LOCUS       NM_001399196            2831 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus lon peptidase 2, peroxisomal (Lonp2), mRNA.
ACCESSION   NM_001399196 XM_006255238
VERSION     NM_001399196.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2831)
  AUTHORS   Okumoto,K., Kametani,Y. and Fujiki,Y.
  TITLE     Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal
            lon protease (PsLon), cooperatively regulate fatty acid
            beta-oxidation in peroxisomal matrix
  JOURNAL   J Biol Chem 286 (52), 44367-44379 (2011)
   PUBMED   22002062
REFERENCE   2  (bases 1 to 2831)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   3  (bases 1 to 2831)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2831)
  AUTHORS   Omi,S., Nakata,R., Okamura-Ikeda,K., Konishi,H. and Taniguchi,H.
  TITLE     Contribution of peroxisome-specific isoform of Lon protease in
            sorting PTS1 proteins to peroxisomes
  JOURNAL   J Biochem 143 (5), 649-660 (2008)
   PUBMED   18281296
REFERENCE   5  (bases 1 to 2831)
  AUTHORS   Sajedi,E., Gaston-Massuet,C., Andoniadou,C.L., Signore,M.,
            Hurd,P.J., Dattani,M. and Martinez-Barbera,J.P.
  TITLE     DNMT1 interacts with the developmental transcriptional repressor
            HESX1
  JOURNAL   Biochim Biophys Acta 1783 (1), 131-143 (2008)
   PUBMED   17931718
REFERENCE   6  (bases 1 to 2831)
  AUTHORS   Yokota,S., Haraguchi,C.M. and Oda,T.
  TITLE     Induction of peroxisomal Lon protease in rat liver after
            di-(2-ethylhexyl)phthalate treatment
  JOURNAL   Histochem Cell Biol 129 (1), 73-83 (2008)
   PUBMED   17929048
REFERENCE   7  (bases 1 to 2831)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006255238.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166411.1, SRR22582424.1041217.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               JAXUCZ010000019.1  36671889-36672242   c
            355-589             JAXUCZ010000019.1  36664054-36664288   c
            590-721             JAXUCZ010000019.1  36661225-36661356   c
            722-844             JAXUCZ010000019.1  36658875-36658997   c
            845-1008            JAXUCZ010000019.1  36657392-36657555   c
            1009-1103           JAXUCZ010000019.1  36656059-36656153   c
            1104-1362           JAXUCZ010000019.1  36653003-36653261   c
            1363-1504           JAXUCZ010000019.1  36646049-36646190   c
            1505-1655           JAXUCZ010000019.1  36637522-36637672   c
            1656-1782           JAXUCZ010000019.1  36635627-36635753   c
            1783-1916           JAXUCZ010000019.1  36628032-36628165   c
            1917-2059           JAXUCZ010000019.1  36588326-36588468   c
            2060-2267           JAXUCZ010000019.1  36584185-36584392   c
            2268-2458           JAXUCZ010000019.1  36583627-36583817   c
            2459-2831           JAXUCZ010000019.1  36580736-36581108   c
FEATURES             Location/Qualifiers
     source          1..2831
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..2831
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /note="lon peptidase 2, peroxisomal"
                     /db_xref="GeneID:291922"
                     /db_xref="RGD:1305466"
     exon            1..354
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2680
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /EC_number="3.4.21.53"
                     /note="peroxisomal Lon protease homolog 2; lon protease 2;
                     lon protease-like protein 2"
                     /codon_start=1
                     /product="lon protease homolog 2, peroxisomal"
                     /protein_id="NP_001386125.1"
                     /db_xref="GeneID:291922"
                     /db_xref="RGD:1305466"
                     /translation="MSSVNPIQIPSRLPLLLTHESVLLPGSTMRTSVDTARNLQLVRS
                     RLLKGTSLQSTILGVIPNTPDPASDSQDLPPLHRIGTAALAVQVVGSNWPKPHYTLLI
                     TGLCRFQIVQVLKEKPYPVAEVEQLDRLEEFPNTCKTREELGELSEQFYRYSVQLVEM
                     LDMSVPAVAKLRRLLDSLPREALPDILTSIIRTSNKEKLQILDAVSLEDRFKMTIPLL
                     VRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRITHIPGALEDEEEEEDNDDIVMLEKK
                     IRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRA
                     ARILLDNDHYAMEKLKRRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTL
                     GREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKS
                     LQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEII
                     QVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQLTTLAIITRYTREAGVRSLDR
                     KFGAICRAVAVKVAEGQHKEAKLDRSDVADGEGCKEHVLEDAKPESIGDAADLALPPE
                     MPILIDSHALKDILGPPLYELEVSERLSQPGVAIGLAWTPLGGKIMFVEASRMDGEGQ
                     LTLTGQLGDVMKESAHLAISWLRSNAKKYHLTNAFGSFDLLDNTDIHLHFPAGAVTKD
                     GPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKHI
                     IIPQRNEKDLEEIPSNVKQDLSFVTASCLDEVLNAAFDGGFTVKTRPGLTDSKL"
     exon            355..589
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     exon            590..721
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     exon            722..844
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1008
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1103
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1362
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1504
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1655
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1782
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1916
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2059
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2267
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2458
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2831
                     /gene="Lonp2"
                     /gene_synonym="LRRGT00016; RGD1305466"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcaggcct gggggcgggc cgtagtgtta cagctgtggt gcgctccggg ggccttggcg
       61 taggaagtgt agagttggta gctggagtcc tcctgaccgc tctggtgtta acggcgtggc
      121 catgtcctcc gtgaacccca tccagatccc cagccgcctt ccgctgctgt tgacccatga
      181 gagtgtgttg ctgcctggct ccactatgcg cacaagtgtg gacacggccc gtaacttgca
      241 gctggtgcgg agccgtttgc tcaagggcac gtcgttgcag agcaccatcc taggagtcat
      301 ccccaacaca cccgatccgg ccagcgactc tcaggacctg ccaccactgc acagaattgg
      361 aacggctgcc ctggcagttc aggtcgtggg cagtaattgg cccaagccac actacacttt
      421 actgatcacg ggcctgtgcc ggttccagat tgtgcaggtc ttaaaagaga agccataccc
      481 cgtggctgaa gtggagcagc tggaccgact tgaggaattt cccaatacct gcaaaaccag
      541 ggaggagctg ggagagctgt cggagcaatt ctacagatac tcagtacaat tggttgaaat
      601 gttggatatg tccgtccctg cagttgctaa gttgagacgc ctcttagata gtctgccaag
      661 ggaagccctg ccggacattc tcacttccat tattcgaaca agcaacaaag agaagctcca
      721 gatcttagat gctgtgagcc tggaggatcg gttcaagatg accatacctc tgcttgtcag
      781 acagattgaa ggtctgaaat tacttcagaa gactcgaaaa cctaaacaag atgatgacaa
      841 aagggttata gcaatacgcc ccatcaggag gattacacac atcccaggag ctttagaaga
      901 tgaagaggaa gaggaagata atgatgacat tgtcatgctg gagaaaaaaa taagaacatc
      961 tagtatgcca gaacaggctc ataaagtctg tgtcaaggag ataaaaagac tcaaaaaaat
     1021 gcctcagtca atgcctgaat atgctctgac tagaaattat ttggaactta tggtggagct
     1081 tccttggaac aaaagtacaa ctgaccgcct ggacatccgg gcagcccgca tccttctgga
     1141 caatgaccac tatgccatgg aaaagctgaa gaggagggtt ttggagtact tggctgtgag
     1201 acagttgaaa aataacctga agggcccaat cctctgcttc gttggccctc ctggagtagg
     1261 caaaacaagt gtggggcggt cagtggccaa gactctgggc cgagagttcc acaggattgc
     1321 gcttgggggc gtgtgtgacc agtctgacat tcgagggcac aggcgcacct atgtgggcag
     1381 catgcccggc cgcatcatca atggcttgaa gactgtgggg gttaacaacc cagtgttcct
     1441 tttggatgag gttgacaagc tagggaagag cctgcagggg gatcctgcag ccgcactgct
     1501 cgaggtgttg gatcctgaac aaaaccataa cttcacagat cactatctaa atgtggcctt
     1561 tgacctttcc caagttcttt tcatagcgac tgccaacacc actgccacta tcccacctgc
     1621 tttgctggac aggatggaga tcattcaggt tccagggtac acacaggagg agaagataga
     1681 gattgcccac aggcacctga ttcctaagca gctggagcaa cacgggctga ctcctcagca
     1741 gatccagatc ccccagctca ccacgctggc catcatcacc agatacacca gagaagcggg
     1801 agtccgttct ctggacagaa agtttggggc tatttgtcgg gccgttgcag tgaaagttgc
     1861 agaaggccag cataaggaag ccaagctgga ccgttcggat gtggctgacg gagaagggtg
     1921 caaagaacat gtgctggaag atgcaaaacc tgaatccatc ggggatgccg cagacttggc
     1981 cctgccaccc gaaatgccga ttctcatcga ctcccatgcc ctgaaagaca tcctggggcc
     2041 accactgtat gagctggagg tgtccgagcg tttgagtcaa cctggagtgg caatagggtt
     2101 agcatggact cccttgggtg gcaaaattat gtttgtggag gcaagtcgaa tggacggcga
     2161 aggccagcta acactgactg gccagctcgg ggacgtcatg aaggagtctg cccatctcgc
     2221 cattagctgg cttcgaagca atgcgaagaa ataccacctg actaatgctt ttggaagttt
     2281 tgatcttctt gacaacacag acatccatct gcacttccca gctggagctg tcacaaaaga
     2341 tggaccatct gctggtgtta ccatagtaac ttgtctcgcc tcactcttca gtgggcggct
     2401 tgtgcgctca gatgtagcca tgactgggga aattacactg agaggacttg ttcttccggt
     2461 gggtggaatt aaagacaaag tcctggcagc acaccgagca ggactgaagc atatcataat
     2521 tccgcagagg aacgaaaagg acctcgagga gatcccaagc aacgtcaaac aggatctaag
     2581 ttttgtcaca gcgagctgcc tggatgaagt tctcaatgca gcttttgatg gtggctttac
     2641 tgtcaagacc agacctggtc tcactgacag caaactatag gccctagtgt tagctgaact
     2701 taattatgag gcaccaaatg cgtaagcaga acacccctga cctatggaca taatcagaca
     2761 gcagtgggtc tgtctaagta gttgttgttg attacagaaa tgtcggttta ataaagtaat
     2821 taaatctaga a
//
