LOCUS       NM_001414336            2605 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus lactoperoxidase (Lpo), mRNA.
ACCESSION   NM_001414336
VERSION     NM_001414336.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2605)
  AUTHORS   Morzel,M., Chabanet,C., Schwartz,C., Lucchi,G., Ducoroy,P. and
            Nicklaus,S.
  TITLE     Salivary protein profiles are linked to bitter taste acceptance in
            infants
  JOURNAL   Eur J Pediatr 173 (5), 575-582 (2014)
   PUBMED   24248522
REFERENCE   2  (bases 1 to 2605)
  AUTHORS   Kim,B.W., Esworthy,R.S., Hahn,M.A., Pfeifer,G.P. and Chu,F.F.
  TITLE     Expression of lactoperoxidase in differentiated mouse colon
            epithelial cells
  JOURNAL   Free Radic Biol Med 52 (9), 1569-1576 (2012)
   PUBMED   22343415
REFERENCE   3  (bases 1 to 2605)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 2605)
  AUTHORS   Fragoso,M.A., Torbati,A., Fregien,N. and Conner,G.E.
  TITLE     Molecular heterogeneity and alternative splicing of human
            lactoperoxidase
  JOURNAL   Arch Biochem Biophys 482 (1-2), 52-57 (2009)
   PUBMED   19059195
REFERENCE   5  (bases 1 to 2605)
  AUTHORS   Wijkstrom-Frei,C., El-Chemaly,S., Ali-Rachedi,R., Gerson,C.,
            Cobas,M.A., Forteza,R., Salathe,M. and Conner,G.E.
  TITLE     Lactoperoxidase and human airway host defense
  JOURNAL   Am J Respir Cell Mol Biol 29 (2), 206-212 (2003)
   PUBMED   12626341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.28875.1,
                                           SRR26643297.35418.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN16676787
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                JAXUCZ010000010.1  73123421-73123456   c
            37-114              JAXUCZ010000010.1  73120055-73120132   c
            115-202             JAXUCZ010000010.1  73118809-73118896   c
            203-357             JAXUCZ010000010.1  73116291-73116445   c
            358-475             JAXUCZ010000010.1  73115551-73115668   c
            476-605             JAXUCZ010000010.1  73115124-73115253   c
            606-812             JAXUCZ010000010.1  73114228-73114434   c
            813-1137            JAXUCZ010000010.1  73112520-73112844   c
            1138-1298           JAXUCZ010000010.1  73111908-73112068   c
            1299-1551           JAXUCZ010000010.1  73108057-73108309   c
            1552-1725           JAXUCZ010000010.1  73107057-73107230   c
            1726-1963           JAXUCZ010000010.1  73105014-73105251   c
            1964-2605           JAXUCZ010000010.1  73104188-73104829   c
FEATURES             Location/Qualifiers
     source          1..2605
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2605
                     /gene="Lpo"
                     /note="lactoperoxidase"
                     /db_xref="GeneID:287610"
                     /db_xref="RGD:1310051"
     exon            1..36
                     /gene="Lpo"
                     /inference="alignment:Splign:2.1.0"
     exon            37..114
                     /gene="Lpo"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2171
                     /gene="Lpo"
                     /EC_number="1.11.1.7"
                     /codon_start=1
                     /product="lactoperoxidase precursor"
                     /protein_id="NP_001401265.1"
                     /db_xref="GeneID:287610"
                     /db_xref="RGD:1310051"
                     /translation="MKVLLRLLALLASLILLQTAASARNDPPAKTVIICDTVEEVKAS
                     VNKAFLDSRSRLKKAMSAEVRSTRHLSDYLKHAKGRTRTAIRNGQVWEESLKKLTQFL
                     TNATGQGLDLTSLFWKVGCNPPAPAVTCNISNPYRTITGDCNNRKNPALGSANRALAR
                     WLPAEYEDGLSLPFGWTPGKTRNGYPLPQPREVSNQIAGYLNEEDVLDQKRSVLFMQW
                     GQIVDHDLDFAPDTEMGTDNYTKAQCDEHCIQGDNCFPIMFPTGDPKLKTQGKCMSFF
                     RAGFVCPTPPYQSLTREQINALTSFLDASLVYSPEPSMANRLRNLSSPLGLMAVNEEV
                     SDHGRPFPPFVKMKPSPCEVINATAGVPCFLAGDSRASEQILLATSHTLFIREHNRLA
                     RELSTLNPHWDGETLYQETRKIMGAFIQIITFRDYLPILLGDEMQKWIPPYQGYNESV
                     DPRISNVFTFAFRFGHLEIPSTVSRLDENYQPWGSEPELPLHTVFFNTWRLVKDGGID
                     PLVRGLLAKKAKLMHQDRMMTGELRNKLFQPTHTIHGFDLASINIQRCRDHGMPGYNS
                     WRAFCGLSQPKTLEELSAVMENEVLAKKLLDLYGTPSNIDIWLGAIAEPLVPGGRVGP
                     LLTCLLGHQFQRVRDGDRFWWENPGVFTEKQRESLQKLSFSRLVCDNTGITKVPLNPF
                     LANTYPHGFVDCSSVDKLDLSPWAAVQK"
     exon            115..202
                     /gene="Lpo"
                     /inference="alignment:Splign:2.1.0"
     exon            203..357
                     /gene="Lpo"
                     /inference="alignment:Splign:2.1.0"
     exon            358..475
                     /gene="Lpo"
                     /inference="alignment:Splign:2.1.0"
     exon            476..605
                     /gene="Lpo"
                     /inference="alignment:Splign:2.1.0"
     exon            606..812
                     /gene="Lpo"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1137
                     /gene="Lpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1298
                     /gene="Lpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1551
                     /gene="Lpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1725
                     /gene="Lpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1963
                     /gene="Lpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2605
                     /gene="Lpo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attctagctg ccataggagg tcaaggcgca cggcagtgat gaaagtgctt ctgcgtctcc
       61 tggccctcct ggcttccctg atcttgctcc agactgcagc atctgccaga aatgatccac
      121 ctgccaaaac tgtcatcatt tgtgacacag tggaagaggt caaggcctca gtcaacaagg
      181 ccttcctgga ttcccggtcc aggctgaaga aggccatgag tgccgaggta cgtagcaccc
      241 gtcatctctc agactatctc aagcatgcca aaggccggac acgcacagcc atccgaaacg
      301 ggcaggtgtg ggaggaatct ctaaagaaac tgacccagtt tctcaccaac gccacaggtc
      361 aagggctgga cttgacttcg ctcttttgga aggtgggctg taatccccct gctccagcag
      421 tgacttgcaa cataagtaac ccttaccgga ccatcactgg agactgtaac aacaggaaga
      481 atccagcgct gggatccgcc aacagggcgc tagctcgatg gctgccggca gagtacgagg
      541 atggactctc cctccccttc gggtggacgc cggggaagac gcgaaacggc taccctctcc
      601 cgcagccccg tgaagtctct aaccagatcg ccggctatct gaatgaggag gatgttctgg
      661 accagaagag atctgtgctc ttcatgcagt ggggtcagat cgtggaccat gacctggact
      721 ttgcccctga cactgaaatg gggactgata actacaccaa agcccagtgt gacgagcact
      781 gtatccaggg agacaactgc ttccccatca tgttcccaac tggtgaccct aaactgaaga
      841 ctcaggggaa gtgcatgtct ttcttcagag ccggatttgt ctgccccaca ccaccctacc
      901 aatccctgac ccgagagcag atcaatgctc tcacctcttt cctggatgct agcttagtgt
      961 atagccctga gccgagcatg gcaaatcgac ttcgaaacct cagcagcccc ttgggcctca
     1021 tggctgtcaa tgaagaagtc tcagaccatg gacggccctt cccacctttc gtcaaaatga
     1081 aacccagccc ctgcgaggtc atcaacgcca cagctggtgt gccctgcttc ttggcaggag
     1141 actcccgagc ctcagagcag atcttgctgg ccacatccca cacacttttt atccgggagc
     1201 acaaccggtt agccagagaa ctaagcacac tcaacccaca ctgggacgga gagactctct
     1261 atcaggagac aaggaagatc atgggagcct tcatccagat tattaccttt agggactatc
     1321 tacccatcct actgggcgat gagatgcaga agtggattcc cccataccag ggctacaatg
     1381 agtctgtaga cccccggatt tccaatgttt tcacctttgc cttccgcttt ggccacttgg
     1441 agatcccctc tactgtgtcc cgcctagatg aaaattatca gccgtggggt tcagaacctg
     1501 agctccccct gcacaccgtc ttcttcaaca cctggaggct ggtcaaagat ggtggaattg
     1561 atcctctggt tcgaggcctg ctggccaaga aggccaagtt gatgcatcag gacagaatga
     1621 tgacgggaga gcttcgaaac aagctgttcc agccaactca caccatccat ggctttgacc
     1681 tggcttccat caacatacag cggtgcagag accacgggat gcctgggtac aactcctgga
     1741 gagctttctg tggcctgtcc cagccaaaga cactagagga gctaagtgct gtcatggaaa
     1801 acgaggtgct ggccaagaag ctgctggacc tctacggaac ccccagcaac attgatatct
     1861 ggctcggggc cattgctgaa cccctggttc ctgggggtcg ggtaggacct ctcttgacct
     1921 gtctcttggg ccaccagttc cagcgagtcc gagatggaga caggttctgg tgggagaacc
     1981 ctggggtctt cacagagaag caacgggagt ctctacagaa gttgtccttc tcccgcctcg
     2041 tctgcgacaa cactggcatc accaaggtcc cactgaaccc attcctggcc aacacctacc
     2101 cgcatggctt tgtggactgc tcttcagttg ataagctgga cctctcaccc tgggccgcag
     2161 tgcagaagta gaacactact gcccacagct tcctacattg cgagtgtcca tggtccaaga
     2221 tgccatttcg aacaattcca gtggcctact cctttcaagt tggacaccaa gaccaaaggc
     2281 tgccacagcc tttccagccc ctccactcag ctgtcaccac cctcaccacc ctctcagcct
     2341 atggaaatca tcctctctga tgacacttag gcttcttaag atgtccttcc agcttgtcac
     2401 acaccaccta ccctctccct gagtgatcat tggctgaggc tgtgaccttt gatctttatg
     2461 tttcctccct cctgtcctcc cagactagat cataagcatc ctgagccaga gacttctgcc
     2521 tgccttgtga ttatgacttg ttcaacacac aaagtgctca ataaatatcc gactgtccct
     2581 tcctaggggc aggacttgaa acggc
//
