LOCUS       NM_001108236            5794 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus lipin 2 (Lpin2), mRNA.
ACCESSION   NM_001108236 XM_001055334 XM_237521
VERSION     NM_001108236.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5794)
  AUTHORS   Kok,B.P.C., Dyck,J.R.B., Harris,T.E. and Brindley,D.N.
  TITLE     Differential regulation of the expressions of the PGC-1alpha splice
            variants, lipins, and PPARalpha in heart compared to liver
  JOURNAL   J Lipid Res 54 (6), 1662-1677 (2013)
   PUBMED   23505321
  REMARK    GeneRIF: novel differences in the regulation of lipins 1,2,3,
            PPARalpha, and PGC-1alpha splice variants during fasting in heart
            versus liver, even though the ultimate outcome in both tissues is
            to increase FA turnover and oxidation.
REFERENCE   2  (bases 1 to 5794)
  AUTHORS   Donkor,J., Zhang,P., Wong,S., O'Loughlin,L., Dewald,J., Kok,B.P.,
            Brindley,D.N. and Reue,K.
  TITLE     A conserved serine residue is required for the phosphatidate
            phosphatase activity but not the transcriptional coactivator
            functions of lipin-1 and lipin-2
  JOURNAL   J Biol Chem 284 (43), 29968-29978 (2009)
   PUBMED   19717560
REFERENCE   3  (bases 1 to 5794)
  AUTHORS   Grimsey,N., Han,G.S., O'Hara,L., Rochford,J.J., Carman,G.M. and
            Siniossoglou,S.
  TITLE     Temporal and spatial regulation of the phosphatidate phosphatases
            lipin 1 and 2
  JOURNAL   J Biol Chem 283 (43), 29166-29174 (2008)
   PUBMED   18694939
REFERENCE   4  (bases 1 to 5794)
  AUTHORS   Donkor,J., Sariahmetoglu,M., Dewald,J., Brindley,D.N. and Reue,K.
  TITLE     Three mammalian lipins act as phosphatidate phosphatases with
            distinct tissue expression patterns
  JOURNAL   J Biol Chem 282 (6), 3450-3457 (2007)
   PUBMED   17158099
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474043.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001055334.1, XM_237521.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132264,
                              SAMD00132295 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q38"
     gene            1..5794
                     /gene="Lpin2"
                     /note="lipin 2"
                     /db_xref="GeneID:316737"
                     /db_xref="RGD:1304588"
     exon            1..85
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            86..286
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..2779
                     /gene="Lpin2"
                     /EC_number="3.1.3.4"
                     /codon_start=1
                     /product="phosphatidate phosphatase LPIN2"
                     /protein_id="NP_001101706.1"
                     /db_xref="GeneID:316737"
                     /db_xref="RGD:1304588"
                     /translation="MNYVGQLAGQVLVTVKELYKGINQATLSGCIDVVVVRQQDGSYQ
                     CSPFHVRFGKLGVLRSKEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAY
                     LATSPIPTEDQFFKHIDPPLVKSSGNERPPQSSDVSHTLESEAVFTPSSVKKKKRRRK
                     KCKQDNRKEEQAASPVAEDVGDVAVSSDDEKRAQAARGSSNASLKEEDYKEPPPFHSG
                     DNYPLSDGDWSPLETSYPQTVCPKSDSELEVKPSESLLRSESHMEWTWGGFPESTKVS
                     KRERYDYHPRTATITPSENTHFRVIPSEDSLIREVEKDATVEDTTCTIVKPKPRALCK
                     QLSDAASTELPESPLEAPQISSTLDADPVPSPSAEAPSEPKPAAKVDSPTKRKGVHKR
                     SQHQGPDDIYLDDLKALEPEVAALYFPKSDTDPGSRQWPESDTFSGSQSPQSVGSAAA
                     DSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAENPGLIDNPNL
                     VIRIYNRYYNWALAAPMILSLQVFQKSLPKATVESWVKDKMPKKSGRWWFWRKKESMT
                     KQLPETKEGKSEVPPANDLPSGTEEPVSARPAENDTSSDEGSQELEETIKVDPISMET
                     LSHCGTASYKKSLRLSSDQIAKLKLHDGPNDVVFSITTQYQGTCRCAGTIYLWNWNDK
                     VIISDIDGTITKSDALGQILPQLGKDWTHQGIARLYHSINENGYKFLYCSARAIGMAD
                     MTRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIEKKPEKFKIECLNDIKNLFAP
                     SRQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQERTKGNKSSYHRLSELVE
                     HVFPLLNKEQNSAFPCPEFSSFCYWRDPIPDVDLDDLA"
     exon            287..382
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..684
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..792
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..916
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1256
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1356
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1544
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1638
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1708
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1798
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1881
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2026
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2175
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2262
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2415
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2530
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2634
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..5794
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggggctg gcgaggtgca gttattccct caggccgttg gcttgcccgc cgccgcctcc
       61 tgcaggccgt ggaccaggtt cagattctca aaccatgaat tatgtgggcc agctggctgg
      121 gcaggtgctt gtcactgtga aggaactcta caagggcatt aaccaagcca ctctatctgg
      181 gtgcatcgat gtggtcgtgg tgcggcagca ggatggctcc tatcagtgct caccttttca
      241 cgtgcgcttc gggaagctgg gtgtcctgag gtccaaggag aaggtgattg acatagaaat
      301 caatggcagt gctgtggatc ttcacatgaa attgggtgat aatggagaag ccttctttgt
      361 agaggagact gaagaagaat atgaaaaact gcctgcttat cttgccacct caccaattcc
      421 aactgaagac cagttcttta aacatattga cccccctttg gtgaaatcaa gtggaaatga
      481 aaggccacca cagagttcag atgtttctca taccttggaa tcagaggcag ttttcactcc
      541 gagttctgtg aaaaagaaga aacggaggag aaagaagtgc aaacaggaca ataggaagga
      601 ggagcaggcg gcttcccctg ttgcagaaga tgtaggcgat gtggctgtga gctctgatga
      661 tgagaagaga gcccaggcag caagaggatc ttcaaatgct tccttaaagg aagaggacta
      721 taaggagcct ccgcctttcc attctgggga taactatccc ttatctgatg gagattggtc
      781 tccattggaa accagttacc cacagacagt gtgccccaag agtgactcgg agctggaggt
      841 gaagccatcc gagagcctcc tcagatctga gtcgcacatg gagtggacgt ggggtgggtt
      901 cccagagtcc accaaggtca gcaaaagaga aagatatgac tatcatccaa ggacagctac
      961 aattacacca tcagaaaaca ctcattttag ggtaattccc agtgaagaca gcctcataag
     1021 agaagttgag aaggatgcta ctgttgaaga tactacctgt accatagtga aacccaaacc
     1081 tcgagccctg tgtaagcaac tgagtgatgc agcttccact gaacttcctg aatcgcctct
     1141 tgaagcacct cagatctcat ctacattaga tgcagaccct gttcccagcc catcagcaga
     1201 ggctccctca gagcccaaac cagctgctaa agtagactca cctacaaaga gaaaaggtgt
     1261 tcacaaaaga agccagcacc agggacctga tgacatttac cttgatgact taaaggctct
     1321 tgagcctgaa gtggcagctc tctatttccc taaaagtgac accgatccgg gttctaggca
     1381 gtggcctgag tctgacacat tctctggttc tcagtcccca caatctgtgg gaagtgcagc
     1441 tgcagacagt ggcaccgaat gcctctcgga ttctgccatg gacttgcctg atgtaactct
     1501 ctccctctgt ggaggcctca gtgagaatgg agagatttct aaagagaagt tcatggagca
     1561 catcatcacg taccacgagt ttgcagagaa ccctggcctt atcgacaacc cgaaccttgt
     1621 gatccggatc tataaccgtt actacaactg ggcgttggct gctcccatga tccttagctt
     1681 acaggtattt cagaagagtc tgcctaaggc cacagtcgag tcctgggtta aagacaagat
     1741 gccgaagaaa tctggccggt ggtggttttg gcgaaagaaa gaaagcatga ccaaacagtt
     1801 gccggagacc aaggagggga aatctgaggt ccctccagca aatgacctgc cttccggtac
     1861 tgaggagccc gtcagtgcca gacctgcaga gaatgacact tctagtgacg aggggtcaca
     1921 ggagttagaa gaaaccatca aagttgaccc catctcgatg gagacattga gtcactgtgg
     1981 aacagcctca tataagaagt ctctccgact gtcctcggac cagatagcaa aactgaaact
     2041 ccacgatggc cccaatgatg ttgtattcag tatcacaacc cagtatcagg gcacctgtcg
     2101 gtgtgcgggt accatttacc tgtggaactg gaatgacaaa gtcatcattt ctgacatcga
     2161 tggaacaata accaagtctg atgctttggg acagattctc ccacagctgg gtaaagactg
     2221 gactcatcag ggcatagcta ggctctacca ttccatcaat gagaatggtt acaagtttct
     2281 gtactgttct gcacgcgcca tcggcatggc cgacatgacc cgtggctatt tacactgggt
     2341 caatgacaag ggcacaatct tgcctcgagg ccccctgatg ctgtccccca gcagcttgtt
     2401 ctctgccttc cacagggaag tgatagaaaa gaaaccagag aagttcaaaa ttgagtgtct
     2461 gaatgatatt aagaacttgt ttgccccatc caggcagccc ttctatgctg cctttggaaa
     2521 ccgtcccaac gatgtctatg cttacacaca agtcggagtt ccagactgta ggatattcac
     2581 tgtgaatcca aagggtgaat taatacaaga aaggaccaaa ggaaacaagt catcgtatca
     2641 caggctgagt gagcttgtgg aacacgtgtt cccacttctc aataaggaac agaattctgc
     2701 cttcccatgc ccagagttca gttccttctg ctactggaga gacccaatcc ctgacgtgga
     2761 cctggatgac ctagcttgaa aaaggcctgt ggcaaggtgg gggcactgtc actcacctcc
     2821 cagcagggaa ggtcactggc cctcttacag atgaagaccc aggagctgac aggaacctgc
     2881 tttccagaac agggacagag tccccgaagc tggcactgcc accttctttc agcttcctaa
     2941 gccaccactc agcacctaga cagaggagta aggggcagtc agcctgcatt agaagcctgt
     3001 gctctgaagc ctgtgctcca ttacttgtgg gcctcacatg cctcttgtgg agttgtgtgc
     3061 tgtgcactgg tcagctgcat agtttaaaaa ggaagaaacc agaaactcaa aaagaacaga
     3121 ccagcacatg actacacaaa gtaaagagtt aaaatctcca ctggtcagtt gggatcgttt
     3181 ctctctataa acagggcttt ctgcagaggt ccagttagtg ctgccagctg tgtgtacatg
     3241 tcctcctccg gacacctcca ctcctgctca ctgaactagg acagctgctt catgtgccag
     3301 gcaggcagcg ccagcacctt gagcccagct gcgccagcgt gggctgtaaa gttgggggaa
     3361 ggcagcctag cagcaccatc tcctcgctga gaaggaagtc gtttaggttg tcgttatgac
     3421 ctagcagaag aacaggtgca tatttcatgt ctggagtaac agtgaggcct tggtttaaat
     3481 cacaggagag gcagtggctt tcctcagaag tgtagggcag ttgccttggg ccttgggagt
     3541 cctgttctct gacactgtca ctgccttagg tggtccttgg ggcaggtatt tcaggacagg
     3601 atttttgaaa gtctgggctt cagatttgct aaggaaaaag cctttggctg gtggcattga
     3661 ccagtccttt gaactccagc cacataagaa gtccatggag gcgtgggaga gagggcactg
     3721 agtgcccgtt gagagcgagc accgcggcag gagcccagcc cacctgattc acctgtcagc
     3781 tctgaccctc atgcagttga tagtgggcta cccctgcacc tcgctgcacc tcgctggcag
     3841 caccagacac tggcctagtt aagtgcttgt caatgttgga acacacagca ccagggagag
     3901 ttttgtcctc agatctgcag agccgggacc agctgggtgt ggacagtcac tgcagtgctc
     3961 acatcgagaa gtactgaagg agggcgttcc agagacctca gtggttcagt cacaacctcc
     4021 cctgggaaga tggccgtggc ggcttctgag cagaggggga gccgccctta aagctgttcc
     4081 aaccctgcat gccctgcagc tggatggctg gcctgaccag gcttcagttt gcttcactca
     4141 aaataacgct cgcctagagt tggcttagaa aaggggtggt tattttccag attggagagt
     4201 tgagtgtccc tgcctcattt cagtattgca gttgaatgca gagaccatgg ttgacaatgt
     4261 ttaattaaag aaaaaaagga ccatgtgaag cacagttctc agtggcaaac ctgaaggtac
     4321 atgctcccag agaaggggcc acacaggctt ccacagctga tgtttcccat acaattcact
     4381 tctccttcgt gagttatctg tgttaggtag tagggaaact cagttacgtt tatgtgaaat
     4441 tcttgccggt tagtgaaata agatcctatt aaagcagcca cgtgggattt gatgcccaag
     4501 ccatcagtac cttggtggtg tagcacatct tcgctttagg gaagcagaat tgtgtactta
     4561 acctgagctt ggtaggatct cgtggtacag aatgtctttt atgttttctc tcagaccact
     4621 tctgtttgtc ctttagggag ctttttacct agctagtctg tttgcttttc ctgacaaact
     4681 cttttttttt tttttttttt ttttttggac acatgggcct cttcagaagg tccagcatag
     4741 gctctgggtc tcttggcctg tgccgagagg gtggctggtc tttctgtccg tctgtgtgtc
     4801 tgttagcccg acacttgtca ctgcacattg atcagtgaat atttaggata atgaatgtaa
     4861 ctctttcctt atttaaagga gtcttccttg ctgaaagtag atgattactg ttactgtagt
     4921 gttatgagtg ttaggtttgt gctgaaaatc cattgccatt tgttacaaat gacatttgtt
     4981 ctttctgtga aagagagatg cccttaagtg tgtttgcaca caaaccctta gatggcttgt
     5041 tgcagtgtca ccttgtcttc agtgacaggt gatgctgaag agacactatg gcagaccagc
     5101 cacccgtccc tccatcagtg ttgcatcagt gactacggcc ccatgtcttt ccagttcagt
     5161 ctaatgttag tgtctggtgt cgagtgttgg cacttccact gctgtggaag tgatggctgc
     5221 tctccctgtg gaggttgtac atgtggacct ggagcacaca cacgtaaccg tatgatcagt
     5281 actgcatttc ctgtggtcta tctgcatagt cagttggaaa aagaaatgtg ttggtgtagt
     5341 aacgtaaaaa caaaagctgc taaaacagcc tagagtgggt caggaccaca gctgagcagc
     5401 agggagcctc tgtcctgtgc agcccctgtc catggggcgg gtccggcctt ctgtagtgct
     5461 cttcaaagcc atcatccgag agaagaagcg gttaaggtga cgagcgagtt tatcacatag
     5521 ccctgggaaa ccttgtttga gagcacgctg gggtttatgc aaaacttgaa ggcagaggaa
     5581 agacttccct tttaataatt acactcagct gatgaaggac ttgattatta gagagcagcc
     5641 actgagcagc tttcagtcgt cagtaatgaa ttgtaaacat cagtgcagta ccttcaatgt
     5701 ggtacagaag ttgtcttcag atgaacggct catgttttgg tgcagtgttt gatgttcaca
     5761 aaaatgttac aataataaac taacgtgaac tgag
//
