LOCUS       NM_001371837            5464 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus leucine rich repeats and calponin homology domain
            containing 3 (Lrch3), transcript variant 1, mRNA.
ACCESSION   NM_001371837 XM_003751063 XM_039088327
VERSION     NM_001371837.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5464)
  AUTHORS   O'Loughlin,T., Masters,T.A. and Buss,F.
  TITLE     The MYO6 interactome reveals adaptor complexes coordinating early
            endosome and cytoskeletal dynamics
  JOURNAL   EMBO Rep 19 (4) (2018)
   PUBMED   29467281
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On or before Jul 2, 2021 this sequence version replaced
            XM_039088327.1, NM_001371837.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.37760.1,
                                           SRR26360181.2711271.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               JAXUCZ010000011.1  81377044-81377337   c
            295-439             JAXUCZ010000011.1  81343370-81343514   c
            440-566             JAXUCZ010000011.1  81341696-81341822   c
            567-672             JAXUCZ010000011.1  81338642-81338747   c
            673-809             JAXUCZ010000011.1  81327920-81328056   c
            810-919             JAXUCZ010000011.1  81325659-81325768   c
            920-1013            JAXUCZ010000011.1  81316456-81316549   c
            1014-1134           JAXUCZ010000011.1  81314835-81314955   c
            1135-1283           JAXUCZ010000011.1  81312558-81312706   c
            1284-1360           JAXUCZ010000011.1  81310132-81310208   c
            1361-1412           JAXUCZ010000011.1  81307522-81307573   c
            1413-1562           JAXUCZ010000011.1  81306837-81306986   c
            1563-1613           JAXUCZ010000011.1  81304973-81305023   c
            1614-1667           JAXUCZ010000011.1  81303192-81303245   c
            1668-1739           JAXUCZ010000011.1  81299740-81299811   c
            1740-1788           JAXUCZ010000011.1  81298629-81298677   c
            1789-1896           JAXUCZ010000011.1  81297710-81297817   c
            1897-2000           JAXUCZ010000011.1  81296100-81296203   c
            2001-2138           JAXUCZ010000011.1  81294919-81295056   c
            2139-2216           JAXUCZ010000011.1  81287661-81287738   c
            2217-5464           JAXUCZ010000011.1  81277581-81280828   c
FEATURES             Location/Qualifiers
     source          1..5464
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..5464
                     /gene="Lrch3"
                     /note="leucine rich repeats and calponin homology domain
                     containing 3"
                     /db_xref="GeneID:303883"
                     /db_xref="RGD:1306200"
     exon            1..294
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..2354
                     /gene="Lrch3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat and calponin homology
                     domain-containing protein 3; leucine-rich repeats and
                     calponin homology (CH) domain containing 3; DISP complex
                     protein LRCH3"
                     /codon_start=1
                     /product="DISP complex protein LRCH3 isoform 1"
                     /protein_id="NP_001358766.2"
                     /db_xref="GeneID:303883"
                     /db_xref="RGD:1306200"
                     /translation="MAAAGLVAVVAAAEYSGPVGSGGNLSGANCGPSPGLGPGSWSRS
                     VDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPMETCHFVS
                     LESLNLYQNCIRYIPEAVLNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVS
                     LPEEIGQLRHLTELDVSCNEIQTVPSQIGNLEALRDFNVRRNHLLRLPEELAEVPLIR
                     LDFSCNKITVIPVCYRNLRHLQVITLDNNPLQSPPAQICIKGKIHIFKYLNIQACKIA
                     PDLPDYERRPLGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLR
                     VAEITKEQRLRRESQYQENRSSVVVTNGGVDHDLDQIDYIDSCTTEEEENDVKRPKSL
                     DTSSLSSQFLAYIEQRRISHEGSPVKPIAVRDFQKTEDMKRYSHQNRVPVEPSLVLSV
                     PPSHNQLSHSDLELHQRGEQSVERARREAQLAALQYEGEKIRTKQIQRDAGLDFVKHK
                     VSQNPQKQQPPGNGECPFPSRRSQHTDDSALLVSLSGLDGVSCVATRPHSSAFTPLKS
                     NDRVDVTSSFPMTDTARHSPAYSFPAATQRNQPQRPESFLFRATVRAEASKGRASPLL
                     SSAPATDAADSIARQREEELRLIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANH
                     VRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLDACRKIGVPQEQLCLPLHILEEKGLG
                     QVAVTVQALLELAPPKQQPQQQPPQLSAV"
     exon            295..439
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            440..566
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            567..672
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            673..809
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            810..919
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1013
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1134
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1283
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1360
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1412
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1562
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1613
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1667
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1739
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1788
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1896
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2000
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2138
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2216
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..5464
                     /gene="Lrch3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcgcatg cgcagagccg ggccggagag ttgtcggctg ggaaatggcg gccgcgggct
       61 tggtggctgt ggtagcggct gcggagtact ctggcccagt ggggtccggg ggaaacctct
      121 ccggtgctaa ctgtggaccg agccctgggt tgggcccggg ttcttggagc cgctcggtcg
      181 accgagccct ggaagaggcg gcggtcactg gggtgctgag cttgagcggc cggaaactga
      241 gggagtttcc ccggggagcg gccaaccacg acctgacgga caccacccgg gccgacctgt
      301 cacgaaatcg cctctctgaa attcctatgg aaacgtgcca ctttgtttct ctggaaagtc
      361 ttaacctgta ccagaattgt attcggtata tcccagaggc tgttctaaac ttacaagctc
      421 tgacattcct taatattagt cggaaccagc tgtcaacatt gccagtccac ttgtgtaact
      481 taccactgaa ggtcttaatc gctagcaata acaaattggt ctcccttcct gaagaaattg
      541 gacagctcag acatctgacg gaacttgatg tgagctgcaa tgaaattcaa actgtacctt
      601 cccaaattgg taatctggaa gccttgagag actttaatgt cagaagaaat catctcctac
      661 gcttgcctga agagctggca gaggtgcctt tgatacgact agacttctcg tgcaataaaa
      721 tcacagtaat ccctgtctgt taccggaacc tccggcacct ccaagtgatc accttggaca
      781 acaacccact ccagtcgcct cctgcacaga tatgcataaa aggcaaaatc cacatattta
      841 aatacctgaa catacaagct tgtaagattg ctccagatct gccagattat gaacggagac
      901 ccttgggatt tggctcctgc catgaagaac tgtactcagg ccgtccttac ggagcccttg
      961 attcaggctt caatagtgtg gatagtggtg acaagaggtg gtcagggaat gagcctacag
     1021 acgaattttc ggatctgcct cttcgagtgg cagagattac taaagagcaa agactgcgga
     1081 gagaaagcca gtaccaggag aatcgcagca gtgtggtcgt cacgaatggt ggagtggatc
     1141 atgatctgga tcagattgac tacattgaca gctgcactac ggaagaagaa gaaaacgatg
     1201 tgaaacggcc caaaagcctg gacacgagca gtctcagctc acagttccta gcgtacattg
     1261 aacagcggag aatctcgcat gagggttcac cagtaaagcc aatagccgtt agagattttc
     1321 aaaaaacaga agacatgaaa agatactcac atcaaaacag ggttccagtt gagccatcat
     1381 tggtgttatc agtgccacca agtcacaatc agctttcaca ttcagacttg gagcttcatc
     1441 agaggggaga gcagtctgtt gagcgcgctc ggagagaggc acagcttgct gccctgcagt
     1501 atgaggggga gaaaattagg accaagcaga ttcagagaga tgctggccta gactttgtca
     1561 aacacaaagt atcacaaaat ccacagaaac agcagccccc tggaaatggt gagtgtccct
     1621 tcccatccag aaggtctcag cacactgatg atagtgcctt gttagtgtcc ctatcgggct
     1681 tggatggagt gagctgtgtg gctacccggc ctcattcttc tgccttcaca cctcttaaga
     1741 gcaatgacag agttgatgtc acctcaagct tccctatgac agacacagcc cggcattccc
     1801 ctgcatactc ttttcctgct gctacccaga gaaaccaacc ccagcgccct gaaagcttcc
     1861 ttttccgagc cactgtcagg gcagaagcta gtaaaggtcg cgcatcccca cttctgtcct
     1921 ctgcacctgc aactgatgct gcagactcca tagcaagaca gcgggaagaa gagctgagat
     1981 taatagatca actgcggaaa cacattgaat accggttgaa agtctctttg ccctgtgatc
     2041 ttggagcagc actaactgac ggcgttgtac tttgccactt ggccaatcat gttcgtcctc
     2101 gatctgtccc aagcattcat gtcccatctc cagccgtgcc taaattaaca atggcaaagt
     2161 gcaggcggaa tgtggagaac ttcctggatg cttgcagaaa gattggtgta ccccaggagc
     2221 aattatgttt gcctctgcac attttagaag agaaagggtt gggccaggtt gcagtgacag
     2281 tccaggccct cctggaactt gccccaccca agcagcagcc gcagcagcag ccaccacagc
     2341 tctctgctgt ctgaggtctc cccgggccct gcatgttggc acagcaggac aaggagcagg
     2401 aggacttgat cactggtgct gcctgctcag agtgagccct gcgtgttcct agaagcactg
     2461 tctcatgatt cctgctggga atattgtgtt ccatttctcc attttagggg agattaaacc
     2521 catttccact attgcttatt tttaatgaag acacagtttt tttaattgga actttcattc
     2581 ctgaggaccc atcatggaag actaagctgc ctgtgctttt cttcatgggg agcaggctcg
     2641 ttttccatgc cagagccagt attttcacag ctggatagca agctctttca gaggacagat
     2701 atgttattat ctctgccagc tgccaggtgt ctacagctcg atggtttcca ccattggact
     2761 tgattcttct ggagcatttg tgaaatccag acttgcatca aaggttggga cgtggcctgg
     2821 gagcctgcat tttcagcaga cattgtgttt ctcgggcagt ggagaccact gtttccagac
     2881 acatagttat gtggtttggg gtaccacccc tgctgcagtt ctcaaccaca ttcaaatcaa
     2941 aggctaactt atgatggctt ggacttctct gtcaaagaga gcaaaaccat agagaagccc
     3001 gaggttctgc acagtataac aggtatctaa ggccagtacc caggcccctc cccaggcctg
     3061 cctactccta ccccatcttt ttctagagag tggttccgtg ctcaccctgc tgtttcctga
     3121 acagacacac tccacacaca gttgtaagct ctaaagtgta gcacgcacta cccagcagtg
     3181 tttgcatttg cctcagtgag ccctgcgtgc tgatcccagg cacctggacc aggcacagca
     3241 gactcagttc cccgctcctg ggactgaaca caaagccaat aggactgaag gaaagacatt
     3301 tcttagaatc cttgtaggtg acagctagtt tccatagcta caagaaagca ctgagagcag
     3361 cttcttgtct ctcatctgtc ccctccctga gaccctccac tgtgagcaga gaacaaataa
     3421 accaaggact ccagcacagt gtatggtctt tacttaagca caaaggcttc tctcccgaga
     3481 ttttggactc cttagttgtt agttgtgtct ttggtgtttg ctgcagttag aactcaaata
     3541 cagtaattac ataaagcttt ttattttatg ggtttttttc ctatagatgt taacttttgt
     3601 gggttttctt cccaaggctt gcatttcaga acagtattac cctgtgcagc atctgaaacc
     3661 tttgatactg gaccaggctc catcccatcc ccagcatcac ctgaaaaagg ttcagaggcg
     3721 cacatggcct gtgactccag acatcccaga agtgggcgct ggaggatcag gattgggagc
     3781 ccagtgggct gtacagactg tggctggaga ctcggctcag taagagcacg tgctgctcca
     3841 gcagatcagg gttcagattc caacacccac aggtcagttc acaattgcgt gtaactccaa
     3901 gggcctgcaa gtaccagaca cacacatggt gtacagacat gcatgaaggt aaaacgctca
     3961 tgtacataag atgaatatct agtcaaaata atgtttctcc ttgtttgtgc agagaagtgt
     4021 tgattagaat gctgccactt ttattcaagt ttaaaagtct gtaacagcag ccaggcatga
     4081 tggctcgtgc ctgtaactcc agcaactagg gcaggagaat catgaatttc aggccagcct
     4141 tggctacata gcaagacctt atcttgagaa aaagtaagtg tagcatagag tgtctgcgct
     4201 cctgcccagt ccttggtggt cctcacagaa cagtaggagc agagcccgga gcccagccct
     4261 cgtcagcagt ccacagagcc agcagccaga gcttgcttat gaccagctgt gctctggggt
     4321 gcacagttgc ttccgtctag gcagcataga cctctgcata attcctaaat tccagacttt
     4381 aactgtatag aaaatggctc cagaagacat tgcataatac aacacttgga atggctgcaa
     4441 gagttcctaa gagaaagttg acattgccga gcatggtggc acatgccttt aatcccagct
     4501 tttgagggac agaggaggca gatctggtcc acatactgaa ttccaggcca gtcagggctc
     4561 catagtgaga ccctacttca gagagaagag gaggacattt taacactgtc gctctcctat
     4621 gacacctttg aatggttagg gcaggaacga ctgtggtaca gctcctgtga gtcagcacac
     4681 agcaagaccg ggcttctgtt gggcctttgt gacttcttac aggtttccaa attggaaagg
     4741 acaattcatt tgggtattca accttgctag gccccagcag gagataggct aatatctaat
     4801 tagcttatta gccatgccat agtcccctga ctggaaatgg ctaccttgcc catgctaagg
     4861 tagatatgcc aagagcctgc ccggctctgc cctgccacca cagagacgct atgtcagcag
     4921 tctccaggct gcctggcact ccgaccagga tttccctgta atgaacaagt ctggtaaact
     4981 ctctggagga ggaaccttgg tatctgtcta gaacagatga gaaaaggcag agcagtggat
     5041 ggcttcaacc cagcagctct gtaaatccac ccttgcagct aatgaaggag ccctccattt
     5101 ctttgcctct agtcagcagt gactaacgac gtgataggca gaggagtctg atggactttt
     5161 aagaactaag tacctagatg gttgtagaaa tgaaggaaaa cttggttata gaagcctttt
     5221 gtatacacat tgcagtgagg tggtttacag cagattttat ttctgaaatg ttataaactt
     5281 gtaattaatg aaaggtttta taaacattgt cctatatttg tatgtttgta aatatattgt
     5341 gtaagttcta agtataaata tgtcaatatt gtgtgttatt ttaaattgcc tgtatgtcat
     5401 cttataaatg gacattaaaa taaaagccaa tcctccagta gcatgtaata aacactttaa
     5461 aata
//
