LOCUS       XM_039106103           15693 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus LDL receptor related protein 1B
            (Lrp1b), partial mRNA.
ACCESSION   XM_039106103
VERSION     XM_039106103.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051338.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039106103.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: incomplete on the 5' end.
FEATURES             Location/Qualifiers
     source          1..15693
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            <1..15693
                     /gene="Lrp1b"
                     /note="LDL receptor related protein 1B; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 8 ESTs, 1 Protein, and 99% coverage of the annotated
                     genomic feature by RNAseq alignments, including 9 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:311926"
                     /db_xref="RGD:1306160"
     CDS             <1..14004
                     /gene="Lrp1b"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     1B"
                     /protein_id="XP_038962031.1"
                     /db_xref="GeneID:311926"
                     /db_xref="RGD:1306160"
                     /translation="RGSVPGCQPPRPGQGCRRPVCSTGSPGRSSCPSLLLAILTLSGL
                     LPNAEVLTVGADQDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDQSDESLDTCPKE
                     VEIKCPLNHIACRGSNACVHLSQLCNGVVDCPDGFDEGGHCRELLPSCQQLNCQFKCA
                     MVRNATRCYCEDGFEVTGDGRGCKDQDECSVYGTCSQTCKNTYGSYVCSCVEGYIMQS
                     DNRSCKVKNEPSDKPPMLLIASPETIELFYINGSKMTTLSSANRNEIHTLDFIYSEEM
                     ICWIESRESSNQLKCGQMTKSGRLIDQRIINSLQSFHNVEQMAIDWLTRNIYFVDHVS
                     DRIFVCNFNGSVCVTLIELELHNPKAIAADPIAGKLFFTDFGNAPRIERCDMDGMNRT
                     RIVYSKTEQPSALALDLINRLVYWVDLYLDYVGVVDYQGRNRHTLVQGRHVKHLYGIT
                     VFEDYLYATSSDNLNIVRINRFNSTDIHSIIKMESARGIRTYQKRTQPTVRSHACEVD
                     AYGMPGGCSHICLLGSSYKTRTCRCRTGFNMGSDGRSCKRPKNELFLFYGKGRPGIVR
                     GMDLNTKIADECMIPIENLVNPRALDFHAEANYIYFADTTSFLIGRQKIDGTERETIL
                     KDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRAIVV
                     DPVNGWMYWTDWKEDKIDDSVGRIEKAWMDGVNRQIFVTSKMLWPNGLTLDFHTSTLY
                     WCDAYYDHIEKIFLNGTHRKIVYSGKELNHPFGLSHHGNYVFWTDYMNGSIFQLDLVS
                     REVTLLRHERAPLFGLQIYDPRKQQGDNMCRINNGGCGTLCLAIPGGRVCACADNQLL
                     DENGTTCTFNPEEIIFHICKPGEFRCKNKHCIQARWKCDGDDDCLDGSDEDSVTCFNH
                     SCPEDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQADQFSCGNGRCIPT
                     AWVCDREDDCGDQTDEVTSCEFPTCEPLTQFLCKSGRCISNKWHCDTDDDCGDRSDEV
                     GCVHSCLDDQFRCASGRCIPGHWACDGDNDCGDFSDETHVNCTREEARSPVGCIGNEF
                     QCHPDGNCIPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCKSTGRCINNAWVC
                     DGDVDCEDQSDEEDCDSFLCGPPKYPCANDTSVCLQPEKLCNGRKDCPDGSDEGDLCD
                     ECSLNNGGCSNHCSVVPGKGIVCSCPEGHQLKKDNRTCEIVDYCSSHLKCSQVCEQHK
                     HMVKCSCYEGWALDTDGESCISVDSFEAFIIFSIRHEIRRIDLHKGDYSLLVPGLRNT
                     IALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGN
                     IYWIDSNLDQIEVSKLDGSLRATLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIES
                     ASMSGAGRKTIYKDMKTGAWPNGLTVDHFERRIVWTDARSDAIYSAFYDGTNMIEIIR
                     GHEYLSHPFAVSLYGSEVYWTDWRTNTLAKANKWTGQNVSVIQKTSAQPFDLQIYHPS
                     RQPQAPNPCAANEGRGPCSHLCLINHNRSAACACPHLMKLSSDKKTCYEMKKFLLYAR
                     RSEIRGVDIDNPYANFITAFTVPDIDDVAVIDFDASEERLYWTDIKTQTITRAFINGT
                     GLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQ
                     CLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGN
                     GTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCNKRDGRNPS
                     ILRNKTSGVVHMKVYDKEAQQGSNSCQVNNGGCSQLCLPTSETTRTCMCTVGYYLQKN
                     RMSCQGVESFLMYSVHEGIRGISLEPRDKVDALMPISGAAFAVGIDFHAENDTIYWTD
                     MGLNKISRAKRDQTWKEDIVTNGLGRVEGIAIDWIAGNIYWTDHGFNLIEVARLNGSF
                     RYVIISQGLDQPRSIAVHPEKGFLFWTEWGQVPCIGKARLDGSEKVMIVSMGITWPNG
                     ISIDYEENKLYWCDARSDKIERIDLDTGGNREVLLSGSNVDLFSVAVFGAYIYWSDRA
                     HANGSVRRGHKNDVTETVTMRTGLGVNLKEIKIFNRVREKGTNVCAKENGGCKQLCLY
                     RGNSRRTCACAHGYLAGDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPVRPYENP
                     HYFKNIIALAFDYNQRREGTNRIFYSDAHFGNIQLINDNWEGRQVIVENVGSVEGLAY
                     HRAWDTLYWTSSSTSSITRHTVDQTQPGAIDREAVITMSEDDHPHVLALDECQNLMFW
                     TNWNEQHPSIMRATLTGKNAHVVVSTDILTPNGLTIDHRAEKLYFSDGSLGKIERCEY
                     DGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGETKVLRSDIPHQP
                     MGIIAVANDTNSCELSPCALLNGGCHDLCLLTPDGRVNCSCRGDRTLLASNRCVTKNS
                     SCNIYSEFECGNGDCVDYVLTCDGIPHCKDKSDEKLLYCENRSCRSGFKPCYNRRCVP
                     HGKLCDGTNDCGDGSDELDCKVSTCSTVEFRCTDGTCIPRSARCNQNMDCSDASDEKG
                     CNNTDCTHFYKLGVKSTGFIRCNSTSLCVLPSWICDGSNDCGDYSDELKCPVQNKHKC
                     EENYFGCPSGRCILNTWVCDGQKDCEDGLDELHCDSSCSWNQFACSVHKCISKHWICD
                     GEDDCGDGLDESDNICGAVTCAADMFSCQSSHACVPQHWLCDGERDCPDGSDELSSAG
                     CAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDEFLECGYRQCGPEEFRCADGR
                     CLVNTLWQCDGDFDCPDSSDEAPINPRCTSAEHSCNSSFFMCKNGRCIPRDGLCDNRD
                     DCGDGSDEAKCHINECLSKKISGCSQDCQDLPISYKCKCWPGFQLKDDGKTCVDIDEC
                     STGFPCSQQCINTYGTYKCRCTEGYETQPDNQNGCRSLSDEEPFLILADQHEIRKIST
                     DGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV
                     PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTVLVSKRLKFPRDLSLDPRAGNLYW
                     IDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNHRLYWADENHIEFSNMDGS
                     HRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRVHKTSGADRLSLIYSWHAITDIQ
                     VYHSYRQPDVSKHLCTVNNGGCSHLCLLGPGKTHTCACPTNFYLAADNRTCLSNCTAS
                     QFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFKCQPGRFQCGTGLCALPAFICDG
                     ENDCGDNSDELNCDTHVCLAGQFKCTKNKKCIPVNLRCNGQDDCGDEEDERDCPENSC
                     SPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWR
                     CDSQNDCSDNSDEENCKPQTCTLRDFLCSNGDCVSSRFWCDGEFDCADGSDEKNCETS
                     CSKDQFQCSNGQCLSAKWKCDGHEDCKYGEDEKNCEPAFPVCSSSEYMCASGGCLSAS
                     LKCNGETDCVDGSDEMDCVTECKEDQFQCRNKAYCIPIRWLCDGIYDCVDGSDEENCG
                     RGGSICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEVPDMCVKFLCPPTRPYRCRND
                     RICLQLEKMCNGINDCGDNSDEEHCSGTLSFKSEPCKKDEFTCNNRNCIPMELQCDGL
                     DDCGDGSDEQGCMQTPTQHTCENNGNPCGDDAYCNQIRTSVFCRCKPGFQRNIKGREC
                     ADLNECLVFGICSQHCLNTRGSYKCVCDQNFQEKNNSCIAKGSEDQALYIANDTDILG
                     FVYPFNYSGSHQQISHVEHNSRITGMDVYYQRNVIVWSTQFNPGGIFYTMIDAREKRQ
                     ANSGLICPEFKRPRDIAVDWVTGNVYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGP
                     NCTRLLTNMAGEPYAIAVNPKRGMMYWTVIGDHSHIEEAAMDGTLRRILVQKHLQRPT
                     GLTVDHFGERIYWADFELSIIGSVMYDGSSPVVSVSSKQGLLHPHRIDVFEDYIYGAG
                     PKNGIFRVQKFGHGSVEVLTLDVDKTKSIVVSHRYKQLNLPNPCLGLSCDFLCLLNPS
                     GATCVCPEGKHIRNGTCHENSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGGRC
                     EVNHCSNYCQNGGTCIPSALGRPTCICALGFTGPNCGKTVCEDSCHNGGSCVVTAGNQ
                     PYCHCQADYTGDRCQYYVCHHYCVNSESCSIGNDGSVECVCPTRYEGPKCEIDKCVRC
                     HGGHCIINQDNEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLDPETSVPVCVCSVGFK
                     SQRCDQKENPCDHYCQNEGICTITAFNEPRCKCSTNWSGTQCERPAPKSSKSEHISTR
                     SIAIIVPLVLLVTLVTTLVIGLVVCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEV
                     DHDHSDGGLLEPSFMIDPVKSRYIGGGPSAFRLPHTAPPIYLNSDLKGPLTSGPTNYS
                     NPVYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA"
ORIGIN      
        1 cgcggctcgg ttccaggctg ccagccgccg cggcccggcc aagggtgccg ccgaccagtc
       61 tgcagcacag gctcaccggg aagatcatca tgtcccagtt tgctccttgc catccttact
      121 ctctcgggat tattgcctaa cgccgaggtg ctgactgtgg gagccgacca agatcagcag
      181 ctgtgtgatc ctggtgaatt tctttgccat gaccatgtga cttgtgtctc ccagagttgg
      241 ctgtgcgatg gggaccctga ctgccctgac cagtcagatg agtctttaga tacctgtccc
      301 aaggaggtgg agatcaaatg ccccttgaat cacattgctt gccgtggctc caacgcatgt
      361 gtccatttgt cgcaactgtg taatggagtg gtcgactgcc cagatggctt tgatgaagga
      421 gggcattgcc gggaattgtt acccagttgt cagcagttga attgccagtt caaatgtgca
      481 atggtcagaa atgctacaag atgttattgt gaggatggat ttgaagtaac aggagatggg
      541 agaggctgta aagatcaaga tgaatgtagt gtttatggta cttgcagcca gacctgcaag
      601 aacacatacg gatcctacgt ttgcagttgt gtggaaggct acataatgca gtcagacaac
      661 agatcttgca aagtcaaaaa tgaaccttca gataagccac ctatgttact aattgcaagt
      721 cctgaaacaa ttgagctctt ctacatcaat ggaagcaaaa tgacaactct aagctcagct
      781 aacagaaatg aaatccatac tctagatttt atttatagtg aagaaatgat ttgctggatt
      841 gaatcaagag aatcttctaa tcaactcaaa tgtggccaga tgacaaaatc aggaagattg
      901 atagatcaaa ggataattaa cagtcttcaa tccttccaca atgtggaaca aatggcaatt
      961 gactggctca ccagaaatat ctacttcgtg gaccatgtca gtgaccggat ctttgtttgt
     1021 aatttcaatg gctctgtgtg tgtcaccctg attgaactgg agcttcacaa tcctaaggcc
     1081 atagcagcag atcccattgc aggaaaactt ttctttactg actttgggaa tgctcccaga
     1141 atcgagagat gtgatatgga tgggatgaac agaacaagga tagtttattc gaagacagag
     1201 cagccgtctg ccctggcttt ggacctcatc aacagattgg tttattgggt agatctctac
     1261 ttggactacg tgggagtagt agactaccaa ggcagaaaca ggcatacgct tgttcaaggc
     1321 agacacgtta aacatctcta tggcataact gtatttgaag attatttata tgcaaccagt
     1381 tccgataacc tcaatatagt acgaataaac agatttaata gcactgatat tcactcaata
     1441 attaaaatgg aaagtgctcg aggaatccga acatatcaga agagaaccca gccaacagta
     1501 agaagccatg cctgtgaagt ggacgcatac ggaatgccag ggggatgttc acacatctgt
     1561 ctgctcggca gcagctataa gacaaggacc tgtcgctgta ggaccggctt caacatgggg
     1621 agtgatggca ggtcatgcaa aaggccaaag aatgaattgt tcctctttta tgggaaagga
     1681 cgcccaggaa ttgttagagg aatggacttg aataccaaaa tagctgatga atgcatgatc
     1741 cccatagaaa atctggtaaa ccctcgtgct ttagatttcc atgcggaagc taattatatc
     1801 tactttgctg acacgaccag tttcttaatt ggccggcaga agatagatgg cacagagcga
     1861 gaaaccatcc tgaaagatga tctggataat gtagaaggta ttgcagtgga ctggattgga
     1921 aataaccttt attggaccaa tgatggtcac agaaaaacca ttaatgtggc caggctggaa
     1981 aaggcttctc agagccggaa aactctgctg gagggagaaa tgtctcatcc aagagcaatt
     2041 gtggtagatc cagtcaatgg ttggatgtat tggacagact ggaaggaaga taaaattgat
     2101 gacagtgtcg gaaggattga gaaggcttgg atggatggag tcaatcgaca gatttttgtg
     2161 acttcgaaaa tgctgtggcc aaatggctta acactagact ttcacaccag cacattatat
     2221 tggtgtgatg cctactatga tcatattgag aaaatatttt tgaatggaac acatcgaaag
     2281 attgtataca gtgggaaaga gctgaaccat ccttttggcc tgtcacatca tgggaattat
     2341 gtattctgga cagattacat gaatggttca atttttcaac tcgatttggt gagcagggag
     2401 gtgacgttgc tgaggcacga aagagcaccc ctgtttgggc ttcagattta tgatccacgg
     2461 aaacaacaag gtgacaatat gtgccgcatt aacaatgggg gctgtggcac gctctgcctg
     2521 gccattccag gaggccgtgt gtgcgcctgt gctgataatc agcttttgga tgaaaatgga
     2581 actacttgca catttaatcc tgaagaaata atattccata tatgtaaacc tggagaattt
     2641 cgctgcaaaa acaaacactg tattcaagct cggtggaagt gtgatggcga tgatgactgc
     2701 ctagacggga gcgatgaaga ctctgtaaca tgcttcaatc atagctgccc ggaggatcag
     2761 tttaaatgcc agaataatcg ttgtatcccc aagagatggc tttgtgatgg agcaaatgat
     2821 tgtgggagca atgaagatga gtctaaccaa acctgcacag ccagaacttg tcaagctgac
     2881 caattttctt gtggaaatgg gcgctgcatt cctacagcat gggtatgtga ccgagaggat
     2941 gactgtggtg accagacaga tgaagtgaca tcctgtgaat ttccaacctg tgaaccactg
     3001 actcagttcc tatgcaagag tgggagatgt atcagcaaca aatggcactg tgacactgat
     3061 gatgactgtg gggaccggag tgatgaggtg ggctgtgttc actcttgcct tgatgaccag
     3121 ttcagatgtg cgagcggccg gtgtatacca gggcactggg cctgtgatgg tgacaatgac
     3181 tgcggagact tcagcgatga gacacacgtc aactgtacca gagaggaagc tcgttctcct
     3241 gttggatgca ttgggaatga atttcagtgc caccctgatg gaaactgcat tcctgatcta
     3301 tggcgctgtg atggagagaa agattgtgag gatggcagtg atgaaaaggg ctgcaatggt
     3361 accattcgac tgtgtgacca caaaaccaag ttctcctgca aaagtacagg gcgatgcatc
     3421 aacaatgcct gggtatgtga tggagatgtt gactgtgagg atcagtctga tgaagaagac
     3481 tgcgatagtt tcttgtgtgg accacccaag tacccttgtg ccaatgatac ctctgtgtgc
     3541 ctgcagccag agaaactctg caatgggaga aaggactgtc cagatgggtc agatgaaggc
     3601 gacctttgtg atgaatgttc tctgaacaac ggaggctgta gcaaccactg ttccgttgta
     3661 cctggaaaag gaattgtctg ttcctgccca gaaggacatc agctcaagaa ggacaataga
     3721 acctgtgaaa tcgtagacta ctgctcctcc cacctgaagt gtagccaagt gtgcgaacag
     3781 cacaaacaca tggtcaagtg ctcctgctat gaaggctggg cgttggatac tgatggggaa
     3841 agctgcatca gtgtggattc ttttgaggca ttcatcatat tttctatacg tcatgaaatt
     3901 cgaaggattg atctgcataa aggagactac agcctacttg ttcctggact gagaaacacc
     3961 atagcacttg attttcactt caatcaaagt ttactttatt ggacagatgt tgtggaagac
     4021 agaatataca ggggcaagct gtcagagagt ggaggtgtca gtgccataga agtggttgtg
     4081 gaacatggct tggcaacccc agaaggcctg acagttgact ggatagcagg caacatatat
     4141 tggatagaca gcaatctgga ccaaattgaa gtgtctaaac ttgatggttc tctgagggct
     4201 acactaatag caggagccat ggagcatccc agggccatag cactggatcc acgatatgga
     4261 attcttttct ggacagactg ggatgccaat ttccctcgca ttgaatctgc ctccatgagt
     4321 ggtgctggaa gaaaaaccat ctataaagat atgaaaactg gggcatggcc taatggactg
     4381 accgtggacc actttgaaag aagaatagtc tggacagatg ccaggtcaga tgctatttat
     4441 tcagccttct atgatggaac aaacatgata gaaattatcc gaggacatga atacctgtca
     4501 catccctttg ctgtgtcttt gtatgggagt gaggtgtact ggactgattg gaggaccaac
     4561 acactggcca aagccaacaa gtggacaggg cagaatgtca gtgtgattca gaagaccagc
     4621 gcacagccat ttgaccttca gatttaccat cccagtagac agccacaagc tcccaatcct
     4681 tgtgcagcca atgaagggag aggcccctgc tctcacctgt gtctcatcaa tcataacagg
     4741 agcgcagcct gtgcctgccc ccacctaatg aagctctcct ccgacaagaa aacctgctat
     4801 gaaatgaaaa aatttcttct ttatgcaaga cgttctgaga tccgaggggt ggacatcgac
     4861 aatccatatg cgaacttcat cacagccttc actgtccccg atatcgatga cgttgctgta
     4921 atagacttcg atgcctctga agaacgtttg tactggacag acatcaagac acaaaccatt
     4981 acacgggctt tcattaatgg gacagggcta gagacagtga tttcaagaga tattcagagt
     5041 atcagggggt tagcagtgga ctgggtttca cgtaatttat actggattag ctcagaattt
     5101 gatgaaaccc aaattaatgt ggcaagatta gacggctctt tgaaaacctc aattatccac
     5161 ggcatcgata agccacagtg tctggcagcc cacccagtga gagggaaact ctactggaca
     5221 gatgggaaca cgataaacat ggccaatatg gatggcagta acagcaagat tctctttcag
     5281 aaccaaaagg aaccagttgg tctatcgata gactatgtgg aaaataagct ttattggatc
     5341 agttctggaa atggaaccat aaaccgatgc aacctagatg gtggtaattt agaagtaata
     5401 gagtcaatga aggaagaatt aacaaaagcg acggccttaa ccatcatgga taagaaactc
     5461 tggtgggcag accaaaactt agctcaactg ggcacttgta acaaaagaga tggaagaaat
     5521 cccagcatcc tgagaaataa gacttctgga gttgttcaca tgaaagtgta tgacaaagaa
     5581 gcacaacaag gcagcaattc ttgccaagta aataatggtg ggtgctctca gctttgctta
     5641 ccaacatctg aaacaaccag gacttgtatg tgtacagtgg gatattatct ccagaagaac
     5701 cgcatgtcat gccaaggtgt agaatctttt cttatgtact ctgtccatga agggatccgg
     5761 gggatctctc ttgagccacg agacaaagtg gatgctctga tgcctatatc aggagctgcc
     5821 tttgctgtgg ggatagactt ccatgcagaa aatgacacca tctactggac agacatgggc
     5881 cttaataaaa tcagcagagc taaaagagac cagacttgga aagaagacat tgttaccaat
     5941 ggcttgggga gagtggaagg aatagctatt gactggattg ctggcaacat atattggaca
     6001 gatcatggtt tcaatttaat tgaagttgca agactcaatg gctctttccg ttatgtaatt
     6061 atttcccaag gcctggatca accaagatct atagccgtgc acccagaaaa aggcttcttg
     6121 ttttggactg aatggggaca agtgccctgc attgggaaag ctcgcctaga tggttctgag
     6181 aaggtcatga ttgtaagcat gggaataaca tggcccaatg gcatctccat tgactatgag
     6241 gaaaataaat tatactggtg tgatgctcgc tcggacaaga tagagagaat tgaccttgac
     6301 actggtggga atcgtgaagt gttgctgtct gggagcaatg tggatctgtt ctcagttgca
     6361 gtctttgggg cttacatcta ctggtctgac agagcacacg ccaatgggtc agtcagaagg
     6421 ggccacaaga acgatgtcac agaaacagta accatgagaa caggacttgg agtcaaccta
     6481 aaggagatca aaatttttaa ccgagtaaga gaaaaaggga ccaatgtctg tgccaaagaa
     6541 aatggcggct gtaagcaact atgtctctat cgaggaaatt ctcgaagaac ctgtgcctgt
     6601 gcccatgggt atttggctgg ggatggagtt acttgtctaa ggcacgaagg atatttgcta
     6661 tattcaggaa gaacaatatt aaaaagcata catctttctg atgaaaccaa tttaaattcc
     6721 ccagtacggc cctatgagaa cccacattat ttcaagaaca ttatagccct ggcctttgac
     6781 tataatcaaa gaagagaagg taccaatcgg atcttttaca gtgatgcaca ttttggaaat
     6841 atacagctta ttaacgataa ctgggaaggc agacaagtaa ttgtggaaaa cgtaggctcc
     6901 gtagagggtc tcgcctatca cagagcctgg gatactctgt actggaccag ctccagcaca
     6961 tcgtccatca ccaggcatac agtagaccag actcagcctg gagcaattga cagggaagca
     7021 gtcatcacca tgtcagagga tgaccaccct catgttctag ctttagatga atgccaaaat
     7081 ttgatgtttt ggacgaattg gaatgagcag catccaagca tcatgagagc cacattgact
     7141 ggaaaaaatg cacatgtggt tgtcagcaca gacatactca ctccaaacgg acttaccatc
     7201 gaccaccgtg cagaaaagct gtatttctca gatggcagct taggaaaaat tgagagatgt
     7261 gaatacgatg gatcccaacg acatgtcatt gttaagtctg gaccgggaac tttccttagt
     7321 ctggcagttt atgacaatta tatcttctgg tcagactggg gacgaagagc tattttgcgt
     7381 tccaacaagt acactggagg agaaaccaaa gttcttcgtt cggatattcc acatcagcca
     7441 atgggaatca tagctgttgc taatgacacc aatagctgtg aactctctcc ttgtgcatta
     7501 ctaaatggag gttgccatga cctctgcctt ctaacgccgg atggaagagt gaattgttcc
     7561 tgtagagggg atagaacatt gctggctagc aacagatgtg tgactaaaaa ctcttcttgt
     7621 aatatctatt ctgagttcga gtgtggaaat ggggactgtg ttgactatgt cctcacctgt
     7681 gatggtatcc cacactgtaa ggacaaatca gatgaaaagc tgctctattg tgaaaaccga
     7741 agttgccgaa gtgggtttaa accttgctac aaccgtcgct gtgttcctca tggaaaactg
     7801 tgtgatggta caaatgattg tggagatggc tctgatgaac tggattgtaa agtgtctact
     7861 tgctccacag ttgagtttag atgtacagat gggacttgca ttccaagatc agcacggtgc
     7921 aatcaaaaca tggactgttc agatgcttca gatgaaaagg gctgcaataa tacagattgt
     7981 acacatttct ataaacttgg agtgaaatcc acaggattca tcagatgtaa ctctacctca
     8041 ctgtgtgttc tgccaagctg gatatgcgat ggatctaatg actgtggaga ctattcggat
     8101 gaattaaagt gcccagttca aaacaaacac aaatgtgaag agaattattt tggttgtcct
     8161 agtggaagat gcattttgaa tacctgggta tgtgatggtc agaaggactg cgaggatggg
     8221 ctcgatgagc tacactgtga ttcgtcttgc tcttggaatc aatttgcttg ttccgtacat
     8281 aaatgtattt ctaaacactg gatctgtgat ggcgaggatg actgtggaga tggcttagat
     8341 gaaagtgaca acatttgtgg tgccgtcact tgtgctgctg acatgttcag ctgccagagc
     8401 tcccatgcct gtgtgcccca acactggctg tgtgatggtg agagagactg ccccgacggg
     8461 agtgatgagc tatccagtgc aggctgtgca cctaataata catgtgacga aaatgcattc
     8521 atgtgccata ataaggtgtg cattcccaag cagtttgtgt gtgaccatga cgatgactgt
     8581 ggagacggct cagatgagtt cctggagtgt gggtaccggc agtgtggtcc ggaagagttc
     8641 cgctgtgcag atgggcgctg cctcgtaaac acactatggc agtgtgatgg tgacttcgac
     8701 tgtcctgaca gttctgatga ggcgccaatc aacccaaggt gcacgagtgc agaacattcg
     8761 tgcaacagtt cattttttat gtgcaaaaat ggcaggtgca ttcccagaga tggtctttgt
     8821 gacaataggg atgactgcgg tgatggctca gatgaggcaa aatgccacat aaatgaatgt
     8881 ctgagtaaga aaatcagtgg atgttctcaa gattgtcagg atttgccaat cagttacaag
     8941 tgcaaatgct ggcctggatt ccaactgaag gatgatggta aaacatgtgt agacattgat
     9001 gaatgttcta caggtttccc ctgtagtcag cagtgcatca atacatatgg aacctacaag
     9061 tgccgctgta cagaaggcta tgaaacacag cctgataacc aaaatggctg caggtcactc
     9121 tcagatgaag aacccttctt aattctcgct gaccaacatg aaattagaaa aattagcact
     9181 gatggctcca actacacact tctaaagcag ggactaaaca atgttattgc catagacttc
     9241 gattatagag aggaattcat atattggatt gattccagca gacccaatgg aagtcgcata
     9301 aacagaatgt gtctaaatgg aagtgatatc aaggtagtgc ataacactgc tgtccccaat
     9361 gcacttgctg ttgattggat tggcaaaaac ctctattggt ctgacacaga gaaaaggata
     9421 attgaagtat cgaaactcaa tggcttgtac cctactgtac ttgttagcaa aaggctgaag
     9481 tttcccaggg acctgtcgtt agatccacga gccgggaatt tgtactggat tgattgctgt
     9541 gagtatcctc acattggccg tgtcggaatg gatggaacaa atcagagtgt tgtcatagaa
     9601 accaagattt ctagaccgat ggcactaaca atagactatg tcaaccatag actctactgg
     9661 gctgatgaaa atcacattga atttagcaac atggatggat ctcatagaca caaagtccct
     9721 aatcaagata tcccaggggt gattgcacta acattgtttg aagactacat ctactggact
     9781 gatgggaaaa ccaagtcact cagccgtgtc cataaaacct cgggagcaga cagactttca
     9841 ctgatttact catggcatgc catcacagat atccaggtgt atcattctta tagacaacct
     9901 gatgtctcca aacatctttg cacggtaaat aatggtggtt gcagccattt gtgcctttta
     9961 ggccctggga agacgcacac ctgtgcatgt cctaccaact tctaccttgc agctgacaat
    10021 agaacttgtt tatccaactg cacagcaagt cagtttcgat gcaaaactga taagtgcatc
    10081 cctttctggt ggaaatgtga cactgtggat gactgcggcg atggatctga tgagcctgac
    10141 gactgtcctg aatttaagtg tcagccaggc cgatttcagt gtggaacagg actctgcgca
    10201 ctccctgcct tcatctgtga tggggaaaat gactgtggag acaactcaga tgaacttaac
    10261 tgtgacacac atgtctgcct ggcaggtcag ttcaagtgta ccaagaataa gaaatgcatc
    10321 ccagtaaacc tcagatgtaa tggacaagat gattgtggtg atgaagaaga tgagagagac
    10381 tgtcctgaaa acagctgctc tcccgactat ttccaatgta agacgacgaa gcattgcatc
    10441 tccaagctgt gggtttgtga cgaggaccca gactgtgctg atgcctctga tgaggccaac
    10501 tgtgataaaa agacttgtgg acctcatgaa ttccagtgta agaacaacaa ctgtattcca
    10561 gaccactggc gatgtgatag tcagaatgac tgcagtgata attctgacga agaaaactgc
    10621 aaaccacaga cctgtacatt gagggatttt ctctgcagca atggagactg tgtttcatca
    10681 aggttctggt gtgatggaga gtttgactgt gctgatggtt ctgatgagaa aaattgtgaa
    10741 acgagttgtt ccaaagatca atttcagtgt tccaatggcc aatgtctgtc agcaaaatgg
    10801 aagtgtgatg gacatgaaga ttgtaaatat ggagaagatg agaaaaactg tgagccagcc
    10861 tttcctgtct gctcatcaag tgaatatatg tgtgccagtg gaggatgtct gtcagcatct
    10921 ttgaaatgta atggagaaac tgactgtgtt gatggttcag atgagatgga ctgtgtgaca
    10981 gaatgtaagg aagatcagtt tcaatgcaga aataaagcat attgtattcc aattcggtgg
    11041 ctgtgcgatg gaatttatga ctgtgtggac ggcagtgatg aagagaactg tggcagagga
    11101 ggaagtatat gcagagctga tgagttcctg tgcaataact ccctgtgcaa gctccatttc
    11161 tgggtttgtg atggagaaga tgactgtgga gacaactctg atgaagtgcc tgacatgtgt
    11221 gtcaaatttc tgtgcccacc cacaaggccc tacagatgca gaaatgatag aatctgcctg
    11281 caacttgaga aaatgtgcaa tgggattaat gactgtggcg acaactctga tgaggaacac
    11341 tgcagtggta cattgtcatt taagtccgag ccttgtaaga aggatgagtt tacttgtaac
    11401 aacagaaact gcatccccat ggaactgcag tgtgatggcc ttgatgactg tggtgatggc
    11461 tcagatgaac aaggctgcat gcagactccc actcaacaca cctgtgagaa caatgggaat
    11521 ccatgtggag atgatgcata ttgtaatcaa ataagaacat ctgttttctg tcgctgtaag
    11581 cctggatttc agagaaacat caaaggcaga gaatgtgcag atctcaatga atgcctggtg
    11641 tttggaatat gctcccagca ctgtctaaac acacgaggat catataaatg tgtctgtgac
    11701 cagaactttc aagaaaaaaa caacagctgt atagcaaaag gctctgaaga tcaagctctc
    11761 tacatagcta atgacactga catcctgggt tttgtatatc cattcaacta cagtggcagt
    11821 catcagcaga tttctcatgt tgaacataat tcaagaataa cagggatgga tgtatattat
    11881 caaagaaatg tgattgtctg gagtactcag tttaatccag gcgggatttt ctacacaatg
    11941 atcgatgcca gagaaaagag acaagcgaat agtggcttga tttgtcctga atttaaaagg
    12001 ccccgagaca ttgctgttga ctgggttaca ggaaatgttt attggactga tcattccaga
    12061 atgcactggt tcagctacta tactactcac tggaccagcc tgaggtactc aatcaatgta
    12121 ggacagctca atggccccaa ctgcaccaga ctcttaacaa atatggctgg cgagccctat
    12181 gctattgctg taaatcctaa aagagggatg atgtactgga ctgtaattgg ggatcactcc
    12241 catatagaag aggcggccat ggatggcact ctgcggagga ttttagtaca aaaacacttg
    12301 cagagaccca caggtctgac tgttgatcac tttggtgaac gcatctactg ggcagacttt
    12361 gagctctcca tcattggcag tgtcatgtat gacggttcca gtccagtggt ctctgtcagc
    12421 agcaagcaag gattgttgca tcctcacaga attgatgtct ttgaagatta catatatgga
    12481 gcaggaccta aaaatggtat attcagagtt caaaaatttg gtcatggctc agtagaggtc
    12541 ctaactttag atgttgacaa aacaaagagc attgtggtat cacatcgcta taaacaacta
    12601 aacttaccca atccttgctt gggtttgtca tgtgattttc tctgtttgct gaatccttct
    12661 ggagccacat gtgtctgccc agaaggaaaa catatacgga atggaacctg ccatgagaac
    12721 agtctgttag atgactcttg caaactgact tgtgaaaatg gaggaaggtg cattttaaat
    12781 gagaagggtg atctgagatg tcactgctgg cccagttatt caggaggaag gtgtgaagtc
    12841 aaccactgta gcaattactg tcagaatgga gggacctgca taccatctgc tctaggaaga
    12901 cccacctgta tctgtgcctt gggctttact gggccgaact gcggcaagac agtctgcgaa
    12961 gattcttgtc acaatggtgg gagctgtgtt gtgactgctg ggaaccaacc ttactgccac
    13021 tgtcaggcag actacactgg agacagatgc cagtactatg tgtgccacca ctactgtgtg
    13081 aattccgaat cgtgtagcat tgggaacgat ggaagtgttg aatgtgtctg cccaacacgc
    13141 tatgaaggac caaaatgtga gattgacaaa tgtgtacggt gccacggggg ccactgtatc
    13201 ataaatcaag acaatgagga tatattttgc aactgtacta atgggaagat tgcctctagc
    13261 tgtcagttgt gtgatggcta ctgttacaat ggtggcacat gccaactgga ccctgagact
    13321 agcgtacctg tgtgtgtatg ctctgtgggg tttaaaagtc agcgctgtga ccagaaagag
    13381 aacccttgtg atcactactg tcagaatgag gggatttgca ctataactgc gtttaatgag
    13441 ccgagatgca agtgctccac taattggtca ggtacacagt gtgagaggcc agccccaaag
    13501 agcagcaaat ctgagcatat cagcacaagg agcattgcta tcatcgtgcc acttgtcctc
    13561 ctggtgacct tggtaaccac tctagtcatt ggcttagtgg tttgtaagag aaaaagaaga
    13621 acaaagacaa ttagaaggca gcctatcatc aatggaggaa taaatgtaga aatcggcaat
    13681 ccatcataca atatgtatga agtggatcac gaccacagtg atggcggtct tttagaaccg
    13741 agttttatga tagatccagt aaagtccagg tacatagggg gagggcccag tgctttcagg
    13801 ctcccacaca cagcaccgcc catctaccta aactctgatt tgaaaggacc actaacttct
    13861 gggccaacaa attattccaa cccagtatat gcaaaattgt atatggatgg acagaactgt
    13921 cgaaactcct taggaagtgt ggatgaacgg aaagaactgc ttccaaagaa aattgaaatt
    13981 ggcatcagag agacagtggc ataatgaagg acacttttct atgctgtata aatgtataaa
    14041 atataaggat tacttttata tgttccaaca gtattatact tattttagca tcagcattat
    14101 ctctatcttt ttcctggtta gttgttttct gagttttggg ggttttattt tttgctaatg
    14161 aatatcaatt caccattttt aaggtatttt tatgaaaaat aactgcacta tactaaaact
    14221 tacaatgatg ctgctgatat gacacacctt taaatttgtt aaaagctaaa aaaaaacata
    14281 ttcctttcta gagttaatac gagcaatcta ttttataaga atatttggtt ctccacaatg
    14341 agcaaagtac tctacacttc agcattctgt tttctgaaaa ttgtaataag ttgtcattgt
    14401 agtttctgtt ggattgaaag gacaaactct cttcttcatg cacatgcaag tgaatttaga
    14461 cttggctgag aatatttagc tcgtacaagt tcaacatctc ctgctttgca attagtctct
    14521 gtcaacagag gaataactgg aattttggaa gaaaaaaact tttaaaagta cacaatattg
    14581 ataatttgca tgaatacaaa tgacttattt cccaaatttt actagactct gatatacaaa
    14641 atacacgagc tctgtaacag tagtggtatt taggttgata gaatataaca aacatataac
    14701 tagaacagga ctaataggac ttgctgtgtg ataggatatt ttacttctca accctcaggc
    14761 atacagcgag ctaagagcac agcagcagga tatgggacct catgccttac atatttattt
    14821 ccaagtatgt tcacgttgtg gattaatatt acctcttaat catgctgagc actgtaaaac
    14881 cacacacaat caatcaaaat tatatgaaaa tttcagtttt gtgaatgcac tctctttgtc
    14941 agatcaaata gaattttctt tgtatgaagt aattgataaa gacttttggt gtgccatttg
    15001 actaattatt tgtcctccca attcaactat gattcaagga tgtttcaagg tataagaagt
    15061 acttgctatg atgcctggtg gagagtctcc tctgtgccat tagcattggt aatttggttt
    15121 ctctttgctt atacaaaaca cacagaccca ttcacttggt tctattgttt tcaaattttg
    15181 attgtaacaa atatggttta tttaagttgt ataaaaaaga tagcattttt atacaaatat
    15241 ctttaaaggc acaaaagttt tattcataag ctgtggggcg tttttgtccc tctgatagac
    15301 atgactgact tttagctgtc ataatgtatt aatctaacag atgaaatatg tttgtggttg
    15361 ctctttatcc ctttgtacaa gcattaaaaa ctgctgtttt ataaggaaac tttttgttgt
    15421 actatgtgca tgcacactac ctatttctaa actttgccat actgaggcct ttatagaata
    15481 ttggtttatg taatacttgt gtgatttgct tgaacaatgt tatgcatacc ataaactttt
    15541 tcaggttctt gtttaagtac attttttaaa tcgaacagta tttttcattt tggttataat
    15601 agtcattttg cctatgtttc tacaatgaag tgtcaaatac tttataagaa aattgttgac
    15661 tgatttattt aaatgaaatt ctacatattt aag
//
