LOCUS       NP_001101180            1054 aa            linear   ROD 26-FEB-2024
DEFINITION  leucine-rich repeats and immunoglobulin-like domains protein 2
            precursor [Rattus norvegicus].
ACCESSION   NP_001101180 XP_001065921 XP_227547
VERSION     NP_001101180.1
DBSOURCE    REFSEQ: accession NM_001107710.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1054)
  AUTHORS   van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons
            AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers
            JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T and Pasterkamp
            RJ.
  TITLE     Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance
            Receptors by ADAM Proteases
  JOURNAL   Dev Cell 35 (5), 537-552 (2015)
   PUBMED   26651291
REFERENCE   2  (residues 1 to 1054)
  AUTHORS   Rondahl V, Holmlund C, Karlsson T, Wang B, Faraz M, Henriksson R
            and Hedman H.
  TITLE     Lrig2-deficient mice are protected against PDGFB-induced glioma
  JOURNAL   PLoS One 8 (9), e73635 (2013)
   PUBMED   24023893
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1054)
  AUTHORS   Del Rio T, Nishitani AM, Yu WM and Goodrich LV.
  TITLE     In vivo analysis of Lrig genes reveals redundant and independent
            functions in the inner ear
  JOURNAL   PLoS Genet 9 (9), e1003824 (2013)
   PUBMED   24086156
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474015.2.
            
            On or before Oct 28, 2007 this sequence version replaced
            XP_001065921.1, XP_227547.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1054
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     Protein         1..1054
                     /product="leucine-rich repeats and immunoglobulin-like
                     domains protein 2 precursor"
                     /note="leucine-rich repeats and immunoglobulin-like
                     domains protein 2"
                     /calculated_mol_wt=113806
     sig_peptide     1..38
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=3996
     Region          72..462
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          98..120
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          121..144
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          145..167
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          168..192
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          193..215
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          216..239
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          240..263
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          264..287
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          288..311
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          312..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..359
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..384
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          387..410
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          411..433
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          444..492
                     /region_name="LRRCT"
                     /note="Leucine rich repeat C-terminal domain; smart00082"
                     /db_xref="CDD:214507"
     Region          496..583
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          602..692
                     /region_name="IgI_LRIG1-like"
                     /note="Immunoglobulin (Ig)-like ectodomain of the LRIG1
                     (Leucine-rich Repeats And Immunoglobulin-like Domains
                     Protein 1) and similar proteins; member of the I-set of
                     IgSF domains; cd05763"
                     /db_xref="CDD:409420"
     Region          602..605
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409420"
     Region          609..613
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409420"
     Region          616..625
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409420"
     Region          631..636
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409420"
     Region          639..641
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409420"
     Region          649..653
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409420"
     Region          657..664
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409420"
     Region          670..678
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409420"
     Region          681..692
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409420"
     Region          695..782
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          712..716
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          725..729
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          748..752
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          762..767
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          775..778
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..1054
                     /gene="Lrig2"
                     /coded_by="NM_001107710.1:206..3370"
                     /db_xref="GeneID:310753"
                     /db_xref="RGD:1309554"
ORIGIN      
        1 maaaprgvwe qrrlgcrlgp lapllmlaqa llllpaagag lcpapcscrl plldcsrrkl
       61 palswralsg plspdissld lshnrlsnwn islesetlqe vkmnynelte ipyfgeptpn
      121 itqlslvhnl ipeinaeafq lysalesldl ssniiseikt ssfprmslky lnlsnnritt
      181 leagcfdnls gsllvvklnr nrismippkv fklphlqfle lkrnrikive gltfqgldsl
      241 rslkmqrngi sklkdgaffg lnnmeelele hnnltgvhkg wlyglrmlqq lyvsqnaiek
      301 ispdawefcq rlsaldlsyn qltrldesaf vglsllerln lgdnrvthia dgvfrflsnl
      361 qtldlrnnei swaiedasev fsglksltkl ilqgnriksv tqkafvgles leyldlnnna
      421 imsiqenafs qthlkelvln tssllcdchl kwllqwlvdn nfhhsvnvsc ahpewlagqs
      481 ilnvdlkdfv cddflkpqir thpentvalr gvnvtlmcta vsssdspmst lwrkdseily
      541 dvdienfvry rqqdgealey tsvlrlfsvn ftdegkyqci vtnhfgsnys qkakltvnem
      601 psflktpmdl tirtgamarl ecaaeghptp qiswqkdggt dfpaarerrm hvmpeddvff
      661 ianvkiedmg iyscmaqnia gglsanaslt vletpsfirp ledktvtrge tavlqciagg
      721 spaprlnwtk ddgpllvter hffaaanqll iivdagleda gkytclmsnt lgterghiyl
      781 nvisspncds sqnsighedd gwttvgivii vvvccvvgts liwviviyhm rrkdedysit
      841 nteelnlpad ipsylssqgt lsepqegysn seagshqqlm ppasgythkg tdggtgtrvi
      901 csdcydnani ysrtreycpy tyiaeedald qalsslmvqm pketflshpp qdaanleslm
      961 ppterelsaf ptnhertsen lpfsqrssei fqrplwnmnr dlgllpfpqq pvlespqlae
     1021 rdpncsspvs chrlhdhafd fsrtrniqdg tegt
//
