LOCUS       NM_133404               2969 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus lon peptidase 1, mitochondrial (Lonp1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_133404
VERSION     NM_133404.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2969)
  AUTHORS   He,Y., Ding,Q., Chen,W., Lin,C., Ge,L., Ying,C., Xu,K., Wu,Z.,
            Xu,L., Ran,J., Chen,W. and Wu,L.
  TITLE     LONP1 downregulation with ageing contributes to osteoarthritis via
            mitochondrial dysfunction
  JOURNAL   Free Radic Biol Med 191, 176-190 (2022)
   PUBMED   36064070
  REMARK    GeneRIF: LONP1 downregulation with ageing contributes to
            osteoarthritis via mitochondrial dysfunction.
REFERENCE   2  (bases 1 to 2969)
  AUTHORS   Kim,J.E., Park,H., Kim,T.H. and Kang,T.C.
  TITLE     LONP1 Regulates Mitochondrial Accumulations of HMGB1 and Caspase-3
            in CA1 and PV Neurons Following Status Epilepticus
  JOURNAL   Int J Mol Sci 22 (5), 2275 (2021)
   PUBMED   33668863
  REMARK    GeneRIF: LONP1 Regulates Mitochondrial Accumulations of HMGB1 and
            Caspase-3 in CA1 and PV Neurons Following Status Epilepticus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2969)
  AUTHORS   Venkatesh,S., Li,M., Saito,T., Tong,M., Rashed,E., Mareedu,S.,
            Zhai,P., Barcena,C., Lopez-Otin,C., Yehia,G., Sadoshima,J. and
            Suzuki,C.K.
  TITLE     Mitochondrial LonP1 protects cardiomyocytes from
            ischemia/reperfusion injury in vivo
  JOURNAL   J Mol Cell Cardiol 128, 38-50 (2019)
   PUBMED   30625302
  REMARK    GeneRIF: upregulation of LonP1 mitigates cardiac injury by
            preventing oxidative damage of proteins and lipids, preserving
            mitochondrial redox balance and reprogramming bioenergetics by
            reducing Complex I content and activity. Mechanisms that promote
            the upregulation of LonP1 could be beneficial in protecting the
            myocardium from cardiac stress and limiting I/R injury
REFERENCE   4  (bases 1 to 2969)
  AUTHORS   Teng,H., Wu,B., Zhao,K., Yang,G., Wu,L. and Wang,R.
  TITLE     Oxygen-sensitive mitochondrial accumulation of cystathionine
            beta-synthase mediated by Lon protease
  JOURNAL   Proc Natl Acad Sci U S A 110 (31), 12679-12684 (2013)
   PUBMED   23858469
  REMARK    GeneRIF: Lon protease, a major degradation enzyme in mitochondrial
            matrix, recognized and degraded mitochondrial CBS by specifically
            targeting at the oxygenated heme group of CBS proteins.
REFERENCE   5  (bases 1 to 2969)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2969)
  AUTHORS   Bota,D.A. and Davies,K.J.
  TITLE     Lon protease preferentially degrades oxidized mitochondrial
            aconitase by an ATP-stimulated mechanism
  JOURNAL   Nat Cell Biol 4 (9), 674-680 (2002)
   PUBMED   12198491
REFERENCE   7  (bases 1 to 2969)
  AUTHORS   Hori,O., Ichinoda,F., Tamatani,T., Yamaguchi,A., Sato,N., Ozawa,K.,
            Kitao,Y., Miyazaki,M., Harding,H.P., Ron,D., Tohyama,M., M Stern,D.
            and Ogawa,S.
  TITLE     Transmission of cell stress from endoplasmic reticulum to
            mitochondria: enhanced expression of Lon protease
  JOURNAL   J Cell Biol 157 (7), 1151-1160 (2002)
   PUBMED   12082077
  REMARK    GeneRIF: changes in nuclear gene expression (Lon) triggered by ER
            stress had the potential to impact important mitochondrial
            processes such as assembly and/or degradation of cytochrome c
            oxidase
REFERENCE   8  (bases 1 to 2969)
  AUTHORS   Luciakova,K., Sokolikova,B., Chloupkova,M. and Nelson,B.D.
  TITLE     Enhanced mitochondrial biogenesis is associated with increased
            expression of the mitochondrial ATP-dependent Lon protease
  JOURNAL   FEBS Lett 444 (2-3), 186-188 (1999)
   PUBMED   10050756
REFERENCE   9  (bases 1 to 2969)
  AUTHORS   Fu,G.K. and Markovitz,D.M.
  TITLE     The human LON protease binds to mitochondrial promoters in a
            single-stranded, site-specific, strand-specific manner
  JOURNAL   Biochemistry 37 (7), 1905-1909 (1998)
   PUBMED   9485316
REFERENCE   10 (bases 1 to 2969)
  AUTHORS   Wang,N., Gottesman,S., Willingham,M.C., Gottesman,M.M. and
            Maurizi,M.R.
  TITLE     A human mitochondrial ATP-dependent protease that is highly
            homologous to bacterial Lon protease
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11247-11251 (1993)
   PUBMED   8248235
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB064323.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB064323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2969
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..2969
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /note="lon peptidase 1, mitochondrial"
                     /db_xref="GeneID:170916"
                     /db_xref="RGD:621598"
     exon            1..394
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..2854
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /EC_number="3.4.21.53"
                     /note="serine protease 15; lon protease-like protein;
                     mitochondrial ATP-dependent protease Lon; lon protease
                     homolog, mitochondrial; LONP; protease, serine, 15"
                     /codon_start=1
                     /product="lon protease homolog, mitochondrial precursor"
                     /protein_id="NP_596895.1"
                     /db_xref="GeneID:170916"
                     /db_xref="RGD:621598"
                     /translation="MAASTGYVRLWAAARCWVLRRPLLAVTGGRVPSASGSWLRRGCR
                     VCDTSTPWGGRVPMGGGQWRGLWDAGSRGGSDETSEGGVEDGATASSGEGPVVTALAP
                     MTVPDVFPHLPLIAISRNPVFPRFIKIVEVKNKKLVELLRRKVRLAQPYVGVFLKRDD
                     NNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVTGHRRIHISRQLEVEPEGLEPE
                     AENKQKSRRKLKRGKKEVGDELGAKPQLEMVTEATSDTSKEVLMVEVENVAHEDFQVT
                     EEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESH
                     ELQDVLEETNILKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKI
                     IKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLALLDNHSSEFNVTRN
                     YLDWLTSIPWGRQSDENLDLARAQSVLEEDHYGMEDVKKRVLEFIAVSQLRGSTQGKI
                     LCFHGPPGVGKTSIARSIARALGREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQC
                     LKKTKTENPLVLIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVL
                     FICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAERYLVPQARTLCGLDESKAQLS
                     ATVLTLLIKQYCRESGVRNLQKQVEKVLRKAAYKIVSGEAQTVHVTPENLQDFVGKPV
                     FTVERMYDVTPPGVVMGLAWTAMGGSTLFVETSLRRPQPSGSKEDKDGSLEVTGQLGD
                     VMKESARIAYTFARAFLMEQDPENDFLVTSHIHLHVPEGATPKDGPSAGCTIVTALLS
                     LALGQPVLQNLAMTGEVSLTGKVLPVGGIKEKTIAAKRAGVTCIILPAENRKDFSDLA
                     PFITEGLEVHFVEHYRDIFRIAFPLREHQEALAVER"
     exon            395..483
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            484..603
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            604..841
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            842..903
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1033
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1117
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1338
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1477
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1656
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1744
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1867
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1984
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2125
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2291
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2509
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2674
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2958
                     /gene="Lonp1"
                     /gene_synonym="Lon; Prss15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catggcggca agcacaggtt acgtgcggct gtgggctgct gcgcggtgct gggttctgcg
       61 gcgtccgctc ttggctgtca ccggaggccg agtcccgagt gcgtccgggt cctggctgcg
      121 ccgaggatgt cgggtctgcg acacgtcaac tccctggggc ggccgcgttc ctatgggcgg
      181 gggccagtgg cgggggctgt gggacgcggg gagccgcggt ggcagcgacg agacctccga
      241 gggcggcgtg gaggacgggg ccacggcgag cagcggggaa ggcccggtcg tcacggccct
      301 cgcgcctatg accgtcccgg atgtgtttcc tcacctgccg ctcatcgcca tctcccgcaa
      361 cccggtgttc ccgcgcttta tcaagatcgt ggaggttaaa aataagaagt tggttgagct
      421 gctgagaagg aaagtccgcc tggcacagcc gtatgttggc gtcttcttaa agagagatga
      481 taacaatgag tcagacgtgg tggagagcct ggatgagatc taccatacgg gaacgttcgc
      541 tcagattcat gagatgcagg acctcggaga caagttgcgc atgatcgtta caggccacag
      601 aaggattcac atcagccggc agctggaggt ggaaccagag gggctggagc cagaggcaga
      661 gaacaaacaa aagtccagga ggaagctgaa gcgaggcaag aaagaggtcg gggatgagct
      721 gggtgccaag ccccagctgg agatggtgac tgaggctacc agtgacacat ccaaagaggt
      781 gctcatggtg gaggttgaga atgtagccca tgaagacttt caggtcacag aggaagtgaa
      841 ggccctgact gcagagatcg tgaagaccat tcgggatatc atcgccctga accctctgta
      901 cagagagtcc gtgctgcaga tgatgcaggc aggccagcgt gtggtggaca accccatcta
      961 cttgagcgac atgggtgccg cactcactgg ggctgagtcc catgagctgc aagatgtgct
     1021 ggaagaaaca aacatcctta agcggctcta taaggccctg tctcttttga agaaggagtt
     1081 cgagttgagc aagcttcaac agcgcctggg gcgtgaggtg gaggagaaga tcaagcagac
     1141 gcacaggaag tacctgctgc aggagcagct aaagatcatc aagaaagagt tgggactaga
     1201 gaaggatgat aaagatgcca ttgaggagaa gttccgggaa cgcttaaagg agcttgtggt
     1261 tcccaagcat gtgatggacg tggtagatga ggagctgagc aagctggccc tactggacaa
     1321 ccactcctct gaattcaatg tcactcgcaa ctacctggac tggctgacgt ccatcccatg
     1381 gggccggcag agcgatgaga acttagacct ggctcgggcc cagtcggtgc tggaggagga
     1441 ccactatggc atggaggatg tgaagaagcg agtcttggag ttcattgcag tcagccagct
     1501 ccgaggctcc acacagggca agatcctctg cttccacggc ccaccaggtg tgggcaagac
     1561 cagcattgca cgctccattg cccgtgccct tggccgtgaa tacttccgct ttagtgttgg
     1621 tggcatgaca gatgtggcag aaatcaaggg gcacaggcgt acctatgtgg gggccatgcc
     1681 tgggaagatt atccagtgtc tgaagaaaac caagacagag aacccattag tgctgattga
     1741 tgaggtggat aagattggcc gaggctacca aggggacccg tcatcagcac tgttggagtt
     1801 gttggaccct gagcagaatg ccaacttcct ggaccactac ctggatgtgc cagtggacct
     1861 gtccaaggtg ctattcatct gcacagccaa cgtcactgac actataccgg agccactaag
     1921 ggatcgcatg gagatgatca atgtgtcagg ctatgtagca caggagaagc tggccattgc
     1981 agagcggtac ctggtgccac aggcccgcac cctgtgtggc ctagacgaga gcaaggccca
     2041 actgtcagcg acagtgctca ctctactcat caaacagtac tgcagggaaa gtggtgtgcg
     2101 caacctgcag aagcaggtgg agaaggtgct gcgcaaggct gcatacaaga ttgtaagtgg
     2161 agaggcccag acagtgcacg tgacacctga gaacctgcaa gactttgtag ggaagccagt
     2221 gttcacagtg gagcgcatgt atgatgtcac gcctcctggt gtggtcatgg gtttggcctg
     2281 gactgccatg ggaggctcca cattgttcgt ggagacatct ttaaggaggc cccagcctag
     2341 tggcagcaag gaggacaagg atggcagcct agaggtgaca ggtcagctag gagatgtcat
     2401 gaaagagagt gcccgcatag cctacacctt tgcccgtgcc ttcctgatgg agcaggaccc
     2461 tgaaaatgac tttctggtca catcccacat ccacctgcat gtgcctgagg gcgctacccc
     2521 caaggatggc cctagtgcag gttgcaccat tgtcactgca ttgctgtccc tagctctggg
     2581 gcagccagtg ttgcagaacc tggccatgac tggggaagtc tccctcactg gtaaagtgtt
     2641 gcctgtgggt ggcatcaagg agaagaccat tgcggctaag cgtgcgggag tgacctgcat
     2701 cattttgcct gctgagaaca ggaaggactt ctcagacttg gctcccttca tcacagaggg
     2761 cctggaggtt cacttcgtgg aacactaccg cgacatcttc cgaattgcct tccccctgcg
     2821 agagcaccag gaagcactgg ctgtggaaag atgatggggg tgcagtgggg taggggggtc
     2881 ttaggactaa ataatcatgg tgtggtgggg ccacaagtac agctgtaaaa tcatgagtaa
     2941 aagaaagcct ttcccaaaaa aaaaaaaaa
//
