LOCUS       NM_001271344            1918 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus lysophosphatidylcholine acyltransferase 2
            (Lpcat2), mRNA.
ACCESSION   NM_001271344 XM_002728595 XM_003753086
VERSION     NM_001271344.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1918)
  AUTHORS   Okubo,M., Yamanaka,H., Kobayashi,K., Kanda,H., Dai,Y. and
            Noguchi,K.
  TITLE     Up-regulation of platelet-activating factor synthases and its
            receptor in spinal cord contribute to development of neuropathic
            pain following peripheral nerve injury
  JOURNAL   Mol Pain 8, 8 (2012)
   PUBMED   22296727
  REMARK    GeneRIF: These data show the histological localization of PAF
            synthases and its receptor in the spinal cord following peripheral
            nerve injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1918)
  AUTHORS   Moessinger,C., Kuerschner,L., Spandl,J., Shevchenko,A. and
            Thiele,C.
  TITLE     Human lysophosphatidylcholine acyltransferases 1 and 2 are located
            in lipid droplets where they catalyze the formation of
            phosphatidylcholine
  JOURNAL   J Biol Chem 286 (24), 21330-21339 (2011)
   PUBMED   21498505
REFERENCE   3  (bases 1 to 1918)
  AUTHORS   Agarwal,A.K. and Garg,A.
  TITLE     Enzymatic activity of the human
            1-acylglycerol-3-phosphate-O-acyltransferase isoform 11:
            upregulated in breast and cervical cancers
  JOURNAL   J Lipid Res 51 (8), 2143-2152 (2010)
   PUBMED   20363836
REFERENCE   4  (bases 1 to 1918)
  AUTHORS   Shindou,H., Hishikawa,D., Nakanishi,H., Harayama,T., Ishii,S.,
            Taguchi,R. and Shimizu,T.
  TITLE     A single enzyme catalyzes both platelet-activating factor
            production and membrane biogenesis of inflammatory cells. Cloning
            and characterization of acetyl-CoA:LYSO-PAF acetyltransferase
  JOURNAL   J Biol Chem 282 (9), 6532-6539 (2007)
   PUBMED   17182612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On or before Sep 19, 2012 this sequence version replaced
            XM_002728595.1, XM_003753086.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.75403.1,
                                           SRR26643297.50997.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000019.1  30325406-30325576   c
            172-311             JAXUCZ010000019.1  30317486-30317625   c
            312-529             JAXUCZ010000019.1  30311900-30312117   c
            530-642             JAXUCZ010000019.1  30310527-30310639   c
            643-703             JAXUCZ010000019.1  30308747-30308807   c
            704-762             JAXUCZ010000019.1  30307231-30307289   c
            763-797             JAXUCZ010000019.1  30305931-30305965   c
            798-852             JAXUCZ010000019.1  30302119-30302173   c
            853-935             JAXUCZ010000019.1  30293537-30293619   c
            936-1061            JAXUCZ010000019.1  30290924-30291049   c
            1062-1215           JAXUCZ010000019.1  30289741-30289894   c
            1216-1314           JAXUCZ010000019.1  30271183-30271281   c
            1315-1450           JAXUCZ010000019.1  30266855-30266990   c
            1451-1918           JAXUCZ010000019.1  30262676-30263143   c
FEATURES             Location/Qualifiers
     source          1..1918
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..1918
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /note="lysophosphatidylcholine acyltransferase 2"
                     /db_xref="GeneID:100359680"
                     /db_xref="RGD:2325051"
     CDS             1..1635
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /EC_number="2.3.1.51"
                     /EC_number="2.3.1.23"
                     /EC_number="2.3.1.67"
                     /EC_number="2.3.1.25"
                     /note="acyltransferase-like 1-A; lysoPAFAT; LPC
                     acyltransferase 2; acetyl-CoA:lyso-PAF acetyltransferase;
                     1-acylglycerophosphocholine O-acyltransferase;
                     1-alkylglycerophosphocholine O-acetyltransferase;
                     acetyl-CoA:lyso-platelet-activating factor
                     acetyltransferase; lysoPC acyltransferase 2; 1-AGPAT 11;
                     1-AGP acyltransferase 11; 1-acylglycerol-3-phosphate
                     O-acyltransferase 11; 1-alkenylglycerophosphocholine
                     O-acyltransferase"
                     /codon_start=1
                     /product="lysophosphatidylcholine acyltransferase 2"
                     /protein_id="NP_001258273.1"
                     /db_xref="GeneID:100359680"
                     /db_xref="RGD:2325051"
                     /translation="MNRCAEAAAVAATVPGSGVGDSGLRPPMVPRQASFFPPPVPNPF
                     VQQTRISAARRLQMILLGIILLPVRALLVGLVLLLAWPFAVISTVCCPKKLTHPISDW
                     RRKITQPALKFLGRAMFFSMGFRVTVKGKVASPLEAPIFVVAPHSTFFDGIACVVAGL
                     PSLVSRNENAQTPLVGRLLRALQPVLVSRVDPDSRKNTINEIKKRAMSGGEWPQILVF
                     PEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFIQLCVLTFCQ
                     LFTKVEVEFMPVQAPSEEERNDPVLFASRVRNLMAEALEIPVTDHTYEDCRLMISAGQ
                     LTLPMEAGLVEFTKISRKLKLDWDGIRKHLDEYASIASSAKGGRIGIEEFAEYLKLPV
                     SDVLRQLFALFDRNNDGSIDFREYVIGLAVLCNPANTEDIIQVAFKLFDVDEDGYITE
                     EEFCTILQASLGVPDLNVSGLFREIAQGDSVSYEEFKSFALKHPEYAKIFTTYLDLQT
                     CHVFSLPEDVQTAPSVASNKVSPESHEEGTSGKKVD"
     exon            1..171
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
     exon            172..311
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
     exon            312..529
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
     exon            530..642
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
     exon            643..703
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
     exon            704..762
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
     exon            763..797
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
     exon            798..852
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
     exon            853..935
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1061
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1215
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1314
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1450
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1918
                     /gene="Lpcat2"
                     /gene_synonym="LPCAT-2; RGD1563994"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaccgat gcgccgaggc ggccgctgtg gcggctacgg tgccgggttc gggagtcggg
       61 gactccgggc tgcggccgcc catggtacct cgccaggcgt ccttcttccc tccaccggtg
      121 cccaatccct tcgtccagca gacgaggatc agtgcggccc ggcggctgca gatgattctc
      181 cttggaatta ttctgcttcc agtccgtgct ttactggttg gattagtttt gctgctggca
      241 tggccctttg ctgtaatctc aacagtatgc tgccctaaaa agctgaccca tccaataagc
      301 gattggagga ggaagatcac tcagcccgcc ttgaagttcc tgggtcgtgc catgttcttc
      361 tccatggggt ttagggttac cgtgaaagga aaggtggcta gccctctgga ggcgcccatt
      421 tttgtcgttg ctcctcactc cacgttcttc gatggaattg cctgtgtagt agcggggctg
      481 ccctctctgg tgtcacggaa tgagaacgcc cagacccctc tggttggcag actgttacgg
      541 gctttgcagc cggttttggt atcccgtgtt gatccggatt cccgaaaaaa cacgatcaac
      601 gaaataaaaa agcgagcaat gtcaggcggg gagtggcccc agatactagt tttcccagaa
      661 ggtacttgta ctaatcggtc ctgtttgatt acttttaaac caggagcctt tatcccggga
      721 gttccagtgc aacccgtcct cctcagatat cccaacaagc tggatactgt aacctggacc
      781 tggcaaggat atactttcat ccagctgtgt gtgctcacat tctgtcaact gttcacaaag
      841 gtggaagttg agtttatgcc tgtgcaagca ccaagtgagg aagagaggaa tgatcctgtc
      901 cttttcgcca gtagagtccg gaatttgatg gcggaagctt tggaaatacc agtaacggat
      961 cacacctatg aagactgcag gctgatgatc tcagcggggc agctcacgct gcctatggag
     1021 gctgggctgg tagaattcac taagattagc cggaaactga agctggactg ggacggcatc
     1081 cgaaagcact tggacgagta cgcgtcaatc gcaagctccg ccaaaggagg ccgaattgga
     1141 atcgaggagt tcgcagagta cctgaagctg cccgtttccg atgtcctgcg acaacttttt
     1201 gctctctttg acaggaataa cgacggcagt attgacttcc gggagtacgt gatcggcttg
     1261 gctgtcttgt gcaaccctgc caacacagaa gacatcatcc aggtggcatt taagctcttt
     1321 gatgttgatg aggacggcta catcacggag gaagagtttt gcaccattct gcaggcttct
     1381 ctcggagtgc ctgaccttaa tgtttctggg ctcttcagag aaattgccca aggggactct
     1441 gtttcctacg aggaattcaa aagttttgct ctgaagcacc cagaatatgc caagatattt
     1501 acaacatatt tagacctcca gacatgccat gtgttttcac tgccagaaga cgtccagaca
     1561 gctccctctg ttgctagtaa taaagtgagc cccgagagcc atgaggaggg tacctcaggc
     1621 aaaaaggttg actgaactag tgttcccagt gacggatggt gatacgggaa aggttcgtca
     1681 acaacactgt gaatgtgctt atccacgaat gttgctcaaa atagaaagct cttttttttt
     1741 ttttttacta aaatgacata ttttcttcct aaaacgtttt ttattaacct gcctacatcc
     1801 agaaagttcc tttcgtttta ccttgtgctc tactggttgc gttgactgat gataagtgct
     1861 gtatattttt aatgaatttt tcagtttaat tttcataata aatccattgg tctttctc
//
