LOCUS       NM_001107866            2840 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus lysyl oxidase-like 3 (Loxl3), mRNA.
ACCESSION   NM_001107866 XM_001066093 XM_232107
VERSION     NM_001107866.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2840)
  AUTHORS   Zheng,G.P., Liu,C., Zhang,L., Zhong,Q., Zhang,Y. and Huang,Z.M.
  TITLE     LOXL3 Inhibits Autophagy of Chondrocytes by Activating Rheb in
            Osteoarthritis
  JOURNAL   Curr Med Sci 43 (6), 1195-1200 (2023)
   PUBMED   38153629
  REMARK    GeneRIF: LOXL3 Inhibits Autophagy of Chondrocytes by Activating
            Rheb in Osteoarthritis.
REFERENCE   2  (bases 1 to 2840)
  AUTHORS   Huang,L., Chen,J., Zuo,Y., Li,J., Yue,Y., Wang,M. and Hao,L.
  TITLE     Implications of lysyl oxidase-like protein 3 expression in the
            periodontium of diabetic rats
  JOURNAL   J Appl Oral Sci 30, e20220176 (2022)
   PUBMED   36134856
  REMARK    GeneRIF: Implications of lysyl oxidase-like protein 3 expression in
            the periodontium of diabetic rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2840)
  AUTHORS   Jones,M.G., Andriotis,O.G., Roberts,J.J., Lunn,K., Tear,V.J.,
            Cao,L., Ask,K., Smart,D.E., Bonfanti,A., Johnson,P., Alzetani,A.,
            Conforti,F., Doherty,R., Lai,C.Y., Johnson,B., Bourdakos,K.N.,
            Fletcher,S.V., Marshall,B.G., Jogai,S., Brereton,C.J., Chee,S.J.,
            Ottensmeier,C.H., Sime,P., Gauldie,J., Kolb,M., Mahajan,S.,
            Fabre,A., Bhaskar,A., Jarolimek,W., Richeldi,L., O'Reilly,K.M.,
            Monk,P.D., Thurner,P.J. and Davies,D.E.
  TITLE     Nanoscale dysregulation of collagen structure-function disrupts
            mechano-homeostasis and mediates pulmonary fibrosis
  JOURNAL   Elife 7, e36354 (2018)
   PUBMED   29966587
  REMARK    GeneRIF: Dual inhibition of LOXL2 and LOXL3 in a pulmonary fibrosis
            model was sufficient to normalize collagen fibrillogenesis, reduce
            tissue stiffness, and improve lung function in vivo.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2840)
  AUTHORS   Ma,L., Huang,C., Wang,X.J., Xin,D.E., Wang,L.S., Zou,Q.C.,
            Zhang,Y.S., Tan,M.D., Wang,Y.M., Zhao,T.C., Chatterjee,D.,
            Altura,R.A., Wang,C., Xu,Y.S., Yang,J.H., Fan,Y.S., Han,B.H.,
            Si,J., Zhang,X., Cheng,J., Chang,Z. and Chin,Y.E.
  TITLE     Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3
            Deacetylation and Deacetylimination Modulation
  JOURNAL   Mol Cell 65 (2), 296-309 (2017)
   PUBMED   28065600
REFERENCE   5  (bases 1 to 2840)
  AUTHORS   Zhang,J., Liu,Z., Zhang,T., Lin,Z., Li,Z., Zhang,A., Sun,X. and
            Gao,J.
  TITLE     Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development
            in Mice
  JOURNAL   Sci Rep 6, 33856 (2016)
   PUBMED   27645581
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2840)
  AUTHORS   Kraft-Sheleg,O., Zaffryar-Eilot,S., Genin,O., Yaseen,W.,
            Soueid-Baumgarten,S., Kessler,O., Smolkin,T., Akiri,G., Neufeld,G.,
            Cinnamon,Y. and Hasson,P.
  TITLE     Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber
            Stretch and Integrin-Mediated Adhesion
  JOURNAL   Dev Cell 36 (5), 550-561 (2016)
   PUBMED   26954549
REFERENCE   7  (bases 1 to 2840)
  AUTHORS   Zhang,J., Yang,R., Liu,Z., Hou,C., Zong,W., Zhang,A., Sun,X. and
            Gao,J.
  TITLE     Loss of lysyl oxidase-like 3 causes cleft palate and spinal
            deformity in mice
  JOURNAL   Hum Mol Genet 24 (21), 6174-6185 (2015)
   PUBMED   26307084
REFERENCE   8  (bases 1 to 2840)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   9  (bases 1 to 2840)
  AUTHORS   Peinado,H., Del Carmen Iglesias-de la Cruz,M., Olmeda,D.,
            Csiszar,K., Fong,K.S., Vega,S., Nieto,M.A., Cano,A. and Portillo,F.
  TITLE     A molecular role for lysyl oxidase-like 2 enzyme in snail
            regulation and tumor progression
  JOURNAL   EMBO J 24 (19), 3446-3458 (2005)
   PUBMED   16096638
REFERENCE   10 (bases 1 to 2840)
  AUTHORS   Maki,J.M. and Kivirikko,K.I.
  TITLE     Cloning and characterization of a fourth human lysyl oxidase
            isoenzyme
  JOURNAL   Biochem J 355 (Pt 2), 381-387 (2001)
   PUBMED   11284725
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000004.1.
            
            On Oct 12, 2007 this sequence version replaced NM_001107866.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2315840.1,
                                           SRR22399481.1805057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               JAXUCZ010000004.1  117098358-117098472
            116-459             JAXUCZ010000004.1  117099635-117099978
            460-623             JAXUCZ010000004.1  117101588-117101751
            624-838             JAXUCZ010000004.1  117102469-117102683
            839-1058            JAXUCZ010000004.1  117111404-117111623
            1059-1239           JAXUCZ010000004.1  117112008-117112188
            1240-1394           JAXUCZ010000004.1  117112299-117112453
            1395-1562           JAXUCZ010000004.1  117112619-117112786
            1563-1725           JAXUCZ010000004.1  117112872-117113034
            1726-1969           JAXUCZ010000004.1  117113143-117113386
            1970-2085           JAXUCZ010000004.1  117113486-117113601
            2086-2222           JAXUCZ010000004.1  117113675-117113811
            2223-2334           JAXUCZ010000004.1  117113926-117114037
            2335-2840           JAXUCZ010000004.1  117114168-117114673
FEATURES             Location/Qualifiers
     source          1..2840
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2840
                     /gene="Loxl3"
                     /note="lysyl oxidase-like 3"
                     /db_xref="GeneID:312478"
                     /db_xref="RGD:1311011"
     exon            1..115
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
     exon            116..459
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2408
                     /gene="Loxl3"
                     /note="lysyl oxidase homolog 3"
                     /codon_start=1
                     /product="lysyl oxidase homolog 3 precursor"
                     /protein_id="NP_001101336.1"
                     /db_xref="GeneID:312478"
                     /db_xref="RGD:1311011"
                     /translation="MRAVNVCYCCPWRLLLLHFLCSSSMGSPSPSTDPEKKVGSQGLR
                     FRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHVLCRELGFTEATGWTHSAKYG
                     PGTGRIWLDNLSCKGTEGSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIE
                     VDHQLQVEEVRLRPAVEWGRRPLPVTEGLVEVRLPEGWSQVCDKGWSAHNSHVVCGML
                     GFPGEKRVNMAFYRMLAQKKQHSFGLHSVACVGTEAHLSLCSLEFYRANDTTRCAGGS
                     PAVVSCMLGPLYATSTGQKKQQHSKPQGEASVRLKGGAHPGEGRVEVLKAGTWGTVCD
                     RKWDLQAASVVCRELGFGTAREALSGARMGQGMGAIHLSEVRCSGQEPSLWKCPSKNI
                     TAEDCSHSQDAAVRCNLPYTGVETKIRLSGGRSRYEGRVEVQIGVPGHLRWGLICGDD
                     WGTLEAMVACRQLGLGYANHGLQETWYWDSGNVTEVVMSGVRCTGSELSLNQCAHHNT
                     HVTCKRTGTRFTAGVICSETASDLLLHSALVQETAYIEDRPLHMLYCAAEENCLASSA
                     RSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHSWVWHECHGHYHSMDIFTHYDILT
                     PNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQGITVGCWDLYRHDIDCQWIDI
                     TDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGHRIWVHNCHIGDAFSEEANR
                     RFERYPGQTSNQIV"
     exon            460..623
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
     exon            624..838
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1058
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1239
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1394
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1562
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1725
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1969
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2085
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2222
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2334
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2840
                     /gene="Loxl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggaagggg gggtccagtc tcccctggcc gaacactttt tttctgagaa gtcctgaaag
       61 taatctccag gaccaggact ctgcttccag cctctggagt tctgcctagt cgaagtgccc
      121 cccctccttg agccctaacc gccatgagag ctgtcaatgt gtgctattgc tgcccgtggc
      181 gactactgct gctgcacttt ctgtgcagct ccagtatggg gtctccgtct ccttctaccg
      241 acccagagaa gaaggtagga agccaggggc tgaggttccg tctggctggc tttcctagaa
      301 agccctatga gggccgtgtg gagatacagc gagccggcga atggggcacc atctgtgatg
      361 atgacttcac gctgcaggct gcccacgtcc tctgccggga gctgggcttc acagaagcca
      421 ccggttggac ccacagtgcc aaatacggcc caggaacagg ccgaatctgg ttggacaatc
      481 tgagctgcaa gggtactgaa ggaagtgtga ctgaatgtgc ctcccggggc tggggaaaca
      541 gtgactgtac ccatgacgag gatgctgggg tcatctgcaa ggaccagcgc cttcccggtt
      601 tctcagactc caacgtcatt gaggtggatc atcagctcca agtggaggaa gtgcgactcc
      661 gaccagctgt ggagtggggc aggcgacccc tgcctgtgac tgagggcctg gttgaagtca
      721 ggcttcctga aggctggtcg caagtgtgtg acaaaggctg gagtgcccac aacagccacg
      781 tagtctgcgg tatgctgggt ttccctggag aaaagagagt caacatggcc ttctacagga
      841 tgctggccca gaagaagcaa cactcctttg gtctacacag cgtggcatgt gtgggcacag
      901 aagcccacct ctccctttgc tctctggagt tctatcgtgc caatgacacc accagatgtg
      961 ctggtgggag ccctgcagtg gtgagctgta tgctgggccc tctttatgcc acctctactg
     1021 gtcagaagaa gcagcaacat tctaagcctc aaggggaggc cagtgtgcgt ctaaagggcg
     1081 gtgcccaccc tggagaaggc cgagtggaag tcctgaaggc tggcacatgg ggaacagtct
     1141 gtgaccgaaa gtgggatctg caggcagcca gtgtagtgtg tcgagagctg ggctttggca
     1201 ctgcccgaga agccctgagt ggtgcccgca tggggcaggg catgggtgcc atccacttga
     1261 gtgaagttcg gtgctctggc caggaaccct ccctttggaa atgcccctct aagaacatca
     1321 cagctgagga ctgttcccat agccaggatg cagctgtccg gtgcaacctc ccctacactg
     1381 gggtggagac caagatccga ctcagtgggg gccgcagtcg atacgaaggg cgagtcgagg
     1441 tgcaaatagg ggtacctggg catctacgct ggggcctcat ctgtggggat gactggggaa
     1501 cactggaggc catggtggcc tgtaggcaac ttggtcttgg ctacgccaac cacggcctgc
     1561 aggagacctg gtactgggac tcggggaatg taactgaggt ggtgatgagc ggagtacgtt
     1621 gcacagggtc tgagctgtcc ctgaaccaat gtgctcacca caacacccac gtcacctgca
     1681 agaggacagg cacccgcttc actgcaggag tcatctgttc tgagactgct tcggatctgc
     1741 tgctgcactc agcactggta caggagactg cttatattga agaccgaccg ttgcacatgt
     1801 tgtactgtgc tgctgaagag aactgcctgg caagctccgc ccgctcagct aactggccct
     1861 acggccacag gcgtctgctc cgattctctt cccagatcca caacctagga agagctgact
     1921 ttaggcccaa ggctgggcgc cattcctggg tgtggcatga gtgtcacggg cattaccaca
     1981 gcatggacat cttcactcat tatgatatcc tgacccccaa cggcaccaag gtggctgagg
     2041 gccacaaagc tagtttctgt ctagaagaca ctgagtgtca ggaggatgtc tccaagagat
     2101 atgagtgtgc caactttgga gagcagggca tcactgtggg atgctgggac ctctacaggc
     2161 atgacattga ctgtcagtgg attgacatca cagatgtgaa accaggaaac tacattcttc
     2221 aggtggttat caacccaaat tttgaggtag cagaaagtga cttcaccaac aatgctatga
     2281 agtgcaactg caaatacgac gggcatcgca tctgggtgca caactgccac attggtgatg
     2341 ccttcagtga agaagccaac aggaggtttg agcgctaccc aggccagacc agtaaccaga
     2401 ttgtctaaaa tgctaccgcc ctctctgcaa accaccactg gcccccaatg gcaggggtct
     2461 gaggctgcca ttacctcagg agcttaccac aagaacccct gatgtcagca ggcgcactac
     2521 aaatgatgaa ctgttgaaga gaagttggtg cctcccttac ttggtcagct ggcattacct
     2581 ttggccaagc atggataatc agccaacaga cccagcagta gacagaacac accacaaaga
     2641 actgccccat acaggatggc agcagctcat tctcttgact aggggagatc aagagggtca
     2701 gctcccatag ctctaagttc tcctaagtac cgcgttacct ccagccattt ggtggggaaa
     2761 agatccagcc ccccccccca tgtttgactg taacatgttg ctaggtataa ttttatttta
     2821 tataaaatgt gttcttcaga
//
