagc
     3001 cagaaccagg ctttccggaa tgttttctgt ggcttctcag tttatccacc ctgcagtggc
     3061 accagctgct catcctcaga cctgtgccag gagctgtagt tgaggcctaa aaaggccatg
     3121 agaggggtag ggtggacctc attcatggtg agtactatat tcatccttcc ccacagggtc
     3181 cctaggaaag atgggctagt ggcttctgcc ccagtctcat gcctatggtg gcagcatagg
     3241 cctggctagg ctgggtcagt ccccaagtat catgggtaag gctaaaagta tgagatagga
     3301 tgaccacaag agaggccatt ctatgccttc aaaggagaca gaagccaagg tactggctga
     3361 caatggaaat aaccattctg tcttgcctca gagtctcagt ttccccacct gaagagaggg
     3421 ctgtgctatc ataagtaata gcattcactc tggtgattta tgggaaggac agtagttcca
     3481 gctggggaat ttctgggttc ttctggatgg ccaagttcaa ggtggcgtgg agggttatgg
     3541 atggagcctc attgtcttct atgggcccca tggagccagc ctcaggttca accagcaaaa
     3601 cccactaggg ctgaaaacct cctccatagc accttcccag ctagcaaccc atataccgcg
     3661 ctgaggcatg tctccatgaa ctccccttac acacagaaca accagccctg tttatttaca
     3721 gacttttctg gagaagctag cagggcattg ctaaggcagg aagcccgacc ccagtggcca
     3781 gtcccttaca ataggcctct aagggtcggg tctctttttt tgtgcagaaa aaaaaatttt
     3841 tgaaaacaaa acagaacaca aaccccttct caataaacaa catgtaaaca ga
//
