LOCUS       NM_030827              15437 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus LDL receptor related protein 2 (Lrp2), mRNA.
ACCESSION   NM_030827 XM_346656
VERSION     NM_030827.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 15437)
  AUTHORS   Takano-Kawabe,K., Matoba,K., Nakamura,Y. and Moriyama,M.
  TITLE     Low Density Lipoprotein Receptor-related Protein 2 Expression and
            Function in Cultured Astrocytes and Microglia
  JOURNAL   Neurochem Res 49 (1), 199-211 (2024)
   PUBMED   37702891
  REMARK    GeneRIF: Low Density Lipoprotein Receptor-related Protein 2
            Expression and Function in Cultured Astrocytes and Microglia.
REFERENCE   2  (bases 1 to 15437)
  AUTHORS   Kulkarni,K., Patel,S., Ali,R. and Hussain,T.
  TITLE     Angiotensin II type 2 receptor activation preserves megalin in the
            kidney and prevents proteinuria in high salt diet fed rats
  JOURNAL   Sci Rep 13 (1), 4277 (2023)
   PUBMED   36922642
  REMARK    GeneRIF: Angiotensin II type 2 receptor activation preserves
            megalin in the kidney and prevents proteinuria in high salt diet
            fed rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 15437)
  AUTHORS   Sun,Y., Goes Martini,A., Janssen,M.J., Garrelds,I.M., Masereeuw,R.,
            Lu,X. and Danser,A.H.J.
  TITLE     Megalin: A Novel Endocytic Receptor for Prorenin and Renin
  JOURNAL   Hypertension 75 (5), 1242-1250 (2020)
   PUBMED   32200675
  REMARK    GeneRIF: Megalin: A Novel Endocytic Receptor for Prorenin and
            Renin.
REFERENCE   4  (bases 1 to 15437)
  AUTHORS   Minocha,E., Chaturvedi,C.P. and Nityanand,S.
  TITLE     Renogenic characterization and in vitro differentiation of rat
            amniotic fluid stem cells into renal proximal tubular- and
            juxtaglomerular-like cells
  JOURNAL   In Vitro Cell Dev Biol Anim 55 (2), 138-147 (2019)
   PUBMED   30645697
REFERENCE   5  (bases 1 to 15437)
  AUTHORS   Bryniarski,M.A., Yee,B.M., Jaffri,I., Chaves,L.D., Yu,J.A.,
            Guan,X., Ghavam,N., Yacoub,R. and Morris,M.E.
  TITLE     Increased megalin expression in early type 2 diabetes: role of
            insulin-signaling pathways
  JOURNAL   Am J Physiol Renal Physiol 315 (5), F1191-F1207 (2018)
   PUBMED   29949391
  REMARK    GeneRIF: Renal megalin expression was found to be upregulated in
            early type 2 diabetic rats in a process that may involve high
            glucose and insulin in a PI3K/Akt-dependent manner.
REFERENCE   6  (bases 1 to 15437)
  AUTHORS   Stefansson,S., Lawrence,D.A. and Argraves,W.S.
  TITLE     Plasminogen activator inhibitor-1 and vitronectin promote the
            cellular clearance of thrombin by low density lipoprotein
            receptor-related proteins 1 and 2
  JOURNAL   J Biol Chem 271 (14), 8215-8220 (1996)
   PUBMED   8626514
REFERENCE   7  (bases 1 to 15437)
  AUTHORS   Moestrup,S.K., Cui,S., Vorum,H., Bregengard,C., Bjorn,S.E.,
            Norris,K., Gliemann,J. and Christensen,E.I.
  TITLE     Evidence that epithelial glycoprotein 330/megalin mediates uptake
            of polybasic drugs
  JOURNAL   J Clin Invest 96 (3), 1404-1413 (1995)
   PUBMED   7544804
REFERENCE   8  (bases 1 to 15437)
  AUTHORS   Saito,A., Pietromonaco,S., Loo,A.K. and Farquhar,M.G.
  TITLE     Complete cloning and sequencing of rat gp330/'megalin,' a
            distinctive member of the low density lipoprotein receptor gene
            family
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9725-9729 (1994)
   PUBMED   7937880
REFERENCE   9  (bases 1 to 15437)
  AUTHORS   Zheng,G., Bachinsky,D.R., Stamenkovic,I., Strickland,D.K.,
            Brown,D., Andres,G. and McCluskey,R.T.
  TITLE     Organ distribution in rats of two members of the low-density
            lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the
            receptor-associated protein (RAP)
  JOURNAL   J Histochem Cytochem 42 (4), 531-542 (1994)
   PUBMED   7510321
REFERENCE   10 (bases 1 to 15437)
  AUTHORS   Kerjaschki,D. and Farquhar,M.G.
  TITLE     The pathogenic antigen of Heymann nephritis is a membrane
            glycoprotein of the renal proximal tubule brush border
  JOURNAL   Proc Natl Acad Sci U S A 79 (18), 5557-5561 (1982)
   PUBMED   6752952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_030827.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L34049.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               JAXUCZ010000003.1  74754335-74754535   c
            202-309             JAXUCZ010000003.1  74722245-74722352   c
            310-432             JAXUCZ010000003.1  74720461-74720583   c
            433-549             JAXUCZ010000003.1  74718635-74718751   c
            550-660             JAXUCZ010000003.1  74707312-74707422   c
            661-774             JAXUCZ010000003.1  74706862-74706975   c
            775-891             JAXUCZ010000003.1  74704921-74705037   c
            892-1041            JAXUCZ010000003.1  74703950-74704099   c
            1042-1161           JAXUCZ010000003.1  74702605-74702724   c
            1162-1290           JAXUCZ010000003.1  74696876-74697004   c
            1291-1460           JAXUCZ010000003.1  74694358-74694527   c
            1461-1684           JAXUCZ010000003.1  74693017-74693240   c
            1685-1891           JAXUCZ010000003.1  74692243-74692449   c
            1892-2094           JAXUCZ010000003.1  74691203-74691405   c
            2095-2235           JAXUCZ010000003.1  74689428-74689568   c
            2236-2439           JAXUCZ010000003.1  74687875-74688078   c
            2440-2632           JAXUCZ010000003.1  74686072-74686264   c
            2633-2758           JAXUCZ010000003.1  74683147-74683272   c
            2759-2889           JAXUCZ010000003.1  74682243-74682373   c
            2890-3027           JAXUCZ010000003.1  74679422-74679559   c
            3028-3309           JAXUCZ010000003.1  74678839-74679120   c
            3310-3555           JAXUCZ010000003.1  74677539-74677784   c
            3556-3675           JAXUCZ010000003.1  74676352-74676471   c
            3676-3792           JAXUCZ010000003.1  74676150-74676266   c
            3793-4170           JAXUCZ010000003.1  74674721-74675098   c
            4171-4419           JAXUCZ010000003.1  74673430-74673678   c
            4420-4631           JAXUCZ010000003.1  74672128-74672339   c
            4632-4816           JAXUCZ010000003.1  74671037-74671221   c
            4817-5045           JAXUCZ010000003.1  74670217-74670445   c
            5046-5223           JAXUCZ010000003.1  74669317-74669494   c
            5224-5352           JAXUCZ010000003.1  74667892-74668020   c
            5353-5519           JAXUCZ010000003.1  74665334-74665500   c
            5520-5663           JAXUCZ010000003.1  74664714-74664857   c
            5664-5773           JAXUCZ010000003.1  74661989-74662098   c
            5774-5951           JAXUCZ010000003.1  74661340-74661517   c
            5952-6165           JAXUCZ010000003.1  74658622-74658835   c
            6166-6405           JAXUCZ010000003.1  74657331-74657570   c
            6406-6594           JAXUCZ010000003.1  74655664-74655852   c
            6595-7515           JAXUCZ010000003.1  74652950-74653870   c
            7516-7681           JAXUCZ010000003.1  74652658-74652823   c
            7682-7840           JAXUCZ010000003.1  74652194-74652352   c
            7841-8130           JAXUCZ010000003.1  74651053-74651342   c
            8131-8334           JAXUCZ010000003.1  74649935-74650138   c
            8335-8577           JAXUCZ010000003.1  74649030-74649272   c
            8578-8703           JAXUCZ010000003.1  74648528-74648653   c
            8704-8826           JAXUCZ010000003.1  74646944-74647066   c
            8827-8958           JAXUCZ010000003.1  74645302-74645433   c
            8959-9160           JAXUCZ010000003.1  74643050-74643251   c
            9161-9456           JAXUCZ010000003.1  74639834-74640129   c
            9457-9973           JAXUCZ010000003.1  74638957-74639473   c
            9974-10126          JAXUCZ010000003.1  74638371-74638523   c
            10127-10297         JAXUCZ010000003.1  74637775-74637945   c
            10298-10521         JAXUCZ010000003.1  74636728-74636951   c
            10522-10699         JAXUCZ010000003.1  74633728-74633905   c
            10700-10896         JAXUCZ010000003.1  74632488-74632684   c
            10897-11142         JAXUCZ010000003.1  74631602-74631847   c
            11143-11271         JAXUCZ010000003.1  74630566-74630694   c
            11272-11391         JAXUCZ010000003.1  74629549-74629668   c
            11392-11508         JAXUCZ010000003.1  74627684-74627800   c
            11509-11625         JAXUCZ010000003.1  74626939-74627055   c
            11626-11763         JAXUCZ010000003.1  74625465-74625602   c
            11764-11886         JAXUCZ010000003.1  74622815-74622937   c
            11887-12015         JAXUCZ010000003.1  74619673-74619801   c
            12016-12147         JAXUCZ010000003.1  74615346-74615477   c
            12148-12279         JAXUCZ010000003.1  74614394-74614525   c
            12280-12423         JAXUCZ010000003.1  74613049-74613192   c
            12424-12589         JAXUCZ010000003.1  74611639-74611804   c
            12590-12718         JAXUCZ010000003.1  74610240-74610368   c
            12719-12939         JAXUCZ010000003.1  74609322-74609542   c
            12940-13116         JAXUCZ010000003.1  74608483-74608659   c
            13117-13236         JAXUCZ010000003.1  74606420-74606539   c
            13237-13327         JAXUCZ010000003.1  74604489-74604579   c
            13328-13395         JAXUCZ010000003.1  74603700-74603767   c
            13396-13513         JAXUCZ010000003.1  74603428-74603545   c
            13514-13643         JAXUCZ010000003.1  74602840-74602969   c
            13644-13745         JAXUCZ010000003.1  74602056-74602157   c
            13746-13874         JAXUCZ010000003.1  74601247-74601375   c
            13875-13946         JAXUCZ010000003.1  74598799-74598870   c
            13947-15437         JAXUCZ010000003.1  74597148-74598638   c
FEATURES             Location/Qualifiers
     source          1..15437
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..15437
                     /gene="Lrp2"
                     /note="LDL receptor related protein 2"
                     /db_xref="GeneID:29216"
                     /db_xref="RGD:68407"
     exon            1..201
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..14105
                     /gene="Lrp2"
                     /note="low-density lipoprotein receptor-related protein 2;
                     megalin; gp330; LRP-2; glycoprotein 330; low density
                     lipoprotein-related protein 2"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     2 precursor"
                     /protein_id="NP_110454.2"
                     /db_xref="GeneID:29216"
                     /db_xref="RGD:68407"
                     /translation="MERGAAAAAWMLLLAIAACLEPVSSQECGSGNFRCDNGYCIPAS
                     WRCDGTRDCLDDTDEIGCPPRSCESGLFLCPAEGTCIPSSWVCDEDKDCSDGADEQQN
                     CAGTTCSAQQMTCSNGQCIPSEYRCDHVSDCPDGSDERNCHYPTCDQLTCANGACYNT
                     SQRCDQKVDCRDSSDEANCTTLCSQKEFECGSGECILRAYVCDHDNDCEDNSDERNCN
                     YDTCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGCESNQSHHRCYPREWACPGSG
                     RCISIDKVCDGVPDCPEGDDENNVTSGRTCGMGVCSVLNCEYQCHQTPFGGECFCPPG
                     HIINSNDSRTCIDFDDCQIWGICDQKCENRQGRHQCLCEEGYILERGQHCKSSDSFSA
                     ASVIFSNGRDLLVGDLHGRNFRILAESKNRGMVMGVDFHYQKHRVFWTDPMQEKVFST
                     DINGLNTQEILNVSVDTPENLAVDWINNKLYLVETKVNRIDVVNLEGNQRVTLITENL
                     GHPRGIALDPTVGYLFFSDWGSLSGQPKVERAFMDGSNRKDLVTTKVGWPAGITLDLV
                     SKRVYWVDSRYDYIETVTYDGIQRKTVARGGSLVPHPFGISLFEEHVFFTDWTKMAVM
                     KASKFTETNPQVYHQSSLRPHGVTVYHALRQPNATNPCGSNNGGCAQVCVLSHRTDNG
                     GLGYRCKCEFGFELDDDEHRCVAVKNFLLFSSKTAVRGIPFTLSTQEDVMVPVTGSPS
                     FFVGIDFDAQHSTVFYSDLSKDIIYKQKIDGTGKEVITANRLESVECLTFDWISRNLY
                     WTDGGLKSVTVLRLADKSRRQIISNLNNPRSIVVHPTAGYMFLSDWFRPAKIMRAWSD
                     GSHLMPIVNTSLGWPNGLAIDWSASRLYWVDAFFDKIEHSTLDGLDRKRLGHVDQMTH
                     PFGLTVFKDNVFITDWRLGAIIRVRKSDGGDMTVIRRGISSVMHVKAYDADLQTGSNY
                     CSQTTHANGDCSHFCFPVPNFQRVCGCPYGMKLQRDQMTCEGDPAREPPTQQCGSLSF
                     PCNNGKCVPSFFRCDGVDDCHDNSDEHQCGVFNNTCSPSAFACVRGGQCIPGQWHCDR
                     QNDCLDGSDEQNCPTHATSSTCPSTSFTCDNHVCIPKDWVCDTDNDCSDGSDEKNCQA
                     SGTCQPTQFRCPDHRCISPLYVCDGDKDCADGSDEAGCVLNCTSAQFKCADGSSCINS
                     RYRCDGVYDCRDNSDEAGCPTRPPGMCHLDEFQCQGDGTCIPNTWECDGHPDCIHGSD
                     EHTGCVPKTCSPTHFLCDNGNCIYKAWICDGDNDCRDMSDEKDCPTQPFHCPSTQWQC
                     PGYSTCINLSALCDGVFDCPNGTDESPLCNQDSCSHFNGGCTHQCMQGPFGATCLCPL
                     GYQLANDTKTCEDINECDIPGFCSQHCVNMRGSFRCACDPEYTLESDGRTCKVTGSEN
                     PLLVVASRDKIIVDNITAHTHNLYSLVQDVSFVVALDFDSVTGRVFWSDLLQGKTWSV
                     FQNGTDKRVVHDSGLSVTEMIAVDWIGRNLYWTDYALETIEVSKIDGSHRTVLISKNV
                     TKPRGLALDPRMGDNVMFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSIDYPN
                     RLIYFMDAYLDYIEFCDYDGHNRRQVIASDLVLHHPHALTLFEDFVYWTDRGTRQVMQ
                     ANKWHGGNQSVVMYSVHQPLGITAIHPSRQPPSRNPCASASCSHLCLLSAQAPRHYSC
                     ACPSGWNLSDDSVNCVRGDQPFLMSVRDNIIFGISLDPEVKSNDAMVPISGIQHGYDV
                     EFDDSEQFIYWVENPGEIHRVKTDGSNRTVFAPLSLLGSSLGLALDWVSRNIYYTTPA
                     SRSIEVLTLKGDTRYGKTLIANDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAK
                     IASANMDGTSLKILFTGNLQHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERMILV
                     HHLAHPWGLVVYGSFLYYSDEQYEVIERVDKSSGNNKVVLRDNVPYLRGLRVYHRRNA
                     ADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGRSCSPYNSFMVVSMLPAV
                     RGFSLELSDHSEAMVPVAGQGRNVLHADVDVANGFIYWCDFSSSVRSSNGIRRIKPDG
                     SNFTNVVTYGIGANGIRGVALDWAAGNLYFTNAFVYETLIEVLRINTTYRRVLLKVSV
                     DMPRHIIVDPKHRYLFWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAMDHDTGY
                     IYWVDDSLDLIARIHLDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLKKVFQASK
                     QPGNTDPPVVIRDKINLLRDVTIFDEHAQPLSPAELNNNPCLQSNGGCSHFCFALPEL
                     PTPRCGCAFGTLGNDGKSCATSQEDFLIYSLNNSLRSLHFDPRDHSLPFQVISVAGTA
                     IALDYDRRNNRIFFTQKLNSLRGQISYVSLYSGSSSPTVLLSNIGVTDGIAFDWINRR
                     IYYSDFSNQTINSMAEDGSNRAVIARVSKPRAIVLDPCRGYMYWTDWGTNAKIERATL
                     GGNFRVPIVNTSLVWPNGLALDLETDLLYWADASLQKIERSTLTGTNREVVVSTAFHS
                     FGLTVYGQYIYWTDLYTRKIYRANKYDGSDLVAMTTRLPTQPSGISTVVKTQRQQCSN
                     PCDQFNGGCSHICAPGPNGAECQCPHEGNWYLANDNKYCVVDTGTRCNQLQFTCLNGH
                     CINQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCGNGRCVPYHYRCDYYNDCGDN
                     SDEAGCLFRNCNSTTEFTCSNGRCIPLSYVCNGINNCHDNDTSDEKNCPPHTCPPDFT
                     KCQTTNICVPRAFLCDGDNDCGDGSDENPIYCASHTCRSNEFQCLSPQRCIPSYWFCD
                     GEADCADGSDEPDTCGHSVNTCRASQFQCDNGRCISGNWVCDGDNDCGDMSDEDQRHH
                     CELQNCSSTQFTCVNSRPPNRRCIPQYWVCDGDADCSDALDELQNCTMRTCSAGEFSC
                     ANGRCVRQSFRCDRRNDCGDYSDERGCSYPPCHANQFTCQNGRCIPRFFVCDEDNDCG
                     DGSDEQEHLCHTPEPTCPLHQFRCDNGHCIEMGRVCNHVDDCSDNSDEKGCGINECLD
                     SSISRCDHNCTDTITSFYCSCLPGYKLMSDKRSCVDIDECKESPQLCSQKCENVVGSY
                     ICKCAPGYIREPDGKSCRQNSNIEPYLIFSNRYYIRNLTTDGSSYSLILQGLGNVVAL
                     DFDRVEKRLYWIDAEKQIIERMFLNKTNRETIINHRLRRAESLAVDWVSRKLYWLDAI
                     LDCLFVSDLEGRHRKMIAQHCVDANNTFCFEHPRGIVLHPQRGHVYWADWGVHAYIGR
                     IGMDGTNKSVIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRHTVYDGS
                     LPHPFALTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHKPFDIHVYHPYRQPI
                     MSNPCGTNNGGCSHLCLIKAGGRGFTCACPDDFQTVQLRDRTLCMPMCSSTQFLCGNN
                     EKCIPIWWKCDGQKDCSDGSDEPDLCPHRFCRLGQFQCRDGNCTSPQALCNARQDCAD
                     GSDEDRVLCEHHRCESNEWQCANKRCIPQSWQCDSVNDCLDNSDEDTSHCASRTCRPG
                     QFKCNNGRCIPQSWKCDVDNDCGDYSDEPIDECTTAAYNCDNHTEFSCKTNYRCIPQW
                     AVCNGFDDCRDNSDEQGCESVPCHPSGDFRCANHHCIPLRWKCDGTDDCGDNSDEENC
                     VPRECSESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQCTSGHCVP
                     KALACDGRADCLDASDESACPTRFPNGTYCPAAMFECKNHVCIQSFWICDGENDCVDG
                     SDEEIHLCFNIPCESPQRFRCDNSRCVYGHQLCNGVDDCGDGSDEKEEHCRKPTHKPC
                     TDTEYKCSNGNCISQHYVCDNVNDCGDLSDETGCNLGDNRTCAENICEQNCTQLSSGG
                     FICSCRPGFKPSTLDKNSCQDINECEEFGICPQSCRNSKGSYECFCVDGFKSMSTHYG
                     ERCAADGSPPLLLLPENVRIRKYNTSSEKFSEYLEEEEHIQTIDYDWDPEHIGLSVVY
                     YTVLAQGSQFGAIKRAYIPNFESGSNNPIREVDLGLKYLMQPDGLAVDWVGRHIYWSD
                     AKSQRIEVATLDGRYRKWLITTQLDQPAAIAVNPKLGLMFWTDQGKQPKIESAWMNGE
                     HRSVLVSENLGWPNGLSIDYLNDDRVYWSDSKEDVIEAIKYDGTDRRLIINEAMKPFS
                     LDIFEDKLYWVAKEKGEVWRQNKFGKENKEKVLVVNPWLTQVRIFHQLRYNQSVSNPC
                     KQVCSHLCLLRPGGYSCACPQGSDFVTGSTVQCDAASELPVTMPPPCRCMHGGNCYFD
                     ENELPKCKCSSGYSGEYCEVGLSRGIPPGTTMAVLLTFVIVIIVGALVLVGLFHYRKT
                     GSLLPTLPKLPSLSSLAKPSENGNGVTFRSGADVNMDIGVSPFGPETIIDRSMAMNEH
                     FVMEVGKQPVIFENPMYAAKDNTSKVALAVQGPSTGAQVTVPENVENQNYGRPIDPSE
                     IVPEPKPASPGADEIQGKKWNIFKRKPKQTTNFENPIYAEMDSEVKDAVAVAPPPSPS
                     LPAKASKRNLTPGYTATEDTFKDTANLVKEDSDV"
     exon            202..309
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            310..432
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            433..549
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..660
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            661..774
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            775..891
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1041
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1161
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1290
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1460
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1684
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1891
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2094
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2235
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2439
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2632
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2758
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2889
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3027
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3309
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3555
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3675
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3676..3792
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..4170
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4171..4419
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4420..4631
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4632..4816
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4817..5045
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            5046..5223
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            5224..5352
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            5353..5519
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            5520..5663
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            5664..5773
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            5774..5951
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            5952..6165
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            6166..6405
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            6406..6594
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            6595..7515
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            7516..7681
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            7682..7840
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            7841..8130
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            8131..8334
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            8335..8577
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            8578..8703
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            8704..8826
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            8827..8958
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            8959..9160
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            9161..9456
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            9457..9973
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            9974..10126
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            10127..10297
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            10298..10521
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            10522..10699
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            10700..10896
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            10897..11142
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            11143..11271
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            11272..11391
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            11392..11508
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            11509..11625
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            11626..11763
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            11764..11886
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            11887..12015
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            12016..12147
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            12148..12279
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            12280..12423
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            12424..12589
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            12590..12718
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            12719..12939
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            12940..13116
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            13117..13236
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            13237..13327
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            13328..13395
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            13396..13513
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            13514..13643
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            13644..13745
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            13746..13874
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            13875..13946
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            13947..15437
                     /gene="Lrp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagccagc gggtagtgct gaacaagact cctgttccgg agcggagtaa cctgcctgtg
       61 cccgctgcga cgcgcgccca cctcccgggg aaggaacggc gaggcccggg gccgtctccg
      121 cgatggagcg cggggccgca gcggcggcgt ggatgctgtt gctggcgatc gctgcctgcc
      181 tggagccagt cagtagccaa gaatgcggca gtgggaattt tcgctgtgac aatggatact
      241 gtatccctgc gtcctggagg tgtgatggga ccagagactg tttggatgac acagatgaaa
      301 ttggctgtcc tcccaggtcc tgcgaatcag gccttttcct gtgtcctgct gaggggacct
      361 gcatccctag ctcctgggtg tgtgacgagg ataaggattg ttcggacggt gcagacgaac
      421 agcaaaattg tgctgggacc acgtgctcgg ctcagcagat gacgtgctcc aacggtcagt
      481 gtattccgag cgaatacagg tgcgaccatg tcagcgactg ccccgacggc tctgacgaga
      541 gaaactgcca ttatccaaca tgtgatcaac ttacttgtgc caatggagcc tgctataaca
      601 cgagtcagag gtgtgaccaa aaagttgact gcagggattc ctcggacgaa gctaactgca
      661 ctaccctgtg ttcgcaaaaa gaatttgaat gtggcagtgg agagtgtatc cttcgcgcct
      721 acgtctgtga ccatgacaat gactgcgaag ataacagcga tgagcgcaat tgcaactatg
      781 acacctgcgg aggtcaccag ttcacttgct ccaatggcca gtgcatcaac cagaactggg
      841 tttgtgatgg agatgacgac tgccaagatt ctggtgatga agatggatgt gaaagtaacc
      901 agagtcatca taggtgttac ccaagagaat gggcgtgtcc tgggtctgga cgatgcatct
      961 caattgataa agtttgcgat ggagttcctg actgtccaga aggagacgat gagaacaacg
     1021 tcacaagcgg aagaacctgt ggtatgggtg tctgctctgt cttaaactgt gagtaccagt
     1081 gccatcagac gccatttgga ggagaatgct tctgcccccc aggtcatatt atcaacagca
     1141 atgacagccg tacttgcatt gatttcgacg actgccagat atggggaatt tgtgaccaga
     1201 agtgtgaaaa ccgacagggc cgtcatcagt gcctctgtga agaagggtat atcctggagc
     1261 gagggcagca ttgcaaatcc agtgactcct tcagtgcagc ctctgttatc ttctccaatg
     1321 gtcgggattt gctagttgga gatcttcatg gaagaaactt ccggattcta gcagagtcta
     1381 agaaccgagg aatggttatg ggagtggatt ttcactatca gaaacacaga gttttttgga
     1441 cagaccccat gcaggaaaag gtgttttcca ctgacatcaa tggcttaaat acccaagaaa
     1501 ttcttaatgt ttctgttgac actccagaga atctggctgt ggattggatt aataataaac
     1561 tttatctggt agagacaaag gtcaaccgca ttgacgtggt caacttggag ggaaatcagc
     1621 gtgttactct cataactgaa aacttagggc atcctagagg aattgccctt gatccaactg
     1681 tgggctattt gtttttctca gattggggaa gcctctctgg gcaacccaag gtggagagag
     1741 ccttcatgga tggtagcaat cggaaagacc tggtaacaac caaagtgggg tggcctgctg
     1801 ggatcactct ggatctggtg tccaagcgag tttactgggt ggattctcgt tatgactaca
     1861 ttgaaactgt aacatatgac ggaattcaaa ggaagacggt agctcgtgga ggctcccttg
     1921 ttccgcatcc ctttggaata agcttatttg aggaacacgt gttctttact gattggacaa
     1981 agatggctgt gatgaaagcc agcaagttca cagaaaccaa ccctcaagtg taccaccagt
     2041 cttccctgag gcctcacgga gtgacggttt accatgccct caggcaaccc aatgccacca
     2101 atccgtgcgg gagcaacaat gggggctgtg cgcaggtctg tgtcctcagt cacaggacgg
     2161 ataatggtgg cctgggctac cggtgcaagt gtgaattcgg ctttgaactg gatgatgatg
     2221 agcaccgctg tgttgccgtt aagaacttcc tgctcttctc atcgaaaacg gctgtgcgtg
     2281 gaatcccatt caccctctcc acccaggaag atgtcatggt tcctgtcaca gggagtccat
     2341 ccttcttcgt tggaattgat tttgatgccc aacacagtac tgtcttctat tcagatttgt
     2401 caaaagacat aatttataaa caaaaaattg atggcacagg aaaagaggtt atcacagcaa
     2461 accggttgga aagtgttgag tgtttgactt ttgactggat ctcaaggaat ctttactgga
     2521 cagatggagg actaaagagt gtcactgtcc tgaggctggc tgataagtcc cgacgacaga
     2581 taatcagcaa cttaaacaac cctcgttcca ttgtggtgca tccgaccgct gggtatatgt
     2641 tcctgagtga ttggttccgt cctgcaaaaa ttatgagagc atggagcgat ggttctcacc
     2701 taatgcccat agtcaatact agtctggggt ggcccaatgg cttggccatc gattggagtg
     2761 cttcacgatt gtactgggta gatgcctttt ttgataagat tgaacacagc acccttgatg
     2821 gtttagatag aaaaaggctg ggccatgtag accagatgac tcatccattt ggactcaccg
     2881 tttttaaaga taatgtgttc ataacagact ggagactggg tgctattatt cgagtgagga
     2941 aatcagatgg tggtgatatg acagttattc gaagaggcat cagcagcgta atgcacgtga
     3001 aagcctacga tgctgacctc cagactgggt ctaactactg cagtcagacc acccacgcca
     3061 acggtgactg cagccacttc tgcttcccgg tcccgaactt ccagcgggtg tgtggctgtc
     3121 cctatggaat gaaacttcag agggatcaaa tgacttgtga gggagaccca gcccgagagc
     3181 cacccacaca gcagtgtggc tccctctcct ttccctgcaa caatggcaag tgtgtgccca
     3241 gtttcttccg ctgtgatgga gtggacgatt gccatgacaa cagtgatgag catcagtgcg
     3301 gggtgtttaa taatacttgc tcaccttcgg ctttcgcctg cgtccgcggt ggacagtgca
     3361 tccctggcca gtggcactgt gacagacaga atgactgttt agatggcagt gatgagcaaa
     3421 actgccccac acatgccacg tcgtccactt gcccgtccac ctccttcacc tgcgacaatc
     3481 acgtgtgcat cccaaaagac tgggtctgtg acacagacaa tgattgctcg gatggctcgg
     3541 atgaaaagaa ctgccaagct tcagggacct gccagcctac acagtttcgg tgccctgacc
     3601 accgatgcat cagcccgctg tatgtctgtg atggggacaa ggactgcgcg gatgggtctg
     3661 atgaggcggg ctgtgtgtta aactgtacga gtgcccagtt caaatgtgcc gatgggagtt
     3721 cttgcattaa cagcaggtac cgctgcgatg gggtttacga ctgcagggac aactctgacg
     3781 aggcaggctg ccccaccagg cctcccggca tgtgccacct ggatgagttc cagtgccaag
     3841 gagacggtac atgcatccct aacacctggg agtgtgacgg gcatccagac tgtatccacg
     3901 ggtccgacga gcacactggc tgtgttccta agacctgctc gccgactcat ttcctctgtg
     3961 acaatggaaa ctgcatctac aaagcgtgga tctgtgatgg ggacaatgat tgtagggata
     4021 tgagtgatga gaaggactgt cctacccagc cttttcactg tcctagcacg cagtggcagt
     4081 gcccgggcta cagcacctgt atcaatctga gtgccctgtg tgacggcgtc tttgactgtc
     4141 cgaatgggac tgacgagtcc ccactttgca atcaagacag ctgctcccat tttaatggtg
     4201 gctgtactca tcagtgcatg caagggccct tcggagccac atgcctatgc ccattaggat
     4261 accaacttgc caatgatacc aagacctgtg aagatatcaa tgagtgcgat attccaggct
     4321 tctgcagcca gcactgcgtc aacatgagag gttccttccg gtgcgcttgt gatccagaat
     4381 atacgctgga aagtgatggg cggacttgca aagtcacagg atctgaaaat ccgttgttag
     4441 ttgtagcaag tcgtgacaaa atcattgtgg acaacatcac tgcccacacg cacaatctct
     4501 actcgttggt ccaggatgtt tcttttgtgg ttgctcttga ttttgattca gtcactggtc
     4561 gtgtcttctg gagtgactta ctgcagggta aaacctggag tgtctttcaa aacggaacag
     4621 acaagagagt ggtccatgac agtggcctct ctgtgacaga aatgattgca gtagattgga
     4681 ttggtcgcaa cctttactgg acggactatg ctcttgaaac aatcgaagtt tctaaaattg
     4741 atggaagtca cagaacagta ctgatcagca aaaatgtcac aaaaccgagg ggactcgcgt
     4801 tagatcccag aatgggtgat aatgtaatgt tttggtctga ctggggccat caccctcgca
     4861 ttgagcgagc cagcatggat ggcaccatgc gcacagtcat tgtccaggaa aagatctact
     4921 ggccctgtgg cttaagcatc gactacccca accgcctcat ctacttcatg gatgcctatc
     4981 ttgactacat tgaattctgt gattacgacg gacataaccg aaggcaggtc attgctagcg
     5041 atttggttct ccaccatccg cacgccctca ctctgttcga agactttgtg tactggactg
     5101 accgtggtac tcggcaggtt atgcaggcca acaagtggca tggggggaac cagtcagttg
     5161 taatgtacag cgttcaccaa ccgcttggaa taactgccat tcatccttca aggcaaccac
     5221 cttcccggaa tccatgtgcc tctgcctctt gcagccatct ttgcctgctt tctgcacagg
     5281 cgcctagaca ttattcttgt gcttgccctt caggatggaa cctctccgat gattctgtca
     5341 actgtgtgag aggtgaccaa cctttcttga tgtccgtaag agacaatata atttttggaa
     5401 tctcccttga tcctgaggtg aagagcaatg atgccatggt ccccatatca gggatacagc
     5461 atggttatga tgttgaattt gatgactctg agcaattcat ctactgggtt gagaatccgg
     5521 gtgaaattca cagagtgaag actgatggca gcaacaggac agtgtttgct cctctgtccc
     5581 tgctggggtc ttctttaggc ctggccttgg actgggtatc aaggaacatt tattatacca
     5641 ctcctgcaag tcggtccatt gaggtgttga cgctcaaggg agatacgagg tatggaaaaa
     5701 ccctgattgc caatgacggc acccccctcg gagttggttt ccccgttggc atagctgttg
     5761 atcctgcacg tgggaaacta tattggtcag accacgggac ggacagtggg gttcctgcca
     5821 agatcgcaag tgctaatatg gatggaacat ctttaaaaat tctcttcact gggaacctgc
     5881 agcatctgga ggttgtcacc ctggacattc aggagcagaa gctgtactgg gcagtcacca
     5941 gcagaggcgt gattgagaga ggaaatgtgg acggtacaga gaggatgatc ctggtgcacc
     6001 atctggccca cccatggggc cttgtggtct atggctcctt cctttactac tctgatgaac
     6061 agtatgaggt cattgagaga gttgacaagt cctctgggaa taacaaagtc gtcctcagag
     6121 ataacgttcc gtacctgagg ggtcttcggg tttaccaccg ccgcaatgcc gctgactctt
     6181 ccaatggctg tagcaacaac cccaacgctt gccagcagat ctgcctgccc gtgccaggtg
     6241 gaatgttctc ctgcgcctgt gccagtggct ttaagctcag ccctgacggt cgctcctgtt
     6301 ctccatataa ctcgttcatg gtcgtttcca tgctgcccgc agttagaggc tttagcttgg
     6361 agttgtctga tcactcggag gccatggtgc ccgtagctgg ccaaggacga aatgttctgc
     6421 atgcggacgt ggatgttgcc aacggcttta tttactggtg tgattttagc agctctgtaa
     6481 gatcctctaa tggaattcgt agaatcaaac ccgacgggtc taattttacc aacgtcgtta
     6541 cctatggcat tggggcaaat ggaatccggg gtgttgcact ggactgggca gcaggaaatc
     6601 tttattttac caatgccttt gtgtacgaaa ccctgataga agtgttacgg atcaatacca
     6661 cgtaccgccg tgtactcctc aaagtctcag tggatatgcc ccggcatatt attgttgacc
     6721 ccaagcatag atatctcttc tgggccgact atgggcagaa gccaaagatc gaacgctctt
     6781 ttcttgactg taccaatcga actgtccttg tttccgaagg cattgtcacc cctcggggct
     6841 tggccatgga ccatgacact ggctatattt attgggttga tgactcctta gatttaattg
     6901 ccaggatcca tcttgatgga ggagaatctc aggtggttcg ctatggcagc cgttacccaa
     6961 ctccctatgg catcactgtg tttggagagt ctatcatttg ggtggataga aacttgaaaa
     7021 aagtcttcca agccagcaag caaccaggga atacagatcc acccgtagtg ataagagata
     7081 agatcaacct gctccgtgac gtgaccatct ttgacgagca cgcccagccc ctctcaccag
     7141 cagagcttaa caataaccct tgtctgcaaa gcaatggtgg gtgttcccac ttttgctttg
     7201 ccttacctga gttgcctact cccagatgtg gatgtgcttt tgggactctg ggaaatgatg
     7261 gcaagagctg tgctacctcc caagaagatt tcctcatcta ttccttaaat aattccctga
     7321 gaagtttaca ctttgaccct agagaccata gcctaccttt ccaagtgata agtgtggcgg
     7381 gaactgccat tgcactggat tatgaccgta gaaacaatag aatcttcttc acacaaaagc
     7441 taaactctct ccgtggccag atttcctatg tcagcctgta ttcagggagc agctctccaa
     7501 ctgtcctgct gtcaaatata ggggtgactg atggcattgc ctttgattgg ataaatagaa
     7561 gaatttatta cagtgacttt tcaaatcaga caataaattc catggctgaa gatggatcca
     7621 atcgtgctgt gattgcccgt gtttccaaac ccagagctat tgtattagat ccttgccgag
     7681 ggtacatgta ttggactgac tggggtacca acgccaaaat cgagagagcc acactgggag
     7741 gaaacttccg ggtccccatt gtgaacacca gcttggtttg gcccaatgga ctcgctttgg
     7801 accttgagac tgaccttctg tactgggcag atgctagctt gcagaaaata gaacgcagta
     7861 ctctcacggg cacgaaccga gaagtcgttg tcagcactgc ctttcattcc tttggcttga
     7921 ctgtctatgg ccagtacatt tactggacag acttgtacac cagaaaaatc taccgtgcta
     7981 acaagtacga cgggtcagac ctggtagcaa tgaccacacg tttgcccacc cagcctagtg
     8041 gtatttccac agtggtcaaa acccagcggc agcagtgtag caatccttgt gaccagttca
     8101 acggaggatg cagccatatc tgtgctccag gtccaaatgg agctgagtgt cagtgtcctc
     8161 acgaaggcaa ctggtatctg gccaacgata acaagtactg cgttgtggac acggggaccc
     8221 gctgtaatca actccagttc acctgcctca atgggcattg tattaatcag gattggaaat
     8281 gtgacaatga caacgactgt ggtgatggca gtgacgagct tcctacagtc tgtgcctttc
     8341 acacctgccg atcaacagcc ttcacttgtg gcaacgggcg atgtgtgcca taccactatc
     8401 gctgtgatta ctacaatgac tgcggggaca acagcgacga ggcaggttgc ctgttcagaa
     8461 actgcaacag caccacagag ttcacgtgca gcaatgggcg gtgcataccg ctcagttatg
     8521 tctgcaatgg cataaacaat tgccatgaca atgacacctc ggatgagaaa aactgccctc
     8581 cccacacttg cccgccggat ttcacaaaat gccagaccac gaatatttgt gttccccgag
     8641 ctttcttgtg tgatggagac aatgactgtg gagacgggag tgacgagaac cccatttact
     8701 gcgcctcaca cacatgccgc agcaacgagt tccagtgcct ctcccctcag cggtgtattc
     8761 caagctattg gttctgtgac ggtgaagccg actgtgcaga tggctcggat gaacctgaca
     8821 cttgtgggca ttctgtgaac acctgcaggg ccagtcagtt ccagtgtgat aatggcaggt
     8881 gcatctcagg caattgggtc tgtgatggtg ataacgactg tggggacatg agtgacgagg
     8941 accagcggca tcactgtgag cttcagaact gttccagcac tcagtttacc tgtgtcaaca
     9001 gcagacctcc caacaggagg tgcatcccac agtactgggt ctgtgacggt gatgcggact
     9061 gctcggacgc cctggacgag ctgcagaatt gcaccatgag aacctgctct gcaggggagt
     9121 tcagctgtgc aaacggacga tgtgtcaggc agtcattcag gtgtgatcgg cgcaatgact
     9181 gtggagacta cagtgatgag aggggctgct cgtacccacc ctgccatgca aatcaattta
     9241 cgtgtcagaa cgggcggtgt atccctaggt tctttgtttg tgatgaggac aatgactgtg
     9301 gagatggttc tgatgagcag gagcacctgt gtcacacccc agaacccaca tgcccccttc
     9361 atcaattccg gtgtgacaac gggcactgca tcgagatggg gcgagtctgt aaccatgtgg
     9421 acgactgctc agacaacagc gatgagaaag gctgtggcat taacgagtgc ctagattctt
     9481 caatcagtcg ctgtgaccac aactgtacag ataccataac tagtttctac tgttcctgtc
     9541 tccctggcta caagctcatg tctgacaaac gctcttgcgt ggatattgac gaatgcaagg
     9601 agtcacccca gctctgtagc cagaagtgtg agaatgtggt aggctcctat atttgcaagt
     9661 gtgcccctgg ctacatccgt gagccagatg ggaagagctg ccggcagaat agtaacatcg
     9721 agccctatct catctttagc aaccgttact atataagaaa cttaactaca gatggctcat
     9781 cttactccct gattttgcaa ggattgggca atgttgtggc cctggacttt gatagagtag
     9841 aaaagaggct gtattggatt gatgcagaga agcaaatcat tgagaggatg tttttgaata
     9901 agacaaaccg ggagaccatc ataaaccaca ggttaagacg tgctgaaagt ctggctgtag
     9961 actgggtcag cagaaaactc tattggttgg atgccatctt ggactgcctg tttgtctctg
    10021 accttgaagg tcgacaccgc aaaatgatag cccagcactg tgtggatgct aacaatacct
    10081 tctgctttga acatcccagg ggaattgtcc ttcatcctca aagagggcat gtctactggg
    10141 cagattgggg tgttcacgca tacattggaa ggattggcat ggatggaacc aataagtctg
    10201 tgatcatctc taccaagata gaatggccca atgccatcac cattgactac accaacgatc
    10261 tcttgtactg ggcagatgct cacctgggtt atatcgagtt ctctgatttg gaaggtcacc
    10321 accgacacac ggtgtacgat ggatcactgc ctcacccctt tgctcttacg atttttgaag
    10381 acactgtttt ttggacagat tggaatacac ggacggttga aaagggaaac aaatatgatg
    10441 ggtcaggtcg agtggtgctg gtgaacacaa cgcacaaacc cttcgacatc cacgtgtacc
    10501 atccataccg gcagccgatt atgagcaatc cctgtggtac caacaacggt ggctgttctc
    10561 atctgtgcct catcaaagcg ggggggagag gattcacctg cgcgtgtccc gatgacttcc
    10621 agaccgttca gcttcgagac agaacactct gcatgcccat gtgctccagc acgcagttcc
    10681 tgtgtggcaa caatgaaaag tgtatcccca tatggtggaa atgtgatggc cagaaagact
    10741 gctctgatgg ttctgatgaa ccagacctgt gcccacaccg cttctgccgt ctggggcagt
    10801 tccagtgccg ggatggcaac tgcacgagcc cccaggctct gtgcaatgct cgccaggatt
    10861 gtgctgatgg ctctgatgaa gaccgtgttc tctgtgagca tcaccggtgt gagtccaacg
    10921 agtggcagtg cgccaacaag cgttgcatcc cacagtcctg gcagtgtgac tcagtgaacg
    10981 actgcctgga taactcagat gaggacactt cgcactgcgc cagcaggacc tgcaggcccg
    11041 gccagttcaa gtgtaacaat ggtcgctgta tcccgcagag ctggaagtgt gacgtagaca
    11101 atgattgtgg agactactcc gatgagccca tcgacgagtg cacgaccgct gcttacaact
    11161 gtgacaacca cacagaattc agctgcaaga ctaactaccg ttgcatcccg cagtgggcgg
    11221 tgtgcaatgg ttttgatgac tgcagggaca acagtgatga acaaggctgt gaatcggtgc
    11281 catgccatcc ttctggggat ttccggtgtg cgaatcacca ctgcatccct ctccgctgga
    11341 agtgtgacgg cactgacgac tgtggagata actcggatga ggaaaactgc gttcctcggg
    11401 agtgctcaga gagcgagttt cgatgtgctg atcagcaatg catcccctct cgatgggtct
    11461 gtgaccaaga aaatgactgt ggagacaact cggatgaacg ggactgtgag atgaagacct
    11521 gccatcctga acattttcag tgtacgagtg gacactgtgt gcccaaggcg ttggcatgcg
    11581 atgggagggc agactgtctg gatgcgtctg atgaatctgc ttgtcctact cgctttccca
    11641 acggcaccta ctgcccagcc gccatgttcg aatgtaaaaa ccacgtgtgc atccagtcgt
    11701 tttggatatg tgatggggaa aatgactgtg tcgacggttc cgatgaggag atccacctgt
    11761 gcttcaacat tccgtgtgaa tcaccacagc gattccggtg tgacaacagc cgctgtgttt
    11821 atggccatca gctgtgcaat ggtgtggatg actgcggaga tggaagtgac gagaaagaag
    11881 agcactgtag aaaaccaacc cacaaaccgt gcacagacac tgaatataag tgtagcaatg
    11941 ggaactgcat ttcgcagcac tacgtgtgtg ataatgtgaa tgactgcgga gacctttctg
    12001 atgaaactgg ttgcaatcta ggagataaca gaacgtgtgc tgaaaacata tgtgaacaga
    12061 actgtaccca gctgagcagc ggaggcttta tctgctcctg cagacccggg ttcaaaccca
    12121 gtactttgga caaaaattcc tgtcaagaca tcaatgaatg tgaggagttt ggcatctgcc
    12181 cccagagctg tcgaaacagc aaaggaagtt atgaatgttt ctgtgtcgat ggcttcaagt
    12241 ctatgagtac ccattatgga gaacggtgtg cagctgatgg aagccctcct ctcttgctcc
    12301 tgcctgagaa tgtccgaatc cggaagtaca atacctcctc tgagaagttc tcagagtatc
    12361 tggaagagga ggagcatatc caaactattg actatgactg ggatcccgag cacataggcc
    12421 tcagtgttgt ctattacact gtgctggcac agggctctca attcggtgct atcaaacgtg
    12481 cctacattcc caactttgaa tctggtagta acaatcccat acgtgaagtt gacctgggct
    12541 tgaaatattt aatgcagcca gatggattag ccgtggactg ggtcggaagg catatttact
    12601 ggtcagatgc taagagccaa cggattgagg tggctaccct cgatggaagg taccggaagt
    12661 ggctgatcac cacccaactg gatcagccag ctgccattgc tgtgaatcct aagctagggc
    12721 ttatgttctg gactgaccag ggaaaacagc ccaaaatcga gtctgcctgg atgaacgggg
    12781 aacatcgcag cgttctggtt tctgagaacc ttggctggcc aaacggtctt tccatagatt
    12841 acctgaatga tgaccgggtc tactggagcg actccaaaga agatgtcatt gaagccataa
    12901 aatatgatgg gactgacagg agacttatca taaatgaagc gatgaagccc ttcagtctgg
    12961 acatcttcga agacaagcta tactgggtag ctaaggaaaa gggagaagtg tggagacaaa
    13021 ataaattcgg gaaagagaac aaagagaaag tgctggtggt gaacccgtgg ctcactcaag
    13081 ttcgaatctt ccatcaactg agatacaatc agtcagtgtc caacccttgc aagcaggtct
    13141 gtagtcacct ctgcctgctg agaccaggag gctacagctg tgcctgtccc caaggctccg
    13201 acttcgtaac tggcagcact gtccagtgtg atgcagccag tgaacttccc gtcaccatgc
    13261 ctcccccatg caggtgcatg cacggaggaa attgctattt tgatgagaat gaactcccca
    13321 aatgcaagtg ttccagtggc tatagcggag aatactgtga ggttgggctc tcgagaggca
    13381 tccctccagg gacgacaatg gctgttctgt tgaccttcgt gatagtcatc attgttggag
    13441 ctctggtgct tgttggactc tttcactaca ggaaaactgg ctccctctta cccactctgc
    13501 ccaagctgcc aagcctaagc agccttgcca aaccctctga aaatggaaat ggggtgacgt
    13561 tcaggtcggg ggctgatgtg aacatggaca tcggtgtgtc tcctttcggc cctgagacaa
    13621 ttattgacag atccatggcg atgaatgaac actttgtcat ggaggtgggc aagcagcctg
    13681 tgatatttga aaacccaatg tatgcagcca aggacaacac ttccaaagtg gccctggcag
    13741 ttcaggggcc atcaacaggc gcacaggtga ctgtaccaga aaatgtggaa aaccagaatt
    13801 atggaaggcc catagatcct tctgagatag ttccagagcc aaagccagcc tcccctggag
    13861 ctgatgaaat tcagggcaaa aaatggaaca tcttcaaacg aaaacccaaa cagacaacga
    13921 actttgagaa cccaatctac gcagagatgg acagtgaggt aaaggatgct gtggctgtgg
    13981 ccccccctcc gtctccttct ctccctgcca aagcttcaaa aagaaatttg actccaggct
    14041 acactgccac agaagacacc tttaaagaca ctgcaaatct cgttaaagaa gattccgacg
    14101 tatagcctcg ccagctctct agggaacatt tagacactca cttttgcaca tatatttttt
    14161 acagacaaat gaaaaagaag ttaacattca atactttata aaaaaatata tttttctctg
    14221 tttgcctata attgaaggtg tgtcgtgtgt cttttttact gatgccactt catattttta
    14281 caattatcac gggcactgtg tatatcttgg actgatgttg tctggaggtg atgctgtgaa
    14341 cattactgga cttgtgtaaa ctttggaagg attatcacac ctctgcccct gctaacacga
    14401 aggtgcccgt tgagtgggtc gctgagctga agaatacacg atctggtgag gaaaggaatt
    14461 ggcctagggc tttggatctt tctagagagg agataacact tatatttcct ttgaaacaat
    14521 acaggaattc tttatgctca tttgagggcc catttttaca cattggcact taattaatag
    14581 tcaacgttca acatcacgtg tcaacctgat tagtgagtgt gcagataggg gccagtgttg
    14641 gcttcatgcg ctgtagatgg ctcagacaac acagacggta cacagggtga ctcagctgga
    14701 cccttctgcg ctcctccgcc ttctgaggcc agctatgttt tgattgtgct tcgtccctag
    14761 ttgccaagtc aacatttgca cctgccgtgt cacgtcccat actgagtttc tgtctcatgg
    14821 aacgagctct tgcttgacag accttaaatc aacttaagcc cttgcctgtc atctcaggtg
    14881 tcccctacct tcgtgactgg aattccgtag ttgactgtat gtactaaagc cagacccgtg
    14941 tctccacaga gcagggcgcc gaacagacac cagtcgatcg aagcctcagc tgggtgtctg
    15001 actctgggtg cacaatgtta ttgtactgac tatttatttc ctcagttgac gacgaataga
    15061 aagggaaaac attcttcctg agcctttctc aggcctttgc ctaaatccgt gcatttgtgt
    15121 ccgaacgtac tgtacgtccc agctcttctt ttgagtggtt ggtgtatcct ctgtcacagg
    15181 aagtatggca cgagcatgcg ttttccacag cgagtagcat tcctggttct ctgtgttcac
    15241 cttgcacatg tgttaatgaa tgaatgggag ggtgggagaa tggatgaatg aaatatacta
    15301 ctgattattt tattctcgag tcctcgaaat attttgttgc tcgtattttg agtacccatt
    15361 gtaattactt tgattagaaa ttaaaaagct actggaaacg ctgctgctgg aaatttctaa
    15421 taaatgtgta ttttatc
//
