LOCUS       NM_023969               2348 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus lysophosphatidic acid receptor 3 (Lpar3), mRNA.
ACCESSION   NM_023969 XM_346646
VERSION     NM_023969.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2348)
  AUTHORS   Fayyaz,S., Japtok,L., Schumacher,F., Wigger,D., Schulz,T.J.,
            Haubold,K., Gulbins,E., Voller,H. and Kleuser,B.
  TITLE     Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat
            Hepatocytes via the LPA3 Receptor Subtype and is Increased in
            Obesity
  JOURNAL   Cell Physiol Biochem 43 (2), 445-456 (2017)
   PUBMED   28922661
  REMARK    GeneRIF: Pretreatment of primary hepatocytes with lysophosphatidic
            acid (LPA) resulted in an inhibition of insulin-mediated Gck
            expression, PI3K activation and glycogen synthesis. Pharmacological
            approaches revealed that the LPA3-receptor subtype is responsible
            for the inhibitory effect of LPA on insulin signaling.
REFERENCE   2  (bases 1 to 2348)
  AUTHORS   Alcantara-Hernandez,R., Hernandez-Mendez,A., Campos-Martinez,G.A.,
            Meizoso-Huesca,A. and Garcia-Sainz,J.A.
  TITLE     Phosphorylation and Internalization of Lysophosphatidic Acid
            Receptors LPA1, LPA2, and LPA3
  JOURNAL   PLoS One 10 (10), e0140583 (2015)
   PUBMED   26473723
  REMARK    GeneRIF: Data showed that lysophosphatidic acid receptors LPA1-3,
            are phosphoproteins whose phosphorylation state is modulated by the
            natural agonist, LPA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2348)
  AUTHORS   Inoue,S., Tanabe,E., Shibata,A., Hirane,M., Araki,M., Dong,Y.,
            Fukushima,N. and Tsujiuchi,T.
  TITLE     Ethionine regulates cell motile activity through LPA receptor-3 in
            liver epithelial WB-F344 cells
  JOURNAL   Mol Cell Biochem 383 (1-2), 173-177 (2013)
   PUBMED   23867992
  REMARK    GeneRIF: Lysophosphatidic acid signaling through LPA3 may be
            involved in cell motile activity stimulated by ethionine in WB-F344
            cells.
REFERENCE   4  (bases 1 to 2348)
  AUTHORS   Beltrame,J.S., Sordelli,M.S., Cella,M., Perez Martinez,S.,
            Franchi,A.M. and Ribeiro,M.L.
  TITLE     Lysophosphatidic acid increases the production of pivotal mediators
            of decidualization and vascularization in the rat uterus
  JOURNAL   Placenta 34 (9), 751-756 (2013)
   PUBMED   23790320
  REMARK    GeneRIF: Data suggest that signal transduction involving
            lysophosphatidic acid and Lpar3 is involved in uterine
            vascularization and decidualization, two main processes that
            prepare uterine milieu for embryo invasion during implantation.
REFERENCE   5  (bases 1 to 2348)
  AUTHORS   Yang,J., Nie,Y., Wang,F., Hou,J., Cong,X., Hu,S. and Chen,X.
  TITLE     Reciprocal regulation of miR-23a and lysophosphatidic acid receptor
            signaling in cardiomyocyte hypertrophy
  JOURNAL   Biochim Biophys Acta 1831 (8), 1386-1394 (2013)
   PUBMED   23711961
  REMARK    GeneRIF: These findings identified opposite subtype-specific
            functions for LPA1 and LPA3 in mediating cardiomyocyte hypertrophy
            and indicated LPA1 to be a target of miR-23a
REFERENCE   6  (bases 1 to 2348)
  AUTHORS   Kim,M.K., Lee,H.Y., Park,K.S., Shin,E.H., Jo,S.H., Yun,J.,
            Lee,S.W., Yoo,Y.H., Lee,Y.S., Baek,S.H. and Bae,Y.S.
  TITLE     Lysophosphatidic acid stimulates cell proliferation in rat
            chondrocytes
  JOURNAL   Biochem Pharmacol 70 (12), 1764-1771 (2005)
   PUBMED   16242672
REFERENCE   7  (bases 1 to 2348)
  AUTHORS   Yamada,T., Ohoka,Y., Kogo,M. and Inagaki,S.
  TITLE     Physical and functional interactions of the lysophosphatidic acid
            receptors with PDZ domain-containing Rho guanine nucleotide
            exchange factors (RhoGEFs)
  JOURNAL   J Biol Chem 280 (19), 19358-19363 (2005)
   PUBMED   15755723
REFERENCE   8  (bases 1 to 2348)
  AUTHORS   Siess,W. and Tigyi,G.
  TITLE     Thrombogenic and atherogenic activities of lysophosphatidic acid
  JOURNAL   J Cell Biochem 92 (6), 1086-1094 (2004)
   PUBMED   15258894
  REMARK    Review article
REFERENCE   9  (bases 1 to 2348)
  AUTHORS   Hama,K., Bandoh,K., Kakehi,Y., Aoki,J. and Arai,H.
  TITLE     Lysophosphatidic acid (LPA) receptors are activated differentially
            by biological fluids: possible role of LPA-binding proteins in
            activation of LPA receptors
  JOURNAL   FEBS Lett 523 (1-3), 187-192 (2002)
   PUBMED   12123830
REFERENCE   10 (bases 1 to 2348)
  AUTHORS   Moller,T., Contos,J.J., Musante,D.B., Chun,J. and Ransom,B.R.
  TITLE     Expression and function of lysophosphatidic acid receptors in
            cultured rodent microglial cells
  JOURNAL   J Biol Chem 276 (28), 25946-25952 (2001)
   PUBMED   11340076
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_023969.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF097733.1, AB051164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-716               JAXUCZ010000002.1  237809345-237810060
            717-2348            JAXUCZ010000002.1  237852419-237854050
FEATURES             Location/Qualifiers
     source          1..2348
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..2348
                     /gene="Lpar3"
                     /gene_synonym="Edg7"
                     /note="lysophosphatidic acid receptor 3"
                     /db_xref="GeneID:66025"
                     /db_xref="RGD:620565"
     exon            1..716
                     /gene="Lpar3"
                     /gene_synonym="Edg7"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1045
                     /gene="Lpar3"
                     /gene_synonym="Edg7"
                     /note="LPA-3; snGPCR32; LPA receptor 3; lysophosphatidic
                     acid receptor Edg-7; putative G protein-coupled receptor
                     snGPCR32; endothelial differentiation, lysophosphatidic
                     acid G-protein-coupled receptor 7"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 3"
                     /protein_id="NP_076459.2"
                     /db_xref="GeneID:66025"
                     /db_xref="RGD:620565"
                     /translation="MDFFYNRSNTDTADEWTGTKLVIVLCVGTFFCLFIFFSNSLVIA
                     AVITNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWLLRQGLLDT
                     SLTASLANLLVIAVERHMSIMRMRIHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNC
                     LCNISACSSLAPIYSRSYLIFWTVSNLLAFFIMVVVYVRIYMYVKRKTNVLSPHTSGS
                     ISRRRAPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCKQCNVQHVKRWFLLLALLN
                     SVMNPIIYSYKDEDMYNTMRKMICCAPHDSNAERHPSRIPSTIHSRSDTGSQYLEDSI
                     SQGQVCNKSSS"
     exon            717..2348
                     /gene="Lpar3"
                     /gene_synonym="Edg7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagcggatg gactttttct acaacaggag caacacagac acggcggacg agtggacggg
       61 gacgaagctc gtgatcgtcc tgtgcgttgg gacattcttc tgcctcttta tatttttttc
      121 taactccctg gtcatcgcag cagtgatcac gaataggaag ttccactttc ccttctacta
      181 cctgctggct aacttggcgg ctgcggattt ctttgccgga atcgcttatg tgttcctgat
      241 gtttaacacc ggcccggtgt cgaaaacctt gactgtcaac cgctggcttc tccgccaggg
      301 gctcctagac acaagcctga cggcctccct ggccaatctg ctggtaattg ctgtggaaag
      361 acacatgtca atcatgagga tgagaatcca cagcaacttg accaaaaaac gggtgacgct
      421 gctcatcctg ctggtgtggg ccatagccat tttcatgggg gcggtcccca cgctgggctg
      481 gaattgcctc tgcaacatct cagcctgctc ctctctggcc ccgatttaca gcaggagtta
      541 cctcatcttc tggacggtgt caaacctcct ggccttcttc atcatggtgg tggtgtacgt
      601 gcgcatctac atgtatgtca agaggaaaac caacgtcctc tctccgcaca cgagtggctc
      661 catcagccgc cggagggccc ccatgaagct aatgaagacg gtgatgactg tcttaggagc
      721 cttcgtggtg tgctggaccc cgggtctcgt ggtgctgctg ctggacggcc tgaactgcaa
      781 gcagtgtaat gtgcagcacg tgaagcgctg gttcctgctg ctggcgctgc tcaactccgt
      841 catgaacccc atcatctact cgtacaagga cgaggacatg tacaacacca tgcggaagat
      901 gatctgctgt gccccgcacg acagcaacgc cgagaggcac ccctcccgca tcccctctac
      961 catccacagc aggagcgaca cgggcagcca gtacctggag gacagcatca gccagggcca
     1021 ggtgtgcaat aaaagcagct cctaagccag ggacgcctcc gccctctccc cctggggaaa
     1081 gagcccttaa gagtccttgc ctgtctcaca aagcacatgg acagggttgt ttgagggctc
     1141 catgaatcac tgctgggcct tgtaagtttt cattgtcaag gaagataaga tactgcattt
     1201 agtaagagtg cacagaaaag ggagagatga acagtgggct cctgctcgtc gtctgcgaac
     1261 cgctccgaac atcctccagc tctcgcgcaa agcatgctgg gctctgccac catcttgccg
     1321 ccatggtctg tgtgttttca aagatggtgt tgaaggtcct aggtcaaaag aagtagtaaa
     1381 taatggtacc tgagcctcca tgtgtagctg ctagactcta gttgtttccg cgtgggttta
     1441 aaatgttcag aaaatatttt agcagtggac ttggatttcc ccagaggagc catgatccag
     1501 aactagatgt attgcagaaa tctgggaaca aactgtatag aggggtaaac ttggtgtata
     1561 accacgtgac tttctgagga aagagaacac tgcaagggtg gaggtgtaga agctcttctg
     1621 gagtggaaag agctttttgt cctttgtaca cgtgggtgta catgctacac acacgggtgt
     1681 acatccacct ctacttatac aattcaactt catttaacga agcccatccg tgatggcgag
     1741 tttagaccac tgcctcctag agttttcagt ccaggctagt ggctttagag attgtctttg
     1801 tgttctaaac aagaagagaa aacactattc acttctaaag gggcaactgt acagcagagt
     1861 aagtgatgat attgaccagc aggctgaacc tcttccaaat agcgtcaaat acgagcatga
     1921 ttagatccta gatcctccgt cttggtggtc tggataccac tgatgggttt gctggattcc
     1981 atgtgcaaag aaactgcaca tctagtattt taaccaaagc tgccagcata ctctatctta
     2041 cttgtggact gaatttttga tcttgcattt ttttttctcc ttcaaagacc tatgaaaggc
     2101 agatcagtta aaaacaaaaa tagtgtttca tacacatagg ctactgacca gtgttttcta
     2161 tgtgagacat ttagagacta ttctgactta aagaataact tcaaggcagg tactatggta
     2221 tttatgtagt ttgcaaacgt ttacatgttc tctctctctc tctctctctc tctctctctc
     2281 tctctctctg ctgttgtgat gtaacattta tgtgcacaaa ctacttgtaa taaaagattt
     2341 taagaagt
//
