LOCUS       NM_022280               5329 bp    mRNA    linear   ROD 16-FEB-2024
DEFINITION  Rattus norvegicus lecithin retinol acyltransferase (Lrat), mRNA.
ACCESSION   NM_022280 XM_213090
VERSION     NM_022280.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5329)
  AUTHORS   Koster,C., van den Hurk,K.T., Lewallen,C.F., Talib,M., Ten
            Brink,J.B., Boon,C.J.F. and Bergen,A.A.
  TITLE     The Lrat-/- Rat: CRISPR/Cas9 Construction and Phenotyping of a New
            Animal Model for Retinitis Pigmentosa
  JOURNAL   Int J Mol Sci 22 (13), 7234 (2021)
   PUBMED   34281288
  REMARK    GeneRIF: The Lrat(-/-) Rat: CRISPR/Cas9 Construction and
            Phenotyping of a New Animal Model for Retinitis Pigmentosa.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5329)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   3  (bases 1 to 5329)
  AUTHORS   Alapatt,P., Guo,F., Komanetsky,S.M., Wang,S., Cai,J., Sargsyan,A.,
            Rodriguez Diaz,E., Bacon,B.T., Aryal,P. and Graham,T.E.
  TITLE     Liver retinol transporter and receptor for serum retinol-binding
            protein (RBP4)
  JOURNAL   J Biol Chem 288 (2), 1250-1265 (2013)
   PUBMED   23105095
REFERENCE   4  (bases 1 to 5329)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   5  (bases 1 to 5329)
  AUTHORS   Harrison,E.H.
  TITLE     Mechanisms involved in the intestinal absorption of dietary vitamin
            A and provitamin A carotenoids
  JOURNAL   Biochim Biophys Acta 1821 (1), 70-77 (2012)
   PUBMED   21718801
  REMARK    Review article
REFERENCE   6  (bases 1 to 5329)
  AUTHORS   Shimada,T., Ross,A.C., Muccio,D.D., Brouillette,W.J. and
            Shealy,Y.F.
  TITLE     Regulation of hepatic lecithin:retinol acyltransferase activity by
            retinoic acid receptor-selective retinoids
  JOURNAL   Arch Biochem Biophys 344 (1), 220-227 (1997)
   PUBMED   9244401
REFERENCE   7  (bases 1 to 5329)
  AUTHORS   Matsuura,T. and Ross,A.C.
  TITLE     Regulation of hepatic lecithin: retinol acyltransferase activity by
            retinoic acid
  JOURNAL   Arch Biochem Biophys 301 (2), 221-227 (1993)
   PUBMED   8460936
REFERENCE   8  (bases 1 to 5329)
  AUTHORS   Randolph,R.K. and Ross,A.C.
  TITLE     Vitamin A status regulates hepatic lecithin: retinol
            acyltransferase activity in rats
  JOURNAL   J Biol Chem 266 (25), 16453-16457 (1991)
   PUBMED   1885578
REFERENCE   9  (bases 1 to 5329)
  AUTHORS   Blaner,W.S., van Bennekum,A.M., Brouwer,A. and Hendriks,H.F.
  TITLE     Distribution of lecithin-retinol acyltransferase activity in
            different types of rat liver cells and subcellular fractions
  JOURNAL   FEBS Lett 274 (1-2), 89-92 (1990)
   PUBMED   2253789
REFERENCE   10 (bases 1 to 5329)
  AUTHORS   MacDonald,P.N. and Ong,D.E.
  TITLE     Evidence for a lecithin-retinol acyltransferase activity in the rat
            small intestine
  JOURNAL   J Biol Chem 263 (25), 12478-12482 (1988)
   PUBMED   3410848
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000069.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_022280.4.
            
            On Nov 26, 2020 this sequence version replaced NM_022280.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF255060.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-803               JACYVU010000069.1  34744773-34745575   c
            804-1844            JACYVU010000069.1  34740022-34741062   c
            1845-5329           JACYVU010000069.1  34736513-34739997   c
FEATURES             Location/Qualifiers
     source          1..5329
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..5329
                     /gene="Lrat"
                     /note="lecithin retinol acyltransferase"
                     /db_xref="GeneID:64047"
                     /db_xref="RGD:68362"
     exon            1..803
                     /gene="Lrat"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..959
                     /gene="Lrat"
                     /EC_number="2.3.1.135"
                     /note="phosphatidylcholine--retinol O-acyltransferase;
                     lecithin-retinol acyltransferase
                     (phosphatidylcholine-retinol-O-acyltransferase)"
                     /codon_start=1
                     /product="lecithin retinol acyltransferase"
                     /protein_id="NP_071616.1"
                     /db_xref="GeneID:64047"
                     /db_xref="RGD:68362"
                     /translation="MKNSMLEAASLLLEKLLLISNFKIFSVCAPGGGTGKKHPYEINS
                     FLRGDVLEVSRTHFTHYGIYLGDNRVAHLMPDILLALTSDKERTQKVVSNKRLLPGVI
                     CKVASIRVDTVEDFAYGADILVNHLDETLKKKSLLNEEVARRAEQQLGLTPYSLLWNN
                     CEHFVTYCRYGSPISPQAEKFHETVKILIRDQRSCLASAVLGLVSIIYTGLASYMTLP
                     AVCIPFCLWMMSG"
     exon            804..5329
                     /gene="Lrat"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcaccgc ccaccccagg cgcgctacct ctccagctcc tctagcgggg gtgcctctgt
       61 tcccgcggct gaccaacact acatcctctc tttgatctcc tgcaccgggt ggtccttggc
      121 ttctcctcta gtcttttgct ctcctggccc cgtactgtcc cggcagtgcc gtcggcaggt
      181 gagcagcgct gcagcgcggc gatccggaaa gctcaccttg cacagaccag ttgcggccag
      241 cgagaaactc tggtctttaa aggatgaaga actcaatgct ggaggctgcg tccctccttc
      301 tggagaagct gctccttatt tccaacttca agatctttag cgtgtgcgcc ccgggaggag
      361 gcacagggaa gaaacatccc tatgaaatca actcttttct ccggggtgac gtgttggaag
      421 tgtcacggac ccattttacc cactatggga tctacctggg ggacaaccgt gtcgcccatc
      481 taatgcctga catcctgttg gccctgacca gtgacaagga acgcactcag aaggtggtct
      541 ccaacaagcg tctcctccca ggagtcattt gcaaggtggc cagcatccgt gtggacacag
      601 tagaggactt tgcctatgga gcggacatcc tcgtcaatca cctagacgag actctcaaga
      661 agaagtcctt gctcaatgag gaggtggcac gcagagcaga gcagcagttg gggctgaccc
      721 cctacagcct actgtggaac aactgcgaac actttgtgac ctactgcaga tacggctctc
      781 ctatcagtcc gcaggctgag aagtttcacg agactgtgaa gatactcatt cgtgatcaga
      841 gaagttgtct tgcttcagct gtcttgggat tagtgtctat tatctacaca ggcctggcat
      901 catatatgac ccttcctgca gtctgcatcc cgttctgctt gtggatgatg tctggctagc
      961 ttccaacccc catgggaatg tgtgaaaata tgtttatatt tacagagcac aaaacattat
     1021 aagcattgtc gataaaatgt ggcccacaac acgttctaga taaaaagtga tcgagaatca
     1081 tgcaaagtgc ttaccatgta agccgaacag agcctttctg catcttctca ggctgcagaa
     1141 caccaggagc cctggaagct tgtcagtctg tcagaggtca gcggccccag aggaatggca
     1201 cctgaggtga aagccacagg agataattca ggttattctt tcctcctgta atcattctgt
     1261 tgttaggctt atcagctgag atcactaact ttattgtaat gtattcttat gtaatgaccg
     1321 atattaaagt gaacaatttc cctcatttag atgaatatat gtttgaaaat tagctgaaag
     1381 gaaactaaag ctcacattcc cttttgcctt tctttgtata ataatataat cttaagtatg
     1441 tcaagaatac tattttcatt atttcattat ttcaagatca gtgttgaaag agcttactga
     1501 agtgactggt cagaaagcat aggagtgtag gaacagccac agtagctatt tatatttacc
     1561 tttgaatagc ctgagatttt gttttcttct tttctttcca tatgactgta tggctacttt
     1621 caaaaaggtg aacagaatta ttaaaataat tctggtatta gatatacaca tgtgccaaat
     1681 gaatacacca atacctgcac tcacatattg ataggtaaac tgtacttctg gttgctttat
     1741 tatactagtg tcatttatta atgaggatct acaaaaatga atataaaacc aaatccagtg
     1801 tcttttcctg tcccttgaat ctctctctct ctctctctct ctctgtcact ggatagtttt
     1861 aaagctaaat ttactaatat ccttttttaa aatacaagtt acatgtttta cagttaattt
     1921 tccactttaa gtataattta tgaccataag agaggtatgt cacagcagta tataaagctt
     1981 aaatgaatag agccaaaaaa taattattct gagaaagtca ctaatgccaa gcattgcagg
     2041 tgtgttcact cactctacta gatcagaggg gagacctatc ttgttaaaaa gcacaccttc
     2101 aagactgtca ctaaaatgac acaggttgga gttacatttc aggtactgaa ctgttatcaa
     2161 aggtggtaca tggaatatct gttgtcctta gaaggttgga gcagcaggta gagagctcca
     2221 agcctgtgtg ggctggaaga caatactgtc tgttgtctgg taactgttaa aaggtacaaa
     2281 acaggcactg aagagatgac tcagcactta gagctattgc tactcttgaa gaggaccagg
     2341 atttagttgc cagcagctcc tggtagatca cagccttctg taactccaat ttaaaaagat
     2401 tcaacaccct cttctggcct tcatgtgcat aacatacatg gtagacaaac atgcatgcag
     2461 gcaaaacaca cacacacaca cacacacaca cacacacaca cacacacaca cacacacaaa
     2521 ataaaactta aaaaaaattg aatcacagaa tagccaagca tgtaatccca acccttggaa
     2581 tgtagaggaa ggaagattgg gagttcaagg caaggctgct tacacagggg gtttaagatt
     2641 tgtttgcact gcccaaaggg cttcaagacc agcttgcact gcataggtag ttcaagacta
     2701 gttttggcta catgagaccc agtctcaaaa caacagaaga accacagaac agtgactctt
     2761 ctgtcagaaa agaggatttt ttttttagtc agtgatcggg ctagaacaaa cgaaagtaca
     2821 gattttagtt tagctgaggt cttatgacct agtattttcc tacaacaaat ttagttggag
     2881 tataatgata attaattaaa atttgtttaa tattcaaatt aaatgtttaa ctgcttaagt
     2941 gttttatatc agtaaaacac tgaatggaaa aaatcaaata atacaggtgt tctttgggcc
     3001 tgattcaacc acttaaatta cctgaagtat ctgtgaatgt ggacagccac tgtgttactg
     3061 cctttttctt ttcaccatgg gagttgttta tgtgacttca ttataaccca cctcccacag
     3121 acatcagtat tgtaggtagt agaaaatagt ttgaaattaa atctgtgttc acagatagtg
     3181 gttcctcctt atatactatg agaattcttg gggttagagt taacataaat aatcttgact
     3241 ctcttcatat tattagacca agactcattc atcattcaat ggatgctcac tccatgctaa
     3301 gcattgaagt gctgcaactt catgctctgg tattagtttt cctttttttt ttttttttga
     3361 gacagggtgt cactcagtaa agtaaattta cttagaatga attcactcac agagagttgt
     3421 gtgcctctgt tttccaagtg ctggaactaa aggtgtgctc accactcctg gcctaaaatt
     3481 actttctagc tagctataac agcatgtata tagtgtggtg gaaaatacag agaaaagaac
     3541 aagtaatttc tgcctcagga gtcaggcatt ttacgtgacg gaggcaataa caaccaggaa
     3601 gctgacaaac tgtgaggtaa ctttgttaca ttgacatcat tctactgtcc ttgggaagca
     3661 aggaaaagaa gaaaggttct atttgttaaa tgttacacaa caccagaatt gctgaacttg
     3721 tagatacgaa agtctctttt gttctttcca tttgattcgt tggttaacaa ggtagaaata
     3781 aacatgttgg ttatggggaa aaaaaaactt aggccaatca ttgctttcct aacccatggt
     3841 ggcaggtaat gaatttctct agactttatc agtcaaagct catatttatg atccaagttc
     3901 acgatattat attatttcta ttctgtcttg acagtgatag ctaagtcatg gtgtattata
     3961 tcttttgatt tgttctttgc atagatgaag gacagagggc ctcctgggtt taagatgact
     4021 taatgccaga gtcagggagt aggttgtata gggaatggat gatatatgag atgtggactg
     4081 agatacaggg cctaacagac atagttgcac tggagtttca gtgattgaca gctgaataga
     4141 gctaactgaa ggcacacaga aagaagagac caattttagc tgcagaaccc aaaatcaggc
     4201 aggggatact gagacttaaa tgatcagaca ggttttggat gggacattcc acacatggga
     4261 acggcatggg gaatacatgc aaattgccta gaacacacac catgaatagc tgtgaggtct
     4321 tcgatgtcag acaaatgcaa gtggtttagg ggctgcagag gaagagtggt gactagacat
     4381 gcagaaacac aaagcagtgc tgaggtggcc taagtcttct gtagatcaag atgtttggac
     4441 tttatggata ggcagtggag aacgagcata gaaaggtaac ttccaagaat aaagcagaag
     4501 gatggatggg gttgaggtgg gatagagaga ctggagaggt ttagctaagg tctttgttag
     4561 atttaaggtc tagatcagtc ttctcagtct ccctagtgca gttcttcatg tcgtggtgag
     4621 ctccaaccat ataattatct tcattgctac ttcacaactg taatcttgct actataatct
     4681 tgctactaat cataatgcaa atatctgata tgcaggatat ataataagtg acccctgtga
     4741 aagacttgtt agatgctcaa aagggtcctg acccacaggt agagaatcac cagtgtaaat
     4801 ggtgagatgg ctcagtgatc acccaagttc aaataagggt ctgcacttgc aagtgtagaa
     4861 agcagtgtca aagaagtgcc aagcaacttg gaccacttag atttgattgg tgaacaactg
     4921 tgatggattg ttagggaata tcatgcatcc ttgcttttcc taagaaagag ttgattactg
     4981 taacataaat taacttgtca agtgtgtata cactcctgat agtcaatttg ctaggcatgc
     5041 tccttcctaa ggacatgtaa ggaagtttgg attggttgtt ttaatttttg tcacaatgta
     5101 tttcttactt ttctgtttgc tatttcatat tgttcatgtc caagactaaa agctgttttt
     5161 caggaacacg gagttactgt aatggcaaag tcttttgtta tggatgagaa gcatctgaac
     5221 agaattttta ttttatataa tctatctggg gtttcaataa acttagactt tttttagtta
     5281 aactaagttt atacacatgt attttgaata aaagcagttc tacatatca
//
