LOCUS       NM_012598               3055 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lipoprotein lipase (Lpl), mRNA.
ACCESSION   NM_012598
VERSION     NM_012598.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3055)
  AUTHORS   Hernandez-Baixauli,J., Chomiciute,G., Alcaide-Hidalgo,J.M.,
            Crescenti,A., Baselga-Escudero,L., Palacios-Jordan,H.,
            Foguet-Romero,E., Pedret,A., Valls,R.M., Sola,R., Mulero,M. and Del
            Bas,J.M.
  TITLE     Developing a model to predict the early risk of
            hypertriglyceridemia based on inhibiting lipoprotein lipase (LPL):
            a translational study
  JOURNAL   Sci Rep 13 (1), 22646 (2023)
   PUBMED   38114521
  REMARK    GeneRIF: Developing a model to predict the early risk of
            hypertriglyceridemia based on inhibiting lipoprotein lipase (LPL):
            a translational study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3055)
  AUTHORS   Gao,J., Ding,G., Li,Q., Gong,L., Huang,J. and Sang,Y.
  TITLE     Tibet kefir milk decreases fat deposition by regulating the gut
            microbiota and gene expression of Lpl and Angptl4 in high fat
            diet-fed rats
  JOURNAL   Food Res Int 121, 278-287 (2019)
   PUBMED   31108749
  REMARK    GeneRIF: Tibet kefir milk decreases fat deposition by regulating
            the gut microbiota and gene expression of Lpl and Angptl4 in high
            fat diet-fed rats.
REFERENCE   3  (bases 1 to 3055)
  AUTHORS   Huo,W., Hou,Y., Li,Y. and Li,H.
  TITLE     Downregulated lncRNA-MIAT confers protection against erectile
            dysfunction by downregulating lipoprotein lipase via activation of
            miR-328a-5p in diabetic rats
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (6), 1226-1240 (2019)
   PUBMED   30660685
  REMARK    GeneRIF: Data indicate that long noncoding RNA (lncRNA-MIAT)
            suppressed lipoprotein lipase (LPL) by increasing miR-328a-5p,
            thereby inhibiting vascular endothelial cells (VECs) injury to
            attenuate erectile dysfunction (ED) in diabetic rats.
REFERENCE   4  (bases 1 to 3055)
  AUTHORS   Birrane,G., Beigneux,A.P., Dwyer,B., Strack-Logue,B.,
            Kristensen,K.K., Francone,O.L., Fong,L.G., Mertens,H.D.T.,
            Pan,C.Q., Ploug,M., Young,S.G. and Meiyappan,M.
  TITLE     Structure of the lipoprotein lipase-GPIHBP1 complex that mediates
            plasma triglyceride hydrolysis
  JOURNAL   Proc Natl Acad Sci U S A 116 (5), 1723-1732 (2019)
   PUBMED   30559189
REFERENCE   5  (bases 1 to 3055)
  AUTHORS   Al-Muzafar,H.M. and Amin,K.A.
  TITLE     Thiazolidinedione induces a therapeutic effect on hepatosteatosis
            by regulating stearoyl-CoA desaturase-1, lipase activity, leptin
            and resistin
  JOURNAL   Exp Ther Med 16 (4), 2938-2948 (2018)
   PUBMED   30214514
REFERENCE   6  (bases 1 to 3055)
  AUTHORS   Brault,D., Noe,L., Etienne,J., Hamelin,J., Raisonnier,A., Souli,A.,
            Chuat,J.C., Dugail,I., Quignard-Boulange,A., Lavau,M. et al.
  TITLE     Sequence of rat lipoprotein lipase-encoding cDNA
  JOURNAL   Gene 121 (2), 237-246 (1992)
   PUBMED   1339374
REFERENCE   7  (bases 1 to 3055)
  AUTHORS   Etienne,J. and Brault,D.
  TITLE     [Lipoprotein lipase deficiencies]
  JOURNAL   Ann Biol Clin (Paris) 50 (5), 299-309 (1992)
   PUBMED   1485686
  REMARK    Review article
REFERENCE   8  (bases 1 to 3055)
  AUTHORS   Faustinella,F., Chang,A., Van Biervliet,J.P., Rosseneu,M.,
            Vinaimont,N., Smith,L.C., Chen,S.H. and Chan,L.
  TITLE     Catalytic triad residue mutation (Asp156----Gly) causing familial
            lipoprotein lipase deficiency. Co-inheritance with a nonsense
            mutation (Ser447----Ter) in a Turkish family
  JOURNAL   J Biol Chem 266 (22), 14418-14424 (1991)
   PUBMED   1907278
  REMARK    Erratum:[J Biol Chem 1992 Apr 5;267(10):7194]
REFERENCE   9  (bases 1 to 3055)
  AUTHORS   Beg,O.U., Meng,M.S., Skarlatos,S.I., Previato,L., Brunzell,J.D.,
            Brewer,H.B. Jr. and Fojo,S.S.
  TITLE     Lipoprotein lipaseBethesda: a single amino acid substitution
            (Ala-176----Thr) leads to abnormal heparin binding and loss of
            enzymic activity
  JOURNAL   Proc Natl Acad Sci U S A 87 (9), 3474-3478 (1990)
   PUBMED   2110364
REFERENCE   10 (bases 1 to 3055)
  AUTHORS   Kinnunen,P.K. and Ehnolm,C.
  TITLE     Effect of serum and C-apoproteins from very low density
            lipoproteins on human postheparin plasma hepatic lipase
  JOURNAL   FEBS Lett 65 (3), 354-357 (1976)
   PUBMED   182536
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081836.1.
            
            On Jun 10, 2007 this sequence version replaced NM_012598.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081836.1, L03294.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3055
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3055
                     /gene="Lpl"
                     /note="lipoprotein lipase"
                     /db_xref="GeneID:24539"
                     /db_xref="RGD:3017"
     exon            1..277
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1614
                     /gene="Lpl"
                     /EC_number="3.1.1.34"
                     /EC_number="3.1.1.32"
                     /note="phospholipase A1"
                     /codon_start=1
                     /product="lipoprotein lipase precursor"
                     /protein_id="NP_036730.1"
                     /db_xref="GeneID:24539"
                     /db_xref="RGD:3017"
                     /translation="MESKALLLVALGVWLQSLTAFRGGVAAADGGRDFSDIESKFALR
                     TPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKR
                     EPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWLEEEFNYPLDNVHLLGYSL
                     GAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPG
                     RSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAEKGLGDVDQLVKCSHERSIHLFI
                     DSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNVGYEINKVRAKRSSKMYLKTRS
                     QMPYKVFHYQVKIHFSGTENDKQNNQAFEISLYGTVAESENIPFTLPEVATNKTYSFL
                     IYTEVDIGELLMMKLKWKNDSYFRWSDWWSSPSFVIEKIRVKAGETQKKVIFCAREKV
                     SHLQKGKDAAVFVKCHDKSLKKSG"
     exon            278..438
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            439..618
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            619..730
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            731..964
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1207
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1328
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1511
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1613
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..3031
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctccaag aaattctgcc ccttgtagct gttctgccct cccctttaaa ggttgacttg
       61 ccccgcggcg ctccaccgcg ctctagtcct ctgacgcctc cggctcaacc ctttgcaacg
      121 cggatccccg cccgcctgac tgcccgcgca gcgcagttcc agcagcaaag cagaagggcg
      181 cgcccggaga tggagagcaa agccctgctc ctggtggccc tgggagtttg gctccagagt
      241 ttgaccgcct tccgcggagg ggtggccgca gcagacgggg gaagagattt ctcagacatc
      301 gaaagtaaat ttgccctaag gacccctgaa gacacagctg aggacacttg tcatctgatt
      361 cctggattag cagactctgt gtctaactgc cacttcaacc acagcagcaa aacctttgtg
      421 gtgatccatg gatggacggt gacaggaatg tatgagagtt gggtgcccaa acttgtggct
      481 gccctataca aaagagaacc tgactccaat gtcattgtag tagactggtt gtatcgggcc
      541 cagcaacatt atccagtgtc tgccggctat accaagctgg tgggaaatga tgtggccagg
      601 ttcatcaact ggttggagga agaatttaac taccccctag acaatgtcca cctcttaggg
      661 tacagtcttg gagcccatgc tgctggcgtg gcaggaagtc tgaccaacaa gaaggtcaat
      721 agaattactg gcttggatcc agctgggcct aactttgagt atgcagaagc ccctagtcgc
      781 ctttctcctg atgatgcgga tttcgtagat gtcttacaca catttaccag ggggtcgcct
      841 ggtcgaagta ttgggatcca gaaaccagta gggcatgttg atatttatcc caatggaggc
      901 actttccagc caggatgcaa cattggagaa gccattcgtg taattgcaga gaaggggctt
      961 ggagatgtgg accagctggt gaagtgctcg cacgagcgct ccatccatct cttcattgac
     1021 tccctgctga atgaagaaaa ccccagcaag gcatacaggt gcaattccaa ggaggcattt
     1081 gagaaagggc tctgcctgag ttgcagaaag aatcgctgta acaacgtggg ctatgagatc
     1141 aacaaggtca gagccaagag aagcagtaag atgtacctga agactcgctc tcagatgccc
     1201 tacaaagtat tccattacca agtcaagatt cacttttctg gaactgagaa tgacaagcaa
     1261 aacaaccagg ccttcgagat ttctctgtat ggcacagtgg ctgaaagtga gaacattccc
     1321 ttcaccctgc cggaggtcgc cacaaataaa acctactcct tcttgattta cacggaggtg
     1381 gacatcgggg aattgctgat gatgaagctt aagtggaaga acgactccta cttccgctgg
     1441 tcagactggt ggagcagtcc cagctttgtc atcgagaaga tccgagtgaa agccggagag
     1501 actcagaaaa aggtcatctt ctgtgccagg gagaaagttt ctcatctgca gaaaggaaag
     1561 gacgctgcag tgtttgtgaa atgccatgac aagtctctga agaagtcggg ctgacactgg
     1621 acaaaccaac aagagaagaa agcatctgag ttctttgaag accgaagaaa atgaagtaaa
     1681 ttttatttaa aaaaaatacc cttgtttggg tgtttgaaag tggattttcc tgagtattaa
     1741 tcccagctat atcttgttag ttaaatagaa gacagtgtca aatattaaaa ggtggctaac
     1801 acaacgtgag gaacctaatg gccgatagca tgtcctccag catcagaaga cagcagagag
     1861 gagaagcatg ccatcttata tcccttaaga aggaatcatt tgttcccaac catacaagac
     1921 tccttcatgt gacccatttg gtcatggtct aaaattagta agggcctctt attttcatta
     1981 gatctctgag gttttaaatt gagaccttct caaagttctc ttgaagtcta atatagacaa
     2041 catttttttg tgctgtgagt cagatccatt tctttagcag ttgaaacagc tggccattgt
     2101 aactagttct tttaccatca ggatatagca cccctaccaa ataaaataaa taaataaagt
     2161 gaccagggac atgtgacttt gcaaaagcaa tggaagacgt ggctcgtgga ttcctgaccc
     2221 ttagtcccac cacaacgaag tacaagtcag tagaggtaca aaacctagac tgagtaattc
     2281 ttagtagact tcaagtttta tggcttaatt cctctgtctt ttaaaaacgt gtcacatatt
     2341 ataacattat tctctagaca gatgttgaaa tgagcttgtg attcaggtga catatgaatt
     2401 gagctgagag aaaataatgc cctggctgat tttatttctc tgttttgctt tcttgagaaa
     2461 aggaatactt gtcccactcc gtatctgagc ctgaccaaga actaaactat gtacttcagg
     2521 cttaccttga actctcaacc atcctgcctt ggcttcctga gtgctgggag cttgataacc
     2581 ataattttat tatcagattt ttcttagtca ttttcaccaa tagaacacat tcaatgccca
     2641 atcgttagca tttcgtttga gactcatctt gaccgtacct ctgtcacacg tctaacacat
     2701 cacattaatt tctagtttag aagtgatcaa gttcaaattc tgcactgcgc aaagtacaag
     2761 ttttagagca ggaccatttt tttttaccac gtaaaagtcg aaattactag gaaatgtgta
     2821 tatcgatgct tgtacactgt tgcgtgcaaa gtgaggagcc ttctattgtg atagccatag
     2881 acagtaccag gctcgttgcc gctcttttgt tttactataa aaaaatcaat aatgaagaat
     2941 tatttatgaa caagatctca tatgttcaga ttgcttttac tattcatcaa tataaaatgt
     3001 taaaaaaaaa taaaacaagt tctatctcag aaaaaaaaaa aaaaaaaaaa aaaaa
//
