LOCUS       NM_001108358            2790 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ligand of numb-protein X 1 (Lnx1), mRNA.
ACCESSION   NM_001108358 XM_001067995 XM_001068052 XM_001068098 XM_001068150
            XM_341204
VERSION     NM_001108358.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2790)
  AUTHORS   de la Rocha-Munoz A, Nunez E, Arribas-Gonzalez E, Lopez-Corcuera B,
            Aragon C and de Juan-Sanz J.
  TITLE     E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the
            presynaptic glycine transporter GlyT2
  JOURNAL   Sci Rep 9 (1), 14944 (2019)
   PUBMED   31628376
  REMARK    GeneRIF: E3 ubiquitin ligases LNX1 and LNX2 are major regulators of
            the presynaptic glycine transporter GlyT2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2790)
  AUTHORS   Nie J, McGill MA, Dermer M, Dho SE, Wolting CD and McGlade CJ.
  TITLE     LNX functions as a RING type E3 ubiquitin ligase that targets the
            cell fate determinant Numb for ubiquitin-dependent degradation
  JOURNAL   EMBO J 21 (1-2), 93-102 (2002)
   PUBMED   11782429
REFERENCE   3  (bases 1 to 2790)
  AUTHORS   Rice DS, Northcutt GM and Kurschner C.
  TITLE     The Lnx family proteins function as molecular scaffolds for Numb
            family proteins
  JOURNAL   Mol Cell Neurosci 18 (5), 525-540 (2001)
   PUBMED   11922143
REFERENCE   4  (bases 1 to 2790)
  AUTHORS   Dho SE, Jacob S, Wolting CD, French MB, Rohrschneider LR and
            McGlade CJ.
  TITLE     The mammalian numb phosphotyrosine-binding domain. Characterization
            of binding specificity and identification of a novel PDZ
            domain-containing numb binding protein, LNX
  JOURNAL   J Biol Chem 273 (15), 9179-9187 (1998)
   PUBMED   9535908
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473981.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001067995.1, XM_001068098.1, XM_001068052.1, XM_001068150.1,
            XM_341204.3.
            
            ##Evidence-Data-START##
            CDS exon combination :: EU219404.1, EU219405.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN06621351, SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2790
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..2790
                     /gene="Lnx1"
                     /note="ligand of numb-protein X 1"
                     /db_xref="GeneID:360926"
                     /db_xref="RGD:1308159"
     exon            1..105
                     /gene="Lnx1"
                     /inference="alignment:Splign:2.1.0"
     exon            106..582
                     /gene="Lnx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..2377
                     /gene="Lnx1"
                     /EC_number="6.3.2.19"
                     /note="ligand of numb-protein X 1, E3 ubiquitin protein
                     ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase LNX"
                     /protein_id="NP_001101828.1"
                     /db_xref="GeneID:360926"
                     /db_xref="RGD:1308159"
                     /translation="MNQPDLADDPDPSPEPLCVVCGQNHSPEENHFYTYTEDVDDDLV
                     CHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPVDRKPVVLQHCKKSNILVNKLL
                     NKLLVNCPFTEHCSEVLQRCNLQYHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLT
                     ATTLSPEVSAAATISLMTDEPGLDNPAYTSSVEDGEPVTNPSDTGRSNRTRARPFERS
                     TMRSRSFKKINRALSALRRTKSGSAVANHADQGRDNSENDTVPEVFPRLFHLIPDGEI
                     TSIKINRVDPNESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGM
                     DISNVPHNYAVRLLRQPCQVLRLTVLREQKFRSRSNAPAPDSYGPRDDSFHVILNKSS
                     PEEQLGIKLVRRVDEPGVFIFNVLNGGVADRHGQLEENDRVLAINGHDLRFGSPESAA
                     HLIQASERRVHLVVSRQVRQPSPDIFQEAGCISNGQQSPVSGERSTSSKPAATCHEKV
                     VSVQKDPNESLGMTVGGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVNGIE
                     LTEVSRTEAVAILKSTPSSVVLKALEVKEQETQEDCSPAALDSNHNVTPPGDWSPSWV
                     MWLELPQYLYNCKDVILRRNTAGSLGFCIVGGYEEYSGNQPFFIKSIVEGTPAYNDGR
                     IRCGDILLAVNGRSTSGMMHACLARMLKELKGKITLTIASWPGTFL"
     exon            583..824
                     /gene="Lnx1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..977
                     /gene="Lnx1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1180
                     /gene="Lnx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1552
                     /gene="Lnx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1687
                     /gene="Lnx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1856
                     /gene="Lnx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2082
                     /gene="Lnx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2241
                     /gene="Lnx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2790
                     /gene="Lnx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagttgaga ccagtcacag ctcaggcagc cctagaagct tctggcacag ggatggaggc
       61 gggctggtga ctgctgcttt gaaagcccca gacatctttg aacaggtttg catgtgggtg
      121 actcttagaa tatcttgacc tgcccctgag gaaagtctgc tctcctgggt ttcctaatcc
      181 ctactcagcc atgaaccaac cagaccttgc tgacgaccca gatcccagcc ccgagcccct
      241 gtgcgtagtg tgtggccaaa accactcccc agaggaaaac cacttctaca catacacaga
      301 agatgtagac gacgacctcg tatgccacat ctgcctacaa gcattgctag accctctgga
      361 cactccgtgt ggacacacct actgtaccct gtgtctcacc aacttcctgg tggagaagga
      421 cttctgccct gtggatcgaa agcctgtggt tctgcagcac tgcaagaaat ccaacatctt
      481 ggtcaacaag cttctcaaca agctgttggt caactgccca ttcacagagc actgctccga
      541 ggtgctccag cgctgcaatc tccagtatca tttccagacc agctgcaaag gggcctccca
      601 ctatggcctg accaaagaca ggaaaagacg ctcacaagat ggctgccctg atggttgcgc
      661 cagcctcacg gcaacgacgc tctccccaga ggtttctgct gctgccacca tctctttaat
      721 gacagacgag cctggcctag acaatcctgc ctacacgtcc tcagtggagg atggtgaacc
      781 ggtaaccaac ccctcagaca ctggccggag caaccgaacc agggcacggc cctttgagcg
      841 ctccactatg agaagccgct ctttcaaaaa gatcaaccga gccctgagtg ctctccgaag
      901 gacgaagagt ggaagtgctg ttgccaacca cgctgaccag ggcagggaca actctgagaa
      961 cgacactgtc cccgaagtct tcccaaggtt gtttcacctg attccagatg gtgaaattac
     1021 aagcatcaag atcaatagag tggatcccaa tgaaagcctc tccataaggc ttgtgggagg
     1081 cagcgagacc ccgctggtcc acatcatcat ccagcatatt tatcgtgatg gagtgattgc
     1141 cagagatgga cgactgctgc caggagacat cattctcaag gtcaatggca tggacatcag
     1201 caatgtccct cataactatg ccgtgcggct cctgcggcag ccctgccagg tgctacggct
     1261 aacggtgctg cgggaacaga agttccgtag cagaagcaat gctcctgcgc cggactccta
     1321 cggacctcgg gatgacagct tccatgtaat cctcaacaaa agcagccctg aggagcagct
     1381 tggcataaag ctggtgcgca gggtggatga gcccggggtg ttcatcttca acgtgctgaa
     1441 tggcggtgtt gccgaccgac acggccagct ggaggagaat gatcgtgtgt tggccatcaa
     1501 cggacatgac cttcgatttg gcagtccaga gagcgcagct catctgattc aggccagtga
     1561 aagacgtgtt cacctcgtcg tgtcccgcca ggttcgacag cccagcccag acatctttca
     1621 agaagctggc tgcatcagca acggccagca gtctcctgtc tcaggggaga ggagcacatc
     1681 ttctaagcct gcagccactt gtcatgagaa ggttgtaagt gtccaaaaag accccaacga
     1741 atctctcggc atgaccgttg gagggggagc atcacacaga gaatgggact tgcccatcta
     1801 tgtcatcagt gttgagcccg gaggagtcat aagcagagac ggaagaataa aaacaggtga
     1861 cattttattg aatgtgaatg ggattgagct cacagaggtc agccggacag aggccgttgc
     1921 catactgaag agcacaccct cctcagtggt actcaaagcc ttggaagtca aggaacagga
     1981 gacccaggaa gactgcagcc cagcagccct ggactccaac cacaacgtga ccccgcctgg
     2041 tgactggtcc ccatcctggg tcatgtggct ggaattacca cagtacttat ataactgtaa
     2101 ggatgtgata ctacgaagga acacagcggg aagcctgggc ttctgcattg tgggaggtta
     2161 tgaagaatac agtggtaacc aacctttttt tatcaaatcc atcgtcgagg gaacacccgc
     2221 gtataatgat ggaagaatta gatgtggtga cattcttctt gctgtcaacg gcagaagcac
     2281 gtcggggatg atgcacgcct gcttagcgag gatgctcaaa gaactcaaag ggaaaattac
     2341 tctcaccatt gcttcctggc ctggtacttt tttataaaac caatgatgga tcttagaaaa
     2401 accacaaata ggctagataa aattgtattt atcttgtcga tttttatatt taaagaatat
     2461 attgtaaaaa aaaaaagcca gaaaaagtat gacttatgaa aacaagttac acatcagaga
     2521 atgttctcaa aaataaaaac taatgttaat ttttatttgg tgtggaggat ttctcatcac
     2581 tccaaatctt ttaagtttct atttttttaa ttcaataaaa agcccataaa aacttacatg
     2641 gtttgtatgc cacacttaat tcaaggcaac gtcaaatgtg gtagaagtgg agttgaagac
     2701 acagcacatt atggccattt cagtttaatg gcggaggatt tgaacaagag atgaatatct
     2761 tcttctaagt gaccgcagtc ctcttactgg
//
