LOCUS       NM_001012189            1935 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus lysophosphatidylcholine acyltransferase 3
            (Lpcat3), mRNA.
ACCESSION   NM_001012189 XM_342754
VERSION     NM_001012189.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Hao,J., Wang,T., Cao,C., Li,X., Li,H., Gao,H., Li,J., Shen,H. and
            Chen,G.
  TITLE     LPCAT3 exacerbates early brain injury and ferroptosis after
            subarachnoid hemorrhage in rats
  JOURNAL   Brain Res 1832, 148864 (2024)
   PUBMED   38484924
  REMARK    GeneRIF: LPCAT3 exacerbates early brain injury and ferroptosis
            after subarachnoid hemorrhage in rats.
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Li,Z., Ding,T., Pan,X., Li,Y., Li,R., Sanders,P.E., Kuo,M.S.,
            Hussain,M.M., Cao,G. and Jiang,X.C.
  TITLE     Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver
            lysophosphatidylcholine accumulation promotes very low density
            lipoprotein production by enhancing microsomal triglyceride
            transfer protein expression
  JOURNAL   J Biol Chem 287 (24), 20122-20131 (2012)
   PUBMED   22511767
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 1935)
  AUTHORS   Green,A.R., Aiston,S., Greenberg,C.C., Freeman,S., Poucher,S.M.,
            Brady,M.J. and Agius,L.
  TITLE     The glycogenic action of protein targeting to glycogen in
            hepatocytes involves multiple mechanisms including phosphorylase
            inactivation and glycogen synthase translocation
  JOURNAL   J Biol Chem 279 (45), 46474-46482 (2004)
   PUBMED   15322104
  REMARK    GeneRIF: PTG has a role in phosphorylase kinase inactivation and
            glycogen synthase translocation
REFERENCE   5  (bases 1 to 1935)
  AUTHORS   Kuwamura,M., Maeda,M., Kuramoto,T., Kitada,K., Kanehara,T.,
            Moriyama,M., Nakane,Y., Yamate,J., Ushijima,T., Kotani,T. and
            Serikawa,T.
  TITLE     The myelin vacuolation (mv) rat with a null mutation in the
            attractin gene
  JOURNAL   Lab Invest 82 (10), 1279-1286 (2002)
   PUBMED   12379762
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089869.1.
            
            On Feb 11, 2005 this sequence version replaced XM_342754.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089869.1, SRR8487231.78978.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1935
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /note="lysophosphatidylcholine acyltransferase 3"
                     /db_xref="GeneID:362434"
                     /db_xref="RGD:1310223"
     exon            1..201
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1514
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /EC_number="2.3.1.23"
                     /EC_number="2.3.1.n6"
                     /EC_number="2.3.1.n7"
                     /note="LPLAT 5; lyso-PC acyltransferase 3;
                     1-acylglycerophosphocholine O-acyltransferase;
                     O-acyltransferase domain-containing protein 5;
                     membrane-bound O-acyltransferase domain-containing protein
                     5; gene rich cluster, C3f; O-acyltransferase (membrane
                     bound) domain containing 5; membrane bound
                     O-acyltransferase domain containing 5;
                     1-acylglycerophosphoserine O-acyltransferase;
                     1-acylglycerophosphoethanolamine O-acyltransferase"
                     /codon_start=1
                     /product="lysophospholipid acyltransferase 5"
                     /protein_id="NP_001012189.1"
                     /db_xref="GeneID:362434"
                     /db_xref="RGD:1310223"
                     /translation="MASTADGDVGETLGQMRGLWPGVEDLSLNKLATSLGASEQALRL
                     IFSIFLGYPLALFYRHYLFYKDSYLIHLFHAFSGLSIAYFNFGHQFYHSLLCVVLQFL
                     ILRLMGRTITAVFTTLCFQMAYLLAGYYYTATGDYDIKWTMPHCVLTLKLIGLSIDYY
                     DGGKDRNSLSSEQQKYAILGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVKGQLTD
                     VPGKMPNSTIPALKRLSLGLVYLVGYTLLSPHITEDYLLTEDYDTRPFWFRCMYMLIW
                     GKFVLYKYVTCWLVTEGVCILSGLGFNGFEENGTVKWDACANMKVWLFETTPRFTGTI
                     ASFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLICFQMEFLIVI
                     VEKQATNLIRDSPALSSLASITALQPFYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKV
                     YRSIYFLGHVFFLSLLFTLPYVYKAMVPRKEKLKKRE"
     exon            202..309
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /inference="alignment:Splign:2.1.0"
     exon            310..416
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /inference="alignment:Splign:2.1.0"
     exon            417..510
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /inference="alignment:Splign:2.1.0"
     exon            511..548
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /inference="alignment:Splign:2.1.0"
     exon            549..727
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /inference="alignment:Splign:2.1.0"
     exon            728..836
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /inference="alignment:Splign:2.1.0"
     exon            837..923
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1090
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1238
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1397
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1526
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1904
                     /gene="Lpcat3"
                     /gene_synonym="Grcc3f; Mboat5; Oact5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacattcggg gcgcagagct gggggtcccc ggggggcgcc cgcagttaag atggcgtcta
       61 cagcggacgg ggacgtggga gagacgctag ggcagatgcg gggactgtgg ccgggtgtcg
      121 aggatctgag ccttaacaag ttggcgacgt ccctgggcgc gtcggaacag gcgctgcggc
      181 tcatcttctc catcttcctg ggctacccgt tggctctgtt ttatcggcat taccttttct
      241 acaaggacag ctacctcatc catctcttcc acgccttctc aggcctctca atcgcttatt
      301 tcaacttcgg ccaccagttc taccactcct tgctatgtgt tgtgcttcaa ttcctcatcc
      361 tgcgactcat gggccggacc atcactgccg tttttactac tctttgcttc cagatggcct
      421 accttcttgc tggttattac tacacagcca ccggtgacta cgatatcaag tggacaatgc
      481 cacattgtgt cttgacattg aagctaattg ggctgtctat tgactactat gacggaggca
      541 aagacaggaa ctccttgtcc tctgagcaac agaaatatgc catactgggt gtcccctcat
      601 tgctggaagt cgctggcttc tcctacttct atggagcctt cttggtaggg ccccagtttt
      661 caatgaacca ctacatgaag ctggtgaagg gacagctgac tgacgtacca ggaaagatgc
      721 caaacagcac catacctgct ctcaagcgcc tgagtctggg ccttgtctac ctggtgggct
      781 acaccctgct gagcccccac atcacagaag actatctcct cactgaagac tatgataccc
      841 gccctttctg gttccgctgc atgtacatgc tgatctgggg caaattcgtg ctgtacaaat
      901 acgtcacctg ttggctggtc acagaaggag tgtgcatctt gtcaggcctg ggctttaatg
      961 gctttgaaga aaatgggact gtgaaatggg atgcctgtgc caacatgaaa gtgtggctct
     1021 ttgaaaccac ccctcgcttc actggcacca tcgcctcttt caacatcaat accaatgcct
     1081 gggtagcccg ttacatcttc aaacgcctca agtttcttgg aaataaagag ctctcacaag
     1141 gtctctcctt gctattcttg gccctctggc atggtctgca ctcaggatac ctgatttgct
     1201 tccagatgga gttcctcatt gttatcgtgg aaaagcaggc caccaacctc attcgggaca
     1261 gcccggccct gagcagcctg gcctccatca ctgccctcca gcccttctac tacttggtgc
     1321 aacagaccat ccactggctt ttcatgggct actctatgac tgccttctgc ctcttcacat
     1381 gggacaaatg gcttaaggtg tacagatcca tctatttcct tggacacgtc ttcttcttga
     1441 gcctactttt cacattgcct tacgtttaca aagcaatggt gccaaggaaa gaaaagttaa
     1501 aaaagaggga ataatctgtt tccctggtgg ccgagagctg gactggtgca gaaactactt
     1561 gtctcccttc tcacagcact cctcaccccg gagcagagac accaggagct ggaagtcaca
     1621 gtactcccgg ctgtgcctct gcgacagcca aaggggaagc tcttgtggga ggagcaaagg
     1681 ggctgcaccc cctttggact cccccatgca cgttgcctta tctctcccct ctagccagga
     1741 atctgttgtt tctcttctgc caatctacta cgattgtata tgtgccgata ccgccacccc
     1801 cccatggggg gaggggaggg tacaaggccc tgcctgctcc actttttcta tcttggaact
     1861 ataccagata aaatcacttc tgtttgttca gtttttcact gctaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa aaaaa
//
