LOCUS       NM_001012125            3289 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus lysyl oxidase-like 1 (Loxl1), mRNA.
ACCESSION   NM_001012125 XM_236298
VERSION     NM_001012125.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3289)
  AUTHORS   Hariani,H.N., Ghosh,A.K., Rosen,S.M., Tso,H.Y., Kessinger,C.,
            Zhang,C., Jones,W.K., Sappington,R.M., Mitchell,C.H., Stubbs,E.B.
            Jr., Rao,V.R. and Kaja,S.
  TITLE     Lysyl oxidase like-1 deficiency in optic nerve head astrocytes
            elicits reactive astrocytosis and alters functional effects of
            astrocyte derived exosomes
  JOURNAL   Exp Eye Res 240, 109813 (2024)
   PUBMED   38331016
  REMARK    GeneRIF: Lysyl oxidase like-1 deficiency in optic nerve head
            astrocytes elicits reactive astrocytosis and alters functional
            effects of astrocyte derived exosomes.
REFERENCE   2  (bases 1 to 3289)
  AUTHORS   Kadekawa,K., Nishijima,S., Noguchi,K., Okitsu,S., Karube,K.,
            Matsumoto,S., Yamamoto,H. and Sugaya,K.
  TITLE     Deletion of the lysyl oxidase-like 1 gene induces impaired elastin
            fiber synthesis and inefficient urethral closure in rats
  JOURNAL   Biomed Res 42 (1), 23-31 (2021)
   PUBMED   33563876
  REMARK    GeneRIF: Deletion of the lysyl oxidase-like 1 gene induces impaired
            elastin fiber synthesis and inefficient urethral closure in rats.
REFERENCE   3  (bases 1 to 3289)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 3289)
  AUTHORS   Nilsson,M., Adamo,H., Bergh,A. and Halin Bergstrom,S.
  TITLE     Inhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has
            Tumour-Promoting and Tumour-Suppressing Roles in Experimental
            Prostate Cancer
  JOURNAL   Sci Rep 6, 19608 (2016)
   PUBMED   26804196
  REMARK    GeneRIF: Here we show that orthotopic implantation of rat prostate
            AT-1 tumour cells increased LOX and LOXLs mRNA expressions in the
            tumour and in the surrounding non-malignant prostate tissue
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3289)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   6  (bases 1 to 3289)
  AUTHORS   Chakrabarti,S., Rao,K.N., Kaur,I., Parikh,R.S., Mandal,A.K.,
            Chandrasekhar,G. and Thomas,R.
  TITLE     The LOXL1 gene variations are not associated with primary
            open-angle and primary angle-closure glaucomas
  JOURNAL   Invest Ophthalmol Vis Sci 49 (6), 2343-2347 (2008)
   PUBMED   18223248
REFERENCE   7  (bases 1 to 3289)
  AUTHORS   Miyazaki,H., Oka,N., Koga,A., Ohmura,H., Ueda,T. and Imaizumi,T.
  TITLE     Comparison of gene expression profiling in pressure and volume
            overload-induced myocardial hypertrophies in rats
  JOURNAL   Hypertens Res 29 (12), 1029-1045 (2006)
   PUBMED   17378376
REFERENCE   8  (bases 1 to 3289)
  AUTHORS   Thomassin,L., Werneck,C.C., Broekelmann,T.J., Gleyzal,C.,
            Hornstra,I.K., Mecham,R.P. and Sommer,P.
  TITLE     The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are
            required for deposition onto elastic fibers
  JOURNAL   J Biol Chem 280 (52), 42848-42855 (2005)
   PUBMED   16251195
REFERENCE   9  (bases 1 to 3289)
  AUTHORS   Hayashi,K., Cao,T., Passmore,H., Jourdan-Le Saux,C., Fogelgren,B.,
            Khan,S., Hornstra,I., Kim,Y., Hayashi,M. and Csiszar,K.
  TITLE     Progressive hair loss and myocardial degeneration in rough coat
            mice: reduced lysyl oxidase-like (LOXL) in the skin and heart
  JOURNAL   J Invest Dermatol 123 (5), 864-871 (2004)
   PUBMED   15482472
REFERENCE   10 (bases 1 to 3289)
  AUTHORS   Kim,Y., Peyrol,S., So,C.K., Boyd,C.D. and Csiszar,K.
  TITLE     Coexpression of the lysyl oxidase-like gene (LOXL) and the gene
            encoding type III procollagen in induced liver fibrosis
  JOURNAL   J Cell Biochem 72 (2), 181-188 (1999)
   PUBMED   10022501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001012125.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089224.1, SRR26643297.28578.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1526              JAXUCZ010000008.1  67610699-67612224   c
            1527-1635           JAXUCZ010000008.1  67597423-67597531   c
            1636-1773           JAXUCZ010000008.1  67594244-67594381   c
            1774-1930           JAXUCZ010000008.1  67593641-67593797   c
            1931-2026           JAXUCZ010000008.1  67592823-67592918   c
            2027-2142           JAXUCZ010000008.1  67590721-67590836   c
            2143-3289           JAXUCZ010000008.1  67587636-67588782   c
FEATURES             Location/Qualifiers
     source          1..3289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3289
                     /gene="Loxl1"
                     /note="lysyl oxidase-like 1"
                     /db_xref="GeneID:315714"
                     /db_xref="RGD:1308752"
     exon            1..1526
                     /gene="Loxl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..2149
                     /gene="Loxl1"
                     /EC_number="1.4.3.13"
                     /note="lysyl oxidase homolog 1; lysyl oxidase homolog
                     1-like"
                     /codon_start=1
                     /product="lysyl oxidase homolog 1 precursor"
                     /protein_id="NP_001012125.1"
                     /db_xref="GeneID:315714"
                     /db_xref="RGD:1308752"
                     /translation="MALAGAGSQLGTLVWGACLCVLVHGQQEQPGQGSDPGRWRQLIQ
                     WENNGQVYSLLNSGSEYVPAGPQRGESSSRVLLAGAPQTSQRRSQGGPRRRQAPNLPL
                     PGRVGSDTVRGQTRHPFGFGQVPDNWREVAVGDSNGMARARTSVSQQRHGGSASSSVS
                     ASAFATTYRQPSSYPQQFPYPQAPFVNQYENYDPASRTYEQGYVYYRGAGGGMGAGAA
                     AAAVASAGVIYPFQPRARYEEYGGGGEEQPEYPAQGFYPAPERPYAPQPQPQPQPQPQ
                     PQPQPSDGLDRRYSHSLYNEGTPGFEQAYPDPSTDVSQIPAGAGGTYGAAGDPRLGWY
                     PPYAANVPPEAYVPPRAVEPQPPFRVLEPPYLPVRNSDAPSQGGERNGAQQGRLSVGS
                     VYRPNQNGRGLPDLVPDPNYVQASTYVQRAHLYSLRCAAEEKCLASTAYAPEATDYDL
                     RVLLRFPQRVKNQGTADFLPNRPRHTWEWHSCHQHYHSMDEFSHYDLLDASTGKKVAE
                     GHKASFCLEDSTCDFGNLKRYACTSHTQGLSPGCYDTYNADIDCQWIDITDVQPGNYI
                     LKVHVNPKYIVLESDFTNNVVRCNIHYTGRFVSTTNCKIVQS"
     exon            1527..1635
                     /gene="Loxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1773
                     /gene="Loxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1930
                     /gene="Loxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2026
                     /gene="Loxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2142
                     /gene="Loxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..3289
                     /gene="Loxl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtgggaa agcgccagcc tagagagcag ccagccagtg tggggttggc catgtaaggg
       61 ccccaggagg tcctgcccgt cccgtgccct gcggaaagcc tcgtgcagcc ctgggcaccg
      121 cccctgccct gccctgaccc cttggcctca aaatgctgtc atcggaggag ccgtcccgct
      181 cgggacaagg ccaggatgga caaagctaga gcttgggcag gcgaggagcc atcctgtcct
      241 cgaggccgtg ggaagagaag cacgcaccgg ggcccactcc tgagagcctc tccgcccacc
      301 cggcctctgc agaagggcca ctatggctct ggccggagcc ggcagccagc tggggaccct
      361 ggtgtgggga gcctgcctgt gcgtcctggt gcacgggcag caagagcagc caggacaggg
      421 ctcggaccca ggacgctggc ggcagctgat ccagtgggag aacaacgggc aggtgtacag
      481 cttgctcaat tcgggctctg agtacgtgcc tgcggggccc caaagagggg agagtagctc
      541 cagggtgcta ctggcaggcg cgccccaaac gtcgcagcgg cgcagtcagg gaggaccccg
      601 gcgtcggcag gcgccgaacc tgcccctgcc cggacgcgtg ggttcggaca ctgtgcgcgg
      661 ccaaacgcgg cacccgttcg gcttcggcca ggtgccagac aactggagag aggtggccgt
      721 cggggacagt aacgggatgg ctcgggcccg cacctccgtc tcccagcaac ggcacggggg
      781 ctccgcctcc tcctcggttt cggcctcggc cttcgccacc acttatcgcc agccatcctc
      841 ctacccgcag cagttcccct atccgcaggc gcccttcgtg aaccaatatg agaactatga
      901 ccccgcgtcg cggacctatg aacagggcta cgtgtactac cgcggtgcgg gcggaggcat
      961 gggcgcaggg gcggcggcgg cagctgtagc ctcggctggg gtcatctatc ccttccagcc
     1021 ccgggcacgc tacgaggagt acggcggtgg gggcgaggaa cagcccgagt acccggcgca
     1081 gggcttctac ccagccccag agaggcccta tgcgccccag ccccagcctc agccccaacc
     1141 tcagccgcag cctcagcccc aaccttccga cggccttgac cgtcgttact cgcatagcct
     1201 gtacaatgaa ggcaccccgg gattcgagca ggcctaccct gatcccagca ccgacgtgtc
     1261 gcagatcccc gccggggccg gtggcaccta cggtgccgct ggcgatcccc gtctcggctg
     1321 gtacccgccc tatgcagcca atgtgcctcc cgaggcctat gtccctccgc gtgcggtgga
     1381 gccgcagccc ccattccgcg tgctggaacc accttacttg cctgtgcgaa actctgatgc
     1441 gccctcccag ggtggggaga ggaacggtgc ccagcagggc cgtctcagcg tgggtagtgt
     1501 gtaccgacct aaccagaatg gtcgcggcct ccctgactta gtcccagatc ccaactacgt
     1561 gcaggcatcc acatatgtgc agagagccca tctgtattcc ttgcgttgtg cggcagagga
     1621 gaagtgcctg gccagcacag cctatgctcc tgaggccacc gactatgacc tccgagtgct
     1681 gttacgattc ccccagcgtg tgaaaaacca gggcacggcg gacttcctcc ccaaccggcc
     1741 acgccacacc tgggagtggc atagctgtca ccaacattac cacagcatgg acgagttcag
     1801 ccactatgac ctacttgatg catccacggg caagaaagtt gccgagggac acaaggccag
     1861 cttttgcctg gaggacagca cctgtgactt cggcaacctc aagcgctatg cgtgcacctc
     1921 acacacgcag ggcctgagtc caggctgcta tgacacctac aatgcggaca tcgactgcca
     1981 gtggatcgac ataacagatg tgcagcctgg gaactacatc ctcaaggtgc acgtgaaccc
     2041 caagtacatt gttctggagt ctgacttcac caacaacgtg gtgagatgca acatccacta
     2101 cacaggtcgc ttcgtctcta caacaaactg caaaatcgtc cagtcctgat ctcagtggac
     2161 ggagcccccc ttgtctcccc ttgaaaagca ggacctgctt ccaggcagcc tcccccaaga
     2221 agcatagccg cctagccgga gggcgagggc agctggccgc tggggcatcc ctccctgccg
     2281 gcctcaggga gtgaacatgg accaaaccca cagggattct ggatgccaga ccccgttttg
     2341 tacctaagtc tcctctacaa caccattttg tctgttgttg gttttaattt tgatgttttg
     2401 gccatcccac acagcaagat tgcccgggtg cttaataaaa caagggtttt ctagtctgga
     2461 gttctgctgt gccctggtgg tttggcaaac cacaactggg tcaggcccaa gagatattct
     2521 ggggtttcag tctttgtgta ggaaaatgtt gaaagggtgt ctgctggacg gccaggactc
     2581 cagcaacttc caggttacca accatatcca tcatggaaat gctgaattta gtccaaggtc
     2641 attcctgggt agatgacccc atctcatgga atgagagaag aggtggtagg tggctccagc
     2701 tatctgttct gtctttcccc tttcgcccag tctaccaccc tttactgctc cttctttcct
     2761 tctcagactg tagctcacca gcagcaccag cagcagccgc cgccctggga actagccacc
     2821 cctttcacag tgctgagcag gcaccctccg gacaactggg gagagacaga gaagccttca
     2881 agggggaaag ggctaccttc ccaaagagag aggaacatga attcttggcg gaggggtgga
     2941 ggggttgggc ttaggtagag tagtgggctt ggagactgta gggagtgcag gatagaggag
     3001 ctccactgtc cttccctgga ttggcattct agaactcctg gacaccagtc cggaccaaga
     3061 agaagtggag agagaatgtc aactcctttc ctcttctccc accagctctc aggatttctt
     3121 tccacccacc tgccactgcc attctggaga ataactaata gggaaggaaa agagacttgg
     3181 ctcagggctc tagttcaagc tgtttgatgc tgggccaggc atgctatacc tctgtgcctc
     3241 aggtttcatc atcaataaaa tggaactgtc ctccaacctg gcaaagcca
//
