LOCUS       NM_001109508            2368 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus leucine rich repeat and fibronectin type III
            domain containing 4 (Lrfn4), mRNA.
ACCESSION   NM_001109508 XM_001070693 XM_001070734
VERSION     NM_001109508.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2368)
  AUTHORS   Gu,Y.H., Wang,J., Lu,W.C., Cheng,Y., Tao,R., Zhang,S.J., Xu,T.,
            Zhai,K.W., Luo,S.X. and Xin,W.J.
  TITLE     POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by
            Hypermethylation-Mediated LRFN4 Downregulation Following
            Oxaliplatin Treatment
  JOURNAL   Neurochem Res 48 (12), 3652-3664 (2023)
   PUBMED   37592110
  REMARK    GeneRIF: POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by
            Hypermethylation-Mediated LRFN4 Downregulation Following
            Oxaliplatin Treatment.
REFERENCE   2  (bases 1 to 2368)
  AUTHORS   Li,J., Chen,L., Wang,N., Jiang,G., Wu,Y. and Zhang,Y.
  TITLE     Effect of synaptic adhesion-like molecule 3 on epileptic seizures:
            Evidence from animal models
  JOURNAL   Epilepsy Behav 69, 18-23 (2017)
   PUBMED   28222338
  REMARK    GeneRIF: SALM3 was expressed at significantly higher levels in the
            brains of epileptic rats compared to controls.
REFERENCE   3  (bases 1 to 2368)
  AUTHORS   Mah,W., Ko,J., Nam,J., Han,K., Chung,W.S. and Kim,E.
  TITLE     Selected SALM (synaptic adhesion-like molecule) family proteins
            regulate synapse formation
  JOURNAL   J Neurosci 30 (16), 5559-5568 (2010)
   PUBMED   20410109
REFERENCE   4  (bases 1 to 2368)
  AUTHORS   Morimura,N., Inoue,T., Katayama,K. and Aruga,J.
  TITLE     Comparative analysis of structure, expression and PSD95-binding
            capacity of Lrfn, a novel family of neuronal transmembrane proteins
  JOURNAL   Gene 380 (2), 72-83 (2006)
   PUBMED   16828986
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001070693.1, XM_001070734.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2368
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2368
                     /gene="Lrfn4"
                     /note="leucine rich repeat and fibronectin type III domain
                     containing 4"
                     /db_xref="GeneID:688721"
                     /db_xref="RGD:1585286"
     exon            1..160
                     /gene="Lrfn4"
                     /inference="alignment:Splign:2.1.0"
     exon            161..1519
                     /gene="Lrfn4"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..2081
                     /gene="Lrfn4"
                     /note="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 4"
                     /codon_start=1
                     /product="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 4 precursor"
                     /protein_id="NP_001102978.1"
                     /db_xref="GeneID:688721"
                     /db_xref="RGD:1585286"
                     /translation="MAPPLLLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPP
                     NVDRRTVELRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARSFGDLESLRSLH
                     LDGNRLVELGSSSLRGPVNLQHLILSGNQLGRIAPGAFDDFLDSLEDLDVSYNNLRQV
                     PWAGIGSMPALHTLNLDHNLIDALPPGVFAQLSQLSRLDLTSNRLATLAPDPLFSRGR
                     DAEASPSPLVLSFSGNPLHCNCELLWLRRLARPDDLETCASPPTLAGRYFWAVPEGEF
                     SCEPPLIARHTQRLWVLEGQRATLRCRALGDPVPTMHWVGPDDRLVGNSSRAWAFPNG
                     TLEIGVTGAGDAGAYTCIATNPAGEATARVELRVLALPHGGNTSAEGGRPGPSDIAAS
                     ARTAAEGEGTLESEPAVQVTEVTATSGLVSWGPGRPADPVWMFQIQYNSSEDETLIYR
                     IVPASSQHFLLKHLVPGADYDLCLLALSPAAGPSDLTATRLLGCAHFSTLPATPLCHA
                     LQAHVLGGTLTVAVGGVLVAALLVFTVALLVRGRGAGNGRLPLKLSHVQSQTNGGTSP
                     MPKSHPPRSPPPRPQRSCSLDLGDTGGCYGYARRLGGAWARRSHSVHGGLLGAGCRGM
                     GGSAERLEESVV"
     exon            1520..2368
                     /gene="Lrfn4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccgagag agccggggcc gagggcccga gcgccatggg ccggagggcg cgcggctggc
       61 gggcccggcc tcgctcccgc gagagagcgg cctggagtcg gcagaggccg gctgggtccg
      121 cggggaggcc agcccgagcc ccctgagcga cggacaccag ggcactcacc atggccccgc
      181 cgctcctatt gctgttgctg gccagtggag ccgctgcttg cccgctgccc tgtgtgtgcc
      241 agaacctgtc ggagtcgctc agcacccttt gtgcccaccg aggcctgctg tttgtgccac
      301 ccaacgtgga caggcgcaca gttgaactgc gcctggctga caacttcatc caggccctgg
      361 gaccacctga cttccgcaac atgacagggc tggtggacct aacattgtct cgaaatgcca
      421 tcacccgcat cggggcccgc tcctttgggg acctggagag cctgcgctcc ttgcacctgg
      481 atggcaacag gctggtggaa ctgggcagca gcagcctacg ggggcctgtc aacctccagc
      541 acctcattct tagtggcaat cagctgggcc gaatcgctcc tggggccttc gacgacttcc
      601 ttgacagtct cgaggacctg gatgtgtcct ataacaatct ccggcaggtt ccctgggctg
      661 gcataggctc catgcctgcc ctgcataccc ttaacctgga ccataacctc attgatgcgc
      721 tgcccccagg tgtttttgcc cagcttagcc agctctcccg cctggacctg acctccaacc
      781 gcctggccac cctggcacct gatccactct tctctcgggg tcgggatgct gaggcctcac
      841 cttcccctct ggtgctgagt ttcagcggga acccactgca ctgcaactgt gagctgctgt
      901 ggctgcggag gctggcccgg cctgatgacc tggaaacctg cgcttctcca ccaaccctgg
      961 caggccgcta cttctgggca gtgcctgagg gagagttctc ctgtgagcct ccactgattg
     1021 cccgacacac acagcgcctg tgggtgctag aaggtcagcg ggccactcta cggtgcaggg
     1081 ctcttggtga ccctgtacct accatgcact gggttggtcc tgatgacagg ctggttggca
     1141 actcttctcg agcctgggct ttccccaacg ggaccctaga gattggggtg acaggcgctg
     1201 gagatgcagg agcctatacc tgcattgcta ccaaccctgc cggtgaggcc acagcccgag
     1261 tggagctccg ggtactggcc ttgccccatg gtgggaacac cagtgctgag gggggccgtc
     1321 ctgggccctc ggacattgct gcctctgcta gaactgctgc tgaaggcgag ggaactttag
     1381 aatctgaacc agccgtgcaa gtgacagagg tgactgccac ctctggactg gtgagctggg
     1441 gcccagggcg gccagctgac ccagtgtgga tgttccaaat ccagtacaac agcagcgagg
     1501 atgagaccct catctaccgg attgtaccag cctccagcca acacttcctg ctgaagcacc
     1561 tggttcctgg tgctgactac gacctctgcc tgctggccct gtcacctgct gctgggccct
     1621 ccgacctcac ggccactaga ctgctgggct gtgcccactt ctctacccta ccagccaccc
     1681 ccctgtgcca tgccctacag gcccatgtgc tgggcgggac cctgactgtg gcagtgggag
     1741 gcgtcctagt ggctgcctta ctggtcttca ctgtggcctt gctggttcgg ggccggggag
     1801 ctgggaatgg ccgcctccca ctcaaactca gccatgtcca atcccagacc aatggtggca
     1861 ctagccccat gcccaagagc cacccaccac ggagccctcc accccgtccc cagcgcagct
     1921 gctccctgga cctaggagac accggtggat gctacgggta tgccaggcgc ctgggaggag
     1981 cctgggcccg gcggagccac tctgtacatg gggggctgct gggagctggg tgtcggggta
     2041 tggggggcag tgcggagcgg ctggaggaga gcgtggtgtg aaaaaaaggg cagcctcttg
     2101 ccctgaggaa ggagcagtgc cactgttggg cccaggtggc agcacccagc ctgggtgggc
     2161 agcacggccc tgggtcccac tctgcttttt atcctcagta cctcaggccc ccatgtactt
     2221 ggtgggacag caaacccttt ccttggtttt ggcctccaga ctaaagggac aggtcccacc
     2281 aacaggtgct cagagccacc aaggcagggg ctgcagccac caagagggag tcttgtttct
     2341 atttataata aaattgttgg ggacaatt
//
