LOCUS       NP_001123962            4545 aa            linear   ROD 11-MAR-2025
DEFINITION  prolow-density lipoprotein receptor-related protein 1 precursor
            [Rattus norvegicus].
ACCESSION   NP_001123962
VERSION     NP_001123962.1
DBSOURCE    REFSEQ: accession NM_001130490.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 4545)
  AUTHORS   Wang,H., Liang,L., Yang,C., Xiao,L., Wang,H., Wang,G. and Zhu,Z.
  TITLE     The protective role of hippocampal LRP1 knockdown involves synaptic
            plasticity through the promoting microtubule dynamics and
            activation of Akt/GSK-3beta pathway in depressive rats
  JOURNAL   J Affect Disord 322, 63-75 (2023)
   PUBMED   36372121
  REMARK    GeneRIF: The protective role of hippocampal LRP1 knockdown involves
            synaptic plasticity through the promoting microtubule dynamics and
            activation of Akt/GSK-3beta pathway in depressive rats.
REFERENCE   2  (residues 1 to 4545)
  AUTHORS   Haghjoo,S., Hedayati Ch,M., Rostampour,M. and Khakpour-Taleghani,B.
  TITLE     Red-light radiation: does it enhance memory by increasing
            hippocampal LRP-1 and TRPA-1 genes expression?
  JOURNAL   Int J Radiat Biol 99 (2), 329-339 (2023)
   PUBMED   35446172
  REMARK    GeneRIF: Red-light radiation: does it enhance memory by increasing
            hippocampal LRP-1 and TRPA-1 genes expression?
REFERENCE   3  (residues 1 to 4545)
  AUTHORS   Taghadosi,Z., Zarifkar,A., Razban,V. and Aligholi,H.
  TITLE     The effect of chronic stress and its preconditioning on spatial
            memory as well as hippocampal LRP1 and RAGE expression in a
            streptozotocin-induced rat model of Alzheimer's disease
  JOURNAL   Metab Brain Dis 37 (8), 2699-2710 (2022)
   PUBMED   35930096
  REMARK    GeneRIF: The effect of chronic stress and its preconditioning on
            spatial memory as well as hippocampal LRP1 and RAGE expression in a
            streptozotocin-induced rat model of Alzheimer's disease.
REFERENCE   4  (residues 1 to 4545)
  AUTHORS   Garcia,J., Chang,R., Steinberg,R.A., Arce,A., Yang,J., Van Der
            Eb,P., Abdullah,T., Chandrashekar,D.V., Eck,S.M., Meza,P.,
            Liu,Z.X., Cadenas,E., Cribbs,D.H., Kaplowitz,N., Sumbria,R.K. and
            Han,D.
  TITLE     Modulation of hepatic amyloid precursor protein and lipoprotein
            receptor-related protein 1 by chronic alcohol intake: Potential
            link between liver steatosis and amyloid-beta
  JOURNAL   Front Physiol 13, 930402 (2022)
   PUBMED   36187787
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 4545)
  AUTHORS   Mantuano,E., Azmoon,P., Banki,M.A., Lam,M.S., Sigurdson,C.J. and
            Gonias,S.L.
  TITLE     A soluble derivative of PrPC activates cell-signaling and regulates
            cell physiology through LRP1 and the NMDA receptor
  JOURNAL   J Biol Chem 295 (41), 14178-14188 (2020)
   PUBMED   32788217
  REMARK    GeneRIF: A soluble derivative of PrP(C) activates cell-signaling
            and regulates cell physiology through LRP1 and the NMDA receptor.
REFERENCE   6  (residues 1 to 4545)
  AUTHORS   Brown,M.D., Banker,G.A., Hussaini,I.M., Gonias,S.L. and
            VandenBerg,S.R.
  TITLE     Low density lipoprotein receptor-related protein is expressed early
            and becomes restricted to a somatodendritic domain during neuronal
            differentiation in culture
  JOURNAL   Brain Res 747 (2), 313-317 (1997)
   PUBMED   9046007
REFERENCE   7  (residues 1 to 4545)
  AUTHORS   Ishii,M., Osada,T., Gliemann,J. and Ikai,A.
  TITLE     Neurite-promoting effect of alpha 2-macroglobulin in rat cerebral
            cortex is mainly associated with alpha 2-macroglobulin receptor
  JOURNAL   Brain Res 737 (1-2), 269-274 (1996)
   PUBMED   8930375
REFERENCE   8  (residues 1 to 4545)
  AUTHORS   Stefansson,S., Lawrence,D.A. and Argraves,W.S.
  TITLE     Plasminogen activator inhibitor-1 and vitronectin promote the
            cellular clearance of thrombin by low density lipoprotein
            receptor-related proteins 1 and 2
  JOURNAL   J Biol Chem 271 (14), 8215-8220 (1996)
   PUBMED   8626514
REFERENCE   9  (residues 1 to 4545)
  AUTHORS   Beisiegel,U., Weber,W., Ihrke,G., Herz,J. and Stanley,K.K.
  TITLE     The LDL-receptor-related protein, LRP, is an apolipoprotein
            E-binding protein
  JOURNAL   Nature 341 (6238), 162-164 (1989)
   PUBMED   2779654
REFERENCE   10 (residues 1 to 4545)
  AUTHORS   Herz,J., Hamann,U., Rogne,S., Myklebost,O., Gausepohl,H. and
            Stanley,K.K.
  TITLE     Surface location and high affinity for calcium of a 500-kd liver
            membrane protein closely related to the LDL-receptor suggest a
            physiological role as lipoprotein receptor
  JOURNAL   EMBO J 7 (13), 4119-4127 (1988)
   PUBMED   3266596
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760494
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4545
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     Protein         1..4545
                     /product="prolow-density lipoprotein receptor-related
                     protein 1 precursor"
                     /note="prolow-density lipoprotein receptor-related protein
                     1; low density lipoprotein-related protein 1
                     (alpha-2-macroglobulin receptor); low density lipoprotein
                     receptor-related protein 1"
                     /calculated_mol_wt=502965
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1946
     mat_peptide     20..4545
                     /product="Prolow-density lipoprotein receptor-related
                     protein 1. /evidence=ECO:0000255. /id=PRO_5015091774"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
                     /calculated_mol_wt=502965
     Region          27..60
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(33,42,53..54)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(46,49,53,59..60)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            56..60
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          72..105
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(78,87,98..99)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(91,94,98,104..105)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            101..105
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          120..149
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            137
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          159..189
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            186
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            240
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            275
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          276..315
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          293..335
                     /region_name="LDL-receptor class B 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          317..359
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          336..379
                     /region_name="LDL-receptor class B 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            358
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          362..402
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          380..423
                     /region_name="LDL-receptor class B 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            447
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          487..520
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          552..594
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          572..614
                     /region_name="LDL-receptor class B 4.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          595..634
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          615..660
                     /region_name="LDL-receptor class B 5.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          639..671
                     /region_name="HAT 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          641..690
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          661..711
                     /region_name="LDL-receptor class B 6.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          <701..734
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          712..755
                     /region_name="LDL-receptor class B 7.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            730
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          808..843
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          854..886
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(860,868,879..880)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(872,875,879,885..886)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            882..886
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          896..929
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(901,909,920..921)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(913,916,920,926..927)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            923..927
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            929
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          936..968
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(942,950,961..962)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(954,957,961,967..968)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            964..968
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          979..1012
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(983,991,1002..1003)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(995,998,1002,1008..1009)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1005..1009
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1016..1049
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1021,1029,1040..1041)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1033,1036,1040,1046..1047)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1043..1047
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            1051
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1063..1098
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1068,1077,1088..1089)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1081,1084,1088,1094..1095)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1091..1095
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1105..1141
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1111,1120,1131..1132)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1124,1127,1131,1137..1138)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1134..1138
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1146..1179
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1151,1161,1172..1173)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            1156
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            order(1165,1168,1172,1178..1179)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1175..1179
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1186..1222
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            1196
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            1219
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1310..1356
                     /region_name="LDL-receptor class B 8.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1311..>1504
                     /region_name="Vgb"
                     /note="Streptogramin lyase [Defense mechanisms]; COG4257"
                     /db_xref="CDD:443399"
     Region          1337..1377
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1357..1399
                     /region_name="LDL-receptor class B 9.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1380..1413
                     /region_name="HAT 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1381..1424
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1400..1446
                     /region_name="LDL-receptor class B 10.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1447..1491
                     /region_name="LDL-receptor class B 11.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1470..1503
                     /region_name="HAT 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1492..1532
                     /region_name="LDL-receptor class B 12.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            1512
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            1559
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            1576
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1614..1650
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Site            1617
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1628..1670
                     /region_name="LDL-receptor class B 13.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            1646
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1651..1694
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1653..1684
                     /region_name="HAT 4. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1671..1714
                     /region_name="LDL-receptor class B 14.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1698..1735
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1715..1754
                     /region_name="LDL-receptor class B 15.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            1724
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            1734
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1735..1776
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1755..1799
                     /region_name="LDL-receptor class B 16.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            1764
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            1826
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1851..1887
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          1917..1957
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Site            1934
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1935..1977
                     /region_name="LDL-receptor class B 17.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          1960..2000
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1978..2020
                     /region_name="LDL-receptor class B 18.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            1996
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2001..2044
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Site            2010
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q91ZX7; propagated from
                     UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2021..2064
                     /region_name="LDL-receptor class B 19.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2046..2088
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Site            2049
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2065..2108
                     /region_name="LDL-receptor class B 20.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            2118
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            2128
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2160..2195
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          2254..2295
                     /region_name="LDL-receptor class B 21.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2276..2316
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          2277..2309
                     /region_name="HAT 5. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2296..2344
                     /region_name="LDL-receptor class B 22.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2325..2358
                     /region_name="HAT 6. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2345..2389
                     /region_name="LDL-receptor class B 23.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2345..2387
                     /region_name="Ldl_recept_b"
                     /note="Low-density lipoprotein receptor repeat class B;
                     pfam00058"
                     /db_xref="CDD:459654"
     Region          2371..2412
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          2390..2432
                     /region_name="LDL-receptor class B 24.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2411..2444
                     /region_name="HAT 7. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2433..2474
                     /region_name="LDL-receptor class B 25.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            2473
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2483..2515
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            2503
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            2522
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2528..2558
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(2531,2539,2550..2551)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2543,2546,2550,2556..2557)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2553..2557
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          2567..2601
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(2572,2580,2591..2592)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2584,2587,2591,2597..2598)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2594..2598
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            2602
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2606..2640
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(2611,2619,2630..2631)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            2621
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            order(2623,2626,2630,2636..2637)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2633..2637
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            2639
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          <2667..2689
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(2672,2675,2679,2685..2686)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2682..2686
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          2697..2731
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(2702,2710,2721..2722)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2714,2717,2721,2727..2728)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2724..2728
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          2735..2766
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(2740,2748,2759..2760)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2752,2755,2759,2765..2766)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2762..2766
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          2774..2807
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(2780,2789,2800..2801)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2793,2796,2800,2806..2807)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2803..2807
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            2816
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2818..2850
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(2824,2832,2843..2844)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2836,2839,2843,2849..2850)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2846..2850
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          2858..2891
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(2864,2872,2884..2885)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2877,2880,2884,2890..2891)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2887..2891
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            2906
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          2908..2940
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(2911,2919,2930..2931)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2923,2926,2930,2936..2937)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2933..2937
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          2965..2986
                     /region_name="cEGF"
                     /note="Complement Clr-like EGF-like; pfam12662"
                     /db_xref="CDD:463661"
     Region          2983..>3012
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(2983,2986,2999)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            3049
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          3050..3094
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          3070..3114
                     /region_name="LDL-receptor class B 26.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            3090
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          3095..3137
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          3115..3157
                     /region_name="LDL-receptor class B 27.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          3128..3171
                     /region_name="HAT 8. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          3139..3181
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          3158..3201
                     /region_name="LDL-receptor class B 28.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          3183..3224
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          3202..3244
                     /region_name="LDL-receptor class B 29.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          3224..3256
                     /region_name="HAT 9. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          3225..3265
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          3245..3285
                     /region_name="LDL-receptor class B 30.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            3265
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          3295..3331
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            3334
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          3335..3366
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3340,3348,3359..3360)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3352,3355,3359,3365..3366)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3362..3366
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3375..3409
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3380,3388,3399..3400)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3392,3395,3399,3405..3406)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3402..3406
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3414..3449
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3419,3428,3439..3440)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3432,3435,3439,3445..3446)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3442..3446
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3453..3486
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(3459,3468,3479..3480)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3472,3475,3479,3485..3486)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3482..3486
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            3489
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          3494..3527
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(3500,3509,3520..3521)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3513,3516,3520,3526..3527)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3523..3527
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3537..3571
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3542,3550,3561..3562)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3554,3557,3561,3567..3568)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3564..3568
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3576..3610
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3581,3589,3600..3601)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3593,3596,3600,3606..3607)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3603..3607
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3614..3648
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3619,3627,3638..3639)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3631,3634,3638,3644..3645)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3641..3645
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3654..3686
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(3660,3668,3679..3680)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            3663
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            order(3672,3675,3679,3685..3686)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3682..3686
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3696..3732
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3702,3711,3722..3723)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3715,3718,3722,3728..3729)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3725..3729
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3747..3777
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3748,3756,3767..3768)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3760,3763,3767,3773..3774)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3770..3774
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            3789
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            3840
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          3863..4065
                     /region_name="YncE"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; COG3391"
                     /db_xref="CDD:442618"
     Region          3913..3925
                     /region_name="LDL-receptor class B 31.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            3954
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          3956..3993
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          3971..4013
                     /region_name="LDL-receptor class B 32.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          3995..4027
                     /region_name="HAT 10. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          4014..4057
                     /region_name="LDL-receptor class B 33.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          4014..4055
                     /region_name="Ldl_recept_b"
                     /note="Low-density lipoprotein receptor repeat class B;
                     pfam00058"
                     /db_xref="CDD:459654"
     Region          4038..4079
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          4058..4102
                     /region_name="LDL-receptor class B 34.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            4076
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            4126
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            4180
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            4280
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            4365
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            4425..4445
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Region          4446..4545
                     /region_name="Interaction with MAFB.
                     /evidence=ECO:0000250|UniProtKB:Q91ZX7"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     Site            4461
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07954; propagated from
                     UniProtKB/Swiss-Prot (G3V928.1)"
     Site            4508
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q07954; propagated from
                     UniProtKB/Swiss-Prot (G3V928.1)"
     Site            4518
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07954; propagated from
                     UniProtKB/Swiss-Prot (G3V928.1)"
     Site            4521
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07954; propagated from
                     UniProtKB/Swiss-Prot (G3V928.1)"
     Site            4524
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q91ZX7; propagated from
                     UniProtKB/Swiss-Prot (G3V928.1)"
     CDS             1..4545
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /coded_by="NM_001130490.1:346..13983"
                     /db_xref="GeneID:299858"
                     /db_xref="RGD:1307535"
ORIGIN      
        1 mltpplllll pllsalvaga tmdapktcsp kqfacrdqit ciskgwrcdg erdcpdgsde
       61 apeicpqska qrcppnehsc lgtelcvpms rlcngiqdcm dgsdegahcr elrvncsrmg
      121 cqhhcvptps gptcycnnsf qlqadgktck dfdecsvygt csqlctntdg sftcgcvegy
      181 llqpdnrsck aknepvdrpp vlliansqni latylsgaqv stitptstrq ttamdfsyan
      241 etvcwvhvgd saaqtqlkca rmpslkgfvd ehtinislsl hhveqmaidw ltgnfyfvdd
      301 iddrifvcnr ngdtcvtlld lelynpkgia ldpamgkvff tdygqipkve rcdmdgqnrt
      361 klvdskivfp hgitldlvsr lvywadayld yievvdyegk grqtiiqgil iehlygltvf
      421 enylyatnsd nantqqktsv irvnrfnste yqvvtrvdkg galhiyhqrr qprvrshace
      481 ndqygkpggc sdicllansh kartcrcrsg fslgsdgksc kkpehelflv ygkgrpgiir
      541 gmdmgakvpd ehmipienlm npraldfhae tgfiyfadtt syligrqkid gteretilkd
      601 gihnvegvav dwmgdnlywt ddgpkktisv arlekaaqtr ktliegkmth praivvdpln
      661 gwmywtdwee dpkdsrrgrl erawmdgshr difvtsktvl wpnglsldip agrlywvdaf
      721 ydrietilln gtdrkivyeg pelnhafglc hhgnylfwte yrsgsvyrle rgvagaqptv
      781 tllrserppi feirmydaqq qqvgtnkcrv nnggcsslcl atpgsrqcac aedqvldadg
      841 vtclanpsyv pppqcqpgef acannrciqe rwkcdgdndc ldnsdeapal chqhtcpsdr
      901 fkcennrcip nrwlcdgdnd cgnsedesna tcsartcppn qfscasgrci piswtcdldd
      961 dcgdrsdesa scayptcfpl tqftcnngrc ininwrcdnd ndcgdnsdea gcshscsstq
     1021 fkcnsgrcip ehwtcdgdnd cgdysdetha nctnqatrpp ggchsdefqc rldglciplr
     1081 wrcdgdtdcm dssdekgceg vthvcdpnvk fgckdsarci skawvcdgds dcednsdeen
     1141 cealacrpps hpcanntsvc lspdklcdgk ddcgdgsdeg elcdqcslnn ggcshncsva
     1201 pgegivcscp lgmelgpdnh tcqiqsycak hlkcsqkcdq nkfsvkcscy egwvlepdge
     1261 scrsldpfkp fiifsnrhei rridlhkgdy svlvpglrnt ialdfhlsqs alywtdvved
     1321 kiyrgklldn galtsfevvi qyglatpegl avdwiagniy wvesnldqie vakldgtlrt
     1381 tllagdiehp raialdprdg ilfwtdwdas lprieaasms gagrrtihre tgsggwpngl
     1441 tvdylekril widarsdaiy sarydgsghm evlrghefls hpfavtlygg evywtdwrtn
     1501 tlakankwtg hnvtvvqrtn tqpfdlqvyh psrqpmapnp ceanggrgpc shlclinynr
     1561 tvscacphlm klhndnttcy efkkfllyar qmeirgvdld apyynyiisf tvpdidnvtv
     1621 ldydareqrv ywsdvrtqai krafingtgv etvvsadlpn ahglavdwvs rnlfwtsydt
     1681 nkkqinvarl dgsfknavvq gleqphglvv hplrgklywt dgdnismvnm dgsnrtllfs
     1741 gqkgpvglai dfpesklywi ssgnhtinrc nldgselevi dtmrsqlgka talaimgdkl
     1801 wwadqvsekm gtcnkadgsg svvlrnsttl vmhmkvydes iqlehegtnp csvnngdcsq
     1861 lclptsettr scmctagysl rsgqqacegv gsfllysvhe girgipldpn dksdalvpvs
     1921 gtslavgidf haendtiywv dmglstisra krdqtwredv vtngigrveg iavdwiagni
     1981 ywtdqgfdvi evarlngsfr yvvisqgldk praitvhpek gylfwtewgh ypriersrld
     2041 gtervvlvnv siswpngisv dyqggklywc darmdkieri dletgenrev vlssnnmdmf
     2101 svsvfedfiy wsdrthangs ikrgckdnat dsvplrtgig vqlkdikvfn rdrqkgtnvc
     2161 avanggcqql clyrgggqra cacahgmlae dgascreyag yllysertil ksihlsdern
     2221 lnapvqpfed pehmknvial afdyragtsp gtpnriffsd ihfgniqqin ddgsgrttiv
     2281 envgsvegla yhrgwdtlyw tsyttstitr htvdqtrpga feretvitms gddhprafvl
     2341 decqnlmfwt nwnelhpsim raalsganvl tliekdirtp nglaidhrae klyfsdatld
     2401 kierceydgs hryvilksep vhpfglavyg ehifwtdwvr ravqrankyv gsdmkllrvd
     2461 ipqqpmgiia vandtnscel spcrinnggc qdlcllthqg hvncscrggr ilqedftcra
     2521 mnsscraqde fecangecis fsltcdgvsh ckdksdekps ycnsrrckkt frqcnngrcv
     2581 snmlwcngvd dcgdgsdeip cnktacgvge frcrdgscig nssrcnqfvd cedasdemnc
     2641 satdcssyfr lgvkgvlfqp certslcyap swvcdgandc gdysderdcp gvkrprcpln
     2701 yfacpsgrci pmswtcdked dcengedeth cnkfcseaqf ecqnhrcisk qwlcdgsddc
     2761 gdgsdeaahc egktcgpssf scpgthvcvp erwlcdgdkd cadgadesis agclynstcd
     2821 drefmcqnrl cipkhfvcdh drdcadgsde speceyptcg pnefrcangr clssrqwecd
     2881 gendchdhsd eapknphcts pehkcnassq flcssgrcva eallcngqdd cgdgsdergc
     2941 hvneclsrkl sgcsqdcedl kigfkcrcrp gfrlkddgrt cadvdecstt fpcsqlcint
     3001 hgsykclcve gyaprggdph sckavtdeep flifanryyl rklnldgsny tllkqglnna
     3061 valdfdyrgq miywtdvttq gsmirrmhln gsnvqvlhrt glsnpdglav dwvggnlywc
     3121 dkgrdtievs klngayrtvl vssglrepra lvvdvqngyl ywtdwgdhsl igrigmdgsg
     3181 rsiivdtkit wpngltvdyv teriywadar edyiefasld gsnrhvvlsq diphifaltl
     3241 fedyvywtdw etksinrahk ttganktlli stlhrpmdlh vfhalrqpdv pnhpckvnng
     3301 gcsnlcllsp ggghkcacpt nfylggdgrt cvsnctasqf vckndkcipf wwkcdteddc
     3361 gdhsdeppdc pefkcrpgqf qcstgictnp aficdgdndc qdnsdeancd ihvclpsqfk
     3421 ctntnrcipg ifrcngqdnc gdgederdcp evtcapnqfq csitkrcipr vwvcdrdndc
     3481 vdgsdepanc tqmtcgvdef rckdsgrcip arwkcdgedd cgdgsdepke ecdertcepy
     3541 qfrcknnrcv pgrwqcdydn dcgdnsdees ctprpcsese fscangrcia grwkcdgdhd
     3601 cadgsdekdc tprcdmdqfq cksghciplr wrcdadadcm dgsdeeacgt gvrtcpldef
     3661 qcnntlckpl awkcdgeddc gdnsdenpee ctrfqcppnr pfrckndrvc lwigrqcdgt
     3721 dncgdgtdee dcepptaqnp hckdkkeflc rnqrclsssl rcnmfddcgd gsdeedcsid
     3781 pkltscatna smcgdearcv rtekaaycac rpgfhtvpgq pgcqdinecl rfgtcsqlcn
     3841 ntkgghlcsc arnfmkthnt ckaegseyqv lyiaddneir slfpghphsa yeqafqgdes
     3901 vridamdvhv kagrvywtnw htgtisyrsl ppaappttsn rhrrqidrgv thlnisglkm
     3961 prgiaidwva gnvywtdsgr dvievaqmkg enrktlisgm idephaivvd plrgtmywsd
     4021 wgnhpkieta amdgtlretl vqdniqwptg lavdyhnerl ywadaklsvi gsirlngtdp
     4081 ivavdskrgl shpfsidvfe dyiygvtyin nrvfkihkfg hsplinltgg lshasdvvly
     4141 hqhkqpevtn pcdrkkcewl cllspsgpvc tcpngkrldn gtcvpvpspt pppdaprpgt
     4201 ctlqcfnggs cflnarrqpk crcqprytgd kceldqcwey chnggtcaas psgmptcrcp
     4261 tgftgprctq qvcagycann stctvnqgnq pqcrclpgfl gdrcqyrqcs gfcenfgtcq
     4321 maadgsrqcr ctvyfegtrc evnkcsrclq gacvvnkqtg dvtcnctdgr vapscltcid
     4381 hcsnggsctm nskmmpecqc pphmtgprce eqvvsqqqpg hmtsilipll lllllllvag
     4441 vvfwykrrvr gakgfqhqrm tngamnveig nptykmyegg epddvgglld adfaldpdkp
     4501 tnftnpvyat lymgghgsrh slastdekre llgrgpedei gdpla
//
