LOCUS       NM_001414400            8161 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus lipoxygenase homology PLAT domains 1 (Loxhd1),
            transcript variant 2, mRNA.
ACCESSION   NM_001414400 XM_039096634
VERSION     NM_001414400.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8161)
  AUTHORS   Mitra,A.K., Stessman,H.A., Schaefer,R.J., Wang,W., Myers,C.L., Van
            Ness,B.G. and Beiraghi,S.
  TITLE     Fine-Mapping of 18q21.1 Locus Identifies Single Nucleotide
            Polymorphisms Associated with Nonsyndromic Cleft Lip with or
            without Cleft Palate
  JOURNAL   Front Genet 7, 88 (2016)
   PUBMED   27242896
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8161)
  AUTHORS   Riazuddin,S.A., Parker,D.S., McGlumphy,E.J., Oh,E.C., Iliff,B.W.,
            Schmedt,T., Jurkunas,U., Schleif,R., Katsanis,N. and Gottsch,J.D.
  TITLE     Mutations in LOXHD1, a recessive-deafness locus, cause dominant
            late-onset Fuchs corneal dystrophy
  JOURNAL   Am J Hum Genet 90 (3), 533-539 (2012)
   PUBMED   22341973
REFERENCE   3  (bases 1 to 8161)
  AUTHORS   Grillet,N., Schwander,M., Hildebrand,M.S., Sczaniecka,A.,
            Kolatkar,A., Velasco,J., Webster,J.A., Kahrizi,K., Najmabadi,H.,
            Kimberling,W.J., Stephan,D., Bahlo,M., Wiltshire,T.,
            Tarantino,L.M., Kuhn,P., Smith,R.J. and Muller,U.
  TITLE     Mutations in LOXHD1, an evolutionarily conserved stereociliary
            protein, disrupt hair cell function in mice and cause progressive
            hearing loss in humans
  JOURNAL   Am J Hum Genet 85 (3), 328-337 (2009)
   PUBMED   19732867
REFERENCE   4  (bases 1 to 8161)
  AUTHORS   Schwander,M., Sczaniecka,A., Grillet,N., Bailey,J.S., Avenarius,M.,
            Najmabadi,H., Steffy,B.M., Federe,G.C., Lagler,E.A., Banan,R.,
            Hice,R., Grabowski-Boase,L., Keithley,E.M., Ryan,A.F.,
            Housley,G.D., Wiltshire,T., Smith,R.J., Tarantino,L.M. and
            Muller,U.
  TITLE     A forward genetics screen in mice identifies recessive deafness
            traits and reveals that pejvakin is essential for outer hair cell
            function
  JOURNAL   J Neurosci 27 (9), 2163-2175 (2007)
   PUBMED   17329413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 21, 2022 this sequence version replaced XM_039096634.1.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               JAXUCZ010000018.1  73093142-73093585
            445-559             JAXUCZ010000018.1  73098118-73098232
            560-640             JAXUCZ010000018.1  73104591-73104671
            641-825             JAXUCZ010000018.1  73106546-73106730
            826-924             JAXUCZ010000018.1  73128411-73128509
            925-1073            JAXUCZ010000018.1  73135778-73135926
            1074-1197           JAXUCZ010000018.1  73137430-73137553
            1198-1448           JAXUCZ010000018.1  73139037-73139287
            1449-1584           JAXUCZ010000018.1  73143369-73143504
            1585-1745           JAXUCZ010000018.1  73143915-73144075
            1746-1832           JAXUCZ010000018.1  73145029-73145115
            1833-1968           JAXUCZ010000018.1  73145791-73145926
            1969-2123           JAXUCZ010000018.1  73158589-73158743
            2124-2284           JAXUCZ010000018.1  73159886-73160046
            2285-2361           JAXUCZ010000018.1  73164429-73164505
            2362-2558           JAXUCZ010000018.1  73166135-73166331
            2559-2751           JAXUCZ010000018.1  73169008-73169200
            2752-2912           JAXUCZ010000018.1  73171324-73171484
            2913-3387           JAXUCZ010000018.1  73174136-73174610
            3388-3542           JAXUCZ010000018.1  73175055-73175209
            3543-3676           JAXUCZ010000018.1  73176651-73176784
            3677-3843           JAXUCZ010000018.1  73181677-73181843
            3844-3948           JAXUCZ010000018.1  73183094-73183198
            3949-4077           JAXUCZ010000018.1  73184245-73184373
            4078-4242           JAXUCZ010000018.1  73185503-73185667
            4243-4424           JAXUCZ010000018.1  73190056-73190237
            4425-4541           JAXUCZ010000018.1  73193490-73193606
            4542-4704           JAXUCZ010000018.1  73194413-73194575
            4705-4859           JAXUCZ010000018.1  73198039-73198193
            4860-5069           JAXUCZ010000018.1  73201964-73202173
            5070-5205           JAXUCZ010000018.1  73202300-73202435
            5206-5414           JAXUCZ010000018.1  73204289-73204497
            5415-5600           JAXUCZ010000018.1  73205242-73205427
            5601-5728           JAXUCZ010000018.1  73208164-73208291
            5729-5846           JAXUCZ010000018.1  73211886-73212003
            5847-6021           JAXUCZ010000018.1  73213887-73214061
            6022-6207           JAXUCZ010000018.1  73215757-73215942
            6208-6378           JAXUCZ010000018.1  73225971-73226141
            6379-6511           JAXUCZ010000018.1  73231049-73231181
            6512-6670           JAXUCZ010000018.1  73232164-73232322
            6671-8161           JAXUCZ010000018.1  73244294-73245784
FEATURES             Location/Qualifiers
     source          1..8161
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..8161
                     /gene="Loxhd1"
                     /note="lipoxygenase homology PLAT domains 1"
                     /db_xref="GeneID:291427"
                     /db_xref="RGD:1304815"
     exon            1..444
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..7151
                     /gene="Loxhd1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     lipoxygenase homology domain-containing protein 1;
                     lipoxygenase homology domains 1"
                     /codon_start=1
                     /product="lipoxygenase homology domain-containing protein
                     1 isoform 2"
                     /protein_id="NP_001401329.1"
                     /db_xref="GeneID:291427"
                     /db_xref="RGD:1304815"
                     /translation="MMPQKKKRRKKDIDFLGLYEEELLNYNSEDDEDELEHEYYKAKV
                     YEVVTATGDVRGAGTDANVFITIFGENGLSPKLHLTSKSESAFEKANVDVFRVRTNNV
                     GLIYKIRIEHDNTGLNASWYLDRVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDLL
                     ASFDPMDMPRGNKYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKG
                     AEDKFTLDAPDLGQLMKINVGHNNKGGSAGWFLSKIIIEDIGNKRKYDFPLNRWLALD
                     EDDGKIQRDILVGGAETTAITYIVTVFTGDIRGAGTKSKIYLVMYGARGNRNSGKIFL
                     EGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGWYCEKVVVLCPFTGIQQTF
                     PCSNWLDEKKADGLIERQLYEMVSLRKKRLKKFPWSLWVWTTDLKKAGTNSPIFIQIY
                     GKKGRTDEILLNPNNKWFKPGIIEKFRMELPDLGRFYKIRAWHDRQNPGSGWHLEKMT
                     LMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAEGPTVRRIMGMARYRVTVCTGELEG
                     AGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRKVRRVRVRH
                     DGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELLPSDSNATLK
                     NFRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNNLKDYFERGRVDEFT
                     LETLNIGTIIRLVIGHDSTGMHAGWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRL
                     EVELYPSEVVEIQKLVHYEIEIWTGDVGGAGTTSRVYVQIYGEEGKTEVLFLSSRSKV
                     FDRGSKDIFQLEAADVGEIYKIRLGHTGEGFGPSWFVDTVWLRHLVVQEESLTPEEEA
                     RRKKEKEKLRQLLKKERLKAKLQRKKKKKKKGSDEEEEGDEEEESSSEESSSEEEEEE
                     ESEEEEEEEEYGPGMQEVIVQYKFVANRWLARGKEDNELVVELVPAGQPGPEPNTYEV
                     QVITGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLG
                     ALTKIRIRHDNTGNRPGWFLDRIDITDVNNETTYYFPCQRWLAVEEDDGQLSRELLPV
                     DESYVLPSEDEEGGGQGDNNPLDNLALEQKDKSTTFSVTIKTGDKKNAGTDANVFITL
                     FGTKDNNGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRIGHDNTGKAPGWFV
                     DWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIVRDLFHAELQTRLYTPFVPYEITLYTS
                     DVFAAGTDANVFIVIYGCDAVCTRQKFLCTNKREQKLLFERKSASRFIVELEDVGEII
                     EKIRIGHDNTGINPGWHCSHVDIRRLLPEKDGTETLTFPCDRWLATSEDDKKTIRELV
                     PYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNVPGAGTDAKVYITIYGDLG
                     DTGERYLGKSENRTNKFEKGTADTFIIEAADLGVIYKIKLRHDNTKWCADWYVEKVEI
                     WNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCSSPADFWEIALSSKM
                     ADVDIDTVTGPMVDYVQDGPVIPYYVSVTTGKHKEAATDSRAFVLLIGEDDERTNRIW
                     LDFPQGKRGFSCGSVEEFYVGGLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGT
                     KYTLRCNCWLAKDRGDGVTSRVFDLLDAMVVNIGKKVLYEMTVWTGDVVGGGTDSNIF
                     MTLYGINGSTEEVQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEWFL
                     ERILLKNMNTGDLTMFYYGDWLSQKKGKKTLVCEICAVIDGEEMMEWTSYTVSVKTSD
                     ILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLR
                     VWHDNKGIFPGWHLSYIDVKDNSRDETFRFQCDCWLSKSEGDRQTLRDFACANNEIRD
                     ELEETTYEIVIETGNGGETRENIWLILEGRKNRSKEFLVENSSRQRAFRKGTTDTFEF
                     DSIFLGDIASLCVGHLAREDRFIPKRELVWHVKTITITEMEYGNVYFFNCDCLIPLKR
                     KRKYFKVFEVTKTTESFASKIQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDT
                     GKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYYSGWLVEKVEVTNTS
                     TGVATIFSCGRWLDKSRGDGLTWRELFPSV"
     exon            445..559
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..640
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            641..825
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..924
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1073
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1197
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1448
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1584
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1745
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1832
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1968
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2123
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2284
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2361
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2558
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2751
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2912
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3387
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3542
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3543..3676
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..3843
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..3948
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..4077
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4242
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4243..4424
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4425..4541
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4542..4704
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4705..4859
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4860..5069
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5070..5205
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5206..5414
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5415..5600
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5601..5728
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5729..5846
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5847..6021
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            6022..6207
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            6208..6378
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            6379..6511
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            6512..6670
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            6671..8161
                     /gene="Loxhd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaaccccg ggggaggtgc agaataagag agggtggcag agaacagttg gggacagaag
       61 gggggaaaaa aggaaagaaa acagaagaag ggttgttgtg ctagggcacc agagaagaag
      121 acagggggaa ctctttggaa ctggggaccc agaagaccca gaagacccag ggagagccag
      181 tgtgccatat ccagacctga aatcctagga ggggctgagg gctctgcaac ttgctgagtg
      241 agaggcacag gtctaaggaa gctgagaagg cggaccggtg agcctatagg gtcccagaag
      301 aggcaggcag caaaatgatg ccccagaaga agaagcggcg gaagaaagac atcgacttcc
      361 tgggcttgta cgaggaggag ctgctgaact acaactcgga ggatgatgag gatgagttgg
      421 agcacgaata ctacaaagcc aaggtgtacg aggtggtcac agccacaggg gatgttcgtg
      481 gcgcagggac agatgccaac gtgttcatca cgatctttgg agagaacggg ctctctccca
      541 agctccatct caccagcaag agcgagtctg cttttgagaa agccaacgtt gatgtattcc
      601 gggtacggac caataacgtg ggcctcatct ataaaatcag gatcgagcat gataacacag
      661 gcctgaatgc cagctggtac ctggaccggg ttatagtgac ggacatgaag aggcctcacc
      721 tccgctatta cttcaactgt aacaactggc tgagcaaggt ggagggtgac cgtcagtggt
      781 gccgtgacct cctggccagc ttcgacccca tggacatgcc cagaggaaac aaatatgaaa
      841 tcaaggtata cactggtgat gtgattggtg cagggacaga tgctgatgtc tttatcaata
      901 tctttggaga gtatggagac acaggggagc gtaggctgga aaatgagaaa gacaactttg
      961 aaaagggagc tgaagacaag ttcacactgg atgcaccaga tttggggcag ctgatgaaga
     1021 tcaatgtggg ccacaacaac aaggggggtt cggcaggttg gttcctgtcc aagatcatca
     1081 ttgaagatat tgggaacaaa aggaaatatg atttccccct taaccgctgg ctggccctgg
     1141 atgaagatga tggcaaaatc cagagagaca tcttagtggg cggagctgag accacagcca
     1201 taacctacat tgtcactgtc ttcactgggg atatccgtgg agctgggacc aaatctaaaa
     1261 tctatttggt catgtacgga gccagaggaa ataggaacag tggaaaaatc tttctggaag
     1321 gtggtgtgtt cgacaggggc cgcacagaca tcttccacat cgacctggct gtcctcctta
     1381 gcccactgag ccgggtctcc attgggcacg gcaacatagg cgtcaaccga ggctggtact
     1441 gtgagaaggt ggtggtactg tgccccttca ctggcatcca gcagactttc ccgtgcagca
     1501 actggttgga tgagaagaag gcagacggac tgattgagcg tcagctctat gagatggtgt
     1561 ctctgaggaa gaagcggctg aaaaaatttc cttggtccct ttgggtctgg acaactgatc
     1621 tgaagaaagc tggcaccaac tcgcccatct tcatccagat ttatgggaag aaggggcgga
     1681 cagacgagat tcttctgaat cccaacaaca aatggttcaa accaggcatc attgagaagt
     1741 tcaggatgga gctcccagat ctcgggaggt tttataagat tcgggcgtgg catgacaggc
     1801 agaatcctgg ctctgggtgg catttagaaa agatgactct gatgaatacc ttgaataagg
     1861 acaaatataa cttcaactgc aaccgctggc tggatgccaa tgaggatgac aatgagatcg
     1921 tgagggagat gaccgcagaa ggcccgactg tacggaggat aatgggaatg gcccggtatc
     1981 gtgtgactgt atgcacaggg gaacttgaag gtgcaggaac tgatgccaac gtctacctct
     2041 gcctttttgg tgatgtgggg gacacagggg agagactgct ttacaactgc agaaataaca
     2101 ccgacctgtt tgagaaaggc aatgcggatg aatttaccat tgagtctgtc actatgagga
     2161 aggtgaggcg agtgagggtc aggcacgacg gcaaaggctc gggcagcggc tggtacctgg
     2221 acagggtgct ggtgagagag gaagggcagc cagagagtga caacgtggag ttcccctgcc
     2281 tcaggtggct ggacaaagac aaggatgatg ggcagctggt ccgagagttg ctacccagtg
     2341 acagcaatgc cacgctcaag aacttccgct atcacatcag cgtgaagacg ggggatgtct
     2401 ctggggccag cacagattct cgggtgtaca tcaagctcta tggagagaaa tctgacacca
     2461 tcaagcaagt tcttctcgtc tctgacaaca acctcaaaga ctactttgaa cgtggccgag
     2521 tggatgagtt tactctggag accctgaaca taggaactat catcaggctg gtgattgggc
     2581 acgacagcac tggcatgcat gcaggctggt tcctgggtag cgtccagatc cgcgtgcccc
     2641 gccaaggcaa gcagtacacc ttccctgcca accggtggct ggataagaac caggctgatg
     2701 ggcgtctgga ggtggagctg taccccagcg aggtggtgga gatccagaaa ttggtccact
     2761 acgagattga gatttggacc ggagatgtgg gtggtgccgg caccacttcc cgagtctacg
     2821 tgcagatcta cggggaagaa ggcaagaccg aagtactctt cctctccagc cgctccaaag
     2881 tgtttgatcg ggggtccaag gacatattcc agctggaagc ggcggacgtg ggcgagatct
     2941 acaagatccg actgggacac acgggcgagg gctttgggcc cagctggttt gtggacacag
     3001 tgtggctgcg gcacctggtg gtgcaggagg agagcctgac gccggaggag gaggcccgga
     3061 ggaagaagga gaaggagaag ttgcggcagc tgttgaagaa ggaaaggctg aaggctaagc
     3121 tgcagcggaa gaagaagaaa aagaagaaag gcagcgatga ggaggaggag ggcgatgagg
     3181 aagaagagtc ctcctcagaa gagtcctcct ctgaagagga ggaggaggag gagtcagagg
     3241 aggaagagga ggaagaggag tatgggccag ggatgcagga ggtgattgtg cagtacaagt
     3301 tcgtcgctaa ccgctggctg gcccggggca aggaggacaa tgaacttgtc gtggaattgg
     3361 ttccagctgg tcagccgggt cctgagccca atacctacga ggtccaggtg atcacaggga
     3421 acgtacccaa ggctggcact gatgccaacg tctacctgac catctacggt gaggaatacg
     3481 gggacacagg ggagcgaccc ctgaagaaat cagacaagtc caacaagttt gagcagggcc
     3541 agacagatac cttcaccatc tatgccattg acctgggggc tcttaccaag attcggatcc
     3601 gtcatgataa cacgggcaac aggccgggct ggttcctgga cagaatagac atcaccgacg
     3661 tgaataacga gaccacgtac tacttcccgt gccagcgctg gttagcagtc gaggaggatg
     3721 acggccagtt atccagggag ctgctgccag tggatgagtc ctacgtgcta cctagtgaag
     3781 acgaggaggg cgggggccag ggtgacaata atcccctcga caacctggct ctggagcaga
     3841 aagataaatc aaccacattt tcagtgacca taaagactgg ggacaaaaag aacgcaggca
     3901 cagatgccaa cgtcttcatc acgctctttg gcacgaaaga taacaacggg atgaccctcc
     3961 tgaagtcctc caaaaccaac agtgacaaat ttgaaaggga cagcattgaa atcttcaccg
     4021 tggagacgct ggatctggga gacctttgga aagttaggat cggccatgac aacacaggca
     4081 aggccccagg ctggtttgta gactgggtgg aggtggatgc cccatctctt gggaagtgca
     4141 tgacctttcc ctgcggccgt tggttggcca agaatgagga cgacgggagc atcgtcaggg
     4201 atctcttcca cgcggagctt cagacacggc tctacacgcc atttgtccct tatgagatca
     4261 ccctctacac cagcgatgtc tttgctgctg ggacggacgc caacgtcttc atagtcatct
     4321 acggctgtga tgccgtgtgc acccggcaga agttcctgtg caccaataag agggaacaga
     4381 agctgctctt cgagaggaag tcagcctccc gctttattgt agagttagaa gacgtgggtg
     4441 agatcataga aaaaattcgg attggccatg acaacacagg cataaaccct gggtggcact
     4501 gctcccacgt ggacatccgc aggctcctcc ccgagaaaga cggtacagaa accttgactt
     4561 tcccctgtga tcgatggctc gccacctctg aggatgacaa gaagaccatc cgagaactgg
     4621 tcccctatga catcttcact gagaagtaca tgaaagatgg atccttaagg caggtctaca
     4681 aggaagtgga ggaacctctg gacattgtgc tgtactctgt gcagatcttc acagggaatg
     4741 ttcctggggc ggggacagat gccaaggtct acatcaccat ctacggagac ctcggggaca
     4801 ctggggagcg gtaccttggc aagtcagaga accgcaccaa caagtttgag aaaggaacgg
     4861 ctgacacctt catcatcgag gccgctgacc tgggtgtcat ctacaagatc aagctccgcc
     4921 atgacaacac caagtggtgt gccgactggt atgtggagaa ggtggagata tggaatgaca
     4981 ccaatgagga cgagtttcta ttcctgtgtg ggcgctggct atccctgaag aaggaggatg
     5041 ggcggctgga gaggctcttc tatgagaagg agtacactgg agaccgcagc agcaactgca
     5101 gcagcccggc tgacttctgg gagatcgccc tgagttccaa gatggcagac gtggacattg
     5161 acacagtgac aggacccatg gttgactatg ttcaggatgg ccccgtgatc ccctactatg
     5221 tatcagtgac tactgggaag cacaaggagg cagccactga tagccgcgcc tttgtcctgc
     5281 tcattgggga agatgatgaa cgtaccaacc gcatctggct ggactttccc caggggaagc
     5341 gaggcttcag ctgtggctct gtggaggagt tctacgttgg tggcttggat gtgggcatca
     5401 tcaagaaaat agagctgggc cacgatggag cctcccctga gagctgctgg ctggtggagg
     5461 agctgtgctt ggcagtgcct acccagggta ccaagtacac attacgctgc aactgttggc
     5521 ttgccaagga ccgaggggat ggtgtcacct cccgtgtctt tgacctcctg gatgccatgg
     5581 ttgtgaacat tgggaagaag gtgctgtatg aaatgacggt gtggactggc gatgtggtcg
     5641 gtggaggcac tgactccaat atcttcatga ccctctatgg catcaacggg agcacagaag
     5701 aggtgcagct ggacaagaag aaggccaggt ttgagcggga acaaaatgac accttcatca
     5761 tggagatcct ggacattgct ccctttacga agatgcgcat ccgtatcgac gggctgggga
     5821 gccggccaga gtggttcctg gagaggatcc tgttgaagaa catgaacaca ggggacctga
     5881 ccatgttcta ctacggagac tggctgtccc aaaagaaggg aaagaagaca ctggtgtgtg
     5941 aaatatgtgc ggtcattgat ggagaggaga tgatggagtg gacgtcctac acagtctcgg
     6001 tgaagaccag tgacatcttg ggggcaggca cggacgctaa tgtgttcatc atcatctttg
     6061 gggaaaatgg agacagcggg accctggccc tgaaacagtc agccaactgg aacaagtttg
     6121 agcggaacaa cacagacacc ttcaattttc ctgacatgct gagcctgggc cacctctgca
     6181 aactgagggt ctggcatgac aacaaaggga tatttcctgg atggcatctg agctacattg
     6241 acgtgaagga caattcccgt gacgagacct tccgcttcca gtgtgactgc tggctgtcta
     6301 agagtgaggg tgacagacaa acgctccgag acttcgcgtg tgccaacaat gagatccgcg
     6361 atgagctgga agagaccacc tacgagattg tcatagaaac aggcaacgga ggcgaaacca
     6421 gagagaacat ctggctcatc ttggaaggca ggaagaacag atccaaggaa ttccttgtgg
     6481 aaaattcttc cagacagcgg gcctttcgga aggggaccac agacaccttt gagtttgaca
     6541 gcatcttctt gggtgacatc gcctccctct gtgtgggcca cctggcaagg gaggaccggt
     6601 tcatccccaa gagagagcta gtctggcatg tcaagaccat caccatcacc gagatggagt
     6661 atggcaacgt gtacttcttt aactgtgact gcctcatccc cctcaagagg aagaggaagt
     6721 acttcaaggt attcgaggtc actaaaacga cagagagctt cgccagtaag atccagagcc
     6781 tggtgccagt caagtacgag gtcatcgtga cgacgggcta cgaaccaggg gcgggcactg
     6841 atgccaacgt cttcgtgacc atctttggcg ctaacgggga cacgggcaag cgcgaactga
     6901 aacagaaaat gcgcaacctc ttcgagaggg gcagtacaga ccgcttcttt ctggagacat
     6961 tagagctggg agagctgcgc aaggttcggc tggaacatga cagcagtggc tactactcgg
     7021 gctggctggt ggagaaggtg gaggtcacca atactagtac tggagtggcc accatcttct
     7081 cctgcggcag gtggttagac aagtctcggg gcgatgggct cacctggcga gagctcttcc
     7141 cgtccgtctg aggtgccctg acttcacctt ataccctcca ccttgcattc aacgtccatc
     7201 tcttcagccc tcccgggtgg ggactagggc agtggacctg gggtctcata tccgtcagag
     7261 gctgctcctt gcaagtgact gtttgtgaaa tcctgggctc tactgtctcc ctctctcgga
     7321 catacaagaa ttatattcac cacatgttgc aatccatgac tgtacgaatt attttttttt
     7381 aattttcttt cctcgtaata acagcggtgc ccagggtggg acttgctgca gggtgtggat
     7441 gaaaaattgg ggcttcactc aggggagaca agtggagaag gagaagttat caagacagta
     7501 tattttaagc aaaaactaat taacaccctt tttccaaaaa aagatgggct aattaaatta
     7561 ttatgaacca caccccacag agaacgcatc tgagcatcta tgtgctaaaa catgtatgtt
     7621 tctcccccag ttccaacaaa tccagggtca aatgcagaaa aacatcagga ggaagtgttg
     7681 ggagaccttg accccgtgaa aagtagacaa ttctttctac cactttacag agatcaagag
     7741 agtggaggct gtcagatcct gacaccttgc cccacctgcc caaaactcca tctatatgtc
     7801 tgtctctctg cctattctgc tctctcctct cagcccctcc tccccatcac aaatgaggag
     7861 tccacaccac ttctctgcca catccctctg acaagtgctc agtgacggtg tcactgtgga
     7921 atgtggcatc tactatctct aggggaggag agggctcatg ctttcattct ggtcctgatg
     7981 tatttcataa atgttggctt gctgctcttg gaatagagca agcctggctc caccaggcat
     8041 catgcaggtt tcttgccgtc ttcaacctgc cctgcttgct ttgcattcct tagaaaacct
     8101 gtcaggatct aatgaaacca ttaccaaaaa ctctccacta acctattgat gtgtctgatg
     8161 a
//
