LOCUS       NP_001401329            2278 aa            linear   ROD 31-MAR-2024
DEFINITION  lipoxygenase homology domain-containing protein 1 isoform 2 [Rattus
            norvegicus].
ACCESSION   NP_001401329 XP_038952562
VERSION     NP_001401329.1
DBSOURCE    REFSEQ: accession NM_001414400.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 2278)
  AUTHORS   Mitra,A.K., Stessman,H.A., Schaefer,R.J., Wang,W., Myers,C.L., Van
            Ness,B.G. and Beiraghi,S.
  TITLE     Fine-Mapping of 18q21.1 Locus Identifies Single Nucleotide
            Polymorphisms Associated with Nonsyndromic Cleft Lip with or
            without Cleft Palate
  JOURNAL   Front Genet 7, 88 (2016)
   PUBMED   27242896
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 2278)
  AUTHORS   Riazuddin,S.A., Parker,D.S., McGlumphy,E.J., Oh,E.C., Iliff,B.W.,
            Schmedt,T., Jurkunas,U., Schleif,R., Katsanis,N. and Gottsch,J.D.
  TITLE     Mutations in LOXHD1, a recessive-deafness locus, cause dominant
            late-onset Fuchs corneal dystrophy
  JOURNAL   Am J Hum Genet 90 (3), 533-539 (2012)
   PUBMED   22341973
REFERENCE   3  (residues 1 to 2278)
  AUTHORS   Grillet,N., Schwander,M., Hildebrand,M.S., Sczaniecka,A.,
            Kolatkar,A., Velasco,J., Webster,J.A., Kahrizi,K., Najmabadi,H.,
            Kimberling,W.J., Stephan,D., Bahlo,M., Wiltshire,T.,
            Tarantino,L.M., Kuhn,P., Smith,R.J. and Muller,U.
  TITLE     Mutations in LOXHD1, an evolutionarily conserved stereociliary
            protein, disrupt hair cell function in mice and cause progressive
            hearing loss in humans
  JOURNAL   Am J Hum Genet 85 (3), 328-337 (2009)
   PUBMED   19732867
REFERENCE   4  (residues 1 to 2278)
  AUTHORS   Schwander,M., Sczaniecka,A., Grillet,N., Bailey,J.S., Avenarius,M.,
            Najmabadi,H., Steffy,B.M., Federe,G.C., Lagler,E.A., Banan,R.,
            Hice,R., Grabowski-Boase,L., Keithley,E.M., Ryan,A.F.,
            Housley,G.D., Wiltshire,T., Smith,R.J., Tarantino,L.M. and
            Muller,U.
  TITLE     A forward genetics screen in mice identifies recessive deafness
            traits and reveals that pejvakin is essential for outer hair cell
            function
  JOURNAL   J Neurosci 27 (9), 2163-2175 (2007)
   PUBMED   17329413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 21, 2022 this sequence version replaced XP_038952562.1.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2278
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     Protein         1..2278
                     /product="lipoxygenase homology domain-containing protein
                     1 isoform 2"
                     /note="lipoxygenase homology domain-containing protein 1;
                     lipoxygenase homology domains 1"
                     /calculated_mol_wt=259794
     Region          43..162
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          172..289
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          296..414
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          425..542
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          554..675
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          684..805
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          816..>896
                     /region_name="PLAT"
                     /note="PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin)
                     domain or LH2 (Lipoxygenase homology 2) domain. It
                     consists of an eight stranded beta-barrel. The domain can
                     be found in various domain architectures, in case of
                     lipoxygenases, alpha toxin, lipases and...; cl00011"
                     /db_xref="CDD:412108"
     Region          1026..1146
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          1180..1300
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          1311..1437
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          1465..1585
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          1634..1749
                     /region_name="PLAT"
                     /note="PLAT/LH2 domain; pfam01477"
                     /db_xref="CDD:396180"
     Region          1763..1880
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          1890..2010
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          2023..2124
                     /region_name="PLAT"
                     /note="PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin)
                     domain or LH2 (Lipoxygenase homology 2) domain. It
                     consists of an eight stranded beta-barrel. The domain can
                     be found in various domain architectures, in case of
                     lipoxygenases, alpha toxin, lipases and...; cl00011"
                     /db_xref="CDD:412108"
     Region          2159..2277
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     CDS             1..2278
                     /gene="Loxhd1"
                     /coded_by="NM_001414400.1:315..7151"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:291427"
                     /db_xref="RGD:1304815"
ORIGIN      
        1 mmpqkkkrrk kdidflglye eellnynsed dedeleheyy kakvyevvta tgdvrgagtd
       61 anvfitifge nglspklhlt sksesafeka nvdvfrvrtn nvgliykiri ehdntglnas
      121 wyldrvivtd mkrphlryyf ncnnwlskve gdrqwcrdll asfdpmdmpr gnkyeikvyt
      181 gdvigagtda dvfinifgey gdtgerrlen ekdnfekgae dkftldapdl gqlmkinvgh
      241 nnkggsagwf lskiiiedig nkrkydfpln rwlaldeddg kiqrdilvgg aettaityiv
      301 tvftgdirga gtkskiylvm ygargnrnsg kifleggvfd rgrtdifhid lavllsplsr
      361 vsighgnigv nrgwycekvv vlcpftgiqq tfpcsnwlde kkadglierq lyemvslrkk
      421 rlkkfpwslw vwttdlkkag tnspifiqiy gkkgrtdeil lnpnnkwfkp giiekfrmel
      481 pdlgrfykir awhdrqnpgs gwhlekmtlm ntlnkdkynf ncnrwldane ddneivremt
      541 aegptvrrim gmaryrvtvc tgelegagtd anvylclfgd vgdtgerlly ncrnntdlfe
      601 kgnadeftie svtmrkvrrv rvrhdgkgsg sgwyldrvlv reegqpesdn vefpclrwld
      661 kdkddgqlvr ellpsdsnat lknfryhisv ktgdvsgast dsrvyiklyg eksdtikqvl
      721 lvsdnnlkdy fergrvdeft letlnigtii rlvighdstg mhagwflgsv qirvprqgkq
      781 ytfpanrwld knqadgrlev elypsevvei qklvhyeiei wtgdvggagt tsrvyvqiyg
      841 eegktevlfl ssrskvfdrg skdifqleaa dvgeiykirl ghtgegfgps wfvdtvwlrh
      901 lvvqeesltp eeearrkkek eklrqllkke rlkaklqrkk kkkkkgsdee eegdeeeess
      961 seessseeee eeeseeeeee eeygpgmqev ivqykfvanr wlargkedne lvvelvpagq
     1021 pgpepntyev qvitgnvpka gtdanvylti ygeeygdtge rplkksdksn kfeqgqtdtf
     1081 tiyaidlgal tkirirhdnt gnrpgwfldr iditdvnnet tyyfpcqrwl aveeddgqls
     1141 rellpvdesy vlpsedeegg gqgdnnpldn laleqkdkst tfsvtiktgd kknagtdanv
     1201 fitlfgtkdn ngmtllkssk tnsdkferds ieiftvetld lgdlwkvrig hdntgkapgw
     1261 fvdwvevdap slgkcmtfpc grwlaknedd gsivrdlfha elqtrlytpf vpyeitlyts
     1321 dvfaagtdan vfiviygcda vctrqkflct nkreqkllfe rksasrfive ledvgeiiek
     1381 irighdntgi npgwhcshvd irrllpekdg tetltfpcdr wlatseddkk tirelvpydi
     1441 ftekymkdgs lrqvykevee pldivlysvq iftgnvpgag tdakvyitiy gdlgdtgery
     1501 lgksenrtnk fekgtadtfi ieaadlgviy kiklrhdntk wcadwyvekv eiwndtnede
     1561 flflcgrwls lkkedgrler lfyekeytgd rssncsspad fweialsskm advdidtvtg
     1621 pmvdyvqdgp vipyyvsvtt gkhkeaatds rafvlliged dertnriwld fpqgkrgfsc
     1681 gsveefyvgg ldvgiikkie lghdgaspes cwlveelcla vptqgtkytl rcncwlakdr
     1741 gdgvtsrvfd lldamvvnig kkvlyemtvw tgdvvgggtd snifmtlygi ngsteevqld
     1801 kkkarfereq ndtfimeild iapftkmrir idglgsrpew flerillknm ntgdltmfyy
     1861 gdwlsqkkgk ktlvceicav idgeemmewt sytvsvktsd ilgagtdanv fiiifgengd
     1921 sgtlalkqsa nwnkfernnt dtfnfpdmls lghlcklrvw hdnkgifpgw hlsyidvkdn
     1981 srdetfrfqc dcwlsksegd rqtlrdfaca nneirdelee ttyeivietg nggetreniw
     2041 lilegrknrs keflvenssr qrafrkgttd tfefdsiflg diaslcvghl aredrfipkr
     2101 elvwhvktit itemeygnvy ffncdclipl krkrkyfkvf evtkttesfa skiqslvpvk
     2161 yevivttgye pgagtdanvf vtifgangdt gkrelkqkmr nlfergstdr ffletlelge
     2221 lrkvrlehds sgyysgwlve kvevtntstg vatifscgrw ldksrgdglt wrelfpsv
//
