LOCUS       NM_001106047            2585 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus lysyl oxidase-like 2 (Loxl2), mRNA.
ACCESSION   NM_001106047 XM_001069281 XM_214225
VERSION     NM_001106047.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2585)
  AUTHORS   Zhang,C., Zhu,M., Wang,H., Wen,J., Huang,Z., Chen,S., Zhao,H. and
            Li,H.
  TITLE     LOXL2 attenuates osteoarthritis through inactivating Integrin/FAK
            signaling
  JOURNAL   Sci Rep 11 (1), 17020 (2021)
   PUBMED   34426599
  REMARK    GeneRIF: LOXL2 attenuates osteoarthritis through inactivating
            Integrin/FAK signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2585)
  AUTHORS   Jones,M.G., Andriotis,O.G., Roberts,J.J., Lunn,K., Tear,V.J.,
            Cao,L., Ask,K., Smart,D.E., Bonfanti,A., Johnson,P., Alzetani,A.,
            Conforti,F., Doherty,R., Lai,C.Y., Johnson,B., Bourdakos,K.N.,
            Fletcher,S.V., Marshall,B.G., Jogai,S., Brereton,C.J., Chee,S.J.,
            Ottensmeier,C.H., Sime,P., Gauldie,J., Kolb,M., Mahajan,S.,
            Fabre,A., Bhaskar,A., Jarolimek,W., Richeldi,L., O'Reilly,K.M.,
            Monk,P.D., Thurner,P.J. and Davies,D.E.
  TITLE     Nanoscale dysregulation of collagen structure-function disrupts
            mechano-homeostasis and mediates pulmonary fibrosis
  JOURNAL   Elife 7, e36354 (2018)
   PUBMED   29966587
  REMARK    GeneRIF: Dual inhibition of LOXL2 and LOXL3 in a pulmonary fibrosis
            model was sufficient to normalize collagen fibrillogenesis, reduce
            tissue stiffness, and improve lung function in vivo.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2585)
  AUTHORS   Zhang,X., Wang,Q., Wu,J., Wang,J., Shi,Y. and Liu,M.
  TITLE     Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a
            precursor state
  JOURNAL   Proc Natl Acad Sci U S A 115 (15), 3828-3833 (2018)
   PUBMED   29581294
REFERENCE   4  (bases 1 to 2585)
  AUTHORS   Cuevas,E.P., Eraso,P., Mazon,M.J., Santos,V., Moreno-Bueno,G.,
            Cano,A. and Portillo,F.
  TITLE     LOXL2 drives epithelial-mesenchymal transition via activation of
            IRE1-XBP1 signalling pathway
  JOURNAL   Sci Rep 7, 44988 (2017)
   PUBMED   28332555
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2585)
  AUTHORS   Herranz,N., Dave,N., Millanes-Romero,A., Pascual-Reguant,L.,
            Morey,L., Diaz,V.M., Lorenz-Fonfria,V., Gutierrez-Gallego,R.,
            Jeronimo,C., Iturbide,A., Di Croce,L., Garcia de Herreros,A. and
            Peiro,S.
  TITLE     Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in
            histone H3
  JOURNAL   FEBS J 283 (23), 4263-4273 (2016)
   PUBMED   27735137
REFERENCE   6  (bases 1 to 2585)
  AUTHORS   Xu,L., Go,E.P., Finney,J., Moon,H., Lantz,M., Rebecchi,K.,
            Desaire,H. and Mure,M.
  TITLE     Post-translational modifications of recombinant human lysyl
            oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells
  JOURNAL   J Biol Chem 288 (8), 5357-5363 (2013)
   PUBMED   23319596
REFERENCE   7  (bases 1 to 2585)
  AUTHORS   Li,T.Y., Xu,L.Y., Wu,Z.Y., Liao,L.D., Shen,J.H., Xu,X.E., Du,Z.P.,
            Zhao,Q. and Li,E.M.
  TITLE     Reduced nuclear and ectopic cytoplasmic expression of lysyl
            oxidase-like 2 is associated with lymph node metastasis and poor
            prognosis in esophageal squamous cell carcinoma
  JOURNAL   Hum Pathol 43 (7), 1068-1076 (2012)
   PUBMED   22204712
REFERENCE   8  (bases 1 to 2585)
  AUTHORS   Bignon,M., Pichol-Thievend,C., Hardouin,J., Malbouyres,M.,
            Brechot,N., Nasciutti,L., Barret,A., Teillon,J., Guillon,E.,
            Etienne,E., Caron,M., Joubert-Caron,R., Monnot,C., Ruggiero,F.,
            Muller,L. and Germain,S.
  TITLE     Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and
            type IV collagen assembly in the endothelial basement membrane
  JOURNAL   Blood 118 (14), 3979-3989 (2011)
   PUBMED   21835952
REFERENCE   9  (bases 1 to 2585)
  AUTHORS   Iftikhar,M., Hurtado,P., Bais,M.V., Wigner,N., Stephens,D.N.,
            Gerstenfeld,L.C. and Trackman,P.C.
  TITLE     Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and
            is critically required for differentiation
  JOURNAL   J Biol Chem 286 (2), 909-918 (2011)
   PUBMED   21071451
REFERENCE   10 (bases 1 to 2585)
  AUTHORS   Peinado,H., Del Carmen Iglesias-de la Cruz,M., Olmeda,D.,
            Csiszar,K., Fong,K.S., Vega,S., Nieto,M.A., Cano,A. and Portillo,F.
  TITLE     A molecular role for lysyl oxidase-like 2 enzyme in snail
            regulation and tumor progression
  JOURNAL   EMBO J 24 (19), 3446-3458 (2005)
   PUBMED   16096638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168900.1.
            
            On Sep 14, 2008 this sequence version replaced NM_001106047.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168900.1, SRR8487227.272232.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..2585
                     /gene="Loxl2"
                     /note="lysyl oxidase-like 2"
                     /db_xref="GeneID:290350"
                     /db_xref="RGD:1308435"
     exon            1..110
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            111..486
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..2453
                     /gene="Loxl2"
                     /EC_number="1.4.3.13"
                     /note="lysyl oxidase homolog 2; lysyl oxidase-like protein
                     2"
                     /codon_start=1
                     /product="lysyl oxidase homolog 2 precursor"
                     /protein_id="NP_001099517.2"
                     /db_xref="GeneID:290350"
                     /db_xref="RGD:1308435"
                     /translation="MEIPFGSCLYSCLALLVLLPSLSLAQYESWPYQLQYPEYFQQPP
                     PEHHQHQVPSDVVKIQVRLAGQKRKHNEGRVEVYYEGQWGTVCDDDFSIHAAHVVCRE
                     VGYVEAKSWTASSSYGPGEGPIWLDNIYCTGKESTLAACSSNGWGVTDCKHTEDVGVV
                     CSEKRIPGFKFDNSLINQIESLNIQVEDIRIRPILSAFRHRKPVTEGYVEVKEGKAWK
                     QICDKHWTAKNSHVVCGMFGFPAEKTYNPKAYKTFASRRKLRYWKFSMNCTGTEAHIS
                     SCKLGPPMFRDPVKNATCENGQPAVVSCVPSQIFSPDGPSRFRKAYKPEQPLVRLRGG
                     AQVGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGTAKEAVTGSRLGQGIGPIH
                     LNEVQCTGTEKSIIDCKLNTESQGCNHEEDAGVRCNIPIMGFQKKVRLNGGRNPYEGR
                     VEVLTERNGSLVWGNVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGNIFANKVI
                     MSGVKCSGTELSLAHCRHDEEVVCPEGGVQYGAGVACSETAPDLVLNAEIVQQTAYLE
                     DRPMALLQCAMEENCLSASAVHTDPTRGHRRLLRFSSQIHNNGQSDFRPKNGRHAWIW
                     HDCHRHYHSMEVFTYYDLLSLNGTKVAEGHKASFCLEDTECEGDIQKSYECANFGEQG
                     ITMGCWDMYRHDIDCQWIDITDVPPGDYLFQVVINPNYEVPESDFSNNIMKCRSRYDG
                     YRIWMYNCHVGGAFSEETEQKFEHFSGLLNNQLSVQ"
     exon            487..662
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..874
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1097
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1281
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1433
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1601
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1764
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..2008
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2124
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2261
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2373
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2564
                     /gene="Loxl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcattttc ccctggcttc tccgcgggcg ggccctcggc gatcggcgtg gagaggggcc
       61 accgctgaga tcccagtccc tgcctggcca ccacggagtc cagctaccaa cacaggacaa
      121 ggatggagat cccttttggc tcctgcctct acagctgttt ggcactgctt gtcttgctgc
      181 cctccctgag cctagcacaa tatgagagct ggccctacca gctccaatat cccgagtact
      241 tccagcagcc gcctcccgag caccaccagc atcaggtgcc ctccgacgtg gtgaagatcc
      301 aggtccgcct ggcgggccag aagaggaaac ataatgaagg ccgtgtggag gtctattacg
      361 aaggccagtg gggcactgtg tgcgatgatg atttctctat ccatgctgcc catgttgtct
      421 gccgggaagt gggctatgtg gaggccaagt cctggactgc cagctcctcc tacggcccag
      481 gcgaaggccc catctggttg gacaacatct actgcacagg caaagagtca accctggcag
      541 cttgctcctc taatggctgg ggtgtcactg attgcaagca cactgaagat gttggtgtgg
      601 tgtgcagtga aaaaagaatt ccaggcttca aatttgacaa ttcattgatc aaccaaatag
      661 agagcctaaa tatacaggtg gaagacatcc ggattcgacc catcctgtct gccttccgcc
      721 atcgcaagcc tgtgacagag ggctacgtgg aggtaaagga gggcaaggcc tggaagcaga
      781 tctgtgacaa gcactggaca gccaagaatt cccacgtggt ctgtggcatg tttggcttcc
      841 cagcagagaa gacttacaac cccaaagcct acaaaacctt tgcctcaagg aggaagctgc
      901 gctactggaa gttttctatg aactgcacgg gaactgaagc acacatctcc agctgtaagc
      961 tgggccctcc catgttccgg gaccctgtga agaatgccac ctgtgagaac gggcagccag
     1021 ctgtggtcag ttgtgtgcct agccagatct tcagccctga tggaccctca aggttccgga
     1081 aagcctataa gccggagcaa cccttggtgc gactgagagg tggagcccag gtcggggagg
     1141 gccgcgtgga ggtgctcaag aatggagaat ggggtaccgt ctgcgatgac aagtgggacc
     1201 tggtgtctgc cagcgtggtc tgcagggagc tgggcttcgg cacagctaaa gaggctgtca
     1261 caggctccag gctggggcaa gggattgggc ccatccacct caacgaggtc cagtgcacag
     1321 ggacagagaa gtccatcata gactgcaagc tcaacacaga gtcgcagggc tgcaaccacg
     1381 aggaagacgc cggagtgcga tgcaacatcc ccatcatggg cttccagaaa aaggtgcgcc
     1441 tgaatggagg ccgcaatccc tatgagggtc gagtggaggt actaacagag agaaatgggt
     1501 ccctcgtgtg ggggaatgta tgtggccaga actggggcat tgtggaagcc atggtggtct
     1561 gccggcagct aggattgggc tttgccagca acgccttcca ggaaacctgg tactggcatg
     1621 gaaatatctt cgccaacaaa gtgatcatga gtggagtgaa gtgctcagga acggagttat
     1681 ccctggcaca ctgccgccat gacgaggagg tggtctgccc cgagggtggg gtgcagtatg
     1741 gtgctggagt cgcctgctca gaaactgcac ctgacctggt acttaacgcc gagattgtac
     1801 aacagaccgc ctatctggag gacaggccca tggccttgct gcagtgtgcc atggaggaaa
     1861 actgcctctc agcctccgct gtgcacaccg atcccaccag aggccaccgt cgccttctac
     1921 gcttctcttc ccagatccac aacaatggcc aatctgactt ccgccccaag aatggccgcc
     1981 atgcatggat ttggcatgac tgccacaggc actaccacag catggaagta ttcacttact
     2041 atgacctcct gagcctcaac ggcaccaagg tggctgaggg ccacaaggcc agcttctgct
     2101 tggaggacac tgagtgtgag ggagacattc agaagagtta cgagtgtgcc aacttcggag
     2161 aacaaggcat caccatgggc tgctgggaca tgtatcgtca tgacattgac tgccagtgga
     2221 tagacatcac cgatgtgccc cctggagact acctgtttca ggttgtcatt aaccccaact
     2281 atgaggtgcc agaatcagat ttctctaaca acatcatgaa gtgcaggagc cgctatgatg
     2341 gctaccgcat ctggatgtac aattgtcacg taggtggagc cttcagtgag gagacagaac
     2401 agaagttcga acacttcagt ggactcctaa ataatcagct ctctgtgcag taaagacgac
     2461 tctgggccag gcatgatggc tcatgcctgt aatccccgca ctcaggcagg aggattgcca
     2521 caagattttc actctggaca ctagaccaag cttcagtctc aaaaaaaaaa aaaaaaaaaa
     2581 aaaaa
//
