LOCUS       NM_001012111            3107 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus lipin 1 (Lpin1), mRNA.
ACCESSION   NM_001012111 XM_243142
VERSION     NM_001012111.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3107)
  AUTHORS   Han,X., Huang,S., Zhuang,Z., Zhang,X., Xie,M., Lou,N., Hua,M.,
            Zhuang,X., Yu,S. and Chen,S.
  TITLE     Phosphatidate phosphatase Lipin1 involves in diabetic
            encephalopathy pathogenesis via regulating synaptic mitochondrial
            dynamics
  JOURNAL   Redox Biol 69, 102996 (2024)
   PUBMED   38103341
  REMARK    GeneRIF: Phosphatidate phosphatase Lipin1 involves in diabetic
            encephalopathy pathogenesis via regulating synaptic mitochondrial
            dynamics.
REFERENCE   2  (bases 1 to 3107)
  AUTHORS   Kostic,M., Koricanac,G., Tepavcevic,S., Stanisic,J., Romic,S.,
            Culafic,T., Ivkovic,T. and Stojiljkovic,M.
  TITLE     Low-Intensity Exercise Affects Cardiac Fatty Acid Oxidation by
            Increasing the Nuclear Content of PPARalpha, FOXO1, and Lipin1 in
            Fructose-Fed Rats
  JOURNAL   Metab Syndr Relat Disord 21 (2), 122-131 (2023)
   PUBMED   36625880
  REMARK    GeneRIF: Low-Intensity Exercise Affects Cardiac Fatty Acid
            Oxidation by Increasing the Nuclear Content of PPARalpha, FOXO1,
            and Lipin1 in Fructose-Fed Rats.
REFERENCE   3  (bases 1 to 3107)
  AUTHORS   Wang,M., Xie,M., Yu,S., Shang,P., Zhang,C., Han,X., Fan,C.,
            Chen,L., Zhuang,X. and Chen,S.
  TITLE     Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and Improves
            Diabetic Peripheral Neuropathy
  JOURNAL   Mol Neurobiol 58 (11), 6049-6061 (2021)
   PUBMED   34435332
  REMARK    GeneRIF: Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and
            Improves Diabetic Peripheral Neuropathy.
REFERENCE   4  (bases 1 to 3107)
  AUTHORS   Xie,M., Wang,M., Liu,W., Xu,M., Shang,P., Jiang,D., Ju,L., Wu,F.,
            Sun,A., Yu,S., Zhuang,X. and Chen,S.
  TITLE     Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy
            through the PKD/Limk/Cofilin Signaling Pathway
  JOURNAL   Oxid Med Cell Longev 2020, 1723423 (2020)
   PUBMED   33123308
  REMARK    GeneRIF: Lipin1 Is Involved in the Pathogenesis of Diabetic
            Encephalopathy through the PKD/Limk/Cofilin Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3107)
  AUTHORS   Romic,S., Krskova,K., Olszanecki,R., Balazova,L., Lory,V.,
            Koricanac,G., Slamkova,M. and Zorad,S.
  TITLE     Obesity- and age-related alterations in FAT/CD36 translocation and
            lipin-1 subcellular localization in skeletal muscle of the Zucker
            rats
  JOURNAL   Gen Physiol Biophys 36 (4), 399-406 (2017)
   PUBMED   28653652
  REMARK    GeneRIF: Increase in plasma membrane FAT/CD36 content in obese rats
            and failure in lipin-1 export to nucleus with progression of
            obesity, implying an increase in FA uptake and their different
            channeling into lipid intermediates synthesis pathway in old fa/fa
            rats versus FA usage in lean rats of the same age.
REFERENCE   6  (bases 1 to 3107)
  AUTHORS   Verheijen,M.H., Chrast,R., Burrola,P. and Lemke,G.
  TITLE     Local regulation of fat metabolism in peripheral nerves
  JOURNAL   Genes Dev 17 (19), 2450-2464 (2003)
   PUBMED   14522948
REFERENCE   7  (bases 1 to 3107)
  AUTHORS   Huffman,T.A., Mothe-Satney,I. and Lawrence,J.C. Jr.
  TITLE     Insulin-stimulated phosphorylation of lipin mediated by the
            mammalian target of rapamycin
  JOURNAL   Proc Natl Acad Sci U S A 99 (2), 1047-1052 (2002)
   PUBMED   11792863
REFERENCE   8  (bases 1 to 3107)
  AUTHORS   Peterfy,M., Phan,J., Xu,P. and Reue,K.
  TITLE     Lipodystrophy in the fld mouse results from mutation of a new gene
            encoding a nuclear protein, lipin
  JOURNAL   Nat Genet 27 (1), 121-124 (2001)
   PUBMED   11138012
REFERENCE   9  (bases 1 to 3107)
  AUTHORS   Klingenspor,M., Xu,P., Cohen,R.D., Welch,C. and Reue,K.
  TITLE     Altered gene expression pattern in the fatty liver dystrophy mouse
            reveals impaired insulin-mediated cytoskeleton dynamics
  JOURNAL   J Biol Chem 274 (33), 23078-23084 (1999)
   PUBMED   10438476
REFERENCE   10 (bases 1 to 3107)
  AUTHORS   Langner,C.A., Birkenmeier,E.H., Ben-Zeev,O., Schotz,M.C.,
            Sweet,H.O., Davisson,M.T. and Gordon,J.I.
  TITLE     The fatty liver dystrophy (fld) mutation. A new mutant mouse with a
            developmental abnormality in triglyceride metabolism and associated
            tissue-specific defects in lipoprotein lipase and hepatic lipase
            activities
  JOURNAL   J Biol Chem 264 (14), 7994-8003 (1989)
   PUBMED   2722772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC083651.1.
            
            On Feb 11, 2005 this sequence version replaced XM_243142.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..3107
                     /gene="Lpin1"
                     /note="lipin 1"
                     /db_xref="GeneID:313977"
                     /db_xref="RGD:1307646"
     exon            1..259
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..460
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..3043
                     /gene="Lpin1"
                     /EC_number="3.1.3.4"
                     /codon_start=1
                     /product="phosphatidate phosphatase LPIN1"
                     /protein_id="NP_001012111.1"
                     /db_xref="GeneID:313977"
                     /db_xref="RGD:1307646"
                     /translation="MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVVRQPNGSLQ
                     CSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMY
                     LATSPILSEGASRMESQLKRNSVDRIRGLDPTTAAQGLPPSDTPSTGSLGKKRRKRRR
                     KAHLDNLKRDDNVNTSEDEDMFPIEMSSDEDTALMDGSRALPNDVPPFQDDIPKENLP
                     SISTYPQSASYPNSDREWSPSPSSLVDCQRTPPHLAEGVLSSSCPLQSCHFHASESPS
                     GSRPSTPKSDSELVSKSADRLTPKNNLEMLWLWGELPQAAKSSSPHKMKDSSPLGGRK
                     MADKIHFQTIHSESSDTFSDQSPTMARGLLIHQSKAQTEMQFVNEEDLEALGAAAPPL
                     SVAEELKAPASSTAQTSSKSDSPSRKKDKRSRHLGADGVYLDDLTDMDPEVAALYFPK
                     NGDPGGLPKQASDNGARSANQSPQSVGSSGIDSGVESTSDSLRDLPSIAISLCGGLSD
                     HREITKDAFLEQAVSYQQFADNPAIIDDPNLVVKIGNKYYNWTTAAPLLLAMQAFQKP
                     LPKATVESIMRDKMPKKGGRWWFSWRGRNATIKEESKPEQGLPGKGHNTGEQPAQLGL
                     TTRIKHESSSSDEEHSATKPSSSSHLSLLSNVSYKKTLRLTSEQLKSLKLKNGPNDVV
                     FSVTTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIA
                     KLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALH
                     REVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVN
                     PKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSCDFPCSDTFSNFTFWREPLPPF
                     ENQDVHSASA"
     exon            461..556
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..864
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..990
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1089
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1219
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1526
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1620
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1811
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1905
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..1975
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2068
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2148
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2275
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2424
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2511
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2664
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2779
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2883
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3083
                     /gene="Lpin1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagaataa gtggggggaa gtgggggagg gaggatgggg aggaaagaac aggaagaggg
       61 agactcgggg agccagtcat gcctacccta atcgaaacca cagagggtgg gtctaggaga
      121 ctaataccta taggacggtg aggaaaaaag aacaatccac tggggtacta aaaagttcac
      181 aagcagggac cttcctgtga agctgatgga agaaaaatgg agtcctcaca ggagaagagg
      241 ctttcttcag gcaactaagg ttcagacaat gaattacgtg gggcagttgg ccggccaggt
      301 gtttgtgacg gtgaaggagc tctacaaggg actgaaccct gccacgctgt caggatgcat
      361 cgacatcatt gttgtccgcc agcccaatgg cagtctgcag tgctccccgt tccacgtccg
      421 cttcgggaag atgggtgtcc tacgctcccg agagaaagtg gtggacatag aaatcaatgg
      481 ggagtctgtg gatttgcaca tgaagttggg agacaacgga gaagcgtttt ttgttcaaga
      541 gactgacaac gatcaggaag tcatccccat gtacctagcc acgtccccca tcctgtcaga
      601 aggagcttcg agaatggaaa gccagctgaa aaggaactct gtggacagaa tccggggcct
      661 ggatcccact acagctgccc agggcctgcc tcccagcgac accccatcca ctggttctct
      721 ggggaagaag agaaggaaaa ggaggaggaa ggcccatttg gacaatctca aaagagatga
      781 caatgtcaac acatctgagg acgaggacat gtttcccata gagatgagct cggatgagga
      841 cacagcactg atggatggga gcagagctct tcctaatgat gtaccaccat tccaagatga
      901 tattcctaag gaaaacctcc cctcgatttc aacatatccc cagtcagcat cgtaccccaa
      961 ttcagacaga gagtggtccc ccagccccag cagcctggta gattgtcaga ggactccccc
     1021 tcacctggcc gagggagttc tctctagctc ttgtcctctg cagtcttgcc acttccatgc
     1081 ttcggaaagt ccttcaggct cccggccctc aacaccaaaa agtgattctg agctggtcag
     1141 taagtctgca gacagattga cgccaaagaa taacctggaa atgctctggc tatggggtga
     1201 attgccacag gctgcaaagt cgtcttctcc acacaagatg aaagactcca gccccttagg
     1261 aggtcggaag atggctgata aaatccactt ccagaccatt cacagcgagt cttcagacac
     1321 tttcagtgac cagtccccaa caatggcccg ggggctgctc atccaccaga gcaaggctca
     1381 gacggaaatg cagtttgtga atgaggagga ccttgaggcc ttgggggccg cagccccacc
     1441 tttgtctgta gccgaagagc tcaaggcccc agcctccagc acagcacaga catcaagcaa
     1501 gtcagattcc ccttccagaa aaaaagataa acgaagccgg cacctcggag ctgatggcgt
     1561 ttatctggat gacctcacag acatggaccc ggaagtggct gccctgtatt tccccaagaa
     1621 tggggatccc ggtgggcttc ccaaacaagc gagtgacaac ggagccaggt cagccaacca
     1681 gtccccacag tcggtgggta gctcgggcat tgacagcggc gtggagagca cctccgacag
     1741 cctgagggac ctgccgtcca tcgccatctc cctctgcggt ggcctcagtg accacagaga
     1801 gatcaccaaa gatgcatttt tggaacaagc cgtgtcatat cagcaatttg ccgacaaccc
     1861 tgctatcatc gatgatccca acctcgtggt caagattggt aataagtact acaactggac
     1921 aacagcagct cctctacttc tggcgatgca ggctttccag aaacctttgc caaaggccac
     1981 tgtggaatcc atcatgagag ataagatgcc caaaaaggga gggagatggt ggttttcctg
     2041 gagaggaaga aacgccacaa tcaaagagga gagcaagcct gagcagggcc tgcctgggaa
     2101 gggccacaat accggagagc agcctgcaca gcttggcctg accaccagaa taaagcatga
     2161 gtcatcctct agtgatgaag agcactcagc taccaagcca tcgagctcga gccacctctc
     2221 tctcttgtcc aacgtcagct acaaaaagac cctgcggctc acatcggagc agttgaaaag
     2281 cttgaagttg aagaatggcc ccaacgatgt ggtgttcagt gtcactaccc agtaccaggg
     2341 cacctgtcgc tgtgagggta ccatctacct gtggaattgg gatgacaaag tcatcatctc
     2401 agatatcgat ggtaccatca caagatctga tactcttggt cacatattgc ccacactggg
     2461 aaaggattgg actcaccagg gcatcgcaaa gctgtatcac aaagtaagcc agaatggcta
     2521 caagtttctc tattgttctg cacgtgccat tgggatggca gacatgacga ggggctatct
     2581 gcactgggtc aacgagaggg gcacagtgct gccacagggg ccgcttctgc tgagccccag
     2641 cagcctcttc tccgccttgc acagagaagt gattgaaaag aagccagaaa agttcaaagt
     2701 ccagtgtttg acagacatca aaaacctgtt tttcccaaac acagagccct tttatgctgc
     2761 ttttgggaac cggcctgccg atgtgtattc ctacaagcaa gtgggagtgt ccctgaatag
     2821 aatcttcacc gtcaacccca agggtgagct ggtgcaggag catgccaaga ccaacatcag
     2881 ctcgtatgtg cggctctgcg aagtggtcga ccacgtcttc cccttgctga agagaagcca
     2941 ttcctgcgac ttcccctgtt cagacacttt cagtaacttc accttttgga gagagccact
     3001 gccacccttt gaaaaccagg acgtgcattc agcctcagct tgattcgacc cagcattaaa
     3061 ggataggttg tggggaccct ggaaaaaaaa aaaaaaaaaa aaaaaaa
//
