LOCUS       NM_001009717            1326 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus leucine-rich alpha-2-glycoprotein 1 (Lrg1), mRNA.
ACCESSION   NM_001009717 XM_346143
VERSION     NM_001009717.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1326)
  AUTHORS   Gu Z, Xie D, Huang C, Ding R, Zhang R, Li Q, Lin C and Qiu Y.
  TITLE     MicroRNA-497 elevation or LRG1 knockdown promotes osteoblast
            proliferation and collagen synthesis in osteoporosis via
            TGF-beta1/Smads signalling pathway
  JOURNAL   J Cell Mol Med 24 (21), 12619-12632 (2020)
   PUBMED   32975015
  REMARK    GeneRIF: MicroRNA-497 elevation or LRG1 knockdown promotes
            osteoblast proliferation and collagen synthesis in osteoporosis via
            TGF-beta1/Smads signalling pathway.
REFERENCE   2  (bases 1 to 1326)
  AUTHORS   Cartier J, Piyasena C, Sparrow SA, Boardman JP and Drake AJ.
  TITLE     Alterations in glucose concentrations affect DNA methylation at
            Lrg1 in an ex vivo rat cortical slice model of preterm brain injury
  JOURNAL   Eur J Neurosci 47 (5), 380-387 (2018)
   PUBMED   29356143
  REMARK    GeneRIF: Culture of slices in lower glucose concentration was
            associated with lower Lrg1 methylation
            Erratum:[Eur J Neurosci. 2019 Aug;50(4):2750. PMID: 31512324]
REFERENCE   3  (bases 1 to 1326)
  AUTHORS   Meng H, Song Y, Zhu J, Liu Q, Lu P, Ye N, Zhang Z, Pang Y, Qi J and
            Wu H.
  TITLE     LRG1 promotes angiogenesis through upregulating the TGF-beta1
            pathway in ischemic rat brain
  JOURNAL   Mol Med Rep 14 (6), 5535-5543 (2016)
   PUBMED   27840991
  REMARK    GeneRIF: LRG1 may promote angiogenesis through upregulating the
            TGFbeta1 signaling pathway in ischemic rat brain following MCAO.
REFERENCE   4  (bases 1 to 1326)
  AUTHORS   Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X,
            Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins
            MT, Misra S, Stoughton J and Mayr M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 1326)
  AUTHORS   Wang X, Abraham S, McKenzie JAG, Jeffs N, Swire M, Tripathi VB,
            Luhmann UFO, Lange CAK, Zhai Z, Arthur HM, Bainbridge J, Moss SE
            and Greenwood J.
  TITLE     LRG1 promotes angiogenesis by modulating endothelial TGF-beta
            signalling
  JOURNAL   Nature 499 (7458), 306-311 (2013)
   PUBMED   23868260
REFERENCE   6  (bases 1 to 1326)
  AUTHORS   Archambaud C, Nahori MA, Soubigou G, Becavin C, Laval L, Lechat P,
            Smokvina T, Langella P, Lecuit M and Cossart P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   7  (bases 1 to 1326)
  AUTHORS   Vranka JA, Pokidysheva E, Hayashi L, Zientek K, Mizuno K, Ishikawa
            Y, Maddox K, Tufa S, Keene DR, Klein R and Bachinger HP.
  TITLE     Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar
            collagen-rich tissues such as tendons, skin, and bones
  JOURNAL   J Biol Chem 285 (22), 17253-17262 (2010)
   PUBMED   20363744
  REMARK    Erratum:[J Biol Chem. 2010 Jun 25;285(26):20421]
REFERENCE   8  (bases 1 to 1326)
  AUTHORS   Wu Y and Smas CM.
  TITLE     Wdnm1-like, a new adipokine with a role in MMP-2 activation
  JOURNAL   Am J Physiol Endocrinol Metab 295 (1), E205-E215 (2008)
   PUBMED   18492766
REFERENCE   9  (bases 1 to 1326)
  AUTHORS   Palmer DJ, Kelly VC, Smit AM, Kuy S, Knight CG and Cooper GJ.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   10 (bases 1 to 1326)
  AUTHORS   O'Donnell LC, Druhan LJ and Avalos BR.
  TITLE     Molecular characterization and expression analysis of leucine-rich
            alpha2-glycoprotein, a novel marker of granulocytic differentiation
  JOURNAL   J Leukoc Biol 72 (3), 478-485 (2002)
   PUBMED   12223515
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088434.1.
            
            On Jan 13, 2005 this sequence version replaced XM_346143.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088434.1, FQ220477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1326
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..1326
                     /gene="Lrg1"
                     /note="leucine-rich alpha-2-glycoprotein 1"
                     /db_xref="GeneID:367455"
                     /db_xref="RGD:1359464"
     exon            1..35
                     /gene="Lrg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1008
                     /gene="Lrg1"
                     /codon_start=1
                     /product="leucine-rich alpha-2-glycoprotein precursor"
                     /protein_id="NP_001009717.1"
                     /db_xref="GeneID:367455"
                     /db_xref="RGD:1359464"
                     /translation="MASWQHQGRTLFLLALLGGVSGLRECLILQSVKGSTVSCHGPTE
                     FPSSLPADTVHLSVEFSSLTQLPAAALQGCPGLQELHLSSNRLQELSPGLLAPVPRLR
                     VLDLTRNALRSLPPGLFRSSAALNTLVLRENQLQEASARWLQGLDALGYLDLAENRLR
                     SLPARLLANLGALHTLDLGHNLLESLPEGFLRGPRRLQRLHLEGNRLQRLEAGLLAPQ
                     PFLGVLFLNDNQLTAVAADSFRGLKQLDMLDLSNNSLSSTPPGLWAFLGRPTRDMQDG
                     FDVSHNPWVCDKDLVDLCRWLAANRHKMFSQNDTLCAGPEAVRGQRLLDVAELGTL"
     exon            36..1298
                     /gene="Lrg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcagcca tggcctcttg gcagcatcaa gggagaaccc tgttcctcct ggccctcttg
       61 ggcggggtgt cgggcctcag ggaatgcttg atactgcagt cggttaaggg aagcacggtc
      121 tcctgccacg gtcccactga gttcccgagc tccctcccgg ccgacactgt ccatctgtcg
      181 gtggaattct ccagcctgac tcagctgccc gccgccgccc tgcaagggtg tcccggtctg
      241 caggaactgc acctctccag caaccgcctg caggaactgt cccccgggct gctggcgccc
      301 gtgccccggc tgcgcgtcct ggatctgact cgcaatgctc tccgcagcct gccccccggt
      361 ttgttccgca gctcggccgc cctgaacacc ctggtcctga gggagaacca gctgcaggag
      421 gcgagcgcgc gctggctgca gggcctggac gccctgggct acttggacct ggcggagaac
      481 cggctgcgct cgctgcccgc taggctcctt gccaacctag gcgccctgca caccctcgac
      541 cttgggcaca acctgcttga gtcgctgccc gagggattcc tgaggggccc caggcggcta
      601 cagcgcctgc acctggaagg gaaccggctg caaaggctgg aggctggctt acttgcgccc
      661 cagccgttcc tgggcgtcct gttcctgaat gacaaccagc taaccgcagt ggcggccgac
      721 tcctttcggg gcctaaagca gctggatatg ttggatctgt ccaataactc tctgtccagc
      781 actcccccgg gtctgtgggc gttcctgggg agaccgaccc gcgatatgca ggatggtttc
      841 gatgtctccc acaacccctg ggtctgtgac aaggacctcg tggacctgtg ccgctggctg
      901 gccgccaacc gacataagat gttctcgcag aacgacacac tctgtgcggg gcccgaggcc
      961 gtgaggggac agcgactgct ggacgtggca gagctgggga ccttgtgagg atggcaactg
     1021 gggtgcgagc caagggtacc ccgcttgcca ctgaagcaat ttggtcccat gtcagaatgc
     1081 agattcccag catctgccat tccccattcc ctcagccagg aatgctattc cctgactctc
     1141 cctcaggctc ctctccattt gccccaactc ttccacctct cactgttcct gtgctggccc
     1201 ccaggctacc atgtgtttat ctagctttgc ctcatatgtt tcagggtcac caaagcagtt
     1261 aataaaacag ctcccggctg gctgagccgc tcagcgtcaa aaaaaaaaaa aaaaaaaaaa
     1321 aaaaaa
//
