LOCUS       NM_001100735            3621 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lysophosphatidylcholine acyltransferase 1
            (Lpcat1), mRNA.
ACCESSION   NM_001100735 XM_001057012 XM_001057066 XM_341747
VERSION     NM_001100735.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3621)
  AUTHORS   Okubo,M., Yamanaka,H., Kobayashi,K., Kanda,H., Dai,Y. and
            Noguchi,K.
  TITLE     Up-regulation of platelet-activating factor synthases and its
            receptor in spinal cord contribute to development of neuropathic
            pain following peripheral nerve injury
  JOURNAL   Mol Pain 8, 8 (2012)
   PUBMED   22296727
  REMARK    GeneRIF: These data show the histological localization of PAF
            synthases and its receptor in the spinal cord following peripheral
            nerve injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3621)
  AUTHORS   Moessinger,C., Kuerschner,L., Spandl,J., Shevchenko,A. and
            Thiele,C.
  TITLE     Human lysophosphatidylcholine acyltransferases 1 and 2 are located
            in lipid droplets where they catalyze the formation of
            phosphatidylcholine
  JOURNAL   J Biol Chem 286 (24), 21330-21339 (2011)
   PUBMED   21498505
REFERENCE   3  (bases 1 to 3621)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   4  (bases 1 to 3621)
  AUTHORS   Butler,P.L. and Mallampalli,R.K.
  TITLE     Cross-talk between remodeling and de novo pathways maintains
            phospholipid balance through ubiquitination
  JOURNAL   J Biol Chem 285 (9), 6246-6258 (2010)
   PUBMED   20018880
REFERENCE   5  (bases 1 to 3621)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3621)
  AUTHORS   Harayama,T., Shindou,H., Ogasawara,R., Suwabe,A. and Shimizu,T.
  TITLE     Identification of a novel noninflammatory biosynthetic pathway of
            platelet-activating factor
  JOURNAL   J Biol Chem 283 (17), 11097-11106 (2008)
   PUBMED   18285344
  REMARK    GeneRIF: LPCAT1 transfers acetate from acetyl-CoA to lyso-PAF; its
            activity and expression are independent of inflammatory signals
REFERENCE   7  (bases 1 to 3621)
  AUTHORS   Soupene,E., Fyrst,H. and Kuypers,F.A.
  TITLE     Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes
  JOURNAL   Proc Natl Acad Sci U S A 105 (1), 88-93 (2008)
   PUBMED   18156367
REFERENCE   8  (bases 1 to 3621)
  AUTHORS   Chen,X., Hyatt,B.A., Mucenski,M.L., Mason,R.J. and Shannon,J.M.
  TITLE     Identification and characterization of a lysophosphatidylcholine
            acyltransferase in alveolar type II cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (31), 11724-11729 (2006)
   PUBMED   16864775
  REMARK    GeneRIF: Results suggest that lysophosphatidylcholine
            acyltransferase (LPCAT) plays a critical role in regulating
            surfactant phospholipid biosynthesis [LPCAT].
REFERENCE   9  (bases 1 to 3621)
  AUTHORS   Nakanishi,H., Shindou,H., Hishikawa,D., Harayama,T., Ogasawara,R.,
            Suwabe,A., Taguchi,R. and Shimizu,T.
  TITLE     Cloning and characterization of mouse lung-type
            acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1).
            Expression in alveolar type II cells and possible involvement in
            surfactant production
  JOURNAL   J Biol Chem 281 (29), 20140-20147 (2006)
   PUBMED   16704971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF406111.1, CB718601.1, AB244983.2, CK365681.1, EB482109.1,
            CN544249.1 and AW533114.1.
            
            On or before Nov 22, 2008 this sequence version replaced
            XM_001057066.1, XM_001057012.1, XM_341747.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               BF406111.1         1-221
            222-273             CB718601.1         160-211
            274-1742            AB244983.2         2-1470
            1743-2289           CK365681.1         165-711
            2290-2921           EB482109.1         32-663
            2922-3599           CN544249.1         16-693              c
            3600-3621           AW533114.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..3621
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..3621
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /note="lysophosphatidylcholine acyltransferase 1"
                     /db_xref="GeneID:361467"
                     /db_xref="RGD:1311599"
     exon            1..272
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1742
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /EC_number="2.3.1.51"
                     /EC_number="2.3.1.23"
                     /EC_number="2.3.1.67"
                     /EC_number="2.3.1.25"
                     /note="LPCAT-1; lysoPAFAT; LPC acyltransferase 1;
                     acyltransferase-like 2; lysoPC acyltransferase 1; lyso-PAF
                     acetyltransferase; acetyl-CoA:lyso-PAF acetyltransferase;
                     1-acylglycerophosphocholine O-acyltransferase;
                     1-alkylglycerophosphocholine O-acetyltransferase;
                     acetyl-CoA:lyso-platelet-activating factor
                     acetyltransferase; 1-acylglycerol-3-phosphate
                     O-acyltransferase; 1-alkenylglycerophosphocholine
                     O-acyltransferase"
                     /codon_start=1
                     /product="lysophosphatidylcholine acyltransferase 1"
                     /protein_id="NP_001094205.1"
                     /db_xref="GeneID:361467"
                     /db_xref="RGD:1311599"
                     /translation="MRLRGRGPRAAPSSSSGAGDARRLAPPGRNPFVHELRLSALQKA
                     QVAFMTLTLFPIRLLFAAFMMLLAWPFALVASLGPPDKEPEQPLALWRKVVDFLLKAI
                     MRTMWFAGGFHRVAVKGRQALPTEAAILTLAPHSSYFDAIPVTMTMSSIVMKAESRDI
                     PIWGTLIRYIRPVFVSRSDQDSRRKTVEEIKRRAQSNGKWPQIMIFPEGTCTNRTCLI
                     TFKPGAFIPGVPVQPVVLRYPNKLDTITWTWQGPGALKILWLTLCQFQNQVEIEFLPV
                     YCPSEEEKRNPALYASNVRRVMAKALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEF
                     ARLVRGLGLKPENLEKDLDKYSESARMKRGEKIRLPEFAAYLEVPVSDALEDMFSLFD
                     ESGGGEIDLREYVVALSVVCRPSQTLATIQLAFKMYGSPEDGSIDEADLSCILKTALG
                     ISELTVTDLFQAIDQEERGRITFDDFCGFAEMYPDFAEDYLYPDQTHSDSCAQTPPAP
                     TPNGFCIDFSPEHSDFGRKNSCKKVD"
     exon            273..415
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
     exon            416..630
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
     exon            631..743
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
     exon            744..804
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
     exon            805..863
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
     exon            864..898
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
     exon            899..953
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1036
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1162
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1316
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1415
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1557
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..3605
                     /gene="Lpcat1"
                     /gene_synonym="Aytl2; RGD1311599"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcgca tcctaggccc tctcccgcgc gctctgctag ctctgcagct ctcggctctc
       61 ctgcgtttgg ctccgctccg ctgagctcgg tcggctgtgc tccatctgct ccactccttg
      121 ctcaggcgcg agccgccatg aggctgcggg gtcgcgggcc gcgggccgcc ccttcctcca
      181 gctctggggc cggcgacgcg cgacggctag cgcccccggg gcggaacccc ttcgtgcacg
      241 agctgcgact gagcgccctg cagaaggccc aggtggcttt catgacgctg acgctgttcc
      301 ccatccggct cctgtttgct gctttcatga tgctgctggc ctggcctttt gcacttgtgg
      361 cctccctggg acctcctgat aaggagccag agcagcccct ggccttatgg aggaaggtcg
      421 tggacttcct gctcaaggcc atcatgcgca ccatgtggtt tgctggcggc ttccaccgag
      481 tagctgtgaa ggggcggcag gcattgccta ctgaggctgc tatcctcacc ttggccccac
      541 attcctccta ctttgatgcc atcccggtca ccatgaccat gtcctccatt gtgatgaagg
      601 cggaaagcag agacatccca atctggggaa ctctgataag atacatcagg cccgtgttcg
      661 tgtcccgctc tgaccaggac tctcgaagaa agacagtgga agagatcaag cgacgggcgc
      721 agtccaatgg aaagtggcct cagataatga tttttccaga gggaacgtgt acaaatagga
      781 cctgcctcat taccttcaaa cctggtgcat tcattcccgg agttcctgtc caacccgtgg
      841 tgctacgcta cccgaacaaa ttggacacca tcacatggac gtggcaagga cccggagcgt
      901 tgaaaatcct gtggctcacc ctgtgccagt ttcaaaacca agtggaaatt gaatttctgc
      961 ctgtgtattg tccttctgag gaggagaaga ggaatcctgc cctgtatgcc agtaatgtga
     1021 gacgcgtcat ggccaaggcc ctgggtgtct cagtaacaga ctacacgttt gaggactgcc
     1081 agctggctct ggcagaagga caacttcgcc tgcctgccga tacctgcctg ctagagtttg
     1141 ccaggctcgt gaggggcctc ggactaaaac cagaaaatct tgaaaaagat ctagacaaat
     1201 attcagagag cgcaaggatg aagagaggag agaagatcag gcttccagag tttgcagcct
     1261 acttggaagt tcccgtctca gacgcgctag aggacatgtt ctcgcttttt gatgagagtg
     1321 gtggcggtga gatagacctt cgagaatatg tggtcgcctt gtctgtggtg tgcaggccat
     1381 cccagaccct agccaccatc cagctggcat ttaagatgta tgggtctcct gaggatggca
     1441 gcatagatga agccgacctg tcctgcatcc tcaagactgc actgggcata tcagagttga
     1501 cagtgaccga cttgttccag gctattgacc aagaggagag gggaagaatc acatttgatg
     1561 acttctgtgg gtttgcagaa atgtaccctg acttcgcaga ggactacttg taccctgatc
     1621 agacacattc tgacagctgc gcacagacac ccccagcacc aactcccaat ggcttctgca
     1681 ttgacttcag ccccgaacac tcagactttg ggagaaagaa ttcgtgtaag aaagtggact
     1741 agagtggaag cctccggagg gatgaggccc ctgccgcatc atcgtctgcc tccagtggcc
     1801 tggagcccgt ttgtgtgttg cgctttctac cattccctgt ctcctcatgc cgtctctgtg
     1861 tgtctgcaga cctgagggcc acaagactcg tgggtgttat ttgttttctg taaagtctgt
     1921 ctcagggccc agctgggcat tggcagggaa gctgtgtgtg tggcccacct gcctattgcg
     1981 ggcaggcagg cgggtgggcg ctcggggcct ccctgtgggg caggactcca caggctgagt
     2041 gggcacagct gtgactgact gctcacctag actatgccgg gcttgagttc ctgtcggtct
     2101 ttccccttcg tctgtgcggt gtgcacaatg caggacctct gcgcacgctg cacgttccta
     2161 ccctgggaca gtcacctcgt cctaatttag tgcctctgcc gtctctggct ctcatgatgg
     2221 ggcatcatcg gattctaagt gtctctgtgt tcgtgcagga gcttgtgact cttttataaa
     2281 ccttacttag gtactttgaa accattcgac atttttttaa agaagaaaga aaattggttt
     2341 tctacttcat ttttcacgtt aacataagga taatttattt ccaggcttgc ttttgataga
     2401 ctctgagacg tcctggtggc cacaacttaa agggcctctc tgccctcctt ccatttagat
     2461 catgggacat ttagccacaa agactggccc caggatgctt ttcttcttcc cttaagcctt
     2521 cttgaatccc catctttttt ataaacatcg ccagtttggt atttcagttt caatatgaca
     2581 aagtctactt catgtaacta gtaaaagcat cgaatgtggg taaagaatca gccagaggga
     2641 aagaactgga aggcatttcc tctgtgctga ttttagcctt ctgagaagac aaaccgagat
     2701 ggccaggagg tcctgcccag agcccagcac cctctctgca ccagttacca tggtgactta
     2761 ggaaaagtag ccaccgtctg agcataggtg gccttactct gggggtgaca gctgcagggg
     2821 gcaggccaca gagtttacac tcagcccttc atgaagtcag gaaggaacag ggtccaggct
     2881 gtctgtcacc gttgacatta tcggattccg tctttttttt aatgacagac ttcttcgtaa
     2941 agcacagcga ctggaggttt agtttgtttc ctaagctttg gaatcttggt ttctactcct
     3001 aagttagatt ttttttcttt tggggcattg ctctaggaaa tgaccgccag gccagtcaag
     3061 gcaggaaaaa aaagtgtttt ctgagtttct cagagggagt gttagtgtgt gctttcccca
     3121 agagaaatcc acaaacaaaa cctgtcaacc tcagtcacac agcgccacac tgccgcggga
     3181 tgggcaggga gtttgattcc tgagctctta gcgggttagg taggaatgaa atgtgaacac
     3241 agcctttgta gctaacgggt tggttttata actgtagagt acaaattttc agatgagaaa
     3301 agccaccaaa aggccaatga aggagactaa tgaactaaga tgtcccgagg ctggggctct
     3361 gccctgccat ctgcacgtga cggattcctg aggaatgcca ctggtcgtgt tgaaggaatc
     3421 ctgagcagag ctgggacgga tgttcgtctc ctgatgactc tcgccagtaa cctcagtccg
     3481 tgcgtcagaa ctgtgaatgt acagagtggg caggggcagg ggcagcgccc gccctgcccg
     3541 cagggctcct ttgcggtgcg ggcttcaggt tttcagtgga ataaacacaa caacgtaaag
     3601 tttcaaaaaa aaaaaaaaaa a
//
