LOCUS       NM_001107710            4609 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus leucine-rich repeats and immunoglobulin-like
            domains 2 (Lrig2), mRNA.
ACCESSION   NM_001107710 XM_001065921 XM_227547
VERSION     NM_001107710.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4609)
  AUTHORS   van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons
            AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers
            JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T and Pasterkamp
            RJ.
  TITLE     Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance
            Receptors by ADAM Proteases
  JOURNAL   Dev Cell 35 (5), 537-552 (2015)
   PUBMED   26651291
REFERENCE   2  (bases 1 to 4609)
  AUTHORS   Rondahl V, Holmlund C, Karlsson T, Wang B, Faraz M, Henriksson R
            and Hedman H.
  TITLE     Lrig2-deficient mice are protected against PDGFB-induced glioma
  JOURNAL   PLoS One 8 (9), e73635 (2013)
   PUBMED   24023893
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4609)
  AUTHORS   Del Rio T, Nishitani AM, Yu WM and Goodrich LV.
  TITLE     In vivo analysis of Lrig genes reveals redundant and independent
            functions in the inner ear
  JOURNAL   PLoS Genet 9 (9), e1003824 (2013)
   PUBMED   24086156
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474015.2.
            
            On or before Oct 28, 2007 this sequence version replaced
            XM_001065921.1, XM_227547.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4609
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4609
                     /gene="Lrig2"
                     /note="leucine-rich repeats and immunoglobulin-like
                     domains 2"
                     /db_xref="GeneID:310753"
                     /db_xref="RGD:1309554"
     exon            1..441
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..3370
                     /gene="Lrig2"
                     /note="leucine-rich repeats and immunoglobulin-like
                     domains protein 2"
                     /codon_start=1
                     /product="leucine-rich repeats and immunoglobulin-like
                     domains protein 2 precursor"
                     /protein_id="NP_001101180.1"
                     /db_xref="GeneID:310753"
                     /db_xref="RGD:1309554"
                     /translation="MAAAPRGVWEQRRLGCRLGPLAPLLMLAQALLLLPAAGAGLCPA
                     PCSCRLPLLDCSRRKLPALSWRALSGPLSPDISSLDLSHNRLSNWNISLESETLQEVK
                     MNYNELTEIPYFGEPTPNITQLSLVHNLIPEINAEAFQLYSALESLDLSSNIISEIKT
                     SSFPRMSLKYLNLSNNRITTLEAGCFDNLSGSLLVVKLNRNRISMIPPKVFKLPHLQF
                     LELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTG
                     VHKGWLYGLRMLQQLYVSQNAIEKISPDAWEFCQRLSALDLSYNQLTRLDESAFVGLS
                     LLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEVFSGLKSLTKLIL
                     QGNRIKSVTQKAFVGLESLEYLDLNNNAIMSIQENAFSQTHLKELVLNTSSLLCDCHL
                     KWLLQWLVDNNFHHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPENTVA
                     LRGVNVTLMCTAVSSSDSPMSTLWRKDSEILYDVDIENFVRYRQQDGEALEYTSVLRL
                     FSVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAA
                     EGHPTPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNIAGG
                     LSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTER
                     HFFAAANQLLIIVDAGLEDAGKYTCLMSNTLGTERGHIYLNVISSPNCDSSQNSIGHE
                     DDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKDEDYSITNTEELNLPADIPSYLS
                     SQGTLSEPQEGYSNSEAGSHQQLMPPASGYTHKGTDGGTGTRVICSDCYDNANIYSRT
                     REYCPYTYIAEEDALDQALSSLMVQMPKETFLSHPPQDAANLESLMPPTERELSAFPT
                     NHERTSENLPFSQRSSEIFQRPLWNMNRDLGLLPFPQQPVLESPQLAERDPNCSSPVS
                     CHRLHDHAFDFSRTRNIQDGTEGT"
     exon            442..507
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..582
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            583..717
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..861
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1005
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1149
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1293
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1374
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1446
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1515
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1679
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..2000
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2282
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2732
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2882
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3170
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..4609
                     /gene="Lrig2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggacgagcg gtgtctgtca gtgtttcagc tctacgcccc cgaccgccgc cccctccctt
       61 gtggtcacgt cgtttcctcc tctcgcctgc tctaagggac aggtgacggc cagggctctg
      121 ggtggcggtc cagcctccga gcatctctcc tcagccgact ctctgtgcta gctgctgtcc
      181 tcgagcgggt cccggccggg ggaagatggc ggccgcgccc cgcggcgtct gggagcagcg
      241 gcgcctgggc tgtaggttgg gaccccttgc accgctgctc atgcttgcgc aggcgctgct
      301 gctgctgccg gctgccggag ccggcctgtg cccagcgccc tgctcctgcc gccttccttt
      361 gctggactgc agtcgcagga agctgccggc gctcagctgg agggcactgt ccggcccgct
      421 gtcccctgac atctccagcc tggatttgag tcataaccgg ttgtctaact ggaacatcag
      481 cttggaatca gaaacattac aagaagtgaa aatgaattac aatgagctaa cagagatacc
      541 atattttgga gaaccaacac ctaatattac tcaactttca ttggtccata atttaattcc
      601 agaaataaat gcagaagcat tccagcttta ctctgctctt gagagtttag acctcagttc
      661 caatataata tcagaaatca agacatcttc atttcctcga atgtcactga aatacttgaa
      721 tttgagtaat aacaggataa ccaccttgga ggctggctgc ttcgacaact tgtcaggttc
      781 tttgttagtg gtaaagttga accggaaccg aattagcatg attccaccta aagtcttcaa
      841 gctgcctcat ctccagttct tggaactgaa aagaaaccgg attaaaattg tagaaggcct
      901 taccttccaa ggacttgatt ccttacgctc attgaaaatg cagcggaatg gaattagcaa
      961 actcaaagat ggagcgtttt ttggcttgaa taatatggaa gaattagagc tggagcataa
     1021 taacctcaca ggagtgcaca aggggtggct gtatggcttg cggatgttac agcagctgta
     1081 cgtgagccag aatgctattg aaaagatcag cccggatgcg tgggagttct gccagaggct
     1141 gtctgcactg gatttgtcct ataaccagct aacccgcctt gatgaatctg cctttgtggg
     1201 tctgagttta ctggagagat tgaatttagg ggacaataga gtcactcaca ttgctgatgg
     1261 tgtatttagg tttctttcca atcttcagac attagatttg agaaacaatg aaatttcatg
     1321 ggccatagaa gatgctagtg aagtcttttc aggtctcaaa agtctcacta aattaatctt
     1381 gcaaggaaac cggattaagt cagttacaca gaaagcgttc gttggccttg aatcccttga
     1441 gtatctagat ttgaataaca atgctataat gtctatccaa gaaaatgctt tttctcagac
     1501 tcacttaaag gaacttgttc tgaacacaag cagtttactc tgcgattgtc atttgaagtg
     1561 gttgctccag tggctggtgg ataacaactt ccatcattct gtgaatgtaa gctgtgcaca
     1621 tcctgaatgg ttagcagggc aaagcatctt gaatgtggac ctgaaagatt ttgtctgtga
     1681 tgattttctg aagcctcaga taaggacaca ccctgaaaac acagttgcat taagaggtgt
     1741 taatgtgaca ctgatgtgca ctgcagtgag cagcagtgat tcacccatgt ctaccttgtg
     1801 gcgcaaagac agtgagatcc tgtatgatgt ggatattgag aattttgttc gttatcggca
     1861 gcaggacgga gaagccctgg aatatacgag tgtcttgcgc ctcttcagcg tgaacttcac
     1921 agatgaaggg aaatatcagt gcatcgttac taatcacttt ggttctaatt actctcagaa
     1981 agccaaattg actgtaaatg agatgccatc ttttttgaaa actccaatgg atctaactat
     2041 tcgcactggt gccatggcga ggttggaatg tgctgcagag gggcacccta cacctcagat
     2101 ttcctggcag aaggacggtg gtactgattt ccctgcagcc cgagaaagac gcatgcatgt
     2161 tatgcccgag gacgatgtct tcttcattgc caatgtgaag atagaagata tgggaatcta
     2221 cagctgcatg gcacagaata tagcaggagg cctctcggca aacgcctccc tcacggtgtt
     2281 agagaccccg tcatttatta gacctctgga ggacaagact gttacccgag gtgagacggc
     2341 ggtattgcag tgcatcgctg gagggagtcc tgctcctcgc ctcaattgga ccaaagatga
     2401 tgggccactc ctagtaacag aacgacactt ctttgctgca gccaaccagc ttctcatcat
     2461 tgtagatgct ggtctagaag atgctggaaa atatacctgc cttatgtcta acactcttgg
     2521 cacagaacgg ggacatattt acttaaatgt catttcatcc cccaactgtg actcttctca
     2581 gaatagcatt gggcatgagg atgatggttg gaccacagtt ggcatcgtca tcattgttgt
     2641 ggtctgctgt gtcgtgggca cttctttgat ctgggtcatt gttatttacc acatgagaag
     2701 gaaagatgaa gattacagta tcacaaacac agaggagctt aatttgcctg cagacattcc
     2761 cagctatttg tcttcccaag gaacattgtc tgaaccgcag gaaggctaca gcaactctga
     2821 ggcaggcagt catcagcagc ttatgccccc tgccagcgga tacacacaca aaggcactga
     2881 cggtggcact ggtaccaggg tgatctgttc ggattgttat gacaatgcca acatctactc
     2941 gaggaccaga gagtactgtc catacaccta cattgctgag gaagatgctt tagatcaggc
     3001 actctccagc ctcatggtcc agatgcccaa ggagaccttc ttgtcacatc ctccccaaga
     3061 tgctgctaat ctggagagtc tgatgccacc aacagagaga gagttgtctg cctttcccac
     3121 caaccatgag aggacgagtg agaaccttcc cttctcacag aggagcagtg aaatattcca
     3181 gcggcctctg tggaacatga acagagatct gggcctactt cccttccctc agcagcctgt
     3241 ccttgagtca ccacagctgg cagagaggga tccaaactgt tcttcacctg tgtcttgcca
     3301 caggttacat gaccatgctt ttgattttag taggactcgg aacattcaag atggtactga
     3361 aggcacatga agcccatcca ggaggaagtc tgagcaaaga ctcaagctag ttaatttgct
     3421 acctcagaat ttagaagaaa agtcagcatt tgcatttctc tttgcttcga gttacatctg
     3481 accatgtcag agtagccctg atgtttgttt gggtttacac ctggcaaaga gaaggtagta
     3541 gctgacagaa gtgtaccaca gaagtgtgta ccacgttgaa agtacacagt cctggcagaa
     3601 gacgatatgg gcaggtgtcc ttcctgatcc ccatagggat gtacccaggg gctcactacc
     3661 tgtcatgaag agtcattgct gcttagccta ctggattgtt ccagtcctca gaatggtccc
     3721 aagaaagcgt ctctactttg gtaattctac tttgccttct aagcaaggag cagagatata
     3781 tatcttctga gctttcataa gtataacaag tggtgttgag cagagaagag cgactgaggc
     3841 tttgacattc aaggtcttca gctagaatcc caagtttcac caactggtag taccagatca
     3901 aagactttcg tattcttgtg ggttttgtgt gagttgtgtg tgtgtttgtg tgttgagggt
     3961 ttgttttgtc tataactggg gatatcattg taaatataca tgcatttata aataattttt
     4021 ctactcattg ttcttgtgtg ttggatacag tgtaaatatt tttgatatgc ccaaattata
     4081 tataatgtct gtctggttac tgtaggggca gcagcttctc aagatcacag attttacata
     4141 acttagtgta gtgaggtctg caaactctgt gtaaagttct aaaactgtgt gttaccaggt
     4201 gtatgtatag aggcagggca cttagtgact gtgctcatag actcagtctt gtataattaa
     4261 ctgcttgctc catgcctgaa gttctgtgca tctcgtactt gccatccctt tgtaagtgcc
     4321 aggtgacaat cttgttctag cataaacgtc ttgctcttcc agagcccagc agtattgtca
     4381 cagccctgtg agcatagaga tgacttattc tgggactgtc ttcttttagc aaaatacttg
     4441 gttgacaagg aaaccaaaga ttgtttcttt ttgtgtttac tctgtcttta atctcctcca
     4501 tgaatgtagc atattaggaa gggaagtgtg tcttgggagc agatcacaca gaagttcctg
     4561 tactccgtag atttagtgtg ggtctttctt tatacaagta ttgtttaag
//
