LOCUS       NM_001045843            1834 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus lysophosphatidic acid receptor 6 (Lpar6), mRNA.
ACCESSION   NM_001045843 XM_001076218
VERSION     NM_001045843.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1834)
  AUTHORS   Masago,K., Kihara,Y., Yanagida,K., Hamano,F., Nakagawa,S., Niwa,M.
            and Shimizu,T.
  TITLE     Lysophosphatidic acid receptor, LPA6, regulates endothelial
            blood-brain barrier function: Implication for hepatic
            encephalopathy
  JOURNAL   Biochem Biophys Res Commun 501 (4), 1048-1054 (2018)
   PUBMED   29778535
  REMARK    GeneRIF: the up-regulation of serum ATX in hepatic encephalopathy
            may activate the LPA-LPA6-G12/13-Rho pathway in brain capillary
            endothelial cells.
REFERENCE   2  (bases 1 to 1834)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1834)
  AUTHORS   Lee,M., Choi,S., Hallden,G., Yo,S.J., Schichnes,D. and Aponte,G.W.
  TITLE     P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor
            activated by lysophosphatidic acid that reduces intestinal cell
            adhesion
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 297 (4), G641-G654 (2009)
   PUBMED   19679818
  REMARK    GeneRIF: P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled
            receptor activated by lysophosphatidic acid that reduces intestinal
            cell adhesion.
REFERENCE   4  (bases 1 to 1834)
  AUTHORS   Pasternack,S.M., von Kugelgen,I., Al Aboud,K., Lee,Y.A.,
            Ruschendorf,F., Voss,K., Hillmer,A.M., Molderings,G.J., Franz,T.,
            Ramirez,A., Nurnberg,P., Nothen,M.M. and Betz,R.C.
  TITLE     G protein-coupled receptor P2Y5 and its ligand LPA are involved in
            maintenance of human hair growth
  JOURNAL   Nat Genet 40 (3), 329-334 (2008)
   PUBMED   18297070
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098703.1.
            
            On Sep 5, 2006 this sequence version replaced XM_001076218.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC098703.1, FQ228909.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..1834
                     /gene="Lpar6"
                     /gene_synonym="P2ry5"
                     /note="lysophosphatidic acid receptor 6"
                     /db_xref="GeneID:691774"
                     /db_xref="RGD:1595950"
     exon            1..1810
                     /gene="Lpar6"
                     /gene_synonym="P2ry5"
                     /inference="alignment:Splign:2.1.0"
     CDS             610..1644
                     /gene="Lpar6"
                     /gene_synonym="P2ry5"
                     /note="P2Y5; LPA-6; LPA receptor 6; P2Y purinoceptor 5;
                     purinergic receptor 5; oleoyl-L-alpha-lysophosphatidic
                     acid receptor; purinergic receptor P2Y, G-protein coupled,
                     5"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 6"
                     /protein_id="NP_001039308.1"
                     /db_xref="GeneID:691774"
                     /db_xref="RGD:1595950"
                     /translation="MVSANGSHCPYDDSFKYTLYGCMFSMVFVLGLISNCVAIYIFIC
                     ALKVRNETTTYMINLAMSDLLFVFTLPFRIFYFATRNWPFGDLLCKISVMLFYTNMYG
                     SILFLTCISVDRFLAIVYPFKSKTLRTKRNAKIVCIAVWFTVMGGSAPAVFFQSTHSQ
                     GNNTSEACFENFPAATWKTYLSRIVIFIEIVGFFIPLILNVTCSSMVLRTLNKPVTLS
                     RSKMNKTKVLKMIFVHLVIFCFCFVPYNINLILYSLVRTQTFVNCSVGAAVRTMYPIT
                     LCIAVSNCCFDPIVYYFTSDTIQNSIKMKSWSVRRSDSRFSEVQGTENFIQHNLQTLK
                     NKIFDNESAI"
ORIGIN      
        1 catctcacaa tacagccggc aacctcggaa aggcctccat tcagcaagag ctaacatgct
       61 taggaattta tctgggatcc tttaaaagac tctgcctatc accatctgga atcaatgtag
      121 agatacgaag acagaataaa aagaaggaca aagtacccga ggacgacgga ctgcgagtgt
      181 ttaaagacta aagactggta atttacgtct gaacattctg aacgtgaaga cattttaatt
      241 ttggaatatt tgccttgacg gctgaagtac aagtttacat gtggactggt cctgttcaac
      301 ttggaagttt ttccttacgc ttgcagcttt atggattggc ttcctggact gcattttctg
      361 tcagttaact aaactcggac tcatggattt tctaaaccag aaaatgagac tattttcctg
      421 aagaatctac tagaaacttt taagcaacac atttcatgct tcctttgaag agttcagaga
      481 agaaagtatt aataagaaca gaaaagaaac aaataatttg taaataaatt ggttgttgct
      541 gtgaccacat ctgaatacca aggcgaccgc tgccagcaga agggctcctg taggctgtgc
      601 tgcccgacaa tggtaagcgc caacggctcc cactgccctt atgacgactc ctttaagtac
      661 actttgtatg ggtgcatgtt cagcatggtg tttgtgcttg ggctgatatc caactgtgtt
      721 gcgatataca ttttcatctg tgccctcaaa gtgagaaacg aaactacaac gtacatgatt
      781 aacctggcaa tgtcagattt acttttcgtc tttactttgc catttcggat cttttacttt
      841 gcaacacgga attggccgtt tggagatctg ctctgtaaga tttcagtaat gctgttttac
      901 accaatatgt atggaagcat tctgttctta acctgtatca gtgtagatcg atttctggca
      961 attgtctacc catttaagtc gaagacttta agaactaaac gaaatgccaa gattgtttgc
     1021 attgctgtgt ggttcaccgt gatgggagga agtgcgcctg cagttttctt tcagtcgacc
     1081 cactctcagg gtaacaatac ctcagaagcc tgctttgaga actttccagc agccacatgg
     1141 aaaacttatc tctccaggat tgtgattttc attgaaatag tggggttttt tatccccctc
     1201 attttgaacg taacgtgttc tagtatggtg ctaaggactt taaataagcc tgttacttta
     1261 agcagaagca aaatgaacaa aaccaaggtt ttaaaaatga tttttgtcca cttggtcata
     1321 ttctgtttct gttttgtgcc ctataacatc aacctcattt tgtattctct cgtgagaaca
     1381 cagacctttg ttaactgctc tgtgggggct gcagtgagaa cgatgtaccc catcactctc
     1441 tgcattgctg tctccaactg ttgctttgac cccattgttt actacttcac ttcagacacg
     1501 atccagaact caataaagat gaagagctgg tctgttagaa ggagtgactc caggttctct
     1561 gaagttcagg gcaccgagaa ttttatccaa cacaacctac agaccttaaa aaataagata
     1621 tttgataatg aatctgcaat ataagctgcc tgactaaacc actgggactg ctccgtgttc
     1681 aactgtgaaa actgtgctct gggaaactat ttctccagct ccaacagaaa attaacctac
     1741 ggacggttac ctgtttttaa agaaagtttg tgtctgatga gttaacatta aaatatattc
     1801 tattcttgta aaaaaaaaaa aaaaaaaaaa aaaa
//
