LOCUS       NM_001014184            3160 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus lipin 3 (Lpin3), mRNA.
ACCESSION   NM_001014184 XM_342566
VERSION     NM_001014184.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3160)
  AUTHORS   Kok,B.P.C., Dyck,J.R.B., Harris,T.E. and Brindley,D.N.
  TITLE     Differential regulation of the expressions of the PGC-1alpha splice
            variants, lipins, and PPARalpha in heart compared to liver
  JOURNAL   J Lipid Res 54 (6), 1662-1677 (2013)
   PUBMED   23505321
  REMARK    GeneRIF: novel differences in the regulation of lipins 1,2,3,
            PPARalpha, and PGC-1alpha splice variants during fasting in heart
            versus liver, even though the ultimate outcome in both tissues is
            to increase FA turnover and oxidation.
REFERENCE   2  (bases 1 to 3160)
  AUTHORS   Grimsey,N., Han,G.S., O'Hara,L., Rochford,J.J., Carman,G.M. and
            Siniossoglou,S.
  TITLE     Temporal and spatial regulation of the phosphatidate phosphatases
            lipin 1 and 2
  JOURNAL   J Biol Chem 283 (43), 29166-29174 (2008)
   PUBMED   18694939
REFERENCE   3  (bases 1 to 3160)
  AUTHORS   Donkor,J., Sariahmetoglu,M., Dewald,J., Brindley,D.N. and Reue,K.
  TITLE     Three mammalian lipins act as phosphatidate phosphatases with
            distinct tissue expression patterns
  JOURNAL   J Biol Chem 282 (6), 3450-3457 (2007)
   PUBMED   17158099
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089878.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001014184.2.
            
            On Apr 1, 2005 this sequence version replaced XM_342566.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3160
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3160
                     /gene="Lpin3"
                     /note="lipin 3"
                     /db_xref="GeneID:362261"
                     /db_xref="RGD:1588534"
     exon            1..214
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..2557
                     /gene="Lpin3"
                     /EC_number="3.1.3.4"
                     /codon_start=1
                     /product="phosphatidate phosphatase LPIN3"
                     /protein_id="NP_001014206.1"
                     /db_xref="GeneID:362261"
                     /db_xref="RGD:1588534"
                     /translation="MNYVGQLAETVFGTVKELYRGLNPATLSGGIDVLVVKQVDGSFR
                     CSPFHVRFGKLGVLRSREKVVDIEINGEPVDLHMKLGDSGEAFFVQELDSDEEDVPPR
                     LCTSPIPWGGLSGFPSDSQLGTASEPEGLVLTGRRKRRRRRKPRRREDAADSSSEELE
                     AGAESELTLLEKPMPESPSAWKEEEPSSQPKDIYPYSDGECTPQANLSSADLMSPKSD
                     SELELRPLEPSPLRAESHMQWAWGRLPKVAKAEHPEFSLVLESMAEAICALPGEPSPS
                     SMAGVDTLRSPALQPGVREDMFHPDVEAYREETPMDSPLAAPESKETKTQNPRGTGHP
                     PATKSWSWTTPESHTPSGRTEVSRGRASLKRSQHLGPSDIYLDDLPSLDSENVALYFP
                     KSDCGMGARRWSEPSNQKLLENPSREHTAECTLDSVDRIELSLCGGLADTRDISLEKF
                     TQHMVSYEDLTKNPGLLDDPNLVVKINEKHYNWAVAAPMILSLQAFQKNLPESTVDKL
                     QKEKMPRKGGRWWFSWRRRDFPAEERSAQREKAATRKQQGEKTEVLSSDDDVPDSPVI
                     LEVPPLPSSTPGYVPTYKKSLRLSSNQIRCLNLNEGANDVVFSVTTQYQGTCRCKATI
                     YLWNWDDKVVISDIDGTITKSDALGHILPQLGKDWTHQGITSLYHKIHLNGYKFLYCS
                     ARAIGMAHLTKGYLQWVSEHGCGLPKGPILLSPSSLFSALHREVIEKKPEVFKVACLS
                     DIQQLFLPQRQPFYAAFGNRPNDVFAYRQVGLPESRIFTVNPRGELIQELIKNHKSTY
                     QRLGEVVELLFPPVVRGPSTDLANPEYSNLCYWRKPLPCVDFDTLV"
     exon            215..310
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            311..558
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            559..639
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            640..760
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            761..1103
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1203
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1364
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1458
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1528
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1621
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1665
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1804
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1953
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2040
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2193
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2308
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2412
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..3131
                     /gene="Lpin3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagggttgg ccagcagcag ccatgaacta tgtggggcag ctggcagaga cagtgtttgg
       61 aacagttaag gagctataca ggggcctgaa cccagccaca ctgagcggcg gcattgacgt
      121 gctggtggtc aagcaggtgg atggctcctt ccgatgctca cccttccatg tgcggttcgg
      181 caagctgggt gtcctgcggt cacgggagaa ggtggtggac atcgagatca atggagagcc
      241 tgtggacttg cacatgaagt tgggggacag tggcgaggcc ttctttgtcc aggagctgga
      301 cagtgatgag gaagatgtgc ctcctcgact gtgcacctca cccatcccgt ggggaggcct
      361 gtcaggcttt ccctcagact cccagctggg cacagcgagc gagcctgagg gcctcgtcct
      421 tacggggcgg agaaagaggc ggcgcaggag gaaacccagg cgcagggagg atgcggcgga
      481 ctccagttct gaagagctgg aggcaggtgc cgagagtgag ctgaccttgc tggaaaagcc
      541 aatgccagag tccccaagtg cttggaagga agaggagccc tcatcgcagc ctaaagacat
      601 ctacccctac tctgatggcg agtgtacgcc ccaggccaac ctttcatctg ctgacctaat
      661 gtcccctaag agtgactcag aactagagct gcggcccttg gagcccagtc ctctgagggc
      721 tgagtctcat atgcagtggg cctgggggag gctgcctaag gtggcgaaag ctgagcatcc
      781 tgagttctcg ttggtccttg aaagtatggc tgaggcaatc tgtgctcttc ctggggaacc
      841 tagcccttcc tctatggctg gcgtggacac tttgagatcc ccagcgctgc aaccaggagt
      901 cagggaagat atgtttcatc ctgatgtgga ggcatatcgt gaggaaactc ccatggattc
      961 tcctcttgct gccccagaga gtaaggaaac caagactcag aaccccaggg gtacaggaca
     1021 ccctcctgcc acgaaatcat ggagctggac cactccagag agccacacgc cctctggacg
     1081 tacagaagtc tccagaggaa gagcttccct gaagagaagc cagcacctgg gcccaagtga
     1141 tatctacctg gatgatctgc cctccctgga ctctgagaat gtggccctct atttccctaa
     1201 gagtgactgt gggatggggg ccaggaggtg gagcgagccc agcaaccaga agctgctgga
     1261 gaaccccagc cgtgagcaca cagcagagtg cactctggac tccgtggaca gaatagaatt
     1321 gtccctctgt ggtggactgg ccgacactcg cgatatctcc ctggagaagt tcacccagca
     1381 catggtctcc tacgaggacc tcactaagaa ccccgggctc ctggatgacc caaacctcgt
     1441 ggtgaaaatt aacgagaagc attataactg ggctgtggct gcccccatga ttctttctct
     1501 gcaagccttc cagaagaact tacctgagag cactgtggac aagcttcaaa aggagaagat
     1561 gccccggaaa ggtgggcgat ggtggttttc ctggagacgc agggacttcc cagctgagga
     1621 gcgcagtgcc cagagggaga aagcagcaac caggaaacag cagggagaga agacagaggt
     1681 cctaagcagt gatgacgatg tcccagatag ccctgtgatc ctcgaagtgc ccccactgcc
     1741 atcctccact ccgggctatg tccctaccta caagaagtct cttcgtctct cttccaatca
     1801 gatccggtgt ctaaacctga atgaaggagc taacgatgtg gtcttcagcg tgactaccca
     1861 gtaccaaggc acctgccgtt gcaaagccac catctacctg tggaactggg atgacaaggt
     1921 ggtcatctct gacatagacg gcaccatcac caagtcggat gctctgggcc acattctgcc
     1981 ccagctgggg aaagactgga cacaccaggg cattactagt ctctaccaca aaatccatct
     2041 aaatgggtac aagttcctgt actgctctgc acgggctatc ggcatggctc acctcaccaa
     2101 ggggtacctg cagtgggtga gcgagcacgg ctgcggcctc cctaagggcc ccatcctgct
     2161 gtctcccagc agcctcttct ccgccctcca cagggaagta atcgagaaga agccagaggt
     2221 gttcaaggtt gcctgcctga gtgatatcca gcagctgttt ctgccccaaa gacagccttt
     2281 ctatgccgcg tttgggaaca ggcctaacga tgtttttgcc tacaggcagg tgggcctccc
     2341 tgagtctcga atcttcacag tcaacccccg gggagagctc atccaagagc tcataaagaa
     2401 ccacaaatcc acgtaccagc ggcttggaga ggtggtggag cttctcttcc cgcccgtggt
     2461 gcgcggcccc agcacagacc tggccaaccc tgaatacagc aacctctgct attggcggaa
     2521 gccactgccg tgtgtggact ttgacaccct ggtttgagct tgccctgacg gttctccttg
     2581 gcctgaccca ggactgatgg agtacttagg acagtagggg tcagaagatg cgtgccgtgg
     2641 gccaatccaa caaagggctg caagttgact ggcagcctcc gctaccgcca ccttgaaaca
     2701 caaatggccg tgttcgtcag tttgaccgct cggtaccagg gcactgggtt tgaagaactg
     2761 gaacaagatg gcatctgaca gagatggcac cgaatgaggc ccaggtggct gtgggagcat
     2821 ggggagtact cagggaccca cctctctatc aggagtcagg tagctgtccc aggcctcagt
     2881 acagccctga cctccagcta ttaaacgtgt cactagactc ttgcagggtt ctctggctcc
     2941 taggccattg gttctcaatc tgtgggtcgc aaccccttcg gaggtcgaat gaccctttca
     3001 tgggggtttc atatcagata tcctgtttat cagatattta cattatgatt caaaactata
     3061 gttatgaagt agcagtgaaa ataattgtat ttacaaccat gaggaacagt attaaaaagt
     3121 cacagcatta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
