LOCUS       NM_001414003            4536 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus lysyl oxidase (Lox), mRNA.
ACCESSION   NM_001414003 XM_006254713
VERSION     NM_001414003.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4536)
  AUTHORS   Jiang,T., Xiao,H., Li,B., He,H., Wang,H. and Chen,L.
  TITLE     LOX overexpression programming mediates the osteoclast mechanism of
            low peak bone mass in female offspring rats caused by pregnant
            dexamethasone exposure
  JOURNAL   Cell Commun Signal 21 (1), 84 (2023)
   PUBMED   37095518
  REMARK    GeneRIF: LOX overexpression programming mediates the osteoclast
            mechanism of low peak bone mass in female offspring rats caused by
            pregnant dexamethasone exposure.
            Erratum:[Cell Commun Signal. 2024 Mar 26;22(1):192. doi:
            10.1186/s12964-024-01579-w.. PMID: 38532448]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4536)
  AUTHORS   McEnaney,R.M., McCreary,D.D., Skirtich,N.O., Andraska,E.A.,
            Sachdev,U. and Tzeng,E.
  TITLE     Elastic Laminar Reorganization Occurs with Outward Diameter
            Expansion during Collateral Artery Growth and Requires Lysyl
            Oxidase for Stabilization
  JOURNAL   Cells 11 (1), 7 (2021)
   PUBMED   35011567
  REMARK    GeneRIF: Elastic Laminar Reorganization Occurs with Outward
            Diameter Expansion during Collateral Artery Growth and Requires
            Lysyl Oxidase for Stabilization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4536)
  AUTHORS   Zhao,R., Liu,W., Wang,M., Zhang,Y., Pan,L., Feng,F., Xia,T. and
            Yang,L.
  TITLE     Lysyl oxidase inhibits TNF-alpha induced rat nucleus pulposus cell
            apoptosis via regulating Fas/FasL pathway and the p53 pathways
  JOURNAL   Life Sci 260, 118483 (2020)
   PUBMED   32979358
  REMARK    GeneRIF: Lysyl oxidase inhibits TNF-alpha induced rat nucleus
            pulposus cell apoptosis via regulating Fas/FasL pathway and the p53
            pathways.
REFERENCE   4  (bases 1 to 4536)
  AUTHORS   Rosell-Garcia,T., Paradela,A., Bravo,G., Dupont,L., Bekhouche,M.,
            Colige,A. and Rodriguez-Pascual,F.
  TITLE     Differential cleavage of lysyl oxidase by the metalloproteinases
            BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine
            sulfate domain
  JOURNAL   J Biol Chem 294 (29), 11087-11100 (2019)
   PUBMED   31152061
REFERENCE   5  (bases 1 to 4536)
  AUTHORS   Wan,Z.H., Li,G.H., Guo,Y.L., Li,W.Z., Chen,L. and Zhang,Y.J.
  TITLE     Amelioration of Cavernosal Fibrosis and Erectile Function by Lysyl
            Oxidase Inhibition in a Rat Model of Cavernous Nerve Injury
  JOURNAL   J Sex Med 15 (3), 304-313 (2018)
   PUBMED   29502979
  REMARK    GeneRIF: LOX over-activation contributes to penile fibrosis and LOX
            inhibition could be a promising strategy in preventing the
            progression of cavernous nerve injury-induced erectile dysfunction.
REFERENCE   6  (bases 1 to 4536)
  AUTHORS   Trackman,P.C., Pratt,A.M., Wolanski,A., Tang,S.S., Offner,G.D.,
            Troxler,R.F. and Kagan,H.M.
  TITLE     Cloning of rat aorta lysyl oxidase cDNA: complete codons and
            predicted amino acid sequence
  JOURNAL   Biochemistry 30 (33), 8282 (1991)
   PUBMED   1678281
  REMARK    Correction to:[Biochemistry. 1990 May 22;29(20):4863-70. doi:
            10.1021/bi00472a016.. PMID: 1973052]
REFERENCE   7  (bases 1 to 4536)
  AUTHORS   Trackman,P.C., Pratt,A.M., Wolanski,A., Tang,S.S., Offner,G.D.,
            Troxler,R.F. and Kagan,H.M.
  TITLE     Cloning of rat aorta lysyl oxidase cDNA: complete codons and
            predicted amino acid sequence
  JOURNAL   Biochemistry 29 (20), 4863-4870 (1990)
   PUBMED   1973052
  REMARK    Erratum:[Biochemistry. 1991 Aug 20;30(33):8282. doi:
            10.1021/bi00247a025.. PMID: 1678281]
REFERENCE   8  (bases 1 to 4536)
  AUTHORS   Ooshima,A. and Midorikawa,O.
  TITLE     Increased lysyl oxidase activity in blood vessels of hypertensive
            rats and effect of beta-aminopropionitrile on arteriosclerosis
  JOURNAL   Jpn Circ J 41 (12), 1337-1340 (1977)
   PUBMED   24127
REFERENCE   9  (bases 1 to 4536)
  AUTHORS   Starcher,B.C., Madaras,J.A. and Tepper,A.S.
  TITLE     Lysyl oxidase deficiency in lung and fibroblasts from mice with
            hereditary emphysema
  JOURNAL   Biochem Biophys Res Commun 78 (2), 706-712 (1977)
   PUBMED   20889
REFERENCE   10 (bases 1 to 4536)
  AUTHORS   Rowe,D.W., McGoodwin,E.B., Martin,G.R. and Grahn,D.
  TITLE     Decreased lysyl oxidase activity in the aneurysm-prone, mottled
            mouse
  JOURNAL   J Biol Chem 252 (3), 939-942 (1977)
   PUBMED   14140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 14, 2022 this sequence version replaced XM_006254713.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U11038.1, SRR26360190.2555359.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMN12840115 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-885               JAXUCZ010000018.1  48174756-48175640   c
            886-994             JAXUCZ010000018.1  48174327-48174435   c
            995-1132            JAXUCZ010000018.1  48172957-48173094   c
            1133-1289           JAXUCZ010000018.1  48171033-48171189   c
            1290-1385           JAXUCZ010000018.1  48167756-48167851   c
            1386-1501           JAXUCZ010000018.1  48167291-48167406   c
            1502-4536           JAXUCZ010000018.1  48162889-48165923   c
FEATURES             Location/Qualifiers
     source          1..4536
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..4536
                     /gene="Lox"
                     /gene_synonym="H-rev142; Rrg1"
                     /note="lysyl oxidase"
                     /db_xref="GeneID:24914"
                     /db_xref="RGD:3015"
     exon            1..885
                     /gene="Lox"
                     /gene_synonym="H-rev142; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1508
                     /gene="Lox"
                     /gene_synonym="H-rev142; Rrg1"
                     /EC_number="1.4.3.13"
                     /note="protein-lysine 6-oxidase; Lysyl oxidase (an H-rev
                     gene with its expression down-regulated in
                     HRAS-transformed rat 208F fibroblasts)"
                     /codon_start=1
                     /product="protein-lysine 6-oxidase precursor"
                     /protein_id="NP_001400932.1"
                     /db_xref="GeneID:24914"
                     /db_xref="RGD:3015"
                     /translation="MRFAWTVLFLGQLQFCPLLRCAPQAPREPPAAPGAWRQTIQWEN
                     NGQVFSLLSLGAQYQPQRRRDSSATAPRADGNAAAQPRTPILLLRDNRTASARARTPS
                     PSGVAAGRPRPAARHWFQVGFSPSGAGDGASRRAANRTASPQPPQLSNLRPPSHVDRM
                     VGDDPYNPYKYSDDNPYYNYYDTYERPRSGSRHRPGYGTGYFQYGLPDLVPDPYYIQA
                     STYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRP
                     RYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFAC
                     TAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYSNNVVRC
                     EIRYTGHHAYASGCTISPY"
     exon            886..994
                     /gene="Lox"
                     /gene_synonym="H-rev142; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1132
                     /gene="Lox"
                     /gene_synonym="H-rev142; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1289
                     /gene="Lox"
                     /gene_synonym="H-rev142; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1385
                     /gene="Lox"
                     /gene_synonym="H-rev142; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1501
                     /gene="Lox"
                     /gene_synonym="H-rev142; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..4536
                     /gene="Lox"
                     /gene_synonym="H-rev142; Rrg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtgcgct ctcccggacc gtcgtgcgcc gctccccgtc gccttccagg actgggaaag
       61 gggagaggag gacggtgcca cgtccgacgg cctcctgggc tgggggcagg gtctgccgct
      121 cgcccttggc accagtccct gcgacccatc cccgagcctc gccctcctcc tccctgctcg
      181 aagaggtctc cctccttcgc gggatctgag tccctgtctt catttttctc ctagccacgt
      241 ccctccccga gaagggacga gccgggagca tcatgcgttt cgcctggacc gtgctctttc
      301 tgggacagct gcagttctgt ccccttctcc gctgcgcccc gcaggccccg cgcgagcctc
      361 ccgccgcccc cggtgcctgg cgccagacaa tccaatggga gaacaacggg caggtgttca
      421 gtctgttgag cctgggggcg cagtaccagc ctcagcgacg ccgcgactcc agcgccactg
      481 ccccgagagc cgacggcaac gctgcagcac agccacgcac gcccattctg ctgctgcgtg
      541 acaaccgcac tgcctctgcc cgtgcgagga ctccaagccc atctggggtc gccgcgggtc
      601 gtccccggcc cgcagcccgc cactggttcc aagttggttt ctcgccgtcg ggggccggcg
      661 atggagcctc aaggcgcgca gcgaaccgga ctgcgtcgcc acagcctccg cagctcagta
      721 atctgaggcc acccagccac gtagatcgca tggtgggcga cgacccctac aatccctaca
      781 agtactccga cgacaacccc tattataact actatgacac ttatgagaga ccccggtccg
      841 ggagcaggca ccgacctgga tatggcaccg gttacttcca gtacggtctc ccggacctgg
      901 tacccgatcc ctactacatc caggcatcca cgtacgtaca aaagatgtct atgtacaacc
      961 tgagatgcgc tgcggaagaa aactgcctgg ccagttcagc atatagggcg gatgtcagag
     1021 actatgacca cagggtactg ctacgatttc ctcagagagt gaaaaaccaa gggacgtctg
     1081 acttcttacc aagccgcccc cgctactcct gggagtggca cagctgccac caacattacc
     1141 acagcatgga tgaattcagc cactacgacc tgctggatgc cagcacacag aggagagtgg
     1201 ccgagggcca caaagcaagc ttctgtctgg aggacacttc ctgtgattat gggtaccaca
     1261 gacgatttgc ctgtactgca cacacacagg ggttgagtcc cggatgttat gatacttatg
     1321 cagcagacat agactgccag tggattgata ttacagatgt acaacccgga aattacattc
     1381 taaaggtcag tgtaaacccc agctacctgg tgcctgaatc agactacagt aacaatgtcg
     1441 tacgctgtga aattcgctac acaggacatc acgcctatgc ctcaggctgc accatttcac
     1501 cgtattagaa agaagctcac ttcccaaagg atgaagcagt acctggtgtt tggacctatg
     1561 aaaaccgtag attagcttaa gtaggaagac ttagatattt taaaaggcaa acggaaaaac
     1621 aacaaagaag gttttgtttg gactctttca caacaaatca cataactgga ttttgagtgt
     1681 ttaaatcagc attagattgg cacattttaa atacttattc atgttgcttt atgaagtaat
     1741 ggtgtttcaa ttctgtgggt gcatagtggg ctctttcaaa gaattctgaa tttcttacct
     1801 tcttttgaaa ttatagtgca aaaagaagag gatattttaa tgaatgagcc acaatttgaa
     1861 ctgattactt tctaaagtgc agacccatga gacaatgatg atgggtttgt atttgcctca
     1921 acatagattg ctttttaaaa aggtgttcct attgtatagg caaaaatgga tacacttggt
     1981 gctgaggaag ggtcaaatac ctaactattg ttgtcacgaa atataggtct acagcagaga
     2041 gatggtgaag tatatattca gatagttaca tccctatata aaactatgtt tacattttag
     2101 atgcttttct ttctgttaat tgcttaatct cactctgact tgagtcaact tctgttttgg
     2161 aatgaattag ataattccag attctggttt gataattgtt gacattcccc ccatgctact
     2221 ttttctgagg gcagaaacgt ctaatgtgac gatcttcaca ttaccattac gaggattcac
     2281 agcacagcga aatcattccg atgacaggtg tgatagatgg agagctaaca tgcaactgcc
     2341 gagtgtttca ctgttagcca gaactaagtc actgcccaca cagcaattac accatgaatc
     2401 tctaacatca caaccttctt tcaaatactg taaaaaaaaa aaatactgga aaaccttttt
     2461 agatttgttt caatctacca cgcttctgaa atgttcagct attaagggga atgtcaatat
     2521 atatatacag cccaaattag cgaagcccaa attagggaag cacatagcat ggcatacttg
     2581 agaggttggc aaacaagagg gaagcaggta ctttctgcaa aaacagggac tgtgcgccac
     2641 aatgagaccg ctgtgacctt acttcaaact gtgaaactgt gtgcagcagt aggatttgga
     2701 gtcttaaatt cagaaggagc agaaagaaag agagttagac gtttgaattc ctggtgctta
     2761 tgctgacgtt ttctctcatt tgccagcatt aaaatctcaa gtaaggtgtc tcctgtgcca
     2821 ggacgtgtca ggtagacctt tctcagtgag ctggaatcct gccttctgtg tcatagagtt
     2881 gtaagagcag cagtttctac ccatcatgct gtgtactcac tgctgcagag caagtgggag
     2941 gggccagaga tgggccgtcc ccaggggcgg atagcgcggt acacttaatt ctcttctgcc
     3001 tgaaagcaca cttccccgta agcgaataca gacagaactt tgattgagct ggtatctgac
     3061 cgataggatt gcttctttga tgtacctctt tgacctagct agcatttcag ctttgatact
     3121 gcagaacgat cttttcaaat tataatcatt ctgatagaga tatcttaata gacgtgcttt
     3181 taaaaacaaa acggaaacta ctgtcagtat gaatactgag ccagactggc attcatagat
     3241 ttaacaactt gtatttctaa gattcttaac tctataaaag taatatggct tttagatata
     3301 taggataata atttcagtga gaccgttatc tctttactca acattatgtt agggacagta
     3361 taagccaagc acttacctgt tacacattgg agactaaaac gactgccccc aaccttagta
     3421 agtatgaaaa ctagactcac attatttcat ttttaactgc taaaagtatg tctatagaat
     3481 ttaaaattta agcactacta tttgtcctgg ccacattttt caaaaattaa gttaaaagtt
     3541 attaattata tacaggtgtg tatttctaat aattaaaata cctttcaaat ccatggaatg
     3601 tctgcctttt aaatgtaatt tgggcttttt tgtttgattc tttttcactt aactagctgt
     3661 ttatttgtaa acatttcttt ccacgattta aaaacacttc caatcggctt tacttcctga
     3721 tttagcactt cctattttga cccttgggca tctgttcttc gtttaattgg tgtagaataa
     3781 tgataaaaat cccaagctag tctaaccaaa ctgcattctt aagagtacta agtgggaatg
     3841 atgcaaagtt catcaagaat tgaaaagaag ccggtctttg cactaaggaa gacagcataa
     3901 ttaagtcttc tcgttgccat ctgagtaata tcatgatatg gggaccgcag aatccatctc
     3961 cggtgggatg atggtatagc tttcctagtt ccagaaaaat ctccttcaca ttttatataa
     4021 taatttaatc acaatgtcca tcgaattctt ccttaggcat tctttgtaac agtagtgtgc
     4081 tgctctttaa aatattaacc tctgacacat gtgtgaacct cattccctgt ggtcactaaa
     4141 atttcttccc cactgagcat caatctttag cagattttag gaaaatactg aattcttagt
     4201 caggaaatat tttaggaata atcttgctaa cagtatatta agtaataaaa ttacccactc
     4261 tatgtgtgtt tcattttttt taattcacat agacaatggt ttttataaag caatgatttc
     4321 aatttttccc agctacccaa agtcctggtt aatttgtgaa cacaaatttt gttagccttc
     4381 aagtttaaac ggtgctgaat tgtcttaact tgaatgtaaa aatggattaa ggcttatctc
     4441 atgggacaca aacatgtccc atatgactgc ttgctgcgta ctaggggaca tgccatttgg
     4501 tgttaaattg tctataataa agttcggttt ctccca
//
