LOCUS       NM_053936               3376 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Rattus norvegicus lysophosphatidic acid receptor 1 (Lpar1), mRNA.
ACCESSION   NM_053936 XM_346740
VERSION     NM_053936.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3376)
  AUTHORS   He,H., Su,H., Chen,X., Chen,X. and Yang,S.
  TITLE     Interference with GPR4 inactivates NLRP3 inflammasome signaling by
            inhibiting LPAR1 expression to ameliorate oxygen-glucose
            deprivation/reoxygenation-induced inflammation and apoptosis of
            cardiomyocytes
  JOURNAL   Prostaglandins Other Lipid Mediat 174, 106863 (2024)
   PUBMED   38936540
  REMARK    GeneRIF: Interference with GPR4 inactivates NLRP3 inflammasome
            signaling by inhibiting LPAR1 expression to ameliorate
            oxygen-glucose deprivation/reoxygenation-induced inflammation and
            apoptosis of cardiomyocytes.
REFERENCE   2  (bases 1 to 3376)
  AUTHORS   Szepanowski,F., Winkelhausen,M., Steubing,R.D., Mausberg,A.K.,
            Kleinschnitz,C. and Stettner,M.
  TITLE     LPA1 signaling drives Schwann cell dedifferentiation in
            experimental autoimmune neuritis
  JOURNAL   J Neuroinflammation 18 (1), 293 (2021)
   PUBMED   34920725
  REMARK    GeneRIF: LPA1 signaling drives Schwann cell dedifferentiation in
            experimental autoimmune neuritis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3376)
  AUTHORS   Ishii,S., Tsujiuchi,T. and Fukushima,N.
  TITLE     Functional characterization of lysophosphatidic acid receptor 1
            mutants identified in rat cancer tissues
  JOURNAL   Biochem Biophys Res Commun 486 (3), 767-773 (2017)
   PUBMED   28342860
  REMARK    GeneRIF: The data suggest that the LPAR1 mutants perturb
            lysophosphatidic acid signaling in cancer tissues.
REFERENCE   4  (bases 1 to 3376)
  AUTHORS   Wu,J.X., Yuan,X.M., Wang,Q., Wei,W. and Xu,M.Y.
  TITLE     Rho/ROCK acts downstream of lysophosphatidic acid receptor 1 in
            modulating P2X3 receptor-mediated bone cancer pain in rats
  JOURNAL   Mol Pain 12, 1744806916644929 (2016)
   PUBMED   27094551
  REMARK    GeneRIF: Lysophosphatidic acid and its receptor LPAR1, acting
            through the Rho-ROCK pathway, regulate P2X3 receptor in the
            development of both mechanical and spontaneous pain in bone cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3376)
  AUTHORS   Alcantara-Hernandez,R., Hernandez-Mendez,A., Campos-Martinez,G.A.,
            Meizoso-Huesca,A. and Garcia-Sainz,J.A.
  TITLE     Phosphorylation and Internalization of Lysophosphatidic Acid
            Receptors LPA1, LPA2, and LPA3
  JOURNAL   PLoS One 10 (10), e0140583 (2015)
   PUBMED   26473723
  REMARK    GeneRIF: Data showed that lysophosphatidic acid receptors LPA1-3,
            are phosphoproteins whose phosphorylation state is modulated by the
            natural agonist, LPA.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3376)
  AUTHORS   Allard,J., Barron,S., Trottier,S., Cervera,P., Daumas-Duport,C.,
            Leguern,E., Brice,A., Schwartz,J.C. and Sokoloff,P.
  TITLE     Edg-2 in myelin-forming cells: isoforms, genomic mapping, and
            exclusion in Charcot-Marie-Tooth disease
  JOURNAL   Glia 26 (2), 176-185 (1999)
   PUBMED   10384882
REFERENCE   7  (bases 1 to 3376)
  AUTHORS   Fukushima,N., Kimura,Y. and Chun,J.
  TITLE     A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins
            and mediates multiple cellular responses to lysophosphatidic acid
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6151-6156 (1998)
   PUBMED   9600933
REFERENCE   8  (bases 1 to 3376)
  AUTHORS   Allard,J., Barron,S., Diaz,J., Lubetzki,C., Zalc,B., Schwartz,J.C.
            and Sokoloff,P.
  TITLE     A rat G protein-coupled receptor selectively expressed in
            myelin-forming cells
  JOURNAL   Eur J Neurosci 10 (3), 1045-1053 (1998)
   PUBMED   9753172
REFERENCE   9  (bases 1 to 3376)
  AUTHORS   An,S., Dickens,M.A., Bleu,T., Hallmark,O.G. and Goetzl,E.J.
  TITLE     Molecular cloning of the human Edg2 protein and its identification
            as a functional cellular receptor for lysophosphatidic acid
  JOURNAL   Biochem Biophys Res Commun 231 (3), 619-622 (1997)
   PUBMED   9070858
REFERENCE   10 (bases 1 to 3376)
  AUTHORS   Hecht,J.H., Weiner,J.A., Post,S.R. and Chun,J.
  TITLE     Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid
            receptor expressed in neurogenic regions of the developing cerebral
            cortex
  JOURNAL   J Cell Biol 135 (4), 1071-1083 (1996)
   PUBMED   8922387
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2021 this sequence version replaced NM_053936.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089227.1, SRR26643294.21299.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676786,
                                           SAMN16676787 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000005.1  78142067-78142188   c
            123-280             JAXUCZ010000005.1  78090616-78090773   c
            281-1028            JAXUCZ010000005.1  78070602-78071349   c
            1029-3376           JAXUCZ010000005.1  78024139-78026486   c
FEATURES             Location/Qualifiers
     source          1..3376
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..3376
                     /gene="Lpar1"
                     /gene_synonym="Edg2"
                     /note="lysophosphatidic acid receptor 1"
                     /db_xref="GeneID:116744"
                     /db_xref="RGD:620563"
     exon            1..122
                     /gene="Lpar1"
                     /gene_synonym="Edg2"
                     /inference="alignment:Splign:2.1.0"
     exon            123..280
                     /gene="Lpar1"
                     /gene_synonym="Edg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1330
                     /gene="Lpar1"
                     /gene_synonym="Edg2"
                     /note="LPA-1; LPA receptor 1; lysophosphatidic acid
                     receptor Edg-2; endothelial differentiation,
                     lysophosphatidic acid G-protein-coupled receptor, 2"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 1"
                     /protein_id="NP_446388.1"
                     /db_xref="GeneID:116744"
                     /db_xref="RGD:620563"
                     /translation="MAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATE
                     WNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY
                     FYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMS
                     NRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTF
                     VVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLV
                     LLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENP
                     NGPTEGSDRSASSLNHTILAGVHSNDHSVV"
     exon            281..1028
                     /gene="Lpar1"
                     /gene_synonym="Edg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..3376
                     /gene="Lpar1"
                     /gene_synonym="Edg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgtgtgtg aggccgcctg caggaggcga ggctgccctg gcctcccgca ccagccggtg
       61 gaacccagcc cgggagggaa gtcgccgcag ccgccccggc ggctctcctg ccctttggcc
      121 aggctttcag ttcctcctag catgactgag atctgaccag ccgactcacg agttgcttct
      181 tgtgccacca ctgcagtgct ggggcctctt catcgctcca aactacagca ctgtcatggc
      241 agctgcctct acttccagcc ctgtgatttc acagccccag ttcacagcca tgaacgaaca
      301 acagtgcttc tacaacgagt ctatcgcctt cttctataac cggagtggaa agtatctagc
      361 cacagaatgg aacactgtga gcaagctggt gatgggactg ggcatcactg tctgcgtgtt
      421 catcatgctg gccaatctac tggtcatggt ggcaatttac gtcaaccgcc gcttccattt
      481 ccctatttat tacttgatgg ccaacctggc tgctgcagac ttcttcgctg gactggccta
      541 cttctacctg atgttcaaca cgggacctaa tacccggaga ctgaccgtga gcacatggct
      601 tctccggcag ggcctcatcg acaccagcct gacggcttct gtggccaacc tgctggccat
      661 tgccatcgag aggcacatca cagttttccg aatgcagctc catacacgaa tgagcaaccg
      721 acgtgtggtg gtggtgattg tagtcatctg gactatggcc attgtgatgg gtgccatacc
      781 cagtgtgggc tggaactgca tctgtgatat cgatcattgt tccaacatgg cgcccctcta
      841 cagtgactcc tacttagtct tctgggccat tttcaacctg gtgacctttg tggtcatggt
      901 ggttctctac gctcacatct ttggctatgt tcgccagagg actatgagaa tgtcccggca
      961 tagttctgga cccaggagga atcgggacac catgatgagc cttctgaaga ctgtggtcat
     1021 tgtgctgggt gcctttattg tctgctggac tccgggattg gtcttgctac tgctcgatgt
     1081 gtgttgcccg cagtgcgatg tcctggccta tgagaagttc ttcctcctcc tggccgagtt
     1141 caactcggct atgaacccca tcatctactc ctaccgcgac aaagagatga gcgccacctt
     1201 caggcagatc ctgtgttgcc agcgcaacga gaaccccaac ggccccacgg aaggctctga
     1261 ccgctcggcc tcctccctca accacactat tctggctgga gttcacagca atgaccactc
     1321 tgtggtttag aaggaagcca gccggccttt gtggatctgt gaaccccacc ctacccgcat
     1381 tgccagggca aggtggggcg ccagaggaga cgaagacact cctgtactta acactaacca
     1441 atggcagtat ttgtccctag acccaagaga ctttaggatg aacttgcttg gtagccccca
     1501 tcttctcctt tggaaaagag aaggggaccg tcttgcagtg gaattcagaa acggactctg
     1561 gggagaccgt gtatgtagcc ttcactaact agacttaaaa gattttatgt ggtttggcct
     1621 aagccagaaa aaaaaaaaca aatcttccaa atcaagtaca caattcacac aggcttcccc
     1681 tttaaagaac aaacaacaca ttgcatttat taataagtat gtatatgtct gacagcatgt
     1741 ttgtgatcga gaagactgct aaactgactt agatgaattt ttatccacga tggaggaaaa
     1801 ctataaatta gaatgatttt catgttttgt ttagaaagca agcatgtgat gtgtgtatgc
     1861 agtatgcctt tctttaaaga taaaaggata ctattttaaa tcttctaggg aatagaagag
     1921 tctagtaaaa aaaaaaaaat cagtattcat ttaggctatg gaagaaacct accagttacc
     1981 ttttaagtaa tgagacacac atgaaaggca aaggaatgtg agcttgtcac ccaaagagtg
     2041 tgtactctgc aagctttgga gatgaagtgc tgtagcgttg tccctgcaca gtgaggatat
     2101 ccaagttcgt tcttggtgcc agagcgtcgg tgggatttgt tttaaagcct gtggttttcc
     2161 aagttataaa ataatactta ctatagaaaa cttgaaaatt gcagaactct gtgaaaaaag
     2221 gaaaaaaaaa agattatcga tattataacc aggaagtcac cctctttacc agctcacgag
     2281 tgtatgccta tagatatata tatattatat acctttttta cataattggg ttgatattgt
     2341 aaaatgtttt gtaacttttt ctttcagaat tgccaggttt ttctatggca ttttttttaa
     2401 aaacagtgtt agcggctata taatattcca tttaatggat gcagcccctg tttatttaac
     2461 cattcctgta ttgttggcta ggtttttaat ttttttcatt attataatat cggaagaatc
     2521 ttgtgtacat aaagcgttgc cagtaccatt gatgatttac ttaggagcta ttcccatgaa
     2581 ggacctactt tttaaaatgt gaaatgtcct caagtgtttt cactttacaa aaagggatat
     2641 tctactttca aactgcaggg gtggccacgc tgacaaaagc ctgggaaact acctttttac
     2701 aaaagaaatg cagtggctac tttagttgag aatgagttct tgacaagatg tttcccaata
     2761 accaagatgc cctaacgtaa ctagcaaatt tattttagcg ttttttgagg aaatggtgat
     2821 ccctttcttg aatgttgggt agaagtaaac aaagacatca aacatcgaag tgaatccagc
     2881 gttgctgttc caagtagcct tggtggggca tgttagcagc tggctcctgt gtgatctcca
     2941 gcaatcaacc aattggtgcc ctatgttcag agatgcccag tacagtgtcc gggcgactca
     3001 tgtgtctatt gtcgtgctat gaggagcaag gaggaagaag aatagtcctg aagcaggtgt
     3061 ggggaggtca ggaggatgtc tgtgagaagg aagtcctgca gagagtggca ttctggggag
     3121 gaggaaaggc agggtgtggc ttgtgtctgg gtagagggta ggcatgtgac gtgtgcctgg
     3181 tgggaaaaat aagtaggtgg agagccagtt agcaggaaaa agattttgct ccatatttac
     3241 caaaatgcaa agaaatttat attggaaatg agtgaaatga acttggactt ttattgatgc
     3301 cctttttatg ggggatgtaa ggactttaaa ttgaaaagca tactaattga accttaataa
     3361 atcattctca atcagc
//
