LOCUS       NM_001009649            1730 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus leupaxin (Lpxn), mRNA.
ACCESSION   NM_001009649 XM_215158
VERSION     NM_001009649.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1730)
  AUTHORS   Chen PW and Kroog GS.
  TITLE     Leupaxin is similar to paxillin in focal adhesion targeting and
            tyrosine phosphorylation but has distinct roles in cell adhesion
            and spreading
  JOURNAL   Cell Adh Migr 4 (4), 527-540 (2010)
   PUBMED   20543562
REFERENCE   2  (bases 1 to 1730)
  AUTHORS   Tanaka T, Moriwaki K, Murata S and Miyasaka M.
  TITLE     LIM domain-containing adaptor, leupaxin, localizes in focal
            adhesion and suppresses the integrin-induced tyrosine
            phosphorylation of paxillin
  JOURNAL   Cancer Sci 101 (2), 363-368 (2010)
   PUBMED   19917054
REFERENCE   3  (bases 1 to 1730)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 1730)
  AUTHORS   Kaulfuss S, Grzmil M, Hemmerlein B, Thelen P, Schweyer S, Neesen J,
            Bubendorf L, Glass AG, Jarry H, Auber B and Burfeind P.
  TITLE     Leupaxin, a novel coactivator of the androgen receptor, is
            expressed in prostate cancer and plays a role in adhesion and
            invasion of prostate carcinoma cells
  JOURNAL   Mol Endocrinol 22 (7), 1606-1621 (2008)
   PUBMED   18451096
REFERENCE   5  (bases 1 to 1730)
  AUTHORS   Sundberg-Smith LJ, DiMichele LA, Sayers RL, Mack CP and Taylor JM.
  TITLE     The LIM protein leupaxin is enriched in smooth muscle and functions
            as an serum response factor cofactor to induce smooth muscle cell
            gene transcription
  JOURNAL   Circ Res 102 (12), 1502-1511 (2008)
   PUBMED   18497331
REFERENCE   6  (bases 1 to 1730)
  AUTHORS   Chew V and Lam KP.
  TITLE     Leupaxin negatively regulates B cell receptor signaling
  JOURNAL   J Biol Chem 282 (37), 27181-27191 (2007)
   PUBMED   17640867
REFERENCE   7  (bases 1 to 1730)
  AUTHORS   Gupta A, Lee BS, Khadeer MA, Tang Z, Chellaiah M, Abu-Amer Y,
            Goldknopf J and Hruska KA.
  TITLE     Leupaxin is a critical adaptor protein in the adhesion zone of the
            osteoclast
  JOURNAL   J Bone Miner Res 18 (4), 669-685 (2003)
   PUBMED   12674328
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088217.1.
            
            On Jan 13, 2005 this sequence version replaced XM_215158.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088217.1, FQ230386.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1730
                     /gene="Lpxn"
                     /note="leupaxin"
                     /db_xref="GeneID:293783"
                     /db_xref="RGD:1304981"
     exon            1..85
                     /gene="Lpxn"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1233
                     /gene="Lpxn"
                     /codon_start=1
                     /product="leupaxin"
                     /protein_id="NP_001009649.1"
                     /db_xref="GeneID:293783"
                     /db_xref="RGD:1304981"
                     /translation="MEELDALLEELECCTLQDSEDYSNPVSCCLDQQPTQESKLPQTP
                     KTLSTQGNTSPLKVQLVYTTNIQEPNVYSEVQEPKQSVLPPKTSAAAQLDELMAHLNE
                     LQAKVSVKADASRKPLPDKQDHKASLDSMLGGLEQELQDLGIATVPKGHCASCQKPIA
                     GKVIHALGQSWHPEHFVCTHCKEELGSSPFFERNGLAYCSKDYHHLFSPRCAYCAAPI
                     TDKVLTAMNKTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRP
                     VLENYLSAMNTVWHPECFVCGDCFSSFSSGSFFELDGRPFCELHYHHRRGTLCHDCGQ
                     PITGRCISAMGHKFHPEHFVCAFCLTQLPKGIFKEQNNKTYCEKCFIKLFSQ"
     exon            86..243
                     /gene="Lpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            244..290
                     /gene="Lpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            291..390
                     /gene="Lpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            391..558
                     /gene="Lpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            559..732
                     /gene="Lpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            733..814
                     /gene="Lpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            815..963
                     /gene="Lpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1702
                     /gene="Lpxn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttctcttct tcaccacatg ctaatgcagt tcttcacagt cttcaagact agagtattgg
       61 aggtgtagga caatggaaga actggatgcc ttattggagg aactggaatg ctgcaccctt
      121 caggacagtg aggactattc aaatccagtt tcttgttgcc tggatcagca acccacacag
      181 gagagcaagc ttccccaaac accaaagacc ttgtcaacgc agggtaacac aagtcccttg
      241 aaggtgcagc tcgtgtatac aaccaatatc caggaaccca atgtctacag tgaggtccaa
      301 gagccaaaac aatcagtctt acctcctaag acctcagcag ctgctcagtt ggatgagctc
      361 atggcccacc tgaacgaact tcaggccaag gtttcagtga aagcagatgc tagcaggaaa
      421 cccttgccag acaagcagga tcacaaggca tctctcgact caatgcttgg gggtttggaa
      481 caggaactac aagatcttgg gattgctaca gtccccaagg gccactgtgc ttcctgccag
      541 aaaccaattg ctgggaaggt gatccatgct ctggggcaat cctggcaccc agagcacttt
      601 gtctgtactc actgcaagga ggagcttggc tccagtccct tctttgaacg aaatgggtta
      661 gcctactgct caaaagacta ccatcacctg ttctctccac gctgtgccta ctgtgctgct
      721 cccatcacag ataaagtgct gacagcaatg aacaagacat ggcacccaga gcacttcttc
      781 tgctctcact gtggagaggt gtttggtgca gaaggttttc atgagaagga caagaagcca
      841 tactgccgaa aggatttctt agccatgttc tcacccaagt gtggtggctg caaccgcccc
      901 gtgttggaaa actacctttc agccatgaac actgtctggc acccagagtg ctttgtgtgt
      961 ggggactgct tcagtagttt ttcttctggc tccttctttg aactggatgg ccgtccattc
     1021 tgtgaactcc attaccatca ccgccgaggg accctctgcc atgactgtgg gcagcccatc
     1081 actggccgct gcatcagtgc catggggcat aagtttcatc ctgagcactt cgtgtgtgct
     1141 ttctgcctga cacagctgcc caaaggcatc ttcaaggagc agaacaacaa gacctactgt
     1201 gaaaaatgct tcattaagct cttttcacag tagctcccct ttgacctata tctgcttcat
     1261 gttccctata aaactaagga caagatagga agatcacact ttctgtcccc aaccttctgt
     1321 tcagtgggct aatagagtaa aaacaaggaa caagtaaagg catttgtaga tgtttctagg
     1381 cttataatct taattttgaa gatgcttctc attacttttt aattatgtat ttgcatttag
     1441 attcagatca tgctgtcaag acccccaaaa ggtatatttc ttatgtgcac agttcttttc
     1501 actgctgatt ttctctttct cactttttac ttctactgat gccccattca gaccttatgg
     1561 gtcacaaagt tttactctct ctttgctatc aggggtcagg acattactct taaaccctca
     1621 atgtctctgc attttgcttt ttatgtggaa gtgtatttta actgacacgt gtgatgaata
     1681 aagcagcttg tggttttggt gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
