LOCUS       NM_001039699            2716 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus leucine rich repeat and fibronectin type III
            domain containing 2 (Lrfn2), mRNA.
ACCESSION   NM_001039699 XM_001062966 XM_236914
VERSION     NM_001039699.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2716)
  AUTHORS   Morimura,N., Yasuda,H., Yamaguchi,K., Katayama,K.I., Hatayama,M.,
            Tomioka,N.H., Odagawa,M., Kamiya,A., Iwayama,Y., Maekawa,M.,
            Nakamura,K., Matsuzaki,H., Tsujii,M., Yamada,K., Yoshikawa,T. and
            Aruga,J.
  TITLE     Autism-like behaviours and enhanced memory formation and synaptic
            plasticity in Lrfn2/SALM1-deficient mice
  JOURNAL   Nat Commun 8, 15800 (2017)
   PUBMED   28604739
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2716)
  AUTHORS   Wang,P.Y., Seabold,G.K. and Wenthold,R.J.
  TITLE     Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth
  JOURNAL   Mol Cell Neurosci 39 (1), 83-94 (2008)
   PUBMED   18585462
  REMARK    GeneRIF: Data show that the C-terminal PDZ binding domains of
            synaptic adhesion-like molecules (SALMs)1-3 are required for
            neurite outgrowth, and that the N-termini of SALMs 2 and 4 are
            alsoinvolved in neurite outgrowth.
REFERENCE   3  (bases 1 to 2716)
  AUTHORS   Morimura,N., Inoue,T., Katayama,K. and Aruga,J.
  TITLE     Comparative analysis of structure, expression and PSD95-binding
            capacity of Lrfn, a novel family of neuronal transmembrane proteins
  JOURNAL   Gene 380 (2), 72-83 (2006)
   PUBMED   16828986
REFERENCE   4  (bases 1 to 2716)
  AUTHORS   Wang,C.Y., Chang,K., Petralia,R.S., Wang,Y.X., Seabold,G.K. and
            Wenthold,R.J.
  TITLE     A novel family of adhesion-like molecules that interacts with the
            NMDA receptor
  JOURNAL   J Neurosci 26 (8), 2174-2183 (2006)
   PUBMED   16495444
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1 and BE101923.1.
            
            On or before Dec 7, 2007 this sequence version replaced
            XM_001062966.1, XM_236914.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ070869.1, SRR26360194.677586.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1400              JAXUCZ010000009.1  19425460-19426859   c
            1401-2367           JAXUCZ010000009.1  19395477-19396443   c
            2368-2716           BE101923.1         1-349               c
FEATURES             Location/Qualifiers
     source          1..2716
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..2716
                     /gene="Lrfn2"
                     /gene_synonym="Salm1"
                     /note="leucine rich repeat and fibronectin type III domain
                     containing 2"
                     /db_xref="GeneID:316205"
                     /db_xref="RGD:1311831"
     CDS             1..2367
                     /gene="Lrfn2"
                     /gene_synonym="Salm1"
                     /note="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 2; synaptic adhesion-like
                     molecule 1"
                     /codon_start=1
                     /product="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 2 precursor"
                     /protein_id="NP_001034788.1"
                     /db_xref="GeneID:316205"
                     /db_xref="RGD:1311831"
                     /translation="METLLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLL
                     FVPPDIDRRTVELRLGGNFIIHIGRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESL
                     RSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADDAFEDFLLTLEDLDLSYNN
                     LHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIF
                     ARSQASLLTATPFAPPLSFSFGGNPLHCNCELLWLRRLERDDDLETCGSPGGLKGRYF
                     WHIREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSS
                     RTAVYDNGTLDILITTSQDSGPFTCIAANAAGEATATVEVSIVQLPHLSNSTSRMAPP
                     KSRLSDITGSSKTSRGGGGSGAGEPPKSTPERAVLVSDVTTTSALVKWSVSKSAPRVK
                     MYQLQYNCSDDEVLIYRMIPASNKAFVVNNLVSGTGYDLCVLAMWDDTATTLTATNIV
                     GCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIVATLLVFIVILMVRYKVCNHDAPG
                     KMAAATVSNVYSQTNGAQPPPLGGMPVGQLPQAPPKVVVRNELMDFSTSLARACDSSS
                     SSSLGSGEAAGLSRGPWRLPPPAPRPKPSLDRLMGAFASLDLKSQRKEELLDSRTPAG
                     RGAGTSARGHHSDREPLLGPPATRARSLLPLPLEGKAKRSHSFDMGDFAAAAAAAPGG
                     YSPPRRVSNIWTKRSLSVNGMLLPFEENDLVGARGTFGSSEWVMESTV"
     exon            1..1400
                     /gene="Lrfn2"
                     /gene_synonym="Salm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..2700
                     /gene="Lrfn2"
                     /gene_synonym="Salm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagactc tgcttggcgg gctgctggct tttggcatgg cgtttgctgt ggtcgatgcc
       61 tgccccaagt actgcgtctg ccagaatctg tctgagtcac tggggaccct gtgtccttcc
      121 aaggggctcc tcttcgtgcc ccctgacatt gaccggagga cagtggagct gcgtctgggt
      181 ggcaacttca tcatccacat tggccgccaa gactttgcca acatgacagg gctagtggat
      241 ctgaccttgt ctaggaacac catcagccac atccagccct tctccttcct ggaccttgag
      301 agcctccgtt ccctgcacct tgacagcaac cggctaccta gccttgggga ggacacactc
      361 cggggcctag tcaacctgca gcaccttatt gtgaacaata atcagctggg tggcattgct
      421 gatgatgcct ttgaagactt cctgttgact ttagaagatt tggacctatc ttacaacaac
      481 ctccacggtc ttccctggga ttctgtaagg cgcatggtca acctccatca gctgagtctc
      541 gaccacaact tgctggacca catcgctgag ggtaccttcg cagacctgca gaaactggcc
      601 cgcctggacc tcacgtccaa tcggctgcag aagcttcccc cagaccccat ctttgcccgc
      661 tcccaggcct ccttgctcac tgccacaccc tttgccccac ccctgtcctt tagttttgga
      721 gggaacccac tgcactgcaa ttgtgagctt ctctggctgc gaaggctgga gagggatgac
      781 gacctggaga cctgtggatc ccctggaggt ctcaagggtc gctatttttg gcatattcgc
      841 gaggaggagt ttgtgtgtga gccgcccctc atcacccagc acacacacaa gctgctggtt
      901 ctggagggcc aggcagccac tcttaagtgc aaggccattg gggaccccag ccctttgatc
      961 cactgggttg cccccgatga ccgcttggta ggaaactctt ccaggactgc cgtatatgac
     1021 aacggcactc tggacattct aattaccacc tctcaggaca gcggcccctt cacctgcatt
     1081 gcagccaacg cggcaggaga ggctaccgcc accgtagagg tctctatcgt gcagctccca
     1141 cacctcagta acagcactag ccggatggcg ccgcccaagt ctcgcctctc agacatcacg
     1201 ggttccagca agaccagtcg gggaggggga ggtagcgggg ctggggagcc tcccaaaagc
     1261 accccagaga gggctgtgct tgtgtctgat gtgaccacca catctgccct ggtcaagtgg
     1321 tctgtcagca agtcggcacc cagggtgaag atgtatcagc tgcagtacaa ctgctccgac
     1381 gacgaggtac tgatttacag gatgatccca gcctccaaca aggccttcgt ggtcaacaac
     1441 ctggtgtccg gaacgggcta cgacttgtgc gtactggcta tgtgggacga cacagccaca
     1501 acgctcacgg ccaccaacat tgtgggctgc gcccagttct tcaccaaggc tgactaccca
     1561 caatgccagt ctatgcacag ccagatcctg gggggcacta tgattctggt catcggaggt
     1621 atcattgtgg ccacactgct ggtcttcatc gtaatcctca tggtgcggta caaggtctgc
     1681 aaccacgacg ccccaggcaa aatggcagcc gccactgtca gcaatgtata ctcgcagacc
     1741 aatggagctc agcctccacc tctgggtggg atgcctgttg gccagcttcc tcaggcacca
     1801 cccaaggtcg tggtgcggaa tgagttgatg gacttcagta ccagcctggc aagagcctgt
     1861 gactcttctt cctccagttc cctgggcagt ggggaagctg cagggctgag ccggggtccc
     1921 tggaggctcc cacccccagc tcctcgtccc aagcccagcc ttgaccgctt gatgggagct
     1981 tttgcctccc tggacctcaa gagtcaaagg aaagaagaac ttttagactc taggactcca
     2041 gcaggcagag gggcagggac atcagccagg ggccaccact cagaccgaga gccactgctg
     2101 gggcccccag ccacccgtgc caggagcctt ctccctttgc ccctggaggg caaggccaaa
     2161 cgaagccact cttttgacat gggggacttt gcagctgcag ctgcagctgc tcctggtggc
     2221 tacagtcccc ctaggcgggt ctcaaacatc tggacgaagc gcagcctgtc tgtcaatggc
     2281 atgctcttgc cctttgagga gaatgacctg gtgggagctc gggggacatt tggcagctca
     2341 gagtgggtaa tggagagtac tgtgtagcca gggaaggagt accgtccctc ccgcccttcc
     2401 tcaaagtggg agaggaagga gtcagagtca gcactggcaa gtatttgtgg agtttccatg
     2461 gtgatgttta catccaggga cagtcttgtc tccctgtcaa cagcctcatg tccttctgcc
     2521 cagctacacc cccttcccta tgtcaccttc ccaggcctgt ccccaccacc cagcggggtg
     2581 tgctcaggga atgggactcg ctcatgtgtc agactgagcc ctgagtgttt ggaaaggcta
     2641 acaactgcct ttctattcac aaatgtagcg acaagcaagc ggcttcggat tgcttgtgga
     2701 aaaaaaaaaa aaaaaa
//
