LOCUS       NM_001399507            1816 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus loricrin cornified envelope precursor protein
            (Loricrin), mRNA.
ACCESSION   NM_001399507
VERSION     NM_001399507.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1816)
  AUTHORS   Fessing,M.Y., Mardaryev,A.N., Gdula,M.R., Sharov,A.A.,
            Sharova,T.Y., Rapisarda,V., Gordon,K.B., Smorodchenko,A.D.,
            Poterlowicz,K., Ferone,G., Kohwi,Y., Missero,C.,
            Kohwi-Shigematsu,T. and Botchkarev,V.A.
  TITLE     p63 regulates Satb1 to control tissue-specific chromatin remodeling
            during development of the epidermis
  JOURNAL   J Cell Biol 194 (6), 825-839 (2011)
   PUBMED   21930775
REFERENCE   2  (bases 1 to 1816)
  AUTHORS   Cheng,X., Mihindukulasuriya,K., Den,Z., Kowalczyk,A.P.,
            Calkins,C.C., Ishiko,A., Shimizu,A. and Koch,P.J.
  TITLE     Assessment of splice variant-specific functions of desmocollin 1 in
            the skin
  JOURNAL   Mol Cell Biol 24 (1), 154-163 (2004)
   PUBMED   14673151
REFERENCE   3  (bases 1 to 1816)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
REFERENCE   4  (bases 1 to 1816)
  AUTHORS   Koch,P.J., de Viragh,P.A., Scharer,E., Bundman,D., Longley,M.A.,
            Bickenbach,J., Kawachi,Y., Suga,Y., Zhou,Z., Huber,M., Hohl,D.,
            Kartasova,T., Jarnik,M., Steven,A.C. and Roop,D.R.
  TITLE     Lessons from loricrin-deficient mice: compensatory mechanisms
            maintaining skin barrier function in the absence of a major
            cornified envelope protein
  JOURNAL   J Cell Biol 151 (2), 389-400 (2000)
   PUBMED   11038185
REFERENCE   5  (bases 1 to 1816)
  AUTHORS   Lee,C.H., Marekov,L.N., Kim,S., Brahim,J.S., Park,M.H. and
            Steinert,P.M.
  TITLE     Small proline-rich protein 1 is the major component of the cell
            envelope of normal human oral keratinocytes
  JOURNAL   FEBS Lett 477 (3), 268-272 (2000)
   PUBMED   10908733
REFERENCE   6  (bases 1 to 1816)
  AUTHORS   Steinert,P.M. and Marekov,L.N.
  TITLE     The proteins elafin, filaggrin, keratin intermediate filaments,
            loricrin, and small proline-rich proteins 1 and 2 are isodipeptide
            cross-linked components of the human epidermal cornified cell
            envelope
  JOURNAL   J Biol Chem 270 (30), 17702-17711 (1995)
   PUBMED   7543090
REFERENCE   7  (bases 1 to 1816)
  AUTHORS   Mehrel,T., Hohl,D., Rothnagel,J.A., Longley,M.A., Bundman,D.,
            Cheng,C., Lichti,U., Bisher,M.E., Steven,A.C., Steinert,P.M. et al.
  TITLE     Identification of a major keratinocyte cell envelope protein,
            loricrin
  JOURNAL   Cell 61 (6), 1103-1112 (1990)
   PUBMED   2190691
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000002.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.9908.1,
                                           SRR26643294.9850.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680422 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000002.1  180256526-180256572 c
            48-1816             JAXUCZ010000002.1  180253674-180255442 c
FEATURES             Location/Qualifiers
     source          1..1816
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1816
                     /gene="Loricrin"
                     /gene_synonym="Lor; RGD1559993"
                     /note="loricrin cornified envelope precursor protein"
                     /db_xref="GeneID:502541"
                     /db_xref="RGD:1559993"
     exon            1..47
                     /gene="Loricrin"
                     /gene_synonym="Lor; RGD1559993"
                     /inference="alignment:Splign:2.1.0"
     exon            48..1816
                     /gene="Loricrin"
                     /gene_synonym="Lor; RGD1559993"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1561
                     /gene="Loricrin"
                     /gene_synonym="Lor; RGD1559993"
                     /codon_start=1
                     /product="loricrin"
                     /protein_id="NP_001386436.1"
                     /db_xref="GeneID:502541"
                     /db_xref="RGD:1559993"
                     /translation="MSHQKKQPTPCPPVGCGKTSGGGGGGGGGYYSGGGSGGGSSCGG
                     GSSGGGSGCGGGGGGGGSYGGGSSCGGGGGSGGGVKYSGGSSGGSSCGGGYSGGGGGS
                     SCGGGYSGGGGGSSCGGGYSGGGGGGSSCGGGYSGGGGSSCGGGGYSGGGSSCGGGGG
                     SGGGVKYSGGSGGGGGSSCGGGYSGGGGGSSCGGGSGGGGSYCGGSSGGGSSGGCGGG
                     SGGGKYSGGGGGGGSSCGGGYSGGGGSGGGSSCGGGYSGGGGSSCGGGGYSGGGGSSC
                     GGGSSGGGGGGSSGSSQQYQCQSYGGGSSGGSSCGGGYSGGGGSSCGGGYSGGGGSSC
                     GGGSSGGGSSCGGGSGGGYSGGGGGSCGGGSSGGGGGYYSSQQSSQTSCAPQQSYGGG
                     SSGGGGSCGGGSSGGGGGGSGGCYSSGGGGGSGGCGGGYSGGGGGCGGGSSGGSGGGC
                     GGGYSGGGGGGSSCGGGSSGGGSGGGKGVPVCHQTQQKQAPTWPCK"
ORIGIN      
        1 acatcaccat catctccttc cctcactcat ctcccttggt gcttcggggt tccccttctc
       61 cttaaacaag atgtctcacc agaaaaagca gcccactcca tgtcctcccg tgggttgtgg
      121 aaagacctct ggtggaggag gaggcggcgg tggcggttac tatagcggtg gtggtagcgg
      181 tggaggctcc agctgcggag gtggctcatc tggaggaggc tctggctgcg gaggcggagg
      241 cggaggcggt ggttcctatg gaggtggttc cagctgcggc ggcggaggcg gctccggagg
      301 gggcgtcaag tactctggtg gcagcagcgg tggctctagc tgcggcggcg gctactccgg
      361 gggcggcggc ggctccagct gtggaggtgg ctactccggg ggcggcggcg gctccagctg
      421 cggtggcggc tactccgggg gcggcggcgg cggctccagc tgcggtggcg gctactccgg
      481 gggcggcggc tccagctgtg gaggcggcgg ctactctggg ggtggctcca gctgtggagg
      541 tggtggcggc tccggtgggg gcgtcaagta ctccggtggc agtggcggcg gcggcggctc
      601 cagctgcggc ggcggctact ccggcggggg cggaggctcc agctgcggag gcggatcagg
      661 aggcggcggc tcctactgcg gaggctcctc tggaggcggc agctccggtg gctgcggcgg
      721 cggttccgga gggggcaagt actccggcgg cggcggcggc ggtggctcca gctgcggagg
      781 cggctactcc ggcggtggtg gaagtggagg cggctctagc tgtggcggcg gctactcagg
      841 cggtggtgga tccagctgcg gcggcggcgg atactccggt ggcggcggta gcagctgcgg
      901 aggtggctcc tccggtggtg gcggcggcgg ctcctccggg tcgtcccaac agtatcagtg
      961 ccagagctac ggaggcggat ctagcggtgg ctccagctgc ggcggcggct actccggggg
     1021 cggcggctcc agctgcggcg gcggctactc cgggggcggc ggctccagct gcggaggcgg
     1081 gtcctccggt ggtggctcca gttgcggcgg cggcagcggc ggcggctatt ccggtggagg
     1141 cggtggcagc tgcggcggcg gctcctctgg tggcggcggg ggctattact cctcgcagca
     1201 gtccagtcag acctcctgcg ctccccagca gagctacgga gggggctctt caggcggagg
     1261 tggtagctgc ggaggtggct cctccggcgg cggcggcggc ggcagcggcg gctgctactc
     1321 tagcggtggt ggcggcggca gcggtggctg cggtggaggc tactccggag gcggcggtgg
     1381 ctgtggcggc ggctcttccg ggggcagcgg cggtggatgc ggaggcggct actccggagg
     1441 tggtggcggc ggttccagct gcggaggcgg ctcctcaggg ggcggctctg gaggtggcaa
     1501 gggtgtgcca gtctgccacc agacccagca gaaacaggcg cccacctggc cgtgcaagta
     1561 aagtccccgg gctgcagcgg agacaacgga gctggaagag ttctccgtgg acgcctatgg
     1621 gcttaacttt ctcatgaaat tgcccgaggt ttccaaaccc cccattttaa gctcaccccc
     1681 tcaccctcac ccccaagaag aagcctttga gtcgctcaag ttgtatcttg ttctgtcgat
     1741 ttttcctctt ggtttctgaa tgattccctc ccaattccag tgcctactca gtcaataaat
     1801 ttgcaattca tgggaa
//
